program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Oral Sessions

Depression, Anxiety (2)

3-O-E1-19:009:12 Serotonin neuron-specific transcriptome profiling in chronic SSRI-treated mice and chronic social defeat stress model mice Chihiro Andoh¹, Masako Hagiwara¹, Naoya Nishitani², Kazuki Nagayasu¹, Hisashi Shirakawa¹, Shuji Kaneko¹ ¹Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., ²Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.

3-O-E1-29:129:24 Modulation of glutamatergic synaptic transmission in the prelimbic medial prefrontal cortex via delta-opioid receptors Daisuke Yamada¹, Keita Iio², Hiroshi Nagase², Akiyoshi Saitoh¹ ¹Lab Pharmacol, Fac Pharm Sci, ²IIIS, Univ of Tsukuba

3-O-E1-39:249:36 Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through inhibition of indoleamine 2,3-dioxygenase 1 expression in mice Kazuo Kunisawa¹, Willy Jaya Suento^2,3, Bolati Wulaer^2,4, Aika Kosuge¹, Tsubasa Iida¹, Hidetsugu Fujigaki², Yasuko Yamamoto², Andi Jayalangkara Tanra³, Kuniaki Saito^2,4,5, Toshitaka Nabeshima^4,5, Akihiro Mouri^1,5 ¹Fujita Health University・Graduate School of Health Science・Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, ²Fujita Health University・Graduate School of Health Science・Department of Disease Control and Prevention, ³Hasanuddin University・Faculty of Medicine・Department of Psychiatry, ⁴Fujita Health University・Graduate School of Health Science・Advanced Diagnostic System Research Laboratory, ⁵Japanese Drug Organization of Appropriate Use and Research

3-O-E1-49:369:48 Involvement of Dysfunction of Noradrenergic Neuronal System in the Depression-Like Behaviors in MAGE-D1 KO Mice Akihiro Mouri^1,6, Mami Hirakawa¹, Misato Yokoyama², Ken Watanabe³, Mari Kimura², Ryosuke Isobe¹, Kazuo Kunisawa¹, Yuko Mori⁴, Yasuko Yamamoto⁴, Yukihiro Noda^2,6, Kuniaki Saito^4,6, Toshitaka Nabeshima^5,6 ¹Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., ²Div. Clin. Sci. and Neuropsychopharm., Meijo Univ. Grad. Sch. Pharm., ³Dept. Bone and Joint Dis., Natl. Ctr. for Geriatrics and Gerontol., ⁴Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., ⁵Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., ⁶NPO.J-DO.

Oral Sessions

Depression, Anxiety (3)

3-O-E2-110:0010:12 Nicotine attenuated chronic unpredictable mild stress-induced depressive-like behavior via elevation of serum corticosterone level Masaya Hasegawa¹, Akihiro Mouri^1,4, Kazuo Kunisawa¹, Hisayoshi Kubota¹, Hitomi Kurahashi¹, Yasuko Yamamoto², Kuniaki Saito^2,3,4, Toshitaka Nabeshima^3,4 ¹Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., ²Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Uni., ³Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ., ⁴NPO. J-DO

3-O-E2-210:1210:24 Depression-like behaviors induced by chronic social defeat stress in association with myelin abnormalities in the corpus callosum through microglial activation. Sugawara Yumika¹, Kazuo Kunisawa¹, Tsubasa Iida¹, Sei Saitoh², Aika Kosuge¹, Wulaer Bolati^3,4, Yasuko Yamamoto³, Kuniaki Saito^3,4,5, Akihiro Mouri^1,5, Toshitaka Nabeshima^3,5 ¹Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., ²Dept. Anatomy II and Cell Biology, Sch. Medicine, Fujita Health Univ, ³Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ., ⁴Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., ⁵NPO.J-DO.

3-O-E2-310:2410:36 Multiple spatiotemporal patterns of social stress-induced epigenetic regulations in microglia Masayuki Taniguchi¹, Kazutoshi Matsushita¹, Rei Mishima¹, Shiho Kitaoka¹, Shigehiro Kuraku², Mitsutaka Kadota², Tomoyuki Furuyashiki¹ ¹Division of Pharmacology, Kobe University Graduate School of Medicine, ²Laboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research

3-O-E2-410:3610:48 Chronic social stress alters iron metabolism for resilience Shiho Kitaoka¹, Taichi Tamura¹, Yoshio Katayama², Tomoyuki Furuyashiki¹ ¹Div. Pharmacol., Grad. Sch. Med., Kobe Univ, ²Dep. Hematol., Med., Kobe Univ

Oral Sessions

Depression, Anxiety (4), Stress, Myelin

3-O-E3-111:0011:12 Effects of early life stress on emotional behavior and hippocapal function in adolescent Hyodo Risa, Sara Nannno, Akari Nishiyama, Taiga Akuhara, Eri Segi-Nishida Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci.

