program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

CNS: Neurotransmitter, Synapse 1

1-P-00113:1014:10 Regulation of a synaptic pathway in Autism spectrum disorders Reiko T. Roppongi^1,2,3, Shreya Dhume^2,3, Nirmala Padmanabhan^2,3, Prabhisha Silwal^2,3, Nazmeena Zahra^2,3, Chetan Patil³, Kevin Champagne-Jorgensen^2,3, Michael F. Jackson³, Tomoaki Shirao⁴, Tabrez J. Siddiqui^2,3 ¹Gunma Univ. GIAR, ²Dept. Physiol. & Pathophysiol., U of Manitoba, Winnipeg, MB, Canada, ³Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB, Canada, ⁴1 Dept. Neurobiol Behav, Grad Sch Med, Gunma Univ.

1-P-00213:1014:10 Role of dopamine receptors in modulating nicotine-induced tremor in mice Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Yuika Ishikura, Natsuki Hirata, Mizuki Yasunaga, Yukihiro Ohno Dept. Pharmacol., Osaka Univ. Pharm. Sci.

1-P-00313:1014:10 Oxidative stress-mediated neural cell death induced by nanoparticles Yuji Kamikubo, Yoshie Hashimoto, Yuriko Inoue, Hakushun Sakairi, Takashi Sakurai Dept. Pharmacol. Juntendo Univ. Sch. Med.

1-P-00413:1014:10 Development and phenotypic characterization of GAD67 knockdown mice by using a Tet-off system Shigeo Miyata¹, Toshikazu Kakizaki¹, Kazuyuki Fujihara¹, Touko Hirano², Hideru Obinata², Junichi Nakai³, Manabu Abe⁴, Kenji Sakimura⁴, Kenji Tanaka⁵, Masahiko Watanabe⁶, Yuchio Yanagawa¹ ¹Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ., ²Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ., ³Dept. Oral. Func. Mor., Grad. Sch. Den., Tohoku Univ., ⁴Dept. Animal Model Dev., Brain Res. Inst., Niigata Univ., ⁵Dept. Neuropsych., Sch. Med., Keio Univ., ⁶Dept. Anat., Fac. Med., Hokkaido Univ.

1-P-00513:1014:10 Development of new fluorescent probes for imaging of prosocial signaling in the brain Daisuke Ino Dept. Cell Biol Histol., Grad. Sch. Med., Kanazawa Univ.

1-P-00613:1014:10 NMDA receptor-dependent molecular plasticity in dendritic spines of the cerebral cortex after somatosensory stimulation Kazuya Kuboyama^1,2, Takafumi Inoue³, Yuki Hashimotodani⁴, Takuya Itoh¹, Tohsuke Suzuki¹, Aya Tetsuzawa¹, Ryo Kinoshita¹, Yosuke Ohtsuka¹, Ren Takara¹, Tohru Miyazawa¹, Pooja Gusain², Masakiyo Tawata¹, Masanobu Kano⁴, Maki Yamada^1,2 ¹Dept. Neuropharmacol., Kagawa Sch. Pharma., Tokusima Bunri Univ., ²Inst. Neurosci., Kagawa Sch. Pharma., Tokusima Bunri Univ., ³Dept. Life Sci. Med. Biosci., Sch. Adv. Sci. Eng., Waseda Univ., ⁴Dept. Neurophysiol., Grad. Sch. Med., Univ. Tokyo

Poster Sessions

CNS: Signal Transduction

1-P-00713:1014:10 Differential regulation of dopamine D1 receptor signaling in subregions of the striatum Keita Sugiyama¹, Mahomi Kuroiwa¹, Takahide Shuto¹, Takaichi Fukuda², Akinori Nishi¹ ¹Department of Pharmacology, Kurume University School of Medicine, ²Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kumamoto University

1-P-00813:1014:10 Phosphorylation of Collapsin Response Mediator Protein 1 by Semaphorin 3A-Fyn signaling regulates basal dendritic growth and arborization Aoi Jitsuki-Takahashi¹, Takeshi Kawashima², Susumu Jitsuki³, Yoshio Goshima², Fumio Nakamura¹ ¹Dept. Biochem, Tokyo Women's Medical Univ., ²Dept. Mol Pharmacol and Neurobiol, Grad. Sch. Med., Yokohama City Univ., ³Dept. Physiol, Grad. Sch. Med., Yokohama City Univ.

1-P-00913:1014:10 Inactivation of the A-type current is inhibited by ERK5 phosphorylation of Kv4.2 in PC12 cells. Yurina Kashino¹, Yutaro Obara¹, Yosuke Okamoto¹, Takeo Saneyoshi², Yasunori Hayashi², Kuniaki Ishii¹ ¹Dept. Pharmacol., Fac. Med., Yamagata Univ., ²Dept. Sys-Neuropharmacol., Grad. Sch. Med., Kyoto Univ.

1-P-01013:1014:10 M₂ muscarinic receptors possibly facilitate oxytocin synthesis in the mouse supraoptic nuclei Toshihiro Unno^1,2, Ntsuki Inaba¹, Hiroshi Nagano², Takashi Hashimoto³, Satoshi Iino⁴, Hayato Matsuyama¹, Shouichiro Saito⁵, Yasuyuki Tanahashi⁶ ¹Lab. of Pharmacol., Fac. of Appl. Biol. Sci., Gifu Univ., ²Dept. Pathogenetic Vet. Sci., United Grad. Sch. Vet. Sci., Gifu Univ., ³Dept. Pharmaco., Sch. Med., Aichi Med. Univ., ⁴Dept. Anat., Fac. Med., Univ. Fukui, ⁵Lab. Vet. Anat. Fac Appl. Biol. Sci. Gifu Univ., ⁶Lab. Animal. Med. Sci., Fac. Life Sci., Kyoto Sangyo Univ.

1-P-01113:1014:10 Molecular Mechanism of KCNQ Channels For Reward Behavior Daisuke Tsuboi¹, Takeshi Otsuka², Takushi Shimomura³, Yoshihiro Kubo³, Yasuo Kawaguchi², Kozo Kaibuchi¹ ¹Dept. of Cell Pharmacology, Grad. Sch. of Midicine, Nagoya University, ²Division of Cerebral Circuitry, National Institute of Physiological sciences, ³Division of Biophysics and Neurobilogy, National Institute of Physiological Sciences

1-P-01213:1014:10 Neuronal activity backpropagating in dentate circuit Ayako Ouchi, Motoshige Sato, Yuji Ikegaya Lab of Chem. Pharm., Grad. Sch. Pharm. Sci., Tokyo Univ.

Poster Sessions

CNS: Pain, Sensary Neuron 1

1-P-01313:1014:10 Novel PAC1 receptor antagonists alleviate paclitaxel-induced mechanical allodynia by inhibiting astrocytic activation Arata Inoue¹, Takuya Okada², Naoki Toyooka², Hiroaki Goda³, Atsuro Miyata⁴, Takashi Kurihara⁴, Ichiro Takasaki¹ ¹Dept. Pharm., Grad. Sch. Sci. & Eng. Res., Toyama Univ., Toyama 930-8555, Japan, ²Dept. Bio-funct. Mol. Eng., Grad. Sch. Sci. & Eng. Res., Toyama Univ., Toyama 930-8555, Japan, ³Dept. Anal. & Phys. Chem., Sch. Pharm., Showa Univ., Tokyo 142-8555, Japan, ⁴Dept. Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., Kagoshima 890-8544, Japan

1-P-01413:1014:10 Effects of newly developed small-molecule PACAP type 1 receptor antagonists on itch-like behaviors in mice. Ichiro Takasaki¹, Ryuta Ikeda¹, Mayuko Murata¹, Sho Kato¹, Takuya Okada², Naoki Toyooka², Hiroaki Gouda³, Atsuro Miyata⁴, Takashi Kurihara⁴ ¹Dept. Pharmacol., Grad. Sch. Sci. Eng., Univ. Toyama, ²Dept. Bio-func. Mol. Eng., Grad. Sch. Sci. Eng., Univ. Toyama, ³Dept. Analytical and Physical Chem., Sch. Pharmacy, ⁴Dept. Pharmacol., Grad. Sch. Med. Dent., Kagoshima Univ.

