program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Oral Sessions

3-O-10813:5014:02 Involvement of intracellular Fe²⁺ against oxidative stress in CRR cells Kazuo Tomita^1,2, Yoshikazu Kuwahara^1,3, Kento Igarashi^1,2, Yuko Takashi^1,4, Taisuke Nagasawa¹, Sayuri Yamanishi^1,5, Koh-Ichi Tanaka^1,2,6, Jyun-Ichi Kitanaka⁶, Nobue Kitanaka⁶, Akihiro Kurimasa³, Miyawaki Shou-Ich⁵, Yoshihiro Nishitani⁴, Nobuyoshi Nishiyama⁴, Motohiko Takemura⁵, Manabu Fukumoto⁷, Tomoaki Sato¹ ¹Dept. Applied Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ³Dept. Radiation Biol. Med., Facul. Med, Tohoku Med. Pharm. Univ., ⁴Dept. Restorative Dentistry and Endodontology, Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ⁵Dept. Orthodontics and Dentofacial Orthopedics, Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ⁶Dept. Pharmacol., Hyogo Col. Med., ⁷RIKEN, AIP

3-O-10914:0214:14 Anti-leukemia activity of baicalin and baicalein, flavonoids derived from Scutellaria baicalensis Georgi Takeaki Nitto, Takumi Sugimoto, Kohei Sawaki Lab. Pharmacotherapy, Yokohama Univ. Pharm.

3-O-11014:1414:26 Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumour microenvironment. Takeshi Teranayashi¹, Katsuhiro Handa², Takahiro Akamine¹, Toshimasa Ishizaki¹ ¹Dept. Pharm., Oita Univ., ²Clin. Eng. Res. Cent., Oita Univ.

3-O-11114:2614:38 An anti-CD133 monoclonal antibody CMab-43 exerts anti-tumor and anti-metastasis activities for colon cancers Yukinari Kato¹, Mika Kaneko¹, Tomokazu Ohishi², Manabu Kawada² ¹Dept. Antibody Drug Development, Tohoku Univ. Grad. Sch. Med., ²BIKAKEN, Numazu

3-O-11214:3814:50 Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma Akira Nishiyama, Yuki Shibayama, Asadur Rahman Dept. Pharmacol. Kagawa Univ. Med. School

Oral Sessions

3-O-11914:5015:02 Influence of Anticancer Agent on Erectile Function; Vincristine Caused Erectile dysfunction Through Endothelial Dysfunction and Injury to the Cavernous Nerve in Rats Tomoya Kataoka¹, Jun Suzuki², Akimasa Sanagawa³, Yuji Hotta², Yasuhiro Maeda⁴, Kazunori Kimura^1,2,3 ¹Dept. Clinical Pharmacieutics, Grad. Sch. Med., Nagoya City Univ., ²Dept. Hospital Pharmacy, Grad. Sch. Pharm., Nagoya City Univ., ³Dept.Pharmacy, Nagoya City Univ. Hospital, ⁴Dept. Reserch Promotion and Support Headqarters, Fujita Health Univ.

3-O-12015:0215:14 Patient-Derived Cancer Xenograft Xebrafish Model (PDXZ) and Personalized Medicine Kayoko Yamada^1,3, Itsuko Kuroda^1,3, Riho Masukawa^1,3, Yuka Mizutani^1,3, Aoi Hayasaki², Yasuhiro Murata², Naohisa Kuriyama², Masanori Kishiwada², Shuji Isaji², Toshio Tanaka^1,3 ¹Dept. Systems Pharm., Grad. Sch. Med., Mie Univ., ²Dept. Heptobil. Pacreat.Transplant. Surg. Grad. Sch. Med. Mie Univ., ³Mie Univ. Medical Zebrafish Research Center

3-O-12115:1415:26 Chronic exposure to hypoxia facilitates chemotherapy sensitivity with downregulation of MDR1. Licht Miyamoto¹, Yuko Yagi¹, Aya Hatano¹, Yasumasa Ikeda², Shinji Abe³, Toshiaki Tamaki², Koichiro Tsuchiya¹ ¹Dept. Medical Pharmacology, Inst. of Biomedical Sciences, Tokushima Univ., ²Dept. Pharmacology, Inst. of Biomedical Sciences, Tokushima Univ., ³Dept. Clinical Pharmacy Practice Pedagogy, Inst. of Biomedical Sciences, Tokushima Univ.

