program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

Arrhythmia, Channel 1, Heart function, Heart failure 1

3-P2-0113:0014:30 ATX-Ⅱ increases intracellular Na⁺ and Ca²⁺ concentration in pulmonary vein cardiomyocytes by activating reverse-mode Na⁺/Ca²⁺ exchanger Taro Saito, Aiko Ohba, Yuta Takano, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

3-P2-0213:0014:30 Elucidation of mechanisms that trigger torsades de pointes in drug-induced long QT syndrome: a simulation study Kunichika Tsumoto¹, Takao Shimamoto², Akira Amano², Yuhichi Kuda¹, Mamoru Tanida¹, Yasutaka Kurata¹ ¹Dept. Physiol, Kanazawa Med. Univ., ²Dept. Bioinfo, Ritumeikan Univ.

3-P2-0313:0014:30 Different modulatory effects of isoflurane and halothane on arrhythmogenesis elicited by dofetilide in rabbits. Satoshi Kawakami, Yoshinobu Nagasawa, Megumi Aimoto, Akira Takahara Dept. Pharmacol. Therap., Fac. Pharmaceut. Sci. Toho Univ.

3-P2-0413:0014:30 Dulaglutide inhibited perilipin 2-induced atrial fibrillation through the improvement of atrial impulse conduction slowing in transgenic mice Nanae Ishida¹, Shogo Yukawa¹, Satsuki Sato², Jinya Suzuki², Eiichi Taira³, Masamichi Hirose¹ ¹Dept. Pathophysiol. and Pharmacol., Iwate Medical Univ., ²Third Dept. Internal Med., Univ. of Fukui, ³Dept. of Pharmacol., Iwate Medical Univ.

3-P2-0513:0014:30 Manifestation of proarrhythmic properties of IK_ACh blocker tertiapin in the rat dilated atria caused by chronic volume overload Megumi Aimoto, Ryohei Suzuki, Yuka Taneichi, Yoshinobu Nagasawa, Akira Takahara Dept. Pharmacol. Ther., Fdt. Pharmaceut. Sci. Toho Univ.

3-P2-0613:0014:30 Comprehensive and rigorous analysis of drug-induced QT interval prolongation in anesthetized guinea pigs using 11 antihistamines with clinical reports on adverse drug reactions Yoshinobu Nagasawa¹, Miki Shimizu¹, Misa Oshiba¹, Go Minemoto¹, Yuichi Kenmotsu¹, Kengo Kimura¹, Kensuke Omura¹, Naoki Omuro¹, Kaori Fujiwara¹, Haruka Matsuzaki¹, Kazuko Kobayashi^1,2, Satoshi Kawakami¹, Megumi Aimoto¹, Akira Takahara¹ ¹Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ., ²Dept. Pharm. Toho Univ. Ohashi Med. Ctr.

3-P2-0713:0014:30 Characteristics of sudden death in cardiac-specific conditional NCX1 knockout mice Hideaki Tagashira¹, Satomi Kita^1,2, Takahiro Iwamoto¹ ¹Dept. Pharmacol., Fac. of Med., Fukuoka Univ., ²Dept. Pharmacol., Fac. of Pharma. Sci., Tokushima Bunri Univ.

3-P2-0813:0014:30 Hsp90 contributes to cardiac hypertrophy in the development of heart failure via regulating c-Raf. Takumi Itoh, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

3-P2-0913:0014:30 Pathophysiological role of Ca²⁺permeable TRPV2 channel in myocardial ischemia reperfusion injury Yuko Iwata¹, Shigeo Wakabayashi², James Pearson¹ ¹NCVC, Cardiac Physiology, ²Osaka Aoyama Univ., Health Science

3-P2-1013:0014:30 Gender differences in the effect of spontaneous exercise on heart failure in DCM model mice Masami Sugihara¹, Ryo Kakigi², Takashi Murayama³, Takashi Miida¹, Takashi Sakurai³, Sachio Morimoto⁴, Nagomi Kurebayashi³ ¹Dept.Clin.Lab.and Med.,Juntendo Univ., ²Fac. Mgmt. & Info. Sci., Josai Int. Univ., ³Dept.Phamacol.,Juntendo Univ., ⁴Dept. Health Sci. at Fukuoka, IUHW

