March 8 (Mon) Room P2

Poster Sessions
Cardiovascular disorders, Vascular Endothelium
1-P2-0114:0015:30
Moxifloxacin exacerbate aortic aneurysm and aortic dissection by increasing osteopontin protein expressions
Koshun Inada1, Mitsuhisa Koga2, Atsushi Yamauchi3
1Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Drug Design and Drug Delivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 3Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,
1-P2-0214:0015:30
Role of tissue type plasminogen activator in a murine model of type IIa human familial hypercholesterolemia
Arakawa Tomohiro1, Takayuki Iwaki1, Masamitsu Takaba2, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Third Div., Dept. Intern. Med., Hamamatsu Univ. Sch. Med.
1-P2-0314:0015:30
Effect of pretreatment with diltiazem on mast cell degranulation by adrenaline treatment in anaphylactic rats.
Sawano Mayu, Wakana Takatsu, Seiichiro Kano
Fac.Pharm.Sci.,Hokkaido Univ of Sci.
1-P2-0414:0015:30
Development and functional analysis of novel PCSK9/LDLR interaction inhibitors for hypercholesterolemia treatment
Takumi Yokoyama1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ., 5JST, PRESTO
1-P2-0514:0015:30
Effect of uridine triphosphate and uridine diphosphate on vascular function in the carotid arteries of spontaneously hypertensive rats
Katome Tomoki, Takayuki Matsumoto, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.
1-P2-0614:0015:30
Activation of transient receptor potential vanilloid 4 channels dilates the rat retinal arterioles via the production and release of nitric oxide and the activation of large-conductance Ca2+-activated K+ channels in vivo
Asami Mori1,2, Kazuki Takeda1, Kenji Sakamoto1,2, Tsutomu Nakahara1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.
1-P2-0714:0015:30
Endothelial Function in Coronary Arteries from Pneumonia-Infected Pigs
Masashi Tawa, Katsuya Nakano, Qiang He, Takayoshi Masuoka, Takaharu Ishibashi
Dept. Pharmacol., Kanazawa Med. Univ.
1-P2-0814:0015:30
Benzodiazepines and non-benzodiazepine drugs have direct vasorelaxant effects
Satomi Kagota1, Kana Morikawa1, Hirotake Ishida2, Junko Chimoto2, Kana Fumoto1, Shizuo Yamada,2, Kazumasa Shinozuka1
1Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ, 2Centr. for Pharm-Food Res, Univ. of Shizuoka
1-P2-0914:0015:30
Apelin attenuated advanced glycation end products-induced cell death in mouse endothelial cell line bEnd.3.
Yasuhiro Yoshioka, Haruku Yamamoto, Shigenori Yoshizawa, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., Osaka 573-0101, Japan
1-P2-1014:0015:30
Effects of gas phase extract of cigarette smoke generated from heated tobacco and burned cigarette on human vascular endothelial cells
Takahiro Horinouchi1, Yuichi Mazaki1, Soichi Miwa2
1Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ. Sapporo 060-8638, Japan., 2Toyooka Gen. Hosp., Hyogo 668-8501, Japan.
