program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Young Scientists Symposium1

Current situation of behavioral test for experimental animal in pharmacology

1-S04-19:0010:30 Evaluation of emotional behavior characteristics of stress-adaptive and -maladaptive mice Kazuya Miyagawa, Minoru Tsuji, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Hiroshi Takeda Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare

1-S04-29:0010:30 Animal models in addiction research Soichiro Ide, Kazutaka Ikeda Addictive Substance Project, TMiMS.

1-S04-39:0010:30 Examples of animal behavior assessment tools developed through academic-industrial collaborations. Hitoshi Takahashi MUROMACHI KIKAI CO.,LTD

1-S04-49:0010:30 Development of animal behavior evaluation method by image analysis Takahisa Murata, Koji Kobayashi, Seiji Matsushita, Naoyuki Shimizu Animal Radiology, Tokyo Univ.

Company-Organized Symposium

Acceleration of Investigator initiated clinical trials: Recent activities

1-CS-110:3012:00 Current status of drug development in academia Koji Ikeda Clinical Research, Innovation and Education Center, Tohoku University Hospital

1-CS-210:3012:00 Acceleration of TR from basic science to clinical trial at the iACT Eriko Sumi Dept. Strategic Medical Development, iACT, Kyoto Univ. Hosp.

1-CS-310:3012:00 Investigator-initiated clinical trial of an anti-cancer drug targeted on LAT1 Hayato Hikita¹, Hideaki Harada², Minoru Sigekawa¹, Yukio Kato³, Shushi Nagamori⁴, Yoshikatsu Kanai⁵, Tetsuo Takehara¹ ¹Dept. Gastroenterology and Hepatology, Grad. Sch. Med., Osaka Univ., ²Dept. Medical Innovation, Osaka University Hospital, ³Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa Univ., ⁴Dept. Collaborative Research for Bio-Molecular Dynamics, Nara Medical Univ., ⁵Dep. Bio-system Pharmacology, Grad. Sch. Med., Osaka Univ.

1-CS-410:3012:00 Investigator-Initiated Clinical Trial of HGF Plasmid Product Tetsuya Ishihama Clinical Development Department, AnGes Inc.

Oral Sessions

1-O-00614:1514:27 Phenotypic alteration of tumor infiltrating macrophage by PHD inhibitor lead to improve tumor microenvironment in vivo mouse model. Shinji Matsunaga¹, Shunji Nishide^1,2, Kentaro Tokudome¹, Takehiro Yamaguchi¹, Shuhei Tomita¹ ¹Dept. Pharm., Grad. Sch. Med., Osaka City Univ., ²Dept. Uro., Grad. Sch. Med., Osaka City Univ

1-O-00714:2714:39 Angiotensin II stimulates proliferation and metastasis of murine TNBC 4T1 cells by affecting the tumor microenvironment Tomohiro Takiguchi^1,2, Fumi Takahashi², Shin Ishikane², Toshiyuki Sasaguri¹ ¹Dept. Clin. Pharm., Fac. Med. Sci., Kyushu Univ., ²Dept. Pharmacol., Univ. Occup. & Env. Health, sch. Med.

1-O-00814:3914:51 Potential metabolic changes mediated by cGAMP in astrocytes in contact with brain metastatic cancer Hiromi Sato¹, Kurumi Hara¹, Toya Okawa¹, Hiroki Tanaka², Daiki Shirane², Hiroto Hatakeyama¹, Hidetaka Akita², Akihiro Hisaka¹ ¹Clinical Pharmacology & Pharmacometrics, Grad. Sch. Pharmaceut. Sci., Chiba Univ., ²Design and Drug Disposition, Grad. Sch. Pharmaceut. Sci., Chiba Univ.

1-O-00914:5115:03 O-GlcNAcylation-mediated degradation of FBXL2 stabilizes FOXM1 oncogenic transcription factor to promote cancer progression Kazumasa Moriwaki¹, Yasuhiro Ueda², Kazuhide Higuchi², Michio Asahi¹ ¹Dept. Pharmacol. Fac. Med., Osaka Med. College, ²Dept. Int. Med. II, Fac. Med., Osaka Med. College

1-O-01015:0315:15 EP₄ receptor regulates cell migration and apoptosis in oral cancer Yumika Azuma¹, Masanari Umemura¹, Rina Nakakaji^1,2, Akane Nagasako¹, Kohei Osawa^1,2, Ryo Tanaka¹, Yoshihiro Ishikawa¹ ¹Cardiovascular Research Institute, Sch. Med., Yokohama City Univ., ²Department of Oral and Maxillofacial Surgery, Sch. Med., Yokohama City Univ.

