program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

Neurotransmitter, Synapse

1-P1-0114:0015:30 BARP regulates the dynamics of voltage-dependent Ca2+ channel complexes at dendritic spine Yoshihiro Matsunaga¹, Akito Nakao¹, Mizuki Omori¹, Taketoshi Kajimoto^1,2, Yasuo Mori¹ ¹Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ., ²Div. Biochem. Kobe Univ. Grad. Sch. Med.

1-P1-0214:0015:30 Presynaptic inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons in young-adult mice. Etsuko Suzuki, Toshihiko Momiyama Department of pharmacology, Jikei university school of medicine

1-P1-0314:0015:30 Involvement of NO cascade in AT₁ receptor mediated effects of angiotensin II on excitatory synaptic transmission in the rat nucleus tractus. Yoshiaki Ohi, Daisuke Kodama, Akira Haji Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.

1-P1-0414:0015:30 Evaluation of the effect of levetiracetam on methamphetamine-induced hyperactivity in Sv2a^L174Q rats Saki Shimizu, Yui Mimaki, Sayaka Jinno, Shiho Taruya, Tadao Serikawa, Yukihiro Ohno Dept. Pharmacol., Osaka Univ. Pharm. Sci.

1-P1-0514:0015:30 Effect of estradiol on behavioral selection for pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis Kiyoshiro Fukui, Keiichiro Sato, Masabumi Minami, Taiju Amano Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan

1-P1-0614:0015:30 Lysophosphatidylethanolamines with different fatty acid lengths stimulate neurite outgrowth in cultured cortical neurons through distinct signaling cascades Yoshida Hironori^1,3, Kazutoshi Hisano^2,3, Shiori Kawase⁴, Tetsuhiko Mimura^2,3, Hisao Haniu³, Tamotsu Tsukahara⁵, Taiga Kurihara⁶, Yoshikazu Matsuda⁷, Naoto Saito³, Takeshi Uemura^3,4 ¹Grad. Sch. of Sci. ＆ Tech., Shinshu Univ., Nagano, Japan, ²Grad. Sch. of Med., Sci. ＆ Tech., Shinshu Univ., Nagano, Japan, ³IBS-ICCER., Shinshu Univ., Nagano, Japan, ⁴Div. of Gene Res., Res. Cent. for Supports to Advanced Sci., Shinshu Univ., Nagano, Japan, ⁵Dept. Pharmcol. Therap. Innov., Nagasaki Univ., inst. Biomed. Sci., Nagasaki, Japan, ⁶Div. Microbiol. & Mol. Cell. Biol., Nihon Pharmaceutical Univ., Saitama, Japan, ⁷Div. of Clin. Pharm. & Pharmaceut., Nihon Pharmaceutical Univ., Saitama, Japan

1-P1-0714:0015:30 Alteration of parvalbumin expression and perineuronal nets formation in the anterior cingulate cortex of Fabp3 KO mice Yui Yamamoto^1,2, Yuji Owada², Kohji Fukunaga³, Keiju Kamijo¹ ¹Dept. Anatomy, Tohoku Med. and Pharm. Univ., ²Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med., ³Dept. Pharmacology, Tohoku Univ. Grad. Sch. Pharm.

1-P1-0814:0015:30 E3 Ubiquitin Ligase HRD1 regulates the Serotonin Transporter Function Taguchi Kei¹, Masayuki Kaneko³, Serika Motoike², Kana Harada¹, Izumi Hide¹, Shigeru Tanaka¹, Norio Sakai¹ ¹Department of Molecular and Pharmacological Neuroscience, ²Department of Dental Anesthesiology Graduate School of Biomedical and Health Sciences, Hiroshima University, ³Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences

1-P1-0914:0015:30 Regulation of nicotine-induced tremor by the dopaminergic nervous system Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Chihiro Takashima, Kana Tsujimura, Kazuya Horikawa, Yukihiro Ohno Dept. Pharmacol., Osaka Univ. Pharm. Sci.