1-P-01513:1014:10 Inhibitory action of endogenous sulfur on oxidative stress-induced TRPA1 activation Naoko Oguma, Kenji Takahashi, Toshio Ohta Dept. Vet. Pharmacol., Fac. Agri., Tottori Univ.

1-P-01613:1014:10 Inhibitory effect of gabapentin for interstitial cystitis/bladder pain syndrome in rats Masaru Yoshizumi, Chizuko Watanabe, Hirokazu Mizoguchi Dept. Physiol. Anat., Tohoku Med. Pharm. Univ.

1-P-01713:1014:10 Perineural treatment with anti-HMGB1 antibody alleviates nociceptive-like behaviors in mice with chronic constriction injury of distal infraorbital nerve Kochi Takahiro^1,2, Yoki Nakamura¹, Kazue Nakashima¹, Keyue Liu³, Hidenori Waki³, Masahiro Nishibori³, Masahiro Irifune², Norimitu Morioka² ¹Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., ²Dept. Dental Anesthesiology, Grad. Sch. Bio. & Health Sciences, Hiroshima Univ., ³Dept. Pharm., Grad. Sch. Med., Dentistry and Pharmaceutical Sciences, Okayama Univ.

1-P-01813:1014:10 Platelet-activating factor (PAF) is increased in neuropathic pain mice: different regulation of PAF levels between the spinal cord and the dorsal root ganglia Shota Yamamoto¹, Tomomi Hashidate-Yoshida¹, Hideo Shindou^1,2,3,4, Takao Shimizu¹ ¹Department of Lipid Signaling, National Center for Global Health and Medicine, ²Department of Lipid Science, Graduate School of Medicine, The University of Tokyo, ³AMED-CREST, ⁴AMED-P-CREATE

1-P-01913:1014:10 Discovery of a new MrgprA3 agonist and evaluation of its effect for itch sensation Yamashita Tomohiro¹, Mayu Ito², Yuka Kawanami², Koga Keisuke², Kensho Kanehisa², Shiori Fujii², Miho Shiratori-Hayashi², Makoto Tsuda² ¹Dept. Global Health., Grad. Sch. Pharm., Kyushu Univ., ²Dept. Mol. Life Innov., Grad. Sch. Pharm. Sci., Kyushu Univ.

1-P-02013:1014:10 Estrogen deficiency aggravates paclitaxel-induced peripheral neuropathy: involvement of HMGB1 Ayano Kanto¹, Shiori Hiramoto¹, Maho Tsubota¹, Tomoyoshi Miyamoto^1,2, Yuichi Koizumi², Masahiro Nishibori³, Atsufumi Kawabata¹ ¹Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., ²Dept. Pharm., Seichokai Fuchu Hospital., ³Department of Pharmacol., Okayama Univ. Graduate School of Medicine.

1-P-02113:1014:10 Novel small-molecule antagonist of PAC1 receptor ameliorates nitroglycerin-induced migraine-related behaviors in mice Okada Kento¹, Takuya Okada², Naoki Toyooka², Hiroaki Goda³, Atsuro Miyata⁴, Takashi Kurihara⁴, Ichiro Takasaki¹ ¹Dept. Pharm., Grad. Sch. Sci. & Eng. Res., Toyama Univ., Toyama 930-8555, Japan, ²Dept. Bio-funct. Mol. Eng., Grad. Sch. Sci. & Eng. Res., Toyama Univ., Toyama 930-8555, Japan, ³Dept. Anal. & Phys. Chem., Sch. Pharm., Showa Univ., Tokyo 142-8555, Japan, ⁴Dept. Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., Kagoshima 890-8544, Japan

1-P-02213:1014:10 Middle molecular weight heparinylphenylalanine, an RAGE blocker, prevents oxaliplatin-induced peripheral neuropathy and butyrate-induced colonic pain in mice Kurumi Higashimoto¹, Kiriko Uenoyama¹, Hiroyuki Nishikawa^1,2, Fumiko Sekiguchi¹, Maho Tsubota¹, Takuya Okada³, Naoki Toyooka^3,4, Atsufumi Kawabata¹ ¹Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University, ²Fuso Pharmaceutical Industries, Ltd., ³Graduate School of Innovative Life Science, University of Toyama, ⁴Graduate School of Science and Engineering, University of Toyama

Poster Sessions

CNS: Drug Abuse, Addiction

1-P-02313:1014:10 Establishment of an assessment method by oral administration and proposal of a new data analysis method using conditioned place preference (CPP) in rats Masahiko Iino, Atsushi Fujiwara, Naoya Murota, Mikio Sasaki, Shinichi Sato Ina Research Inc.

1-P-02413:1014:10 Distinct regulation of morphine-induced conditioned place preference and withdrawal in MDGA1 knockout mice Takashi Kubota¹, Tohru Yamamoto², Yasushi Kishimoto¹ ¹Lab. Neurobiophys., Kagawa sch. pharm. sci., Tokushima Bunri Univ., ²Dept. Mol Neurobiol., Sch. Med., Kagawa Univ.

1-P-02513:1014:10 In vivo evaluation of effects of various histamine H₃receptor inverse agonists on methamphetamine-induced hyperlocomotion and stereotyped behavior in mice Nobue Kitanaka¹, Junichi Kitanaka¹, Yukie Amatsu¹, Rena Ozawa¹, Miho Sato¹, Kotaku Hashimoto¹, Erina Hisatomi¹, Eri Kitao¹, Mari Mimura¹, Miyu Nakamura¹, Kenta Tagami¹, Koh-Ichi Tanaka², Kento Igarashi³, Kazuo Tomita^2,3, Tomoaki Sato³, Nobuyoshi Nishiyama², F. Scott Hall⁴, George R. Uhl⁵, Motohiko Takemura¹ ¹Dept. Pharmacol., Hyogo Col. Med., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Hlth. Sci., ³Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. Dent. Sci., ⁴Univ. Toledo・Col. Pharm. & Pharmaceut. Sci., ⁵New Mexico VA Healthcare System/BRINM

1-P-02613:1014:10 Inhibitory effect of tetrabenazine, a VMAT2 inhibitor, on morphine-induced hyperlocomotion in mice without affecting expression levels of dopamine transporter Junichi Kitanaka¹, Nobue Kitanaka¹, Takashi Kandori¹, Ayaka Murakami¹, Kazuki Muratani¹, Tae Nakano¹, Koh-Ichi Tanaka², Kento Igarashi³, Kazuo Tomita^2,3, Tomoaki Sato³, Nobuyoshi Nishiyama², Motohiko Takemura¹ ¹Dept. Pharmacol., Hyogo Col. Med., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Hlth. Sci., ³Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. Dent. Sci.