3-P2-1113:0014:30 Development of drugs for anticancer drug-induced cardiotoxicity using acyl ghrelin and des-acyl ghrelin extracted from the stomach of salmon and tuna Toshiki Kawashima^1,2, Miki Nonaka², Minoru Kihara³, Hidekazu Katayama⁴, Kaori Ohshima^2,5, Kanako Miyano⁶, Kazumi Yoshizawa¹, Yasuhito Uezono^2,7 ¹Lab. of Pharmacol. and Ther., Dept. of Pharm., Fac. of Pharmaceut. Sci., Tokyo Univ. of Sci., Chiba, Japan, ²Dept. of Pain Control Res., The Jikei Univ. Sch. of Med., Tokyo, Japan, ³Dep. of Mar. Biol. and Sci., Sch. of Biol. Sci., Tokai Univ., Hokkaido, Japan, ⁴Dep. of Appl. Biochem., Sch. of Eng., Tokai Univ., Kanagawa, Japan, ⁵Patho., Immunol. & Microbiol., Grad. Sch. of Med., Univ. of Tokyo, Tokyo, Japan, ⁶Div. of Cancer Pathol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan, ⁷Div. of Support. Care Res., Explor. Oncol. Res. & Clin. Trial Ctr., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan

3-P2-1213:0014:30 Arresten, a cleaved fragment of type IV collagen α1 chain, regulates functions of cardiac fibroblasts and left atria Akira Sugiyama, Shiho Tajima, Riki Yamamoto, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

3-P2-1313:0014:30 Chronic toxicity assessment of nilotinib using human-induced pluripotent stem cell-derived cardiomyocytes Hayashi Sayo, Ayano Satsuka, Shota Yanagida, Yasunari Kanda Div. Pharmacol, NIHS

3-P2-1413:0014:30 Assessment of drug-induced contractility in iPS-CMs by cell motion imaging and cell-induced electrical impedance monitoring. Satsuka Ayano, Sayo Hayashi, Yasunari Kanda Div. Pharmacol, NIHS

3-P2-1513:0014:30 Tanshinone VI promotes the differentiation of cardiosphere-derived cells into cardiomyocytes. Tetsuro Marunouchi, Minami Ikoshi, Emi Yano, Kouichi Tanonaka Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

3-P2-1613:0014:30 The effect of chemical sympathetic dennervation on the postnatal heart development. Takuro Numaga-Tomita¹, Hiroyuki Kawagishi¹, Tsutomu Nakada², Mitsuhiko Yamada¹ ¹Dept Mol Pharamcol, Sch Med, Shinshu Univ, ²Res Center Supp Adv Sci, Shinshu Univ

3-P2-1713:0014:30 A novel intracellular drug-delivery system specific for cardiomyocytes using RNA aptamer Takeshi Honda¹, Hiroki Sakai¹, Makoto Inui^1,2 ¹Dept. Pharmacol. Grad. Sch. Med., ²YIC Rehab. Col.

Poster Sessions

Exocrine, Endocrine, Metabolism, Genital Organ, Muscle tissue

3-P2-1813:0014:30 Analysis of the molecular mechanism of compensatory hypertrophy-associated enhancement of salivary secretion using the intravital Ca²⁺imaging and gene analysis. Akihiro Nezu¹, Shigeru Takahashi², Takao Morita³, Akihiko Tanimura¹ ¹Div. Pharmacol, Health Sci. Univ. Hokkaido Sch. Dent., ²Dept. Oral Functional. Anat., Hokkaido Univ. Grad. Sch. Dent. Med., ³Dept. Biochem., Nippon Dent. Univ. at Niigata

3-P2-1913:0014:30 Cdc42-deficiency induces salivary hyposecretion and maintains lacrimal secretion in mice. Nagase Haruna, Akiko Shitara, Yuta Ohno, Masanori Kashimata Asahi Univ., Dent., Pharmacol.