1-P1-1014:0015:30 Applying Ca²⁺ Image Sensor to visualize extracellular Ca²⁺ dynamics in hippocampus. Parajuli Bijay¹, Hideo Doi³, Eiji Shigetomi^1,2, Youichi Shinozaki^1,2, Toshihiko Noda^3,4, Kazuhiro Takahashi³, Kazuaki Sawada³, Schuichi Koizumi^1,2 ¹1Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan, ²Yamanashi Interdisciplinary Brain-Immune Research Center (YiBIC), University of Yamanashi, Yamanashi, Japan, ³Integrated Biosensor. MEMS group, Department of Electrical and Electronic Information Engineering,, ⁴Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) Toyohashi University of Technology

1-P1-1114:0015:30 Human excitatory amino acid transporters (EAATs) were functional in the human induced pluripotent stem cell (hiPSC)-derived human neural networks Kanako Takahashi¹, Kaori Chujo¹, Ikuro Suzuki², Kaoru Sato¹ ¹Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci.,, ²Dept. Electro., Grad. Sch. Engineering, Tohoku Inst. Tech.,

1-P1-1214:0015:30 Expanding the repertoire of the genetically-encoded fluorescent transmitter sensors Daisuke Ino Dept. Cell Biol Histol., Grad. Sch. Med., Kanazawa Univ.

Poster Sessions

Glia Cell 1, Cerebral organoid

1-P1-1314:0015:30 Degradation of oligomeric α-Synuclein in brain pericytes is enhanced by cyclosporin A Shinya Dohgu¹, Miki Yokoya¹, Fuyuko Takata¹, Junichi Matsumoto¹, Takuro Iwao¹, Kazunori Sano², Yasufumi Kataoka¹ ¹Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., ²Dept. Physiol. & Pharmacol., Fac. Pharmaceut. Sci., Fukuoka Univ.

1-P1-1414:0015:30 Brain pericytes increase sodium-dependent glutamate uptake in astrocytes. Fuyuko Takata¹, Kenta Sakai^1,2, Takuro Iwao^1,2, Junichi Matsumoto², Yasufumi Kataoka¹, Atsushi Yamauchi², Shinya Dohgu¹ ¹Department of Pharmaceutical Care and Health Sciences, ²Department of Pharmaceutical Care and Health Sciences

1-P1-1514:0015:30 Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice Koichi Kawahara, Yukina Kojima, Natsuki Kumakura, Masaaki Sano, Kota Hosokai, Takumi Yamada, Takuya Hasegawa, Takehiko Maeda Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.

1-P1-1614:0015:30 Cholesterol induced calcium oscillation found in astrocytes Adachi Chihiro, Takafumi Inoue Dept. Life. Sci. & Med. Biosci. Waseda Univ.

1-P1-1714:0015:30 Zinc-aggravated M1 microglia suppress astrocytic engulfing activity via P2X7 receptors Youichirou Higashi¹, Takaaki Aratake^1,2, Tomoya Hamada¹, Takahiro Shimizu¹, Shogo Shimizu¹, Suo Zou¹, Masaki Yamamoto¹, Rina Nakamura¹, Toshifumi Akizawa¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., ²JSPS Research Fellow

1-P1-1814:0015:30 Prostaglandin E₂ increases the expression of cyclooxygenase-2 protein in microglia. Takayuki Nagano, Naohiko Tsuda, Kenichi Fujimura, Yuji Ikezawa, Yuki Higashi, Shinya Kimura H., Motohiko Takemura Dept. Pharmacol., Hyogo Coll. Med.

1-P1-1914:0015:30 Study of immunocytochemistry in expression of nucleoside transporter ENT3 in astrocytes Koh-ichi Tanaka^1,2,3, Wataru Suzuki¹, Kento Igarashi^1,2, Kazuo Tomita^1,2, Nobue Kitanaka³, Junichi Kitanaka³, Tomoaki Sato², Motohiko Takemura³ ¹Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ²Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci., ³Dept. Pharmacol., Hyogo Col. Med.

