program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

Pain, Sensary Neuron, Inflammation 2, Drug Addiction, Drug Abuse

3-P1-0113:0014:30 Human mesenchymal stem cells from adipose tissue and umbilical cord improved neuropathic pain by regulating inflammation and recovery of the demyelination of sciatic nerve in rats Kanako Miyano^1,2, Minori Ikehata³, Kaori Ohshima^2,4, Yuki Yoshida⁵, Yasuhiro Nose³, Sei-ichi Yoshihara³, Katsuyuki Oki³, Seiji Shiraishi⁶, Miaki Uzu⁷, Miki Nonaka², Yoshikazu Higami⁵, Minoru Narita^1,8, Yasuhito Uezono² ¹Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., ²Dept. Pain & Cont. Res., The Jikei Univ. Sch. of Med., ³R&D Dept. Biomimetics Sympathies Inc., ⁴Pathol., Immunol. and Microbiol., Grad. Sch. of Med., The Univ. of Tokyo., ⁵Lab. Mol. Pathol. and Metab. Disease, Faculty of Pharm. Sci., Tokyo Univ. of Sci., ⁶Div. Cancer Pathophysiol., Natl. Hosp. Org. Kure Med., ⁷Vitrigel Prj., Inst. of Agrobiol. Sci., NARO., ⁸Dept. Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharma. Sci.

3-P1-0213:0014:30 KCNQ (Kv7) K⁺ channel opener retigabine inhibits pain and itch. Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

3-P1-0313:0014:30 Mechanisms of hyperalgesia in dry eye model rats: involvement of the glial cells and the voltage-gated Ca²⁺ channel α2δ subunit in the trigeminal nucleus Yuto Tei^1,2, Yoshinori Mikami¹, Masanori Ito¹, Taichiro Tomida¹, Daisuke Ohshima¹, Yuichi Hori², Satomi Adachi-Akahane¹ ¹Department of Physiology, Faculty of Medicine, Toho University, ²Department of Ophthalmology, Faculty of Medicine, Toho University

3-P1-0413:0014:30 TRPV1 and TRPA1 are cooperatively involved in the tooth movement-related pain. Kazunori Adachi¹, Misato Yugawa² ¹Div. Pharmacol. Meikai Univ. Schol. Dent., ²Div. Orthodont. Meikai Univ. Schol. Dent.

3-P1-0513:0014:30 Implicated in spinal cholecystokinin-8 and hemokinin-1 in type 1 diabetes allodynia in mice Takafumi Hayashi¹, Chizuko Watanabe², Syu-ichi Kanno³, Masaru Yoshizumi², Yasuyuki Agatsuma¹, Akiyoshi Hara³, Shinobu Sakurada⁴ ¹Lab. Pharmaceut. Sci., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ., ²Dept. Physiol. Anato., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ., ³Dept. Clin. Pharmacotherap., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ., ⁴Tohoku Med. Pharmaceut. Univ.

3-P1-0613:0014:30 Two-way association between sleep disturbance and persistent pain Yabe Shuhei¹, Yusuke Hamada^1,2, Kenichi Tanaka¹, Yoshiyuki Yamabe¹, Michiko Narita^2,3, Naoko Kuzumaki¹, Minoru Narita^1,2 ¹Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, ²Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan, ³Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan

3-P1-0713:0014:30 Comparison of the effects of Goreisan and loxoprofen on cerebral blood flow dynamics in meteoropathy model mice Sumika Ryu¹, Yuki Kurauchi^1,2, Risako Tanaka¹, Makito Haruta³, Kiyotaka Sasagawa³, Takahiro Seki^1,2, Jun Ohta³, Hiroshi Katsuki^1,2 ¹Dept Chemico-Pharmacol Sci, Sch Pharm, Kumamoto Univ, ²Dept Chemico-Pharmcol Sci, Grad Sch Pharm Sci, Kumamoto Univ, ³Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology

3-P1-0813:0014:30 Itch and pain caused by intradermal injection of sulfides in mouse cheek: Effect of genetic deletion of Ca_v3.2 T-type calcium channels Shotaro Kurahashi¹, Iyo Nishiyama¹, Rina Minamino¹, Hiroyuki Nishikawa^1,2, Fumiko Sekiguchi¹, Maho Tsubota¹, Atsufumi Kawabata¹ ¹Laboratory of Pharmacology & Pathophysiology, Faculty of Pharmacy, Kindai University, ²Fuso Pharmaceutical Industries, Ltd.