1-P-02713:1014:10 The monoacylglycerol lipase inhibitor JZL184 attenuates methamphetamine-seeking behaviors in methamphetamine self-administered rats Yoko Nawata¹, Taku Yamaguchi², Ryo Fukumori², Tsuyoshi Nishioku¹, Tsuneyuki Yamamoto² ¹Department of Pharmacology, Faculty of Pharmaceutical Science, Nagasaki International University, ²Department of Pharmacotherapeutics and Neuropsychopharmacology, Faculty of Pharmaceutical Science, Nagasaki International University

Poster Sessions

CNS: Psychology, Behavior 1

1-P-02813:1014:10 Can alcohol administration to female mice change their preference and attitude to unattractive male mouse? Yoshinori Ohnishi, Yukie Kawahara, Yoko Ohnishi, Akinori Nishi Dept. Pharmacol., Kurume Univ. Sch. Med.

1-P-02913:1014:10 MEK1/2 inhibitor U0126 blocks the expression of paternal behavior Taiju Amano, Yumi Hamasaki, Masabumi Minami Dept. Pharmacol., Grad. Sch. Pharm Sci., Hokkaido Univ.

Poster Sessions

CNS: Learning, Memory 1

1-P-03013:1014:10 Effects of alcohol on the representation of hippocampal place cells Kousaku Miyake, Saichiro Yagi, Yuki Aoki, Yuji Ikegaya, Takuya Sasaki Lab. of Chem. Pharmacol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo

1-P-03113:1014:10 The administration of glycine induces the dephosphorylation of AMPA receptors and attenuates fear memory of the contextual fear conditioning. Ayako Kobayashi, Tomoyuki Miyazaki, Takahisa Goto Dept.Anesthesiology.,Grad. Sch. Med.,Yokohama City Univ.

1-P-03213:1014:10 The cognitive impairment induced by prolylhydroxylase inhibitors in mice Daisuke Kodama, Yoshiaki Ohi, Akira Haji Lab. Neuropharmacol., Sch. Pharm. Aichi-Gakuin Univ.

1-P-03313:1014:10 Serotonin 5-HT₄ receptor agonists improve facilitation of contextual fear extinction in an MPTP-induced mouse model of Parkinson's disease Toshiaki Ishii, Yoshikage Muroi Dept. Veterinary Pharmacol., Obihiro Univ. of Agri. and Vet. Med.

1-P-03413:1014:10 Nose-to-brain delivery of CGRP against fear memory retention in mice Narumi Hashikawa-Hobara, Hiroki Andou, Himika Morimoto, Naoya Hashikawa Dept. Life Sci., Okayama Univ. of Sci.

1-P-03513:1014:10 Prioritized experience replay for learning in the rat hippocampus Hideyoshi Igata¹, Yuji Ikegaya¹, Takuya Sasaki^1,2 ¹Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, ²Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

Poster Sessions

CNS: Cerebral Circulation, Metabolism, Ischemia

1-P-03613:1014:10 Towards understanding the role of neuroprotective effect of adenosine deaminase Hiroyuki Ohta¹, Risa Tamura², Masashi Arake³, Yuji Morimoto³, Toshiaki Ishizuka¹ ¹Dept. Pharm., NDMC, ²JMSDF Maizuru Hospital, ³Dept. Phisol., NDMC

1-P-03713:1014:10 Hyperlipidemia may attenuate rupture of a cerebral aneurysm in the mouse model. Kazuya Hokamura¹, Hiroshi Makino³, Tomo Suzuki⁴, Takayuki Iwaki², Ryou Imai³, Tetsuro Kimura³, Yoshiki Nakajima³, Hiroki Namba⁴, Kazuo Umemura² ¹Medical Edu., Hamamatsu Univ. Sch. of Med., ²Dept. Pharm., Hamamatsu Univ. Sch. of Med., ³Dept., Anesth., Hamamatsu Univ. Sch. of Med., ⁴Dept. Neurol., Hamamatsu Univ. Sch. of Med.

1-P-03813:1014:10 The effects of ambrisentan, a selective endothelin ET_Areceptor antagonist for vasogenic edema after traumatic brain injury in mice Shotaro Michinaga¹, Ryotaro Ryu¹, Hayato Yamamoto¹, Hiroyuki Mizuguchi¹, Yutaka Koyama² ¹Dept. Pharmacol., Osaka-ohtani Univ., ²Dept. Pharmacol., Kobe Pharmaceutical Univ.

1-P-03913:1014:10 Voluntary exercise after cerebral ischemia ameliorates disability and modifies dendritic spine density Natsumi Yamaguchi, Toshinori Sawano, Kae Fukumoto, Yoshiki Nishikawa, Yosuke Inoue, Jin Nakatani, Hidekazu Tanaka Lab. Pharm., Dept. Biomed Sci., Col. Life Sci., Ritsumeikan Univ.

1-P-04013:1014:10 Differential glial responses to intracerebral hemorrhage between young and middle-aged mice Keita Kinoshita^1,2, Ryo Ohtomo^2,3, Hajime Takase², Gen Hamanaka², Eng Lo H.², Hiroshi Katsuki¹, Ken Arai² ¹Dept. of Chemico-pharmacol. Sci., Grad. School of Pharm., Kumamoto Univ., ²Neuroprotection Res. Lab., Dept. of Radiol., Massachusetts General Hospital, ³Dept. of Neurol., Grad. School of Med., Tokyo Univ.

1-P-04113:1014:10 Development and functional analysis of the in vitro BBB model derived from stroke-prone spontaneously hypertensive rats. Shinsuke Nakagawa¹, Hiroki Ohara², Jun Aruga¹, Masami Niwa³, Kazuo Yamagata⁴, Toru Nabika² ¹Dept. Med. Pharmacol., Grad. Sch. Biomed. Sci., Nagasaki Univ., ²Dept. Fun. Pathol., Fac. Med., Shimane Univ., ³BBB Lab., PharmaCo-Cell Co. Ltd., ⁴Lab. Mol. Health. Food, Nihon Univ. Col. Bioresour. Sci.

1-P-04213:1014:10 Stimulation of LXA₄receptor alleviates motor dysfunction in intracerebral hemorrhage model mice Risa Futokoro, Masanori Hijioka, Yoshihisa Kitamura Lab. Pharmacol. and Neurobiol., Col. Pharm. Sci., Ritsumeikan Univ.

1-P-04313:1014:10 Alterations of lymphocyte count and platelet volume precede development of stroke-related symptoms in stroke-prone spontaneously hypertensive rats Takashi Nishinaka¹, Atsuko Niwa¹, Hidenori Wake², Shuji Mori³, Masahiro Nishibori², Hideo Takahashi¹ ¹Dept. Pharmacol., Facul. Med., Kindai Univ., ²Dept. Pharmacol., Sch. Med. Dent. Pharm. Sci., Okayama Univ., ³Dept. Pharmcol., Sch. Pharmacy, Shujitsu Univ.

1-P-04413:1014:10 The expression and the role of progranulin in the neural stem cells Fushiki Yuna, Ichirou Horinokita, Hideki Hayashi, Norio Takagi Dept. Applied Biochemistry., Tokyo Univ. Pharm, Life Sci.,

1-P-04513:1014:10 Pathophysiological changes of progranulin in active microglia after cerebral ischemia Akane Usui, Ichiro Horinokita, Hideki Hayashi, Norio Takagi Dept. Applied Biochemistry., Tokyo Univ. Pharm, Life Sci.