1-P2-1114:0015:30
Microvascular endothelial model that can predict the inflammatory responses in human microvessels with high reproducibility: Culture model of an hCMEC/D3 cell line fabricated in a collagen vitrigel membrane chamber
Miaki Uzu, Toshiaki Takezawa
Vitrigel Project, Institute of Agrobiological Sciences, NARO
Poster Sessions
Digestive Organ
1-P2-1214:0015:30
Retinoic acid promotes barrier functions in human iPS cell-derived intestinal epithelium
Shigeru Yamada1,2, Yasunari Kanda1
1Div. Pharmacol, NIHS, 2PEIJ
1-P2-1314:0015:30
Maintenance of intestinal homeostasis by NAD metabolism
Yaku Keisuke, Takashi Nakagawa
Dept. of Mol. and Med. Pharmacol., Fac. of Med., Univ. of Toyama
1-P2-1414:0015:30
Oral administration of 5,6-DiHETE attenuates DSS-induced colitis in mice
Shinya Takenouchi, Daiki Imai, Koji Kobayashi, Tatsuro Nakamura, Nanae Nagata, Takahisa Murata
Dept. Animal Radiology, Univ. Tokyo
1-P2-1514:0015:30
Role of TRPM2 expressed in macrophages in TNBS-induced colonic fibrosis in mice
Nakamoto Tomohiro1, Kenjiro Matsumoto1, Hiroyuki Yasuda1, Yasuo Mori2, Shinichi Kato1
1Dept. of Pharmacol. and Exp. Therap., Kyoto Pharmaceut. Univ., 2Dept. of Synthetic Chem. and Biological Chem., Grad. Sch. of Eng., Kyoto Univ.
1-P2-1614:0015:30
Assessment of the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on the contractile responses of guinea pig lower gastrointestinal (LGI) tracts
Keisuke Obara, Keyue Xu, Guanghan Ou, Rikako Inaba, Mirai Kawakita, Ayana Kawaguchi, Rena Kudo, Akari Kurata, Kento Yoshioka, Fumiko Yamaki, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.
1-P2-1714:0015:30
Daikenchuto attenuates visceral pain and suppresses eosinophil infiltration in inflammatory bowel disease in murine models
Kogure Yoko1, Hirosato Kanda1,2,3, Shenglan Wang1,4, Satoshi Yamamoto1, Koichi Noguchi3, Yi Dai1,2,3
1Dept. Pharm. Sch. Pharm. Hyogo Univ. Health Sci., 2Tral Med. Res. Ctr, Chn Med. CI at Hyogo Col. Med., 3Dept. Anat. Neurosci., Hyogo Col. Med., 4Sch. Acup-Mox & Tuina, Beijing Univ. Chn Med.
1-P2-1814:0015:30
Lacking dietary fiber enhances sensitivity to inflammatory stimuli, that results in intestinal hyper-permeability.
Haruki Usuda, Syoma Kanda, Takayuki Okamoto, Koichiro Wada
Dept. Pharmaco., Fac. Med., Shimane Univ.
1-P2-1914:0015:30
Effect of oyster extract on gastrointestinal and myeloid toxicity of 5-FU in rats
Noriyuki Yamazaki1, Suzuki Kohtaro1, Keita Saitoh1, Kohei Araki1, Yuki Ishida1, Hiroki Morikawa1, Takuma Nakajima1, Tohru Nonomura1, Makoto Konno1, Tatsuya Ishida2, Hiroyuki Matsui2, Yoshikazu Matsuda2
1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd
Poster Sessions
Immunity, Inflammation, Allergy 1
1-P2-2014:0015:30
Effect of oyster extract on toxicity and pharmacological action of steroids in rats
Makoto Konno1, Hiroki Morikawa1, Masaharu Igarashi1, Masumi Kikuta1, Hitoshi Goto1, Noriyuki Yamazaki1, Katsura Matsuda2, Tatsuya Ishida2, Hiroyuki Matsui2, Yoshikazu Matsuda2
1New Drug Research Center, Inc., 2Central Research Institute, Japan Clinic Co, Ltd.
1-P2-2114:0015:30
Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve fiber outgrowth through inhibition of the interleukin-31 pathway
Masato Ogura, Kumiko Endo, Toshiyuki Suzuki, Yoshimi Homma
Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
1-P2-2214:0015:30
Loss of skeletal muscle mass influences immune homeostasis and accelerates the disease progression of lupus nephritis
Shuang Liu1, Takeshi Kiyoi2, Masaki Mogi1
1Dept. Pharmacol., Grad. Sch. Med., Ehime Univ., 2ADRES, Ehime Univ.