3-P1-0913:0014:30 Phenotypic examination of the endocannabinoid-degrading enzyme alpha/beta-hydrolase domain containing 6 (ABHD6) knockout rat Katsuhiko Noguchi¹, Kimio Sugaya¹, Saori Nishijima¹, Mayuko Sakanashi², Katsumi Kadekawa¹, Shiho Okitsu³, Sayomi Nakamine³, Hidetsugu Torihara³, Hideyuki Yamamoto³ ¹Southern Knights’ Laboratory Co., Ltd., ²Dept. Pharmacy, Col. Pharmacy, Kinjo Gakuin University, ³Dept. Biochemistry, Grad. Sch. Med., Univ. the Ryukyus

3-P1-1013:0014:30 MicroRNA expression profiling in ethanol dependence in mice Keisuke Mizuo, Tomoka Yamaguchi, Satoshi Watanabe Dept. of Legal Med. Sapporo Med. Univ. Sch. of Med.

3-P1-1113:0014:30 Inhibitory effect of SB216763, a selective glycogen synthase kinase-3 inhibitor, on morphine-induced Straub’s tail reaction in mice Junichi Kitanaka¹, Nobue Kitanaka¹, Utau Horie¹, Yumi Kawasaki¹, Takashi Sakamoto¹, Junya Yashiro¹, Koh-ichi Tanaka², Kento Igarashi^2,3, Kazuo Tomita^2,3, Ami Shiomoto⁴, Kaname Watabe⁴, Kiyoshi Nakano⁴, Hitoshi Takahashi⁴, Nobuyoshi Nishiyama², Tomoaki Sato³, Motohiko Takemura¹ ¹Dept. Pharmacol., Hyogo Col. Med., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ³Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ⁴Muromachi Kikai, Co., Ltd.

3-P1-1213:0014:30 Analysis of the tendency of dependence for various targets based on the psychological characteristic in undergraduate students Ken-ichi Tanaka, Michiko Konno Sch. Health Social Services, Saitama Pref. Univ.

Poster Sessions

Depression, Anxiety 2, Psychiatry, Behavior 2

3-P1-1313:0014:30 Chronic pain-induced neuronal plasticity in the extended amygdala causes maladaptive anxiety Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami Dept Pharmacol Grad Sch Pharm Sci, Hokkaido Univ

3-P1-1413:0014:30 Histological analyses of CRF mRNA expression in the dorsolateral bed nucleus of the stria terminalis of chronic pain model rats Saya Arakaki, Daiki Takahashi, Yuta Asaoka, Keisuke Kimura, Ryuto Hara, Keisuke Sakasai, Hiroe Suzuki, Naoki Yamauchi, Hiroshi Nomura, Taiju Amano, Masabumi Minami Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University.

3-P1-1513:0014:30 Development of a novel stress model using a video-recorded scene of the social defeat stress in mice Yuko Nakatake^1,2, Hiroki Furuie², Masatoshi Ukezono³, Misa Yamada², Kazumi Yoshizawa¹, Mitsuhiko Yamada² ¹Lab. Pharmacol. Therap., Grad. Sch. Pharmaceut. Sci., Tokyo Univ. Sci., ²Dept. Neuropsychopharmacol., Natl. Inst. Mental Health, Natl. Center Neurol. Psychiat., ³RIKEN

3-P1-1713:0014:30 Social stress induces subcellular degeneration preceding dendritic loss of prefrontal pyramidal neurons in mice Chisato Numa¹, Hirotaka Nagai¹, Midori Nagai¹, Nobuhiko Ohno², Yuko Mimori-Kiyosue³, Yosky Kataoka⁴, Tomoyuki Furuyashiki¹ ¹Dept. Med. Div. Pharmacol., ²Jichi Med. Univ. Div. Hist. & Cell Biol. Dept. Anat., ³RIKEN BDR Lab. Mol. & Cell. Dyn., ⁴RIKEN BDR Lab. Cell. Funct. Img.