Poster Sessions

CNS: Neurodegenerative 1

1-P-04613:1014:10 Minoxidil suppressed cerebral ischemic injury by direct effect on neural tissues but not by reducing blood pressure. Hayasi Ryosuke, Yuki Honda, Hiroshi Higashi, Toshihiko, Kinjo, Kyosuke, Uno, Nobuyuki Kuramotoi Setsunan. Unv. Pharm. Sci. Mol. Pharmacol.

1-P-04713:1014:10 Protection mechanism of gadolinium trichloride against hemorrhagic brain injury Masatoshi Ohnishi, Shunpei Tasaka, Takao Kai, Yuki Shimizu, Yuui Urabe, Yukino Yano, Marina Akagi, Atsuko Inoue Dept. Pharmacother., Fac. Pharm., Fukuyama Univ.

1-P-04813:1014:10 Cleavage of LRP1 and increase in LRP1-ICD in ischemic brain and excitotoxic neuronal injury Yui Iwatani, Mariko Yamada, Kaori Suzuki, Hideki Hayashi, Norio Takagi Dept. Applied Biochem., Sch. Pharm., Tokyo Univ of Pham & Life Sci.

1-P-04913:1014:10 α-Synuclein-induced production of inflammatory mediators through Toll-like receptors in brain pericytes Shinya Dohgu¹, Minami Akizuki¹, Atsushi Kobayashi¹, Shunya Morita¹, Fuyuko Takata¹, Junichi Matsumoto¹, Takuro Iwao¹, Atsushi Yamauchi¹, Kazunori Sano², Yasufumi Kataoka¹ ¹Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., ²Dept. Physiol. & Pharmacol., Fac. Pharmaceut. Sci., Fukuoka Univ.

1-P-05013:1014:10 Functional evaluation of the patient-derived iPS cells from PDGFB-variants in idiopathic basal ganglia calcification Naoki Shibuya, Tomohiko Masaka, Hisaka Kurita, Masatoshi Inden, Isao Hozumi Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.

1-P-05113:1014:10 Role of the microsomal prostaglandin E synthase-1 in cuprizone-induced demyelination and motor dysfunction. Fumiaki Kojima^1,2, Hiroki Sekiya^1,2, Hayato Kawada³, Hitoshi Kashiwagi⁴, Yoshitaka Imamichi⁴, Koh-Ichi Yuhki⁴, Fumitaka Ushikubi⁴, Hidero Kitasato³, Takafumi Ichikawa² ¹Department of Pharmacology, Kitasato University, ²Department of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, ³Department of Environmental Microbiology, Kitasato University Graduate School of Medical Sciences, ⁴Department of Pharmacology, Asahikawa Medical University

1-P-05213:1014:10 p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy Masatoshi Inden, Tomoyuki Ueda, Taosei Ito, Hisaka Kurita, Isao Hozumi Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ.

1-P-05313:1014:10 ALS-associated mutant ubiquilin 2 impairs protein degradation via autophagy-lysosome system Akiko Idera¹, Takahiro Seki^1,2, Masahiro Sato², Yuki Kurauchi^1,2, Hiroshi Katsuki^1,2 ¹Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., ²Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.

1-P-05413:1014:10 Accumulation of sphingomyelin in Niemann-Pick disease type C cells disrupts Rab9-dependent vesicular trafficking of cholesterol Hiroyuki Nakamura, Masahiro Wanikawa, Shunsuke Emori, Naohiro Hashimoto, Toshihiko Murayama Lab. Chem Pharmacol., Grad. Sch. Pharmaceu Sci., Chiba Univ.

Poster Sessions

Digestive Organ 1

1-P-05513:1014:10 Lansoprazole promotes peritoneal fibrosis by bleomycin Yuta Yamamoto, Akira Tanichi, Shota Nasu, Naoko Yamagishi, Takao Ito, Yoshimitsu Kanai Dept. Cell Biol., Wakayama Med. Univ.

1-P-05613:1014:10 Study on measurement of internal anal sphincter movement in dogs (application as evaluation method on defecation disorder)-2^nd report Kazuaki Sasaki¹, Masakazu Imaizumi¹, Seiiti Katayama¹, Keiko Harada¹, Katsuhide Nishi^1,2 ¹Pharm.Dept.,LSImedience Corporation., ²The Maruta Hospital

1-P-05713:1014:10 Effect on contractile response due to carbachol and bradykinin stimulation in the rat inflammatory colon. Hiromi Nobe Dept. Health Sci. Tech., Bunkyo Gakuin Univ.

1-P-05813:1014:10 Carbon tetrachloride mediated liver fibrosis is alleviated in α7 nicotinic acetylcholine receptor knockout mice Taiki Mihara¹, Noriyuki Kaji², Masatoshi Hori¹ ¹Dept. of Vet. Pharmacol., Grad. Sch. Of Agri. & Life Sci., The Univ. of Tokyo, ²Dept. of Vet. Pharmacol., Azabu Univ.

1-P-06013:1014:10 Effects of bezafibrate to high trans-fat diet (HTD) -induced nonalcoholic steatohepatitis (NASH) model in mice Toshinori Moritani, Kagari Kimura, Noriko Minobe, Shoko Kosugi, Hitomi Matsuda, Akihiro Ishimoto, Ayahito Kimura, Takeshi Iidaka Shiga Laboratory, NISSEI BILIS Co., LTD.

1-P-06113:1014:10 Protective　effect　of　nitric　oxide　on　QOL　and　mucosal　injury　induced　by　a　constitutive　administration of methotrexate to rats. Saki Shiga¹, Takuji Machida¹, Takumi Yanada¹, Maiko Machida², Ashiko Hirafuji¹, Kenji Iizuka¹ ¹Dept. Pharmacol. Sci., Sch. Pharm. Sci., Health Sci. Univ. of Hokkaido, ²Div. Pharmacother., Fac. Pharmaceut. Sci., Hokkaido Univ. Sci.

Poster Sessions

Genital Organ

1-P-06213:1014:10 Role of CPI-17 on uterine smooth muscle contraction depending on pregnancy stage Io Shibasaki, Qunhui Yang, Noriyuki Kaji, Masatoshi Hori Dept. of Veterinary Pharmacol., Grad. Sch. of Agr. & Life Sci., The Univ. of Tokyo

Poster Sessions

Cardiovascular: Hear function, Heart failure 1

1-P-06313:1014:10 Dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates left ventricular remodeling after myocardial infarction via DPP-4-independent pathway. Takehiro Yamaguchi¹, Yasukatsu Izumi^1,2, Masayuki Shiota¹, Shinji Matsunaga¹, Kentaro Tokudome¹, Katsuyuki Miura^1,3, Hiroshi Iwao^1,4, Shuhei Tomita¹ ¹Dept. Pharm., Grad. Sch. Med., Osaka City Univ., ²Takaishikamo Hospital, ³Ishikiriseiki Hospital, ⁴Shitnnoji Univ.