3-O-12215:2615:38 Establishment of orthotopic transplantation model of mouse gallbladder cancer organoid for development and efficacy evaluation of anti-tumor agents. Kato Shingo¹, Tetsuya Matsuura², Daisuke Kurotaki³, Yoshitaka Hippo⁴, Tomohiko Tamura³, Atsushi Nakajima² ¹Dept. Clinical Cancer Genomics, Yokohama City University Hospital, ²Dept. Gastroenterology and Hepatology, Grad. Sch. Med., Yokohama Univ., ³Dept. Immunology., Grad. Sch. Med., Yokohama Univ., ⁴Division of Molecular Carcinogenesis, Chiba Cancer Center Research Institute

Student Sessions

1-SS-0617:0017:11 ERK1/2-containing MPs from diabetic mice induce endothelial dysfunction via the vascular ERK1/2 activity. Nozomu Kaneko, Kumiko Taguchi, Kazuki Magota, Rio Maeda, Shun Nishiura, Kana Funami, Chisato Ito, Mie Sasaki, Takayuki Matsumoto, Tsuneo Kobayashi Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.

1-SS-0717:1117:22 Influence of long-term exposure of advanced glycation endproducts on vascular contraction in rat carotid artery Keisuke Takayanagi, Takayuki Matsumoto, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.

1-SS-0817:2217:33 Effects of advanced glycation endproducts on uridine diphosphate-induced contraction in rat carotid artery Mihoka Kojima, Takayuki Matsumoto, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.

1-SS-0917:3317:44 SIRT1, an NAD⁺-dependent protein deacetylase, maintains oxidative muscle fiber in the skeletal muscle and contributes to exercise capacity in mice. Seidai Asakura, Ryusuke Hosoda, Atsushi Kuno, Yoshiyuki Horio Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

1-SS-1017:4417:55 Liver blood flow is regulated by hepatic stellate cells and sympathetic nerve in the sinusoid Naoki Dohi¹, Kyosuke Iwami¹, Momoka Yamaguchi¹, Shin-Ya Saito^1,2, Tomohisa Ishikawa¹ ¹Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, ²Fac. Vet. Med., Okayama Univ. Sci.

Student Sessions

1-SS-2718:0018:11 Facilitation of Schwann cell differentiation can be a novel approach to suppress paclitaxel-induced peripheral neuropathy Iwamitsu Yuuki, Satoshi Imai, Madoka Koyanagi, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Shunsaku Nakagawa, Yuki Sato, Takayuki Nagawa, Kazuo Matsubara Dept. Clin. Pharmacol. Therap., Kyoto Univ. Hosp.

1-SS-2818:1118:22 Functional analysis of primary ciliogenesis related factors in zebrafish Shibata Ryohei, Takashi Shiromizu, Yuhei Nishimura Dept. Integrative Pharmacol, Mie Univ. Grad. Sch. Med.

1-SS-2918:2218:33 Establishment of a drug screening system for chondrogenic differentiation of mesenchymal stem cells. Marina Ishida¹, Shuang Liu², Masaki Mogi² ¹Dept. Pharmacol., Sch. Med., Ehime Univ., ²Dept. Pharmacol., Grad. Sch. Med., Ehime Univ.

1-SS-3018:3318:44 Elucidation of neurite outgrowth by Wnt5a Ca^{2 +}-dependently produced in periodontal ligament cells Kaori Takahashi, Takashi Yoshida, Minoru Wakamori Div. Mol. Pharmacol. Cell Biophys., Tohoku Univ. Grad. Sch. Dent.

1-SS-3118:4418:55 The activation of mouse hepatic stellate cells is suppressed by DIF-1, a morphogen produced by cellular slime molds. Ooka Akira¹, Momoka Yamaguchi¹, Shohei Furukawa^1,2, Shin-Ya Saito^1,3, Tomohisa Ishikawa¹ ¹Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, ²Kyoto Pharmaceut. Ind., Ltd., ³Fac. Vet. Med., Okayama Univ. Sci.