3-P1-1813:0014:30 Left-right asymmetry in chronic stress-induced neuroinflammation Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

3-P1-1913:0014:30 Role of Microsomal prostaglandin E synthase-1 in acute stress Kawabata Yuta¹, Asumi Doumae¹, Hiromi Hirata¹, Aki Sakahara¹, Satoshi Uematsu², Shizuo Akira³, Tatsuo Takahashi¹, Yuri Ikeda-Matsuo¹ ¹Lab. Pharmacol., Dept. Clin. Pharmacy, Fac. Pharmac. Sci., Hokuriku Univ., ²Dept. Immunol. Genomics, Osaka City Univ. Grad. Sch. Med., ³Lab. Host Defense, WPI Immunol. Front. Res. Ctr, Osaka Univ.

3-P1-2013:0014:30 Loss of function in mouse GAD67 leads to emotional impairments Shigeo Miyata¹, Toshikazu Kakizaki¹, Kazuyuki Fujihara¹, Hideru Obinata², Touko Hirano², Junichi Nakai³, Mika Tanaka⁴, Shigeyoshi Itohara⁴, Kenji Tanaka⁵, Masahiko Watanabe⁶, Manabu Abe⁷, Kenji Sakimura⁷, Yuchio Yanagawa¹ ¹Dept. Gen. Behav. Neurosci., Grad. Sch. Med., Gunma Univ., ²Lab. Anal. Instr., Grad. Sch. Med., Gunma Univ., ³Div. Oral Physiol., Dept. Oral Funct. Mor., Grad. Sch. Dent., Tohoku Univ., ⁴Lab. Behav. Gen., RIKEN Brain Sci. Inst., ⁵Dept. Neuropsychiat., Sch. Med., Keio Univ., ⁶Dept. Anat., Fac. Med., Hokkaido Univ., ⁷Dept. Anim. Mod. Devel., Brain Res. Inst., Niigata Univ.

3-P1-2113:0014:30 Glutamatergic neurons from medial prefrontal cortex to dorsal raphe nucleus regulates maternal aggression in mice Yoshikage Muroi, Toshiaki Ishi Dep. Vet. Med., Obihiro Univ.

3-P1-2213:0014:30 The amygdalohippocampal area that projects to the medial preoptic area mediates aggression toward the infant Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Masabumi Minami, Taiju Amano Dept. of Pharmacol, Grad. Sch. of Pharmaceut. Sci. Hokkaido Univ.

3-P1-2313:0014:30 Synaptic inputs derived from the central nucleus of amygdala that suppresses neurons in the rhomboid nucleus of the bed nucleus of the stria terminals of paternal mice Shunsaku Murakawa, Haruka Uki, Masabumi Minami, Taiju Amano Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Science, Hokkaido Univ, Hokkaido, Japan

3-P1-2413:0014:30 Long-term administration of D₂ receptor blocker sulpiride changes social behavioral pattern in male mice Hamasaki Yumi, Masabumi Minami, Taiju Amano Dept. of Pharmacology, Grad. Sch. of Pharmaceutical Sciences, Hokkaido Univ, Hokkaido, Japan

3-P1-2513:0014:30 Blonanserin and 1-(2-Pyriidinyl)-piperazine suppress impulsive action in rats Hitomi Sasamori¹, Naoya Nishitani², Yu Ohmura¹, Mitsuhiro Yoshioka¹ ¹Dept. Neuropharmacol. Hokkaido Univ., ²Lab. Mol. Pharmacol. Kanazawa Univ.

3-P1-2613:0014:30 Serotonergic activity in the dorsal raphe nucleus is required for model-based decision making Yu Ohmura¹, Kentaro Iwami², Hitomi Sasamori¹, Chiaki Sugiura¹, Youcef Bouchekioua¹, Mitsuhiro Yoshioka¹ ¹Dept Neuropharmacol, Hokkaido Univ, Hokkaido, Japan, ²Hokkaido Univ Sch Med, Hokkaido, Japan

3-P1-2713:0014:30 Behavioral Characterization of Dopamine D₅ Receptor Knockout(D₅KO) Mice Chiaki Sugiura Dept. Neuropharmacol. Hokkaido Univ.