1-P-06413:1014:10 Protective role of an NAD⁺-dependent deacetylase SIRT1 in doxorubicin-induced cardiotoxicity. Kohei Tada, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

1-P-06513:1014:10 Production of functional antibody targeting Ca²⁺permeable channel TRPV2 ameliorating dilated cardiomyopathy in animal models Yuko Iwata¹, Shin Ito¹, Shigeo Wakabayashi², Masafumi Kitakaze¹ ¹Dept. Clin.Res.Develop., NCVC, ²Dept. Pharma., Osaka Med Collage

1-P-06613:1014:10 Development and assessment of a new in vitro platform of human induced pluripotent stem cell-derived cardiomyocytes for evaluating the drug-induced biological phenomena predicting clinically observed cardiac effects Hiroko Izumi-Nakaseko^1,2, Koki Chiba², Mihoko Hagiwara-Nagasawa¹, Ai Goto², Yoshio Nunoi¹, Ryuichi Kambayashi¹, Akio Matsumoto³, Yasunari Kanda⁴, T. Atsuhiko Naito⁵, Atsushi Sugiyama^1,2,3 ¹Dept. Pharmacol., Faculty Med., Toho Univ., ²Dept. Pharmacol., Grad. Sch. Med., Toho Univ., ³Dept. Aging Pharmacol., Faculty Med., Toho Univ., ⁴Div. Pharmacol., NIHS., ⁵Dept. Physiol., Div. Cell Physiol., Toho Univ. Sch. Med.

1-P-06713:1014:10 Elucidation of expression and regulation mechanism of cell adhesion factor Gicerin/CD146 in cardiac hypertrophy model Mami Obara¹, Sachiko Sato², Kumi Takahashi², Yukiko Kondo², Masamichi Hirose³, Koji Nata¹, Eichi Taira² ¹Iwate Medical Univ. Med. Biochem., ²Iwate Medical Univ. Signal Transduction Dept. of Pharmacol., ³Iwate Medical Univ. Mol. and Cell. Pharmacol.

1-P-06813:1014:10 Roles of Hsp90 on cardiac remodeling in the development of chronic heart failure. Yumi Abe, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

1-P-06913:1014:10 Analysis of therapeutic effects of the Japanese herbal medicine ninjinyoeito on oxidative stress-induced cardiotoxicity with in vitro experimental system Toshiki Kawashima^1,2, Miki Nonaka², Kaori Ohshima^1,2, Yuki Yoshida^1,3, Kanako Miyano¹, Yoshikazu Higami³, Kazumi Yoshizawa², Yasuhito Uezono^1,4 ¹Laboratory of Pharmacology and Therapeutics, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan, ²Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan, ³Department of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan, ⁴Division of Supportive Care Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Research Institute, Tokyo, Japan

1-P-07013:1014:10 Developmental changes in sarcoplasmic reticulum (SR) dependency of contraction and relaxation mechanisms in the mouse ventricular myocardium Shogo Hamaguchi, Kota Nagahara, Iyuki Namekata, Hikaru Tanaka Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

Poster Sessions

Cardiovascular: Vascular Endothelium

1-P-07113:1014:10 Changes of thoracic and mesenteric arterial vascular function in angiotensin Ⅱ-induced hypertensive mice Masa-Aki Ito, Takahiro Hayashi, Teruaki Koyama, Kazuki Yoshida, Isao Matsuoka Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

1-P-07213:1014:10 Highly neurotoxic amyloid-bassemblies from Alzheimer's disease brain, amylospheroids, inhibit endothelial Na⁺, K⁺-ATPase α3 activity, resulting in the inhibition of eNOS activity in human brain microvascular endothelial cells. Tomoya Sasahara^1,2, Kaori Satomura^1,2, Mari Tada³, Akiyoshi Kakita³, Minako Hoshi^1,4 ¹Center for Brain Neurodegene. Res., IBRI, FBRI at Kobe, ²Res.&Develop. Division, Kobe Lab., TAO Health Life Pharm., ³Dept. Pathol., Brain Res. Institute, Niigata Univ., ⁴Dept. Anatomy and Developmental Bio., Grad. Sch. Med., Kyoto Univ.

1-P-07313:1014:10 Valproic acid prevents retinal angiogenesis via a proteasome-dependent mechanism in neonatal mice Akane Morita, Kanako Takahashi, Naoto Iizuka, Keigo Saito, Daiki Asano, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.

1-P-07413:1014:10 Role of glial cells in angiogenesis in the neonatal rat retina with neurodegenerative injury Daiki Asano, Masaki Hokazono, Shogo Hirano, Akane Morita, Asami Mori, Tsutomu Nakahara Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.

1-P-07513:1014:10 Oxidative stress induces cell death via the suppression of Orai1-mediated Ca²⁺ entry in brain capillary endothelial cells. Hideto Yamamura¹, Yoshiaki Suzuki¹, Kiyofumi Asai², Yuji Imaizumi¹, Hisao Yamamura¹ ¹Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci., Nagoya City Univ., ²Dept. Mol. Neurobiol., Grad. Sch. Med. Sci., Nagoya City Univ.

1-P-07613:1014:10 Ca²⁺-activated Cl^-channels are involved in the proliferation and migration of brain capillary endothelial cells. Takahisa Suzuki¹, Miki Yasumoto¹, Yoshiaki Suzuki¹, Kiyohumi Asai², Yuji Imaizumi¹, Hisao Yamamura¹ ¹Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., ²Dept. Mol. Neurobiol., Grad. Sch. Med., Nagoya City Univ.

1-P-07713:1014:10 Development of tissue-specific histamine-responsive vascular endothelial models using a collagen vitrigel membrane Miaki Uzu, Toshiaki Takezawa National Agriculture and Food Research Organization

Poster Sessions

Muscle tissue

1-P-07813:1014:10 Elucidation of the pathogenesis of muscle sarcopenia caused by liver fibrosis Momo Goto¹, Tamaki Kurosawa^1,2, Satoshi Aikiyo¹, Madoka Uezumi², Noriyuki Kaji³, Akiyoshi Uezumi², Masatoshi Hori¹ ¹Lab. of Veterinary Pharmacol., Grad. Sch. of Agr. and Life Sci., Tokyo Univ., ²Muscle Aging and Regenerative Med., Tokyo Metropolitan Inst. of Gerontol., ³Lab. of Veterinary Pharmacol., Sch. of Veterinary Med., Azabu Univ.

1-P-07913:1014:10 Effects of saturated fatty acids on skeletal muscle differentiation in an intrauterine hyperglycemic environment Tokunaga Yayoi¹, Ritsuko Kawaharada², Chisato Ishida³, Akio Nakamura¹ ¹Department of Food and Health Sciences, Jissen Women’s University, Hino, Japan, ²Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan, ³Department of nutrition, Japanese Haramachi Red Cross Hospital, Japan

1-P-08013:1014:10 The role of calcineurin B homologous protein 3 (CHP3) in C2C12 myoblasts. Soushi Kobayashi^1,2, Koji Nobe^1,2 ¹Dept. Pharmacol., Showa Univ., ²Showa Univ., Pharmacol. Res. Ctr

1-P-08113:1014:10 Anti-apoptotic function of PDZRN3 protein in myoblasts Takeshi Honda, Ukyo Shinagawa, Yu Mizuno, Yuki Yokosuka, Makoto Inui Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med., Japan

Poster Sessions

Bone, Joint, Dental

1-P-08213:1014:10 Effect of bone matrix protein osteocalcin on proliferation and neuronal differentiation of PC12 cells Ando Eika^1,2, Sen Higashi², Akiko Mizokami³, Tomoko Ohsumi², Seiji Watanabe¹, Masato Hirata⁴, Hiroshi Takeuchi² ¹Div. Dental Anesthesiology, Kyushu Dental Univ., ²Div. Appl. Pharmacol., Kyushu Dental Univ., ³OBT Res. Ctr., Fac. Dental Sci., Kyushu Univ., ⁴OM Res. Ctr., Sch. Dent. Med., Fukuoka Dental College.