1-P1-2014:0015:30 An in vivo macroscopic Ca²⁺ imaging method for analysis of astrocytic Ca²⁺ activities in neurodegenerative disease model mice Yuki Motegi, Masamitsu Iino, Kazunori Kanemaru Division of Cellular and Molecular Pharmacology, Nihon University School of Medicine

1-P1-2114:0015:30 Three-dimensional co-culture model using human iPSC derived brain organoid and microglia-like cells Mayuko Takata, Kaneyasu Nishimura, Kazuyuki Takata Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

1-P1-2214:0015:30 The role of nicotinic acetylcholine receptors on differentiation of iPSC-derived macrophages and dopaminergic neurons Koki Harada¹, Takeshi Kato¹, Kaneyasu Nishimura¹, Masahiro Hirao¹, Shun Shimohama², Kazuyuki Takata¹ ¹Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan, ²Dept. Neurol., Sapporo Med. Univ. Sch. of Med., Sapporo, Japan

1-P1-2314:0015:30 Robust induction of nigro-striatal neurons from human induced pluripotent stem cells by small compound-based signal controlling Kaneyasu Nishimura, Naoya Amimoto, Takeshi Kato, Masahiro Hirao, Kazuyuki Takata Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., Kyoto, Japan

1-P1-2414:0015:30 Toward the generation of thalamic organoids from human induced pluripotent stem cells Masatoshi Nishimura¹, Nao Morimoto^1,2, Fumitaka Osakada^1,2,3 ¹Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University, Japan, ²Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University, Japan, ³Institute of Nano-Life-Systems, Institutes for Innovation for Future Society, Nagoya University, Japan

1-P1-2514:0015:30 Generation of cortical organoids with axial polarity from marmoset embryonic stem cells Tomoki Kodera¹, Taiki Hara^1,2, Nao Morimoto^1,3, Fumitaka Osakada^1,3 ¹Lab. of Cell. Pharmacol., Grad. Sch. of Pharmaseut. Sci., Nagoya Univ., ²Mitsubishi Tanabe Pharma Corp., ³Lab. of Neural Info. Processing, Inst. for Adv. Res., Nagoya Univ.

Poster Sessions

Neurodegeneration

1-P1-2614:0015:30 Astrocyte-microglia interaction promotes rotenone-induced dopaminergic neurotoxicity Ikuko Miyazaki¹, Ryo Kikuoka¹, Nami Isooka¹, Shinki Murakami¹, Chiharu Sogawa², Norio Sogawa³, Yoshihisa Kitamura⁴, Masato Asanuma¹ ¹Dept. of Medical Neurobiology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., ²Dept. of Dental Pharmacology, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., ³Dept. of Dental Pharmacology, Matsumoto Dental Univ., ⁴Dept. of Pharmaceutical Care and Health Sciences, Sch. of Pharmacy, Shujitsu Univ.

1-P1-2714:0015:30 Inhibitory effect of neurite outgrowth via glycer-AGEs dependent β-tubulin abnormal aggregation Ryuto Nasu¹, Furukawa Ayako¹, Masayoshi Takeuchi², Yoshiki Koriyama¹ ¹Grad. Sch. of Pharm. Sci., Suzuka Univ. of Med. Sci., ²Dept. of Adv. Med., Kanazawa Med. Univ.

1-P1-2814:0015:30 Construction of PDGFRβ activation system using optogenetics. Kimura Yuna, Masatoshi Inden, Hisaka Kurita, Isao Hozumi Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.

1-P1-2914:0015:30 High glucose enhances oxidative stress-induced cell death in cultured neuronal cells Yuki Ishimaru, Reina Miura, Akinori Tanimura, Tokiyo Yamaguchi, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda Lab. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.

1-P1-3014:0015:30 Effects of the Alzheimer's disease drug rivastigmine on nerve growth factor via sigma receptor Matsushima Yukari¹, Kazuki Terada², Kaoru Umehara¹, Iwao Sakakibara¹ ¹Department of Kampo and Natural Product Chemistry, Faculty of Pharmaceutical Sciences,Yokohama University of Pharmacy, ²Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University

1-P1-3114:0015:30 Effect of forest bioresources for amyloid-β protein and working memory performance Iwasa Kensuke¹, Kei Maruyama¹, Masashi Asai², Kuniyoshi Shimizu³, Keisuke Yoshikawa¹ ¹Dept. Pharmacol., Saitama Med University., ²Dept. Faculty of Pharmacy, Yokohama University of Pharmacy., ³Dept. agro-environmental sciences, Faculty of Agriculture, Graduate School of Kyushu University.