1-P2-2314:0015:30
Activated coagulation factors induce histamine release of human skin mast cells and peripheral basophils through activation of complement system
Yuhki Yanase1, Yoshimi Matsuo2, Tomoko Kawaguchi2, Kaori Ishii2, Koichiro Ozawa1, Michihiro Hide2
1Dept. of Parmacotherapy, Hiroshima University, 2Dept. of Dermatology, Hiroshima University
1-P2-2414:0015:30
Anti-inflammatory mechanism of Nrf2-ARE activator in chronic contact hypersensitivity model mice
Nonoguchi Mana1, Yuki Takada-Takatori1, Risa Imai1, Namiko Shouno1, Yasuhiko Izumi2,3, Akinori Akaike2,4, Toshiaki Kume2,5, Katsuharu Tsuchida1, Kei-ichi Ozaki1
1Fac. Pharmaceut. Sci., Doshisha Women's Coll., 2Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 3Kobe Pharmaceut. Univ., 4Wakayama Med. Univ., 5Dept. Appl. Pharmacol., Grad. Sch. Medicinal and Pharmaceut. Sci., Univ.Toyama
1-P2-2514:0015:30
A Discussion on the Mechanism of Actions of a gold compound, Auranofin
Masamichi Yamashita
Dept. Biosci. Daily Life, Coll. Biores. Sci., Nihon Univ.
1-P2-2614:0015:30
The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells
Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto, Kazuhito Tsuboi
Kawasaki Med. Sch.
1-P2-2714:0015:30
Upregulation of P2X7 receptor  signaling by interleukin-33 in mouse bone marrow-derived mast cells
Kazuki Yoshida, Yuu Ishida, Masaaki Ito, Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare
1-P2-2814:0015:30
P2Y receptor activation and PI3K(δ) enhance human-derived mast cell degranulation
Haruhisa Nishi1, François Niyonsaba2,3
1Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med., 2Atopy Res. Cent., Grad. Sch. Med., Juntendo Univ., 3Fac. International Liberal Arts
1-P2-2914:0015:30
Development and functional analysis of novel IL-6R/IL-6 interaction inhibitors for autoimmune disease treatment
Yukio Takamori1, Takehiro Ando1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ., 5JST, PRESTO
1-P2-3014:0015:30
Development and functional analysis of novel TNF-alpha/TNFR interaction inhibitors for autoimmune disease treatment
Keita Tsukamoto1, Takehiro Ando1, Yukio Takamori1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ, 5JST, PRESTO
1-P2-3114:0015:30
Transrepression-selective liver X receptor (LXR) ligands regulate inflammasome activation
Sayaka Takahashi1, Kaori Umeda-Endo2, Makoto Makishima2, Hashimoto Yuichi3, Toshiaki Ishizuka1, Minoru Ishikawa4
1National Defense Medical College, 2Nihon University School of Medicin, 3Institute for Quantitative Biosciences, The University of Tokyo, 4Graduate School of Life Sciences, Tohoku University
1-P2-3214:0015:30
Risk management of L-Asparaginase-induced allergy: focusing on the influence of cyclophosphamide
Ai Nogami-Hara1, Yuta Hori1, Chie Mitsuhata1, Koji Kajiyama1, Kentaro Susuki1, Akira Shimada2, Mitsunobu Mio1
1Lab. Pharmacol., Sch. Pharm., Shujitsu Univ., 2Dept. Pediatr. Hematol. Oncol., Okayama Univ.
1-P2-3314:0015:30
Pharmacological evaluation in atopic dermatitis models induced by mite antigen in mice
Nagayama Manami, Ayaka Yamaguchi, Ryota Yagi, Kumiko Kitta, Atsuko Ichikawa, Jun-ichi Fuchikami, Yasuki Akie
CMIC Pharma Science Co., Ltd.
1-P2-3414:0015:30
FK506-binding protein contributes to tacrolimus distribution in red blood cells
Naoki Yoshikawa1, Ayako Matsuo2, Tsubasa Yokota1, Tomomi Iwakiri1, Ryuji Ikeda1
1Dept. Pharm., Univ. Miyazaki Hosp., 2Dept. Respiratory Med., Univ. Miyazaki Hosp.
