program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Symposium5

Pathology of lymphatic vessel/lymphoid tissue-related diseases and its significance as therapeutic targets

1-S05-19:0010:30 Lymphatic vessels in health and disease Timothy Padera E.L Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA

1-S05-29:0010:30 Neuropeptide CGRP regulates inflammation by increasing lymphangiogenesis Kanako Hosono^1,2, Yoshiya Ito^1,2, Hideki Amano^1,2, Masataka Majima^1,2 ¹Dept. Pharm., Sch. Med., Kitasato Univ., ²Dept. Mol. Pharm., Grad. Sch. Med., Kitasato Univ.Dept.

1-S05-39:0010:30 Regulation of dermal lymphatic vascular formation by blood vessel-related factors Masanori Hirashima Div. Pharmacol., Grad. Sch. Med. Dent. Sci., Niigata Univ.

Symposium12

Pharmacology of sleep-wake cycle and circadian clocks

1-S12-110:3012:00 SIK family regulates sleep/wakefulness in mice Hiromasa Funato^1,2 ¹Dept. Anatomy, Faculty Med, Toho Univ., ²IIIS, Univ Tsukuba

1-S1210:3012:00 Toward clinical application of torpor: active hypometabolism research in mice Genshiro Sunagawa BDR, RIKEN

1-S12-210:3012:00 CaMKII-dependent control of sleep duration in mammals Koji Ode^1,2, Hiroki Ueda^1,2 ¹Dept. Sys. Biol., Grad. Sch. of Med., the Univ. of Tokyo, ²Lab. Synth. Biol., BDR, RIKEN

1-S12-310:3012:00 Small molecule modulators of the circadian clock function Tsuyoshi Hirota ITbM, Nagoya Univ.

Oral Sessions

1-O-01114:2014:32 Astrocytes in the critical period regulate synapse-scaling microglia Yosuke Danjo, Eiji Shigetomi, Youichi Shinozaki, Parajuli Bijay, Schuichi Koizumi Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med., Univ. Yamanashi

1-O-01214:3214:44 Melatonin receptor agonist ameliorates PTSD-like behaviors in Fabp3^-/- mice. Yasushi Yabuki^1,2, Kazuya Matsuo², Yuji Owada³, Norifumi Shioda¹, Kohji Fukunaga² ¹Dept. Genomic Neurology., IMEG., Kumamoto Univ., ²Dept. Pharmacol., Grad. Sch. Pharm., Tohoku Univ, ³Dept. Org Anato., Grad. Sch. Med., Tohoku Univ.

1-O-01314:4414:56 Histamine neurons in the tuberomammillary nucleus modulate memory retrieval Hiroshi Nomura, Ayame Kubo, Kyoka Nishimura, Shohei Ohmori, Masabumi Minami Dept. Pharmacol., Grad. Sch. Pharmaceut., Hokkaido Univ.

1-O-01414:5615:08 Role of glutamate release from melanin-concentrating hormone neurons in REM sleep regulation Fumito Naganuma¹, Tadaho Nakamura¹, Ramalingam Vetrivelan², Nobuyuki Okamura¹ ¹Div. Pharmacol. Med. Tohoku Med Pharm Univ., ²Dept. Neurology, BIDMC., Harvard. Med. Sch.

1-O-01515:0815:20 HDAC3 inhibition ameliorates dystrophic axons and memory function via M2 microglia in a transgenic mouse model of Alzheimer's disease Tomoharu Kuboyama, Chihiro Tohda Div. of Neuromedical Science, Instit. of Natural Med., Univ. of Toyama

YIA

1-YIA-1915:2515:37 Analysis of interaction between dimerized receptor and β-arrestin Nuttawadee Ngamlertwong, Hiroyoshi Tsuchiya, Yoko Fujiwara, Morio Azuma, Taka-Aki Koshimizu Dept. Mol. Pharm., Jichi Med Univ.

1-YIA-2015:3715:49 Identification of substrates in the brain of OCTN1/SLC22A4 based on untargeted metabolomics Misa Nishiyama, Tomoyuki Yoshimura, Yusuke Masuo, Takahiro Ishimoto, Noritaka Nakamichi, Junichi Matuo, Yukio Kato Fac. Pharm., Kanazawa Univ.