1-P-08313:1014:10 Effect of phenytoin on PI3K/Akt signaling pathway in human gingival fibroblasts Hiroko Matsumoto¹, Reiri Takeuchi², Junichi Yamane¹, Hitoshi Nishimura³, Masamichi Komiya³ ¹Dept. Pharmacol., Nihon Univ. Sch. Dent. Matsudo, ²Dept. Biochem., Nihon Univ. Sch. Dent. Matsudo, ³Dept. Oral Surg., Nihon Univ. Sch. Dent. Matsudo

1-P-08413:1014:10 Participation of TRPV1 in tooth movement-related pain Kazunori Adachi¹, Naoya Hasegawa², Misato Yugawa², Takako Tsuchiya², Au Sasaki², Naoto Suda² ¹Div. Pharmacol., Meikai Univ. Sch. of Drnt., ²Div. Orthodontics, Meikai Univ. Sch. of Dent.

1-P-08513:1014:10 Analysis of compensatory hypertrophy-associated enhancement of salivary secretionusing the intravital Ca²⁺imaging and comprehensive gene analysis. Akihiro Nezu¹, Takao Morita², Akihiko Tanimura¹ ¹Div. Pharmacol., Dept. Oral Biol., Sch. Dent., Health Sci. Univ. Hokkaido, ²Dept. Biochem., Nippon Dent. Univ. at Niigata

1-P-08613:1014:10 Globo-series glycosphingolipids deficiency in mice resulted in the attenuation of bone formation through decrease of osteoblasts Kazunori Hamamura¹, Kosuke Hamajima^1,2, Yoshitaka Mishima^1,2, Koichi Furukawa³, Ken Miyazawa², Shigemi Goto², Akifumi Togari¹ ¹Dept. Pharmacol., Sch. Dent., Aichi Gakuin Univ., ²Dept. Orthodontics, Sch. Dent., Aichi Gakuin Univ., ³Dept. Biomed. Sci., Chubu Univ.

1-P-08713:1014:10 S1P/S1PR2 signaling pathway promotes bone formation on rat apicoectomy model Etsuko Matsuzaki¹, Noriyoshi Matsumoto¹, Masahiko Minakami¹, Ryo Matsuyuki¹, Kazuma Matsumoto¹, Junko Hatakeyama¹, Fumi Takahashi², Hisashi Anan¹ ¹Sec. Operative Dent and Endod, Dept. Odontol., Fukuoka Dent. Coll., ²Dept. Pharmacol, School of Med, Univ. Occupational and Environmental Health

1-P-08813:1014:10 Petunidin, one of the major anthocyanins which possess potent antioxidative activity, prevents bone loss in sRANKL-induced osteopenic mice. Masahiro Nagaoka¹, Shumpei Niida², Keiko Suzuki³ ¹Dept. Pharmacol., Sch. Dent., Ohu Univ., ²Med. Genome Centr., Natl Centr. Geriatr. & Gerontol., ³Dept. Pharmacol., Sch. Dent., Showa Univ.

1-P-08913:1014:10 Effects of the vigabatrin, a newer antiepileptic drug, on bone metabolism in rat Junkichi Kanda¹, Nobuo Izumo², Megumi Furukawa², Taketoshi Shimakura³, Noriaki Yamamoto³, Kenji Onodera⁴, Hiroyuki Wakabayashi¹ ¹Dept. Clin. Pharmacother., Niigata Univ. Pharm. Appli. Life. Sci., ²Genar. Health Medi. Cen. Yokohama Col. Pharm., ³Niigata Bone Sci. Inst., ⁴Dept. Clin. Pharmaco. & Pharm. Epilep. Hosp. BETHEL

Poster Sessions

Immunity, Inflammation, Allergy 1

1-P-09013:1014:10 Possible involvement of VEGF in sepsis-associated lung vascular hyperpermeability Kengo Tomita¹, Yuna Saito², Samar Imbaby³, Yuichi Hattori⁴ ¹Medical Enviroment Engineeing Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, ²Center for Clinical Training, Juntendo University Urayasu Hospital, ³Dept. of Mol. Med. & Pharmacol., Graduate Sch. of Med. and Pharm. Sci, Univ. of Toyama, ⁴The Research Institute of Cancer Prevention, Health Sciences University of Hokkaido

1-P-09113:1014:10 IL-5/eosinophils are involved in acquisition of steroid resistance in severe asthma of mice Kennosuke Hashimoto, Mari Minakawa, Hayato Shimora, Miku Nomura, Naoki Takemoto, Ryogo Terakawa, Masaya Matsuda, Kazuyuki Kitatani, Takeshi Nabe Lab. of Immunopharmacol., Fac. of Pharm. Sci., Setsunan Univ.

1-P-09213:1014:10 Effects of LPS and TNFα on the histamine responsiveness of vascular endothelial cells Yuhki Yanase¹, Tomoko Kawaguchi¹, Kazue Uchida¹, Tomoaki Urabe², Norio Sakai², Michihiro Hide¹ ¹Dept. of Dermatology, Hiroshima University, ²Dept. of Molecular and Pharmacological Neuroscience, Hiroshima University

1-P-09313:1014:10 Effect of STAT inhibitor on the murine chronic graft-versus-host disease (GVHD) scleroderma model using an X-ray irradiation device Shiruku Hosoi¹, Yumi Wako², Hajime Wada¹, Kousuke Morizumi¹, Seiichi Katayama¹, Naoyuki Hironaka¹, Katsuhide Nishi¹ ¹Pharm Dept., LSI Medience Corp., ²Pathol Dept., LSI Medience Corp.

1-P-09513:1014:10 Development of Retrievable Molecular Target Drug using Intelectin Shotaro Obata^1,2, Yasuhiro Moriwaki¹, Hidemi Misawa¹, Shotaro Tsuji² ¹Div Pharmacol, Dept Pharm, Keio Univ, ²Res Inst, Kanagawa Cancer Ctr

Poster Sessions

Stress, Fatigue

1-P-09613:1014:10 Effects of increased or decreased red blood cells on exercise performance in mice Yoshinori Iba¹, Hiroki Murai¹, Kenichiro Yasuda¹, Kai Ueno¹, Atsunobu Sugano¹, Syunpei Horiguchi¹, Ayami Mori², Yoshiyuki Ishida², Keiji Terao² ¹Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ., ²CycloChem Bio Co., Ltd.

1-P-09713:1014:10 Change in expression of ubiquitin ligase in the hippocampus of stress-maladaptive mice Hiroko Miyagishi^1,2, Yasuhiro Kosuge¹, Minoru Tsuji², Hiroshi Takeda², Kumiko Ishige¹ ¹Lab. Pharmacol., Sch. Pharm., Nihon Univ., ²Dept. Pharmacol., Sch. Pharm., IUHW

Poster Sessions

Aging

1-P-09813:1014:10 SIRT1 activitors ameliorate the ability of cell membrane repair. Azekami Kuya, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio Dept. Pharmacol., Sapporo Med. Univ.,Sch.Med.

1-P-09913:1014:10 The influence of sarcopenia on immune homeostasis Tomoya Kawanami Dept. Pharmacol., Sch. Med., Ehime Univ.

Poster Sessions

Intracelluar, Extracelluar Signal Transduction

1-P-10013:1014:10 Antioxidative activity of dexmedetomidine as a direct free radical scavenger Ogata Kazue¹, Kota Yoshida², Shigekiyo Matsumoto¹, Chihiro Shingu¹, Takaaki Kitano¹, Osamu Tokumaru³ ¹Dept. Anesthesiol., Oita Univ. Fac. Med., ²Medical Student, Sch Med., Oita Univ. Fac. Med., ³Dept. Physiol., Fac. Welfare Health Sci., Oita Univ.