1-P1-3214:0015:30 Neuropathological analysis of Niemann-Pick disease type C using patient-derived iPSCs Ryo Saito^1,2, Takashi Miyajima^1,3, Chen Wu^1,3, Arif Hossain Mohammad^1,2, Miyo Munakata¹, Ken Suzuki¹, Takeo Iwamoto², Takumi Era⁴, Yoshikatsu Eto^1,5 ¹Adv. Clin. Res. Ctr., Southern Tohoku Res. Inst. for Neurosci., ²Core Res. Facilities for Basic Sci., The Jikei Univ. Sch. of Med., ³Rare disease res. ctr., AnGes Inc., ⁴Dept. of Cell Modulation, IMEG, Kumamoto Univ., ⁵The Jikei Univ. Sch. of Med.

1-P1-3314:0015:30 D-Cysteine regulates chaperone-mediated autophagy and microautophagy through the generation of hydrogen sulfide. Ueda Erika¹, Takahiro Seki^1,2, Ayumu Konno³, Hirokazu Hirai³, Yuki Kurauchi^1,2, Hiroshi Katsuki^1,2 ¹Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, ²Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci, Kumamoto Univ, ³Dept Neurphysiol Neural Rep, Gunma Univ Grad Sch Med

1-P1-3414:0015:30 Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p Chisato Kinoshita¹, Nobuko Matsumura¹, Koji Aoyama¹, Toshio Nakaki^1,2 ¹Dept. Pharmacol., Teikyo Univ. Sch. Med., ²Fac. Pharma-Sci., Teikyo Univ.

1-P1-3514:0015:30 Involvement of cochlear macrophages in the loss of inner hair cell synapses by noise exposure Taro Yamaguchi, Yusuke Onaka, Masanori Yoneyama Lab. Pharmacol. Sci., Sestunan Univ.

Poster Sessions

Cerebral Circulation, Metabolism, Ischemia,Sleep, Awake, Biological rhythm

1-P1-3614:0015:30 Establishment of a new tri-culture system for elucidating crosstalk mechanisms between brain microvascular endothelial system and central nervous system in Alzheimer’s disease brains Tomoya Sasahara^1,2, Minako Hoshi^1,3 ¹Depart. Brain and Neurodegener Dis Res, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, ²Research & Development Division, TAO Health Life Pharma, ³Depart. Anat and Dev Biol, Graduate School of Medicine, Kyoto Univ.

1-P1-3714:0015:30 Hypercholesterolemia may attenuate cerebral aneurysm Kazuya Hokamura^1,3, Hiroshi Makino², Takayuki Iwaki¹, Ryou Imai², Tetsuro Kimura², Yoshiki Nakajima², Kazuo Umemura¹ ¹Dept. Pharm., Hamamatsu Univ. Sch. of Med., ²Dept., Anesth., Hamamatsu Univ. Sch. of Med., ³Medical Edu., Hamamatsu Univ. Sch. of Med.

1-P1-3814:0015:30 CUD003, a novel synthetic derivative of curcumin, can mitigate middle cerebral artery occlusion (MCAO)-induced ischemic injury by suppressing inflammation in rats Hirokazu Matsuzaki¹, Nazuki Sekine¹, Hayato Sato¹, Azumi Horikoshi², Takashi Asano¹, Naohiro Iwata³, Xuan Meiyan², Jun Takayama², Yuan Bo¹, Yasihide Hibino³, Takeshi Sakamoto², Mari Okazaki¹ ¹Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., ²Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ., ³Immunobiochem., Fac. Pharm. Sci., Josai Univ.

1-P1-3914:0015:30 Effect of traditional Japanese medicine, ninjin’yoeito, on cerebral blood flow in urethane-anesthetized mice Nobuhiro Watanabe, Kaori Iimura, Harumi Hotta Dep. Auton. Neurosci., Tokyo Metro. Inst. Gerontol.