1-YIA-2115:4916:01 Repagermanium attenuates H₂S-induced acceleration of Ca_v3.2 T-type calcium channel activity and pain sensitivity by directly interacting with H₂S Nene Koike¹, Kaho Sugimoto¹, Hiroshi Masuda¹, Yasuhiro Shimada², Katsuyuki Sato², Takashi Nakamura², Hiroaki Yamaguchi³, Genzou Tanabe⁴, Shinsuke Marumoto⁵, Yoshihito Kasanami¹, Fumiko Sekiguchi¹, Tsuyako Ohkubo⁶, Shigeru Yoshida⁷, Atsufumi Kawabata¹ ¹Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., ²Asai Germanium Res Inst., ³Yamagata Univ. Grad. Sch. Med. Sci., ⁴Lab. Org. Chem., Fac. Pharm., Kindai Univ., ⁵Joint Res. Cent., Kindai Univ., ⁶Div. Basic Med. Sci. Fund. Nurs., Fac. Nurs., Fukuoka Nurs. College, ⁷Dep. Life Sci. Engineer., Kindai Univ.

1-YIA-2216:0116:13 Comparison of two downstream signaling pathways in the µ-opioid receptors activated by several opioids Sei Manabe^1,2,3, Kanako Miyano², Yusuke Mizobuchi^1,2,3, Eiko Uezono^2,4, Kaori Oshima^2,5, Akane Komatsu^2,4, Miki Nonaka², Yoshikazu Matsuoka⁶, Tetsufumi Sato³, Hiroshi Morimatsu¹, Yasuhito Uezono^2,7,8 ¹Dept. Anesthesiol. & Resusctiol., Okayama Univ. Sch. Med., ²Div. Cancer Pathophysiol., NCCRI., ³Div. Anesthesiol. & Critical Care Unit Med., NCCH, ⁴Dept. Anesthesiol. & Pain Manegement., Juntendo Univ., ⁵Lab. Pharmacol. Therapy., Grad. Pharmaceu., Tokyo Univ Sci., ⁶Dept.ICU, Okayama Univ., Sch. Med., ⁷Div. Suppo. Care Res., EPOC, NCC., ⁸Cent. Suppo. Care., NCCH.

1-YIA-2316:1316:25 GPR143, a L-DOPA receptor, is involved in monocrotaline-induced pulmonary hypertension in rats Masayuki Nakano^1,3, Tatsuo Hashimoto^1,3, Motokazu Koga², Daiki Masukawa¹, Shinya Oku², Yusuke Mizuno², Takahisa Goto², Kouichi Tamura³, Yoshio Goshima¹ ¹Dept. Mol. Pharmacol. Neurobiol., Yokohama City Univ. Grad. Sch. Med., ²Dept. Anesthesiology Crit. Care Med., Yokohama City Univ., Sch. Med., ³Dept. Medical Science and Cardiorenal Medicine, Yokohama City Univ., Sch. Med.

Student Sessions

1-SS-1717:0017:11 Establishment of the method of three-dimensional organoid culture derived from liver tissues of non-alcoholic steatohepatitis (NASH) model mice Yamanaka Megumi¹, Elbadawy Mohamed¹, Kimika Hayasi¹, Yuta Goto¹, Ryouichi Tsunedomi², Shoichi Hazama^2,3, Hiroaki Nagano², Toshinori Yoshida⁴, Makoto Shibutani⁴, Ryo Ichikawa⁴, Junta Nakahara⁴, Tsutomu Omatsu⁵, Tetsuya Mizutani⁵, Yukie Katayama⁵, Yuta Shinohara^1,6, Masahiro Kaneda⁷, Hideyuki Yamawaki⁸, Tatsuya Usui¹, Kazuaki Sasaki¹ ¹Lab. Vet Pharm., Dept Vet Med., Tokyo Agri&Tech Univ., ²Dept. Gastro-Breast & Endocrine Surgery, Grad. Sch. Med, Yamaguchi Univ., ³Dept.Translational Res. & Develop. Therap. against Cancer., Sch. Med, Yamaguchi Univ., ⁴Lab. Vet Pathol., Dept Vet. Med., Tokyo Agri&Tech Univ., ⁵Res & Edu Ctr., Dept Vet Med., Tokyo Agri&Tech Univ., ⁶Pet Health & Food Division, Iuskura Industry, ⁷Lab. Vet Anatomy., Dept Vet Med., Tokyo Agri&Tech Univ., ⁸Lab. Vet Pharm., Dept Vet Med., Kitasato Univ.

