Neurodevelopmental disorders, including autism spectrum disorder, are a group of early-onset neurological diseases. The pathogenesis of these disorders remains unresolved. These problems could be attributed to using rodents as a model despite many differences in brain functions between rodents and humans. The thalamocortical connections are crucial for relaying sensory signals, and its impediment is associated with neuropsychiatric disorders. However, in vitro human thalamic models for understanding these disorders have been poorly established. Thalamic organoids derived from human induced pluripotent stem cells (hiPSCs) can be used to model these disorders in vitro. Here we aimed to generate thalamus organoids from hiPSCs. hiPSCs were dissociated to single cells and quickly re-aggregated to form organoids. By qPCR analysis and immunostaining, we found the expression of GBX2 and TCF7L2, markers of thalamic progenitors, following that of the caudal forebrain markers PAX6 and OTX2. These results suggest that hiPSCs are differentiated into thalamus-like organoids. We will fuse brain-region-specific organoids, such as cortex-like and thalamus-like organoids, into one 3D assembly of organoids to model higher-level complexity such as inter-regional interaction and neural circuit formation, as well as neuropsychiatric disorders in vitro.