1-P1-4014:0015:30 Effects of IL-6 family cytokines on blood-brain barrier function Sho Hamada, Natsuko Hitora-Imamura, Masabumi Minami Department of Pharmacology, Hokkaido University

1-P1-4114:0015:30 Transport of docosahexaenoic acid across the blood–brain barrier is decreased in aged mice Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yasufumi Kataoka, Shinya Dohgu Fukuoka University

1-P1-4214:0015:30 Reptiles, sleep, and the claustrum Norimoto Hiroaki¹, Lorenz Fenk¹, Hsing-Hsi Li¹, Maria Tosches^1,2, Tatiana Tatiana¹, David Hain¹, Sam Reiter^1,3, Riho Kobayashi^1,4, Gilles Laurent¹ ¹Max Planck Institute for Brain Research, ²Columbia University・Department of Biological Sciences, ³Computational Neuroethology Unit, ⁴Nagoya City University・Graduate School of Pharmaceutical Sciences

1-P1-4314:0015:30 Influence of circadian rhythm on the delayed recovery from isoflurane anesthesia induced by hypnotics in mice Yoshinori Iba, Atsunobu Sugano, Hiroki Murai, Syunpei Horiguchi, Yuki Amano Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ.

1-P1-4414:0015:30 Real time recording of Period1 gene in the central and peripheral tissues of the freely moving streptozotocin-treated diabetic mouse. Nagasawa Koki¹, Yuki Ishii¹, Ryosuke Sato¹, Mizuki Nakaya¹, Juri Hayashi¹, Yukina Yoshida¹, Masayori Ishikawa², Michitaka Ozaki³, Kazuko Hamada¹, Toshiyuki Hamada¹ ¹IUHW.Dept.Phamaceut, ²Hokkaido.Uni.Fac.Health Sci, ³Hokkaido.Uni.Fac.Health Sci

1-P1-4514:0015:30 The analysis of Period1 gene expression in freely moving mouse using micro PMT system. Yuki Ishii¹, Juri Hayashi¹, Mizuki Nakaya¹, Ryosuke Sato¹, Yukina Yoshida¹, Kouki Nagasawa¹, Masayori Ishikawa², Michitaka Ozaki³, Kazuko Hamada¹, Toshiyuki Hamada¹ ¹IUHW.Dept.Phamaceut, ²Hokkaido,Uni.Fac.Heaith Sci., ³Hokkaido,Uni.Fac.Heaith Sci.

Late-Breaking Session

1-P1-LB4614:0015:30 Clustering of acetylcholine receptors in a muscular atrophy model Yuko Fukunaga, Yo Kimura, Hina Kikuchi, Haruka Furuyama Animal Risk Management, Chiba Institute of Science

1-P1-LB4714:0015:30 Differential projection patterns between the insular and medial prefrontal cortices to the the nucleus accumbens in rats Yuka Nakaya, Kiyofumi Yamamoto, Masayuki Kobayashi Department of Pharmacology, Nihon University School of Dentistry

1-P1-LB4814:0015:30 Presynaptic NK1 receptor activation by substance P suppresses EPSCs via nitric oxide synthesis in the rat insular cortex Matsumura Sachie, Kiyofumi Yamamoto, Masayuki Kobayashi Dept. Pharmacol., Nihon Univ. Sch. of Dent.

1-P1-LB4914:0015:30 Assessment of CB agonist CP55940 in maturity for rat hippocampal neurons using a high-throughput immunocytochemical assay and image digital analysis Mitsuoka Toshinari¹, Shogo Mase^1,2, Noriko Koganezawa², Yuichi Katou¹, Izuo Tutui¹, Tomoaki Shirao², Yuko Sekino¹ ¹Lab. HCBDD, Grad. Sch. Pharm, Univ Tokyo, ²Dept Pharmacol, Gunma Univ, Grad Sch Med.

1-P1-LB5014:0015:30 Deficit of cognitive function induced by the reduction of mice hippocampal Shati/Nat8l Ikejima Daiki¹, Shin-ichi Muramatsu^2,3, Atsumi Nitta¹ ¹Grad. Sch.Med. Pharm Sci., Toyama Univ, ²Jichi Medical Univ, ³Tokyo Univ

March 8 (Mon) Room P1