3-P2-2013:0014:30 Regulation by purinergic signal of glucose-induced insulin secretion from iGL insulinoma cells. Masa-aki Ito, Chinatsu Machida, Kazuki Yoshida, Isao Matsuoka Lab. Pharmacol., Fac. Pharm, Takasaki Univ. Health and Welfare

3-P2-2113:0014:30 Effect of sucrose beverage intake on blood glucose level and insulin secretion Sato Sachiko, Yukiko Kondo, Eiichi Taira Dept. of Pharmacol., Iwate Med. Univ., Morioka, Japan

3-P2-2213:0014:30 Thyrotropin receptor antibodies (TRAbs) induced by Epstein-Barr virus reactivation: Significance on Graves’ disease Nagata Keiko¹, Kazuhiko Hayashi², Yukio Satoh³, Mitsuhiko Osaki⁴, Junichiro Miake¹, Yoshinori Ichihara¹, Tatsuya Sawano¹, Yuhang Zhou¹, Agung Priyono¹, Kazuhiko Matsuzawa¹, Takeshi Imamura¹ ¹Div. Pharmacol. Fac. Med. Tottori Univ., ²Pathol.Dept. Fac. Med. Tottori Univ., ³Div. Developmental Biol. Sch. Life Sci. Fac. Med. Tottori UNiv., ⁴Div. Exp. Pathol Sch. Life Sci. Fac. Med. Tottori Univ.

3-P2-2313:0014:30 Possible roles of autophagy related proteins ATG2A and ATG7 in the differentiation of human endometrial stromal cells Saito Yuri¹, Junya Kojima², Atsuya Tsuru¹, Mikihiro Yoshie¹, Kazuya Kusama¹, Kazuhiro Tamura¹, Hirotaka Nishi² ¹Dept. Endocrine Pharmacol.,Tokyo Univ. Pharm. & Life Sci., ²Dept. Obstet. & Gynecol., Tokyo Med. Univ.

3-P2-2413:0014:30 Effect of adipose tissue-derived stem/stromal cells on muscle atrophy Yuki Ohta¹, Tsukasa Kobayashi¹, Yuko Takeba¹, Masanori Ootaki¹, Keisuke Kida¹, Minoru Watanabe², Taroh Iiri¹, Mitsuko Takenaga³, Naoki Matsumoto¹ ¹Dept. of Pharmacol., St Marianna Univ. Sch. of Med., ²Inst. for Anim. Exp., St. Marianna Univ. Grad. Sch. of Med., ³Inst. of Med. Sci., St Marianna Univ. Sch. of Med.

3-P2-2513:0014:30 17β-estradiol attenuates sepsis-induced myopathy in mice Shunya Takeshita, Chihiro Hibi, Kazuho Sakamoto, Junko Kurokawa Dept. Bio-Info. Pharmacol., Univ. Shizuoka

3-P2-2613:0014:30 Identification of binding site for a novel RyR1-selective inhibitor Takashi Murayama¹, Nagomi Kurebayashi¹, Takuya Kobayashi¹, Haruo Ogawa², Masami Kodama², Shuichi Mori³, Hiroyuki Kagechika³, Takashi Sakurai¹ ¹Dept. Pharmacol., Juntendo Univ. Sch. Med., ²IQB, Univ. Tokyo, ³IBB, Tokyo Med. Dent. Univ.

3-P2-2713:0014:30 Characterization of novel RyR1 selective inhibitors identified by ER Ca²⁺ measurements Matsukawa Hiroyuki¹, Takashi Murayama¹, Takuya Kobayashi¹, Nagomi Kurebayashi¹, Toshiko Yamazawa², Mari Ikegami-Yuasa³, Shuichi Mori³, Hiroyuki Kagechika³, Takashi Sakurai¹ ¹Dept. Pharmacol., Juntendo Univ. Sch. Med., ²Dept. Mol. Physiol., Jikei Univ. Sch. Med., ³IBB, Tokyo Med. Dent. Univ.

3-P2-2813:0014:30 Effects of Palmitoleic acids on skeletal muscle differentiation in hyperglycemic environment. Yayoi Tokunaga¹, Hitomi Yoshizaki², Akiyo Toriumi², Chisato Ishida³, Ritsuko Kawaharada⁴, Masatoshi Hori¹, Akio Nakmura² ¹Lab. of Veterinary Pharmacol., Grad. Sch. of Agr. and Life Sci., Tokyo Univ., ²Department of Food and Health Sciences, Jissen Women’s University, Hino, Japan, ³Department of nutrition, Japanese Haramachi Red Cross Hospital, Japan, ⁴Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan

Poster Sessions

Liver

3-P2-2913:0014:30 Evaluation of the usefulness of three-dimensional organoid culture in the drug screening of non-alcoholic steatohepatitis (NASH) disease Yamamoto Haru¹, Megumi Yamanaka¹, Elbadawy Mohamed², Tatsuya Usui¹, Kazuaki Sasaki¹ ¹Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, ²Department of Pharmacology, Faculty of Veterinary Medicine, Benha University

3-P2-3013:0014:30 Disruption of steroidogenic acute regulatory protein-related lipid transfer domain containing 10 (STARD10) prevents the development of nonalcoholic steatohepatitis (NASH) Masanori Ito, Daisuke Ohshima, Yoshinori Mikami, Taichiro Tomida, Satomi Adachi-Akahane Department of Physiology, Faculty of Medicine, Toho University

3-P2-3113:0014:30 Effects of Bezafibrate on Carbon Tetrachloride and T0901317-Induced Nonalcoholic Steatohepatitis Model Yukiko Kawasaki, Shoko Otsu, Yuri Noda, Takahito Imaizumi, Hisami Matsushita, Katsumi Endo, Yasushi Hirasawa Nihon Bioresearch Inc.

3-P2-3213:0014:30 Roles of heparan sulfate against CCl₄cytotoxicity in HepG2 cells Takuro Matsuzawa, Ai Shimane, Kazuhiko Yanai, Takeo Yoshikawa Dept Pharmacol. Tohoku Univ Grad Sch Med

3-P2-3313:0014:30 Platelets attenuate monocrotaline-induced liver injury Fumisato Otaka^1,2, Yoshiya Ito^1,2, Kanako Hosono^1,2, Kou Hatanaka^1,2, Wasaburo Koizumi³, Hideki Amano^1,2 ¹Department of Molecular Pharmacology, Kitasato University Graduate School of Medical Sciences, ²Department of Pharmacology, Kitasato University School of Medicine, ³Department of Gastroenterology, Kitasato University School of Medicine

3-P2-3413:0014:30 Expression of the growth-related factors in the liver of fetal rats Tsukasa Kobayashi¹, Yuko Takeba¹, Yuki Ohta¹, Masanori Ootaki¹, Keisuke Kida¹, Minoru Watanabe², Taroh Iiri¹, Naoki Matsumoto¹ ¹Department of Pharmacology, St Marianna University School of Medicine, ²Institute for Animal Experimentation, St Marianna University Graduate School of Medicine

3-P2-3513:0014:30 CRAC channel blockers attenuate the activation of human hepatic stellate cells Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

3-P2-3613:0014:30 The alternation of adenosine-related genes likely progress HSC activation in inflammatory condition. Naoki Dohi¹, Momoka Yamaguchi¹, Sin-ya Saito^1,2, Tomohisa Ishikawa¹ ¹Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, ²Fac. Vet. Med., Okayama Univ. Sci.

3-P2-3713:0014:30 The formation of lymphatic vessels and macrophages contribute to liver repair after liver injury Shuji Nakamoto^1,2,3, Yoshiya Ito^1,2, Takuya Goto^1,2,3, Kanako Hosono^1,2, Ko Hatanaka^1,2, Masataka Majima^1,2,4, Hideki Amano^1,2 ¹Dept. Mol. Pharmacol., Kitasato Univ. Grad. Sch. Med., ²Dept. Pharmacol., Kitasato Univ. Sch. Med., ³Dept. Surg., Kitasato Univ. Sch. Med., ⁴Dept. Med. Therap., Kanagawa Inst. Tech.

3-P2-3813:0014:30 In vivo S-allyl-L-cysteine and some analogues accelerates liver regeneration in 70% partially hepatectomized rats. Kazuki Kurihara¹, Hajime Moteki¹, Hideshi Natsume², Masahiko Ogihara¹, Mitsutoshi Kimura¹ ¹Dept. Clin. Pharmacol., Fac. Pharma. Sci., Josai Univ., ²Dept. pharmaceutics, Fac. Pharma. Sci., Josai Univ.