3-P1-2813:0014:30 Ameliorating effects of guanfacine, an adrenergic α_2A receptor agonist, on AD/HD-like behaviors in an AD/HD model rat, male adolescent SHRSP/Ezo Taku Yamaguchi, Ryosuke Shinozaki, Tatsuya Oka Dept. Pharmacother. and Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.

3-P1-1613:0014:30 Withdraw

Poster Sessions

Receptor, Channel, Transporter, Intracellular and Intercellular Signaling, Methodology, Technology, Others

3-P1-2913:0014:30 Inhibitory effects of local anesthetics on muscarinic receptors: effects on the Ca²⁺ release from intracellular store and recruitment of beta-arrestin. Shimatani Mari¹, Akihiro Nezu², Akihiko Taimura² ¹Div. Reconstructive Surg Oral Maxillofac Reg., Health Sci. Univ. Hokkaido, Sch. of Dent., ²Div. Pharmacol., Health Sci. Univ. Hokkaido, Sch. of Dent.

3-P1-3013:0014:30 Annexin A2 is involved in activation of AKT upon endothelin-1 stimulation in melanoma cells Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ.

3-P1-3113:0014:30 Localization analysis of several NCKX2-NCLX chimeras into plasma membrane/mitochondrial inner membrane Takayuki Nemoto¹, Tomo Kita¹, Hideaki Tagashira¹, Satomi Kita^1,2, Takahiro Iwamoto¹ ¹Dept. Pharmacol., Fac. Med., Fukuoka Univ., ²Dept. Pharmacol., Fac. Pharma. Sci., Tokushima Bunri Univ.

3-P1-3213:0014:30 Distribution of mammal-like melanin concentrating hormone type 1 and 2 receptor expressing neurons in the brain of a basal actinopterygian fish, Polypterus senegalus Morio Azuma, Taka-aki Koshimizu Div. of Mol. Pharmacol., Dept. of Pharmacol., Jichi Med. Univ.

3-P1-3313:0014:30 Receptor functional analysis of leptin resistance by adenosine- BRET analysis Toru Hosoi¹, Takenori Matsuura³, Anisia Silva⁴, Momoe Wada³, Syu Matsuzaki³, Michitaka Sugiyama², Naoshi Kodama², Ralf Jockers⁴, Julie Dam⁴, Koichiro Ozawa² ¹Dept. Clin. Pharmacology, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ., ²Dept. Pharmacotherapy, Grad. Sch. Biomed. Health Sci., Hiroshima Univ., ³Dept. Pharmacotherapy, Sch. Pharm. Hiroshima Univ., ⁴Inserm U1016, Institut Cochin, Dept Endocrinology, Metabolism and Diabetes, Paris, France

3-P1-3413:0014:30 Collapsin response mediator protein 2 was one of targets for 15-deoxy -Δ^12,14-prostaglandin J₂ Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma Dept. Pharmaceutic. Health, Himeji Dokkyo Univ.

3-P1-3513:0014:30 Differentiation-inducing factor 1 activates AMP-regulated kinase/Cofilin pathway to regulate the actin cytoskeleton. Koichi Miura, Takeru Inoue, Ruzhe Han, Toshiyuki Sasaguri Kyushu Univ., Fac. of Med. Sci.

3-P1-3613:0014:30 Development of Histamine N-methyltransferase Inhibitors for Brain Disorders Takeo Yoshikawa, Rina Otsuka, Yuki Sato, Kazuhiko Yanai Dept Pharmacol Tohoku Univ Grad Sch Med

3-P1-3713:0014:30 The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system Nobuko Matsumura¹, Chisato Kinoshita¹, Toshio Nakaki², Koji Aoyama¹ ¹Dept. Pharmacol., Teikyo Univ. Sch. Med., ²Fac. Pharma-Sci., Teikyo Univ.