Poster Sessions

NO, NOS 1

1-P-10113:1014:10 Activation of ribosomal p70 S6 kinase by selective serotonin (5-HT)_2B receptor agonist BW723C86 is mediated by epidermal growth factor/transforming growth factor-α receptor tyrosine kinase in primary cultures of adult rat hepatocytes. Kazuki Kurihara, Hajime Moteki, Masahiko Ogihara, Mitsutoshi Kimura Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ.

1-P-10213:1014:10 Up-regulation of melatonin synthesizing enzymes in mast cells Haruhisa Nishi¹, Francois Niyonsaba² ¹Dept. Pharmacol., Sch. Med., Jikei Univ. Sch. Med., ²Dept. Atopy Cent., Sch. Med., Juntendo Univ.

1-P-10313:1014:10 The dual role of STIM1 O-GlcNAcylation on SOCE activity Atsuo Nomura, Shunichi Yokoe, Michio Asahi Dept. Pharmacol. Fac. Med., Osaka Med. College

1-P-10413:1014:10 Regulation of epidermal growth factor receptor of cultured lung epithelial cells by interleukin-1β Hideyuki Yamamoto¹, Izumi Nakayama^1,2, Sayomi Higa-Nakamine¹ ¹Dept. Biochem. Univ. Ryukyus, ²ICU, Chubu Hosp

1-P-10513:1014:10 PTH receptor-mediated G_s signaling is suppressed by direct binding of the subcortical cytoskeletal protein 4.1G to adenylyl cyclase type 6 Masaki Saito¹, Linran Cui¹, Marina Hirano^1,2, Guanjie Li¹, Teruyuki Yanagisawa^1,3, Takeya Sato¹, Jun Sukegawa^1,2 ¹Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med., ²Dept. Hum. Health Nutr., Shokei Gakuin Univ., ³Dept. Nursing, Tohoku Fukushi Univ.

Poster Sessions

Endocrine, Metabolism

1-P-10613:1014:10 Role of NAD metabolism in maintaining intestinal homeostasis Yaku Keisuke, Takashi Nakagawa Dept. of Mol. and Med. Pharmacol., Grad. Sch. Med., Univ. of Toyama

1-P-10713:1014:10 Low body weight at weaning in V1a vasopressin receptor knockout mice Hiroyoshi Tsuchiya, Yoko Fujiwara, Taka-Aki Koshimizu Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

1-P-10813:1014:10 Regulation of nutritional environmental responses and disease predisposition by osteocalcin in utero Tomoyo Kawakubo-Yasukochi¹, Akiko Mizokami², Masato Hirata³ ¹Dept. Immunol. Mol. Pharmacol., Fac. Pharm. Sci, Fukuoka Univ., ²OBT Res. Ctr., Fac. Dent Sci., Kyushu Univ., ³Fukuoka Dent. Coll., OM Res. Ctr.

1-P-10913:1014:10 The role of the novel sex steroid membrane receptor mPRε on metabolic homeostasis. Watanabe Keita, Ryuji Ohue, Ikuo Kimura Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology

1-P-11013:1014:10 Novel Epac2 isoforms and their roles in pancreatic β-cell functions Harumi Takahashi, Yuuka Fujiwara, Chihiro Seki, Norihide Yokoi, Susumu Seino Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine

1-P-11113:1014:10 Tight regulation of the mitochondrial Ca²⁺ signal during glucose stimulation in pancreatic β-cells. Isamu Taiko^1,2, Kazunori Kanemaru¹, Masamitsu Iino¹ ¹Dept Cell Mol Pharmacol, Nihon Univ Sch Med, ²Dept Physiol, Nihon Univ Sch Med

1-P-11213:1014:10 Functional effect of laminin α chains on endocrine cells in rat anterior pituitary gland Morio Azuma, Taka-Aki Koshimizu Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

1-P-11313:1014:10 Anti-obesity effects of cuprizone on high fat diet-induced obese mice. Kazuko Takigawa, Aya Hirose, Kentarou Ishida, Yoshinori Ichihara, Tatsuya Sawano, Yuhang Zhou, Agung Priyono, Junichiro Miake, Takeshi Imamura Dept.Pharm., Sch. Med., Tottori Univ.

Poster Sessions

Food, Luxury Goods

1-P-11413:1014:10 The target of canola oil toxicity in SHRSP and mechanisms underlying the toxicity Naoki Ohara¹, Mai Nishikawa¹, Kenjiro Tatematsu², Yukiko Naito³, Daisuke Miyazawa¹, Harumi Okuyama¹ ¹Kinjo Gakuin Univ.Coll.Pharm., ²Gifu Pharmaceut.Univ.Radiochem., ³Kitasato Univ.Sch.Allied Health Sci.

1-P-11513:1014:10 Risk assessment of green tea EGCG for pharmacokinetic interaction with prescription drugs Masamichi Yamashita Dept. Biosci. Daily Life, Coll. Biores. Sci., Nihon Univ.

1-P-11613:1014:10 Examination of left-right asymmetry in gustatory stimulus-induced brain activity in rat brain using fMRI Yukiko Kondo¹, Satomi Higuchi², Fumio Yamashita², Makoto Sasaki², Masamichi Hirose³, Eiichi Taira¹ ¹Dept. Signal transduction Pharmacol., Iwate Med. Univ., ²Dept. Ultrahigh-field MRI, Inst. Biomed. Sci. Iwate Med. Univ., ³Mol. Cell. Pharmacol., Dept. Basic Med., Iwate Med. Univ.

1-P-11713:1014:10 Coriandrum sativum leaf extract attenuates cytotoxicity induced by oxidative stress in PC12 cells Rena Obara¹, Nobuo Izumo³, Saki Aihara¹, Tomomi Shimazu¹, Rina Iwasaki², Akihiro Sumino³, Makoto Nakano³, Yasuo Watanabe^1,3 ¹Lab of Functional Materials, Yokohama Univ. Pharm., ²Lab of Food Chem. Yokohama Univ. Pharm., ³Gener. Health Med. Ctr. Yokohama Univ. Pharm.

1-P-11813:1014:10 Japanese Nuru-Neba Diet extends Healthy Life Longevity (1): Reduction of Abdominal Fat in High Calorie-Diet Mice Tomomi Shimazu¹, Nobuo Izumo², Rena Obara¹, Saki Aihara¹, Yoshiki Hirokawa¹, Kohsuke Hayamizu², Kimiko Tsuzuki³, Yasuo Watanabe^1,2 ¹Lab of Functional Materials, Yokohama Univ. Pharm., ²Gener. Health Med. Ctr. Yokohama Univ. Pharm., ³Tsuzuki Sch. Group

1-P-11913:1014:10 Japanese Nuru-Neba Diet extends healthy life longevity (２): Evaluations of Mechanism of Anti-obesity effects using normal and High Calorie-Diet Mice Hirokawa Yoshiki¹, Nobuo Izumo², Rena Obara¹, Saki Aihara¹, Tomomi Shimazu¹, Kimiko Tsuzuki³, Yasuo Watanabe^1,2 ¹Lab of Functional Materials, Yokohama Univ. Pharm., ²Gener. Health Med. Ctr. Yokohama Univ. Pharm., ³Tsuzuki Sch. Group

1-P-12013:1014:10 Coriandrum sativum seed extract improves aging-induced memory impairment in SAMP8 mice Saki Aihara¹, Nobuo Izumo³, Rena Obara¹, Tomomi Shimazu¹, Yurina Mima², You Tabuchi², Suh-Ching Yang⁴, Yasuo Watanabe^1,3 ¹Lab of Functional Materials, Yokohama Univ. Pharm., ²Lab of Food Chem. Yokohama Univ. Pharm., ³General Health Medical Center, Yokohama University of Pharmacy, ⁴Nutrition Res. Ctr. Sch. Nutrition & Health Sci. Taipei Med. Univ.