YIA

1-YIA-1315:2015:32 Differentiation-inducing factor-1 suppresses breast cancer cell proliferation by reducing STAT3-mediated cyclin D1 expression Fumi Tetsuo^1,2, Masaki Arioka¹, Fumi Takahashi-Yanaga³, Fusanori Nishimura², Toshiyuki Sasaguri¹ ¹Kyushu Univ., ²Kyushu Univ., ³Sangyo Univ.

1-YIA-1415:3215:44 Cancer cells co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance Takahashi Nobuaki^1,2 ¹Kyoto University, the Hakubi Center, ²Harvard Medical School, Dept. Cell Biology

1-YIA-1615:5616:08 Whole-organ profiling of cancer metastasis by tissue clearing and light-sheet fluorescent microscopy Shimpei I. Kubota¹, Kei Takahashi¹, Jun Nishida¹, Shogo Ehata¹, Kabuki Tanaka², Hiroki R. Ueda³, Kohei Miyazono¹ ¹Dept. Molecular Pathology, Grad. Sch. Med., The Univ. Tokyo, ²Dept. System Pathology for Neurological Disorders, Center for Bioresources, Brain Research Institute, Niigata Univ., ³Dept. Systems Pharmacology, Grad. Sch. Med., The Univ. Tokyo

1-YIA-1716:0816:20 Critical moieties of aromatic amino acid probes causing renal accumulation in tumor imaging Chunhuan Jin¹, Ling Wei¹, Ryuichi Ohgaki¹, Suguru Okuda¹, Shushi Nagamori², Yoshikatsu Kanai^1,3 ¹Dept. Bio-sys Pharm., Grad. Sch. Med., Osaka Univ., ²Dept. Col Res., Nara Med. Univ., ³Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ.

1-YIA-1816:2016:32 Rapid measurement of plasma concentration of a molecular-targeted agent, pazopanib, with diamond sensor. Saiki Takuro^1,2, Genki Ogata¹, Rito Kato¹, Olga Razvina¹, Seishiro Sawamura¹, Yoshifumi Matsumoto², Ai Hanawa³, Kai Asai³, Yasuaki Einaga³, Yasuo Saijo², Hiroshi Hibino¹ ¹Dept Mol Physiol, Niigata Univ Sch Med, ²Dept Med Oncol, Niigata Univ Sch Med, ³Dept of Chem, Fac of Sci and Tech, Keio Univ

Student Sessions

1-SS-1116:5517:06 The roles of progesterone receptor membrane component 1 (PGRMC1) in cyclic AMP-induced human endometrial and trophoblast cells differentiation Tsuru Atsuya¹, Mikihiro Yoshie¹, Ryo Yonekawa¹, Junya Kojima², Hirotaka Nishi², Keiichi Isaka², Kazuhiro Tamura¹ ¹Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci., ²Dept. OB/GYN., Tokyo Med. Univ.

1-SS-1217:0617:17 Hypoxia stimulates CXCR4, an EMT-related factor expression in endometrial epithelial cells Naoya Tsubata, Kazuya Kusama, Kazuhiro Tamura Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.

1-SS-1317:1717:28 Comparative analysis of anti-diabetic effects of citrus flavonoids on pancreatic β-cell function Megumi Kaji¹, Yukiko Kaneko¹, Yuki Tara¹, Moe Yamamoto¹, Yuki Aoyagi¹, Kiriko Akiyama¹, Toshiyuki Kan², Tomohisa Ishikawa¹ ¹Dept. Pharmacol., Grad. Sch. Pharm., Univ. Shizuoka, ²Sch. Pharm. Sci, Univ. Shizuoka

1-SS-1417:2817:39 Attenuation of 5α-reductase-mediated progesterone metabolism promotes differentiation of human endometrial stromal cells for the establishment of pregnancy Kazumi Kawamura¹, Mikihiro Yoshie¹, Sayaha Nakajima¹, Tsubasa Chiba¹, Junya Kojima², Hirotaka Nishi², Keiichi Isaka², Kazuhiro Tamura¹ ¹Dept. Endocrine Pharmacol.,Tokyo Univ. Pharm. Life Sci., ²Dept. OB/GYN.,Tokyo Med. Univ.