3-P1-3813:0014:30 Evaluation of seizure sensitivity and potential excitation foci in Phf24-KO rats Naofumi Kunisawa¹, Hiroaki Hisadumi¹, Masaki Kato¹, Saki Shimizu¹, Kazuaki Sato², Masato Kinboshi¹, Masao Matsuhashi³, Akio Ikeda³, Tadao Serikawa¹, Yukihiro Ohno¹ ¹Dept. Pharmacol., Osaka Univ. Pharmaceut. Sci., ²Dept. neurol., Ijinkai takeda general Hosp., ³Dept. Epilepsy, Mov. Dis. and Physiol., Kyoto Univ.

3-P1-3913:0014:30 Lifelong measurement of locomotor activity and body temperature in group-housed laboratory mice by wireless power transmission Kazuhiko Yanai¹, Takeo Yoshikawa¹, Kenichi Sagara², Shu Sasaki² ¹Tohoku Univ. Sch. Med. Dept. Pharmacol., ²HIKARIDENSHI, CO., LTD

3-P1-4013:0014:30 Our preclinical support of neurological research approaches using cerebrospinal fluid Kohei Araki, Keita Saito, Kotaro Suzuki, Toru Nonomura, Noriyuki Yamazaki New Drug Research Center, Inc.

3-P1-4113:0014:30 Efforts for promotion of Use of Radioisotopes (RI)　-RI Experimental Protocols for Beginners- Rikako Azuma¹, Hiroyuki Tsunokuni¹, Keiichi Matsunami², Masayuki Hara³, Shinsuke Katoh⁴, Hiroyuki Iizuka⁵ ¹Japan Radioisotope Association, ²Grad. Sch. of Medicine, Juntendo Univ., ³Res. Core, Inst. of Res., Tokyo Medical and Dental Univ., ⁴Dept. of Health Pharm., Yokohama Univ. of Pharm., ⁵Sch. of Eng. Environ. Health and Safety Office., Univ. of Tokyo

3-P1-4213:0014:30 Structure prediction of the N-terminal regulatory domain of the human tryptophan hydroxylase 2 Masanori Ootaki¹, Tomoko Hiroi², Yuki Ohta¹, Yuko Takeba¹, Keisuke Kida¹, Hiroaki Matsui², Naoki Matsumoto¹ ¹St. Marianna Univ. Sch. Med. Dept. Pharmacol., ²Inst. Radioisotope Res. St. Marianna Univ. Grad. Sch. Med.

3-P1-4313:0014:30 Comparison of medication self-management for older adults supported by nurses at general hospitals and home-visit nursing stations Kanako Sakane¹, Yuta Kobayashi¹, Mayumi Miyamoto¹, Miki Fukuma¹, Yuko Tsumoto¹, Hiromi Uchida² ¹Shimane Uni., Fac. Med., Dept. Nursing, ²Tenri Helth Care Uni.

3-P1-4413:0014:30 Integrated safety evaluation of benzodiazepines using human iPS cell technology Tsunemoto Kazunobu¹, Shigeru Yamada^1,2, Yasunari Kanda¹ ¹Div. Pharmacol, NIHS, ²PEIJ

3-P1-4513:0014:30 Antioxidative activity of fructose 1,6-bisphosphate as a direct free radical scavenger Kazue Ogata¹, Kahona Ono², Osamu Tokumaru¹ ¹Department of Physiology, Facalty of Welfare and Health Sciences, Oita University, ²Medical student, School of Medicine, Oita University Faculty of Medicine

Late-Breaking Session

3-P1-LB4613:0014:30 Electrophysiological and anatomical properties of neurons in the ventrolateral part of the periaqueductal gray matter in the rat Kawasaki Shiori, Yuka Nakaya, Masayuki Kobayashi Dept. Pharmacol., Nihon Univ Sch Dent.

3-P1-LB4713:0014:30 Influences of prenatal stress by the communication box on GABAergic system in the amygdala of mice. Takayoshi Mamiya¹, Ping Lu¹, Lingling Lu¹, Hiroshi Oda¹, Akihiro Mouri^1,2, Toshitaka Nabeshima^1,2, Masayuki Hiramatsu¹ ¹Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ., ²Adv. Diagn Sys. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ.

March 10 (Wed) Room P1