1-P2-3514:0015:30
Exploring the mechanism of action of maoto, a traditional Japanese medicine, on acute systemic inflammation induced by polyI:C administration
Keisuke Ogura, Ayumi Kadota, Akinori Nishi, Akiko Nakayama, Hitomi Kannno, Yoshiki Ikeda
Tsumura Kampo Research Laboratories, Tsumura and Co.
1-P2-3614:0015:30
Investigation of genetic variants in SARS-CoV-2-interacting molecules of ACE2, TMPRSS2 and TLR3/7/8 across populations
Lee Ji-Won1, In-Hee Lee2, Sek Won Kong2,3, Tadahiro Iimura1
1Dept. Pharmacol., Grad. Sch., Hokkaido Univ., 2Boston Children’s Hospital, 3Harvard Med. Sch.
Poster Sessions
Cancer, Chemotherapy, Antibody Therapy 1
1-P2-3714:0015:30
Development and functional analysis of novel HER3/HRG interaction inhibitors for cancer treatment
Takehiro Ando1, Takumi Yokoyama1, Rina Iwamoto1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ., 5JST, PRESTO
1-P2-3814:0015:30
Development and functional analysis of novel VEGFR2/VEGF interaction inhibitors for angiogenesis inhibition
Horiuchi Daisuke1, Takehiro Ando1, Fuji Daisuke2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Gred. Fac. Interdiscip. Res., Yamanashi Univ., 5JST, PRESTO
1-P2-3914:0015:30
Development and functional analysis of novel PD-L1/PD-1 interaction inhibitors for cancer immunotherapy
Iwamoto Rina1, Takehiro Ando1, Daisuke Horiuchi1, Daisuke Fuji2, Mizuki Yamamoto3, Takashi Kawakami4,5
1Dept. Life Environ. Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 2Dept. Biotechnol., Fac. Life Environ. Sci., Yamanashi Univ., 3Dept. Integr. Appl. Life Sci., Integr. Grad. Sch. Med. Eng. Agr. Sci., Yamanashi Univ., 4Fac. Life Environ. Sci., Grad. Fac. Interdiscip. Res., Yamanashi Univ., 5JST, PRESTO
1-P2-4014:0015:30
Cytotoxic effects of mushroom extracts banked in FMRC
Kenji Takahashi1,2, Atsushi Ishihara2, Toshio Ohta1,2
1Tottori Univ. Joint Dep Vet Med. Vet Pharmacol., 2Tottori Univ. Fac. Agr. FMRC
1-P2-4114:0015:30
Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Hepatocellular Carcinoma Cells
Masato Inazu1,2, Akane Hase1, Kaho Hirai1, Saiichiro Watanabe1, Kaoru Shibata1, Tsuyoshi Yamanaka2
1Inst. Med. Sci., Tokyo Med. Univ., 2Dept. Mol. Preventive Med., Tokyo Med. Univ.
1-P2-4214:0015:30
Dysfunction of DUSP22 induces synthetic lethality in poly(ADP-ribose) glycohydrolase (PARG) knocked down lung cancer cell lines.
Yuka Sasaki1,2, Hiroaki Fujimori2, Takae Onodera1,2, Tadashige Nozaki1,3, Fumiaki Koizumi1,4, Mitsuko Masutani1,2
1Dept. Molecular and Genomic Biomedicine, Grad. Sch. Biomed. Sci. & CBMM, Nagasaki Univ., 2Natl. Cancer Ctr. Res. Inst., 3Dept. Pharmacol. Osaka Dent. Univ.., 4Div. Clin. Res. Support, Komagome Hosp.