Poster Sessions

Disease Model, Transgenic Animals

1-P-12113:1014:10 Deletion of PHD finger protein 24 (Phf24) causes elevated seizure sensitivity, emotional defects and cognitive impairment in rats. Naofumi Kunisawa¹, Tadao Serikawa^1,2, Masaki Kato¹, Higor Alves Iha¹, Hisao Nishikawa³, Yu Shirakawa³, Masashi Sasa⁴, Yukihiro Ohno¹ ¹Dept. Pharmacol., Osaka Univ. Pharm. Sci., ²Inst. Lab. Anim., Kyoto Univ., ³KAC Co. Ltd., ⁴Nagisa Clinic.

1-P-12213:1014:10 Molecular analyses of heart tissue in mice lacking mitochondrial protein p13 Satomi Hara¹, Norihito Shintani¹, Hiroki Ueno¹, Yohei Morota¹, Sae Ogura¹, Naoki Inoue¹, Hitoshi Hashimoto^1,2,3,4,5 ¹Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., ²Mol. Res. Ctr. Children's Mental Dev., United Grad. Sch. Child Dev., Osaka Univ., ³Div. of Biosci., Inst. for Datability Sci., Osaka Univ., ⁴Transdimentional Life Imaging Div., Inst. for Open & Transdisciplinary Res. Initiatives, Osaka Univ., ⁵Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ.

1-P-12313:1014:10 Bleomycin-induced pulmonary fibrosis in cynomolgus monkeys Sachi Okabayashi, Takashi Sakuraba, Hitoshi Yasuda, Tomohiko Yamanouchi, Mai Sasaki, Chihomi Mitsuoka, Noriyuki Yamazaki, Chiaki Tateda, Shunichi Kitajima New Drug Research Center, Inc.

1-P-12413:1014:10 Decrease the inhibitory synapse-related gene expression caused autism-like behavior in rats treated prenatal hypoxia condition Kentaro Tokudome, Shinji Matsunaga, Takehiro Yamaguchi, Shuhei Tomita Dept. Pharm., Grad. Sch. Med., Osaka., Osaka City Univ.

1-P-12513:1014:10 Fast and easy construction method of ryanodine receptor mutants aiming at genetic screening of malignant hyperthermia diagnosis Hideto Oyamada^1,2, Masahide Nakano^1,3, Takahiro Hayashi¹, Yusuke Ubukata^1,4, Takashi Makino¹, Masaaki Tanaka^1,5, Takuya Kikuchi^1,6, Katsuji Oguchi^1,2, Yuji Kiuchi^1,2 ¹Dept Pharmcol, Sch Med, SHOWA Univ, ²Pharmacol Res Centr, SHOWA Univ, ³Dept Surg, Thyroid Centr, SHOWA Univ, Northern Yokohama Hosp, ⁴Dept Anesthesiol, Ebara Hosp, ⁵Dept Anesthesiol, Heisei Yokohama Hosp, ⁶Kikuchi Eye Clinic

Poster Sessions

Methodology, Technology

1-P-12613:1014:10 Imaging of extracellular Ca²⁺ in the hippocampus by a novel CMOS ion image sensor Bijay Parajuli¹, Hideo Doi², Eiji Shigetomi¹, Youichi Shinozaki¹, Youna Lee², Toshihiko Noda², Kazuhiro Takahashi², Kazuaki Sawada², Schuichi Koizumi¹ ¹Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med., Univ. Yamanashi, ²Dept. Electrical and Electronic Information Tech., TUT

1-P-12713:1014:10 Development of carbon nanotube MEA system enabling simultaneous measurement of neurotransmitter release and field potential Naoki Matsuda¹, Aoi Odawara¹, Shun Nakajima², Yoshiki Mizuno², Ikuro Suzuki¹ ¹Tohoku Institute of Technology, Department of Electronics, ²SCREEN Holdings Co

1-P-12813:1014:10 Analysis of oxidative stress in immune cells Naomi Kamimura, Kiyomi Nishimaki, Yoshiko Iwai Dept. Biochem. Cell Biol., Grad. Sch. Med., Nippon Med. Sch.

1-P-12913:1014:10 Novel ionic current measurement method and system for drug screening Hirano Minako¹, Nobuyuki Kawashima², Masahisa Tomita², Toru Ide³ ¹Grad. Sch. Creation Photon Indust, ²SYSTEC Corp., ³Okayama Univ

1-P-13013:1014:10 Development of photoswitchable protein that inhibits actin filament polymerization by near-infrared light irradiation Takashi Yoshida, Minoru Wakamori Divi. Molec. Pharmaco. & Cell Biophys., Tohoku Univ. Grad. Sch. Dent.

1-P-13113:1014:10 Less-invasive measurements using the small device, nano tag^®, for locomotor activity, body temperature and gastrointestinal motility in cynomolgus monkeys or beagle dogs Kishida Tomoyuki, Yoshiyuki Motokawa, Syoji Ushikoshi, Toru Tahara, Ayaki Murayama, Ryohei Yokoi, Shinji Souma Safety Research Loboratory, Kissei Pharmaceutical Co., Ltd.

1-P-13213:1014:10 Machine learning-based quality control for contraction of cultured human-induced pluripotent stem cell-derived cardiomyocytes Ken Orita¹, Kohei Sawada², Nobuyoshi Matsumoto¹, Yuji Ikegaya¹ ¹Grad. Sch. Pharm. Sci., Tokyo Univ., ²Grad. Sch. Pharm. Sci., Tokyo Univ.

1-P-13313:1014:10 Rapid measurement of plasma concentration of a vancomycin with diamond sensor. Olga Razvina¹, Takuro Saiki^1,2, Genki Ogata¹, Seishiro Sawamura¹, Rito Kato¹, Ai Hanawa³, Kai Asai³, Yasuo Saijo², Yasuaki Einaga³, Hiroshi Hibino¹ ¹Dept Mol Physiol, Niigata Univ Sch Med, ²Dept Med Oncol, Niigata Univ Sch Med, ³Dept of Chem, Fac of Sci and Tech, Keio Univ

1-P-13413:1014:10 Development of a novel chemical tag tool for calcium imaging by near-infrared fluorescence Isono Yuki¹, Daisuke Asanuma^2,3, Yohei Okubo², Shigeyuki Namiki², Kenzo Hirose² ¹Pharmacol., Dept. of Med., The Univ. of Tokyo, ²Dept. of Phamacol., Grad. Sch. Med., The Univ. of Tokyo, ³PRESTO, JST

1-P-13513:1014:10 Influence on decoding accuracy of EEG in denoised EMG using machine learning Yusuke Shibata, Motoshige Sato, Nobuyoshi Matsumoto, Yuji Ikegaya Lab of Chemi Pharmacol, Grad Sch of Pharmaceuti Sci, The Univ of Tokyo

March 16 (Mon) Poster