1-SS-1517:3917:50 Stimulatory effect of the extract of fruit body of Cordyceps militaris on the secretion of testosterone in rats Mayuko Miyagawa¹, Kazuya Kusama¹, Hiroaki Miyaoka², Koichiro Ota², Toyokazu Nakasone³, Shigemi Okamatsu³, Kazuhiro Tamura¹ ¹Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci., ²Dept. Biomolecular Organic Chem., Tokyo Univ. Pharm. Life Sci., ³Okinawa UKAMI Sericulture Co.,Ltd.

1-SS-1617:5018:01 Establishment of high HPRT activity Urat1-Uox double knockout mouse and the effects of xanthine oxidoreductase inhibitor Takuji Hosoya^1,3, Shunya Uchida², Shigeru Shibata², Naoko H.tomioka¹, Makoto Hosoyamada¹ ¹Dept. Human Physiol. Pathol., Grad. Sch. Pharma-Sci., Teikyo Univ., ²Dept. Int. Med., Sch. Med., Teikyo Univ., ³Dept. Biol. Res., FUJIYAKUHIN CO., LTD.

Student Sessions

1-SS-3218:0718:18 Effects of estrogen on septic inflammatory responses in skeletal muscle Chihiro Hibi, Kazuho Sakamoto, Taito Kuwahara, Junko Kurokawa Dept. Bio-Inform Pharmcol., Sch. Pharm. Sci., Univ Shizuoka

1-SS-3318:1818:29 The effects of Histidine-Rich Glycoprotein(HRG) on neutrophil-like differentiated cell lines Yukinori Yoshii, Hidenori Wake, Kiyoshi Teshigawara, Dengli Wang, Keyue Liu, Yohei Takahashi, Masahiro Nishibori Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

1-SS-3418:2918:40 Oral administration of gluten induces anaphylactic reaction in mice sensitized percutaneously by various kinds of hydrolyzed wheat protein Daiki Tokumitsu¹, Shotaro Obinata¹, Kazumi Sasaki², Masashi Nakamura^3,5, Hirotaka Yamashita^1,4, Kayoko Matsunaga³, Naoki Inagaki⁶, Eiichi Hinoi^1,4, Hiroyuki Tanaka^1,4 ¹Gifu Pharm Univ, ²Natl Inst Tech Eval, ³Fujita Health Univ, ⁴Uni Grad Sch Drug Disc Med Info Sci, Gifu Univ, ⁵HOYU R＆D, ⁶Gifu Univ Med Sci

1-SS-3518:4018:51 Phosphodiesterase 5 inhibitor is effective both CKD and nephrotic syndrome models by protecting glomerular filtration barrier. Tomita Natsumi¹, Yuji Hotta¹, Aya Naiki-Ito², Mayu Yoshikawa¹, Tomoya Kataoka³, Satoru Takahashi², Kazunori Kimura^1,3 ¹Dept. Hospital Pharm., Grad. Sch. Pharm., Nagoya City Univ., ²Dept. Experimental Pathol. Tumor Biol., Grad. Sch. Med., Nagoya City Univ., ³Dept. Clinical Pharm., Grad. Sch. Med., Nagoya City Univ.

1-SS-3618:5119:02 Development of nafamostat-induced hyperkalemia in rats. －A model of decreased renal excretion by a concomitant administration of amiloride－ Teppei Yamada¹, Hiromichi Kaneko², Sawako Tanaka-Nakadate³, Toshifumi Takasusuki¹, Shinsuke Hamaguchi¹, Shigeki Yamaguchi¹, Tomoe Fujita³ ¹Dept. Anesth.,Dokkyo Med. Univ., ²Lab. Animal Res. Cent., Dokkyo Med. Univ., ³Dept. Pharmacol. Toxico., Dokkyo Med. Univ.

1-SS-3719:0219:13 Age-related differences in responses to hydrogen sulfide in the bladder of spontaneously hypertensive rats Suo Zou¹, Takahiro Shimizu¹, Shogo Shimizu¹, Hideaki Ono^1,2, Yohei Shimizu^1,2, Yurika Hata^1,2, Masaki Yamamoto¹, Takaaki Aratake^1,3, Yoshiki Nagao¹, Tomoya Hamada¹, Youichirou Higashi¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., ²Cent. for Innovative and Translational Med., Kochi Univ., ³Research Fellow of Japan Society for the Promotion of Science

March 16 (Mon) Room F