1-P2-4314:0015:30
Study of Anti-proliferative Effects of Chaga Mushroom and Panax Notoginseng-containing Traditional Chinese Medical Supplement, Shibe-ria on Dog Bladder Cancer Stem Cells
Yuta Shinohara1,2, Yomogi Sato1, Mohamed Elbadawy1,3, Megumi Yamanaka1, Yuta Goto1, Kimika Hayashi1, Amira Abugomaa1, Tatsuya Usui1, Kazuaki Sasaki1
1Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech., 2Division. Pet Health and Food., Iskara Industry CO., LTD., 3Dept. Pharm., Fac. Vet med., Benha Univ.
1-P2-4414:0015:30
Development of an anti-cancer drug sensitivity test using a urine sample-derived organoid culture for dog bladder cancer
Mori Masahiro, Yomogi Sato, Mohamed Elbadawy, Tatsuya Usui, Kazuaki Sasaki
Lab. of Veterinary Pharmacology, Dept of Veterinary Medicine, Fac. of Agriculture, Tokyo Univ. of Agriculture and Technology
1-P2-4514:0015:30
Establishment of a culture method of the human bladder cancer organoid using the urine sample
Kodai Fujisaka1, Mohamed Elbadawy1,2, Yomogi Sato1, Haru Yamamoto1, Hiroaki Matsumoto3, Hideyasu Matsuyama3, Masahiro Kaneda4, Tatsuya Usui1, Kazuaki Sasaki1
1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 3Department of Urology, Graduate School of Medicine, Yamaguchi University, 4Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
1-P2-4614:0015:30
Establishment of a culture method of the dog lung cancer organoid
Sato Yomogi1, Mohamed Elbadawy1,2, Daigo Azakami3, Masahiro Kaneda4, Tatsuya Usui1, Kazuaki Sasaki1
1Lab. Veterinary Pharmacol., Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech., 2Benha Univ, Fac. Veterinary Med., Dept. Pharmacol., 3Lab. Veterinary Clin. Oncology, Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech., 4Lab. Veterinary Anatomy., Dept. Veterinary Medic., Fac. Agri., Tokyo University of Agri. and Tech.
Late-Breaking Session
1-P2-LB4714:0015:30
Enhancement of myogenic differentiation by MMP inhibition and attenuation of the enhancement effect in senescent cells
Hiroki Sakai1, Takeshi Honda1, Kouetsu Ogasawara2, Masataka Asagiri1
1Yamaguchi Univ. Grad. Sch. Med., 2IDAC. Tohoku Univ.
1-P2-LB4814:0015:30
Changes in expression of fibrosis-related factors in alveolar epithelial cells and macrophages by forced expression of p16
Yasuhiro Takenouchi, Yoshifumi Niiyama, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto
Dept. Pharmacol., Kawasaki Med. Sch.
1-P2-LB4914:0015:30
Signal transduction mechanism for S-allyl-L-cysteine-induced cell proliferation in primary cultures of adult rat hepatocytes
Hajime Moteki, Kazuki Kurihara, Masahiko Ogihara, Mitshtoshi Kimura
Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ.
1-P2-LB5014:0015:30
The oxidative stress response and signaling pathways in diffuse- and intestinal-type gastric cancer.
Shihori Tanabe1, Sabina Quader2, Ryuichi Ono3, Horacio Cabral4, Kazuhiko Aoyagi5, Akihiko Hirose1, Ed Perkins6, Hiroshi Yokozaki7, Hiroki Sasaki8
1Div. Risk Assess., CBSR, Natl. Inst. Health Sci., 2iCONM, 3Div. Cell. Mol. Tox., CBSR, Natl. Inst. Health Sci., 4Grad. Sch. Engineer., The Univ. of Tokyo, 5Dept. Clin. Genomics, FIOC, Natl. Cancer Ctr. Res. Inst., 6USACE ERDC Environ. Lab., 7Dept. Path. Grad. Sch. Med., Kobe Univ., 8Dept. Transl. Oncol., FIOC, Natl. Cancer Ctr. Res. Inst.
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