Poster Sessions

Receptor, Channel, Transporter 2

3-P2-3913:0014:30 Functional analysis of FSGS-associated TRPC6 channels and its relationship to early-onset and late-onset of the renal disease Ryo Okada¹, Tatsuya Komaki^1,2, Onur K. Polat^3,4, Hideyuki Kobayashi¹, Takanori Kihara², Masayuki X. Mori¹ ¹Bio-materer. Chem., Sch. Med., UOEH, ²Graduate School of Environmental Engineering, The University of Kitakyushu, ³Dept. Synth. Chem. Biol. Chem., Grad. Sch. Eng., Kyoto Univ., ⁴Rush Univ., Chicago, USA

3-P2-4013:0014:30 Inhibition of CRAC channel current by TRPV1 channel agonist and antagonist in RBL cells Ayumi Nakayama, Minoru Wakamori Div. Mol. Pharmacol. Cell Biophys., Grad. Sch. Dent., Tohoku Univ.

3-P2-4113:0014:30 Role of TRPM7 channel in pancreatic cancer Hosokoshi Atsuki¹, Nobuaki Takahashi², Reiko Sakaguchi¹, Atsusi Masamune³, Hiroshi Harada⁴, Yasuo Mori¹ ¹Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, ²The Hakubi Cent., Kyoto Univ, ³Dept. Gastroente., Grad. Sch. Med., Tohoku Univ, ⁴Dept. Genome Dynamics., Radiation Biology Cent., Grad. Sch. Bio., Kyoto Univ

3-P2-4213:0014:30 TRPC channels selective compounds for novel fibrotic disease treatment and trafficking of antisense oligonucleotides Tomorrow Amatani¹, Yuuya Kasahara², Masahito Shimojo³, Motohiro Nishida^4,5, Ryu Nagata³, Satoshi Obika^2,3, Yasuo Mori¹ ¹Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ, ²Natl. Inst. Biomed. Innov. Health. & Nut. (NIBIOHN), ³Dept. Bioorg. & Chem., Grad. Sch. Pharmaceut. Sci., Osaka Univ, ⁴Dept. Pharm., Grad. Sch., Kyushu Univ, ⁵Nat. Ins. Physiol. Sci. (NIPS), Nat. Ins. Natural Sci. (NINS)

3-P2-4313:0014:30 Regulation of mitochondrial activities by TRPA1 channel Yoshiaki Hasegawa¹, Satoru Hamano¹, Yasuo Mori¹, Nobuaki Takahashi^1,2 ¹Lab. Mol. Biol. Grad. Sch. Eng. Kyoto Univ., ²The Hakubi Cent., Kyoto Univ.

3-P2-4413:0014:30 Different Zinc sensitivity of TRPA1 between human and chicken. Masaki Matsubara, Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University

3-P2-4513:0014:30 C-terminal domain regulates the plasma membrane localization of aquaporin-5 Shin-ichi Muroi, Yoichiro Isohama Lab. Appl. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.

3-P2-4613:0014:30 Characterization of G-protein coupled receptors selectively localized in primary cilia in ciliated cellular models Yuki Kobayashi¹, Nobuya Nishimura¹, Yuki Tokubaga¹, Tatsuo Miyamoto², Yumiko Saito¹ ¹Hiroshima Univ. Grad. Sch. Integrate Sci. Life, ²Hiroshima Univ. Res. Inst. Radiobiol.

3-P2-4713:0014:30 A dual prokaryotic (E. coli) expression system (pdMAX) Manabu Murakami¹, Agnieszka Murakami¹, Shirou Itagaki² ¹Department of Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki, ²Collaboration Center for Community and Industry, Sapporo Medical University

Late-Breaking Session

3-P2-LB4813:0014:30 Relationship between plasma extracellular vesicles (EV) and systemic blood pressure in Otsuka Long-Evans Tokushima Fatty (OLETF) rats Risa Teranishi, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

3-P2-LB4913:0014:30 Reduced white adipose tissue amount in mice lacking mitochondrial protein p13 Hara Satomi¹, Hiroki Ueno¹, Masafumi Noguchi², Wakana Matsuo¹, Hitoshi Hashimoto^1,3,4,5,6, Norihito Shintani¹ ¹Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., ²Dept. Biol., Univ. Padova, ³United Grad. Sch. Child Dev., Osaka Univ., ⁴Div. Biosci., Inst. Datability Sci., Osaka Univ., ⁵Transdimensional Life Imaging Div., Inst. Open Transdiscip. Res. Initiatives, Osaka Univ, ⁶Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ.

3-P2-LB5013:0014:30 Novel Reporter Systems Monitoring NFkB activation Can Be Applied toHigh-Throughput Screening. Yonezawa Tomo

March 10 (Wed) Room P2