1-SS-1817:1117:22 Thromboxane A2 receptor signaling attenuates monocrotaline-induced liver injury by affecting endothelial cells, but not platelets Fumisato Otaka^1,2, Yoshiya Ito², Tomoyoshi Inoue^1,2, Hirotoki Ohkubo³, Seri Tsuru², Kanako Hosono², Wasaburo Koizumu¹, Masataka Majima² ¹Dept. Gastroenterology, Sch. Med., Kitasato Univ., ²Dept. Pharmacology, Sch. Med., Kitasato Univ., ³Dept. Cardiovascular Surgery, Sch. Med., Kitasato Univ.

1-SS-1917:2217:33 DAIKENCHUTO, A TRADITIONAL JAPANEASE (KAMPO) MEDICINE, FACILITATES CONTRACTION IN ISOLATED MOUSE DISTAL COLONS: INVOLVEMENT OF TRPA1 CHANNEL AND CALCITONIN GENE-RELATED PEPTIDE Toshihisa Futakami, Yuki Goto, Kimihito Tashima, Synji Horie Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, JAPAN

1-SS-2017:3317:44 Establishment of novel post-inflammatory irritable bowel syndrome model mice with dextran sulfate sodium Saito Eiki, Wakana Uematsu, Yasuhiro Mori, Kimihito Tashima, Syunji Horie Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, JAPAN

1-SS-2117:4417:55 Involvement of thermo-sensitive TRPM8 channels in visceral hypersensitivity in irritable bowel syndrome animal models Hirohide Muramatsu, Yoshiki Nishimura, Yurika Arase, Wakana Uematsu, Takumi Yamakawa, Kimihito Tashima, Syunji Horie Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, Chiba, JAPAN

Student Sessions

1-SS-3818:0018:11 Osteoblastic mTORC1 accelerates acute myeloid leukemia growth via IL-6 signaling Kazuya Fukasawa^1,2, Takanori Yamada¹, Tetsuhiro Horie¹, Manami Hiraiwa^1,2, Katsuyuki Kaneda², Atsushi Hirao³, Eiichi Hinoi¹ ¹Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceutical Univ., ²Lab. Mol. Pharmacol., Inst. Med. Pharmaceut. Health Sci., Kanazawa Univ., ³Div. of Molecular Genetics, Cancer Research Inst., Kanazawa Univ.

1-SS-3918:1118:22 The role of stathmin in the antiproliferative effects of eribulin in breast cancer cells Haruka Ohashi, Akari Ishida, Mikihiro Yoshie, Kazuhiro Tamura Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.

1-SS-4018:2218:33 Suppression of LAT1 in endothelial cells of tumor tissues exhibits an anti-angiogenesis effect Lili Quan¹, Ryuichi Ohgaki¹, Suguru Okuda¹, Shushi Nagamori², Yoshikatsu Kanai^1,3 ¹Dept. Bio-sys Pharm., Grad. Sch. Med., Osaka Univ.,, ²Lab. Bio-Mol. Dynamics, Dept. Collab. Res., Nara Med. Univ., ³Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ.

1-SS-4118:3318:44 Time-course analysis of the changes in intracellular amino acid concentrations and amino acid-related signaling pathways in cancer cells induced by the inhibition of cancer-type amino acid transporter LAT1 Kou Nishikubo¹, Ryuichi Ohgaki¹, Hiroki Okanishi¹, Suguru Okuda¹, Yoshikatsu Kanai^1,2 ¹Dept. Bio-sys Pharm., Grad. Sch. Med., Osaka Univ., ²Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ.

1-SS-4218:4418:55 Doxorubicin-caused cardiomyopathy is due to an inhibition of the fusion step on the autophagy flux Guanjie Li¹, Masaki Saito¹, Noriko Toda^1,2, Masanori Yamauchi², Kazuhiko Yanai^1,3, Takeya Sato¹ ¹Dept. Mol. Pharmacol., Tohoku Univ., Grad. Sch. Med, ²Dept. Anes and Perio Med., Tohoku Univ,. Grad. Sch. Med, ³Dept. Pharm., Tohoku Univ Grad. Sch. Med

1-SS-4318:5519:06 Anti-tumor activity and adverse effects of a novel compound with high specificity to tetraplex DNA Hikaru Fukuda^1,3, Shinobu Satou², Sen Higashi¹, Manabu Habu³, Tomoko Osumi¹, Masaaki Sasaguri³, Kazuhiro Tominaga³, Shigeori Takenaka², Hiroshi Takeuchi¹ ¹Div. Appl. Pharmacol., Kyushu Dent. Univ., ²Dept. Appl. Chem., Res. Ctr. Bio-microsens. Tech., Kyushu Inst. Tech., ³Div. Maxillofacial Surg., Kyushu Dent. Univ.

March 16 (Mon) Room G