3-O-E3-211:1211:24 The role of neurotrophin-3 in the hippocampal neurogenesis and maturation-related phenotypes Kasakura Nanami¹, Yuka Murata¹, Ryota Someya¹, Shiho Kitaoka², Tomoyuki Furuyashiki², Eri Segi-Nishida¹ ¹Dept. Biol. Sci. and Tech., Tokyo Uni. of Sci, ²Div of Pharmacol., Grad. Sch. of Med., Kobe Univ.

3-O-E3-311:2411:36 Roles of TRPC3 and TRPC6 in the medial prefrontal cortex in the antidepressant-like actions of ketamine Satoshi Deyama, Katsuyuki Kaneda Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.

3-O-E3-411:3611:48 The protective effect of flesinoxan on myelin damage caused by maladaptation to stress in mice Kazuhiro Kurokawa¹, Kohei Takahashi¹, Kazuya Miyagawa¹, Atsumi Mochida-Saito¹, Hiroshi Takeda², Minoru Tsuji¹ ¹Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare, ²Dept. Pharmacol., Sch. Pharm. Fukuoka, Int. Univ. Health and Welfare

3-O-E3-511:4812:00 The positive effect of Hypoxia-inducible factor on peripheral nerve remyelination. Yuka Ujiie-Kobayashi, Shuji Wakatsuki, Toshiyuki Araki Dept. of Peripheral Nervous System Res., NCNP

Oral Sessions

Psychiatric Disoder, Developmental Disoder

3-O-E4-114:3014:42 Hypo-serotonergic function is involved in the prenatal valproic acid-induced behavioral changes and hyper-excitation in the prefrontal cortex of mice Kurahashi Hitomi¹, Mouri Akihiro^1,4, Kunisawa Kazuo¹, Kubota Hisayoshi¹, Hasegawa Masaya¹, Yamamoto Yasuko², Saito Kuniaki^2,3,4, Nabeshima Toshitaka^3,4 ¹Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., ²Dept. Disease Control & Prevention., Grad. Sch. Health Sci., Fujita Health Univ., ³Adv. Diagnostic. Syst. Res. Lab., Grad. Sch. Health Sci., Fujita Health Univ., ⁴NPO. J-DO

3-O-E4-214:4214:54 Intranasal oxytocin administration improves impaired social behavior in the POGZ-Q1038R mutant mice Kitagawa Kohei¹, Kensuke Matsumura¹, Masayuki Baba¹, Momoka Kondo¹, Tomoya Takemoto¹, Kazuki Nagayasu^1,2, Yukio Ago^1,3, Atsushi Kasai¹, Kazuhiro Takuma^4,5, Hitoshi Hashimoto^1,4,6,7,8, Takanobu Nakazawa^1,9 ¹Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., ²Lab. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., ³Lab. Cell. & Mol. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., ⁴United Grad. Sch. Child Dev., Osaka Univ., ⁵Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., ⁶Div. Biosci., Inst. Datability Sci., Osaka Univ., ⁷Transdimensional Life Imaging Div., Inst. Open Transdiscip. Res. Initiatives, Osaka Univ, ⁸Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., ⁹Dept. Biosci., Tokyo Univ. Agr.

3-O-E4-314:5415:06 Behavioral changes in rats neonatally treated with midazolam: deficits in the sociability and its recovery by acute administration of methylphenidate. Niikura Ryo¹, Akiko Doi¹, Tomoyuki Miyazaki¹, Kenkichi Takase², Takahisa Goto¹ ¹Dept. Anesth. Crit. Care Med., Yokohama City Univ., ²Sch. Med., Jichi Med. Univ.

3-O-E4-415:0615:18 Local injection of D-amino acid oxidase inhibitor into the prefrontal cortex improves AD/HD-like behaviors of SHRSP/Ezo. Hiroki Shikanai, Tsugumi Shindo, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi Dept. Pharmacol., Health Sci. Univ. Hokkaido.

Oral Sessions

Psychiatry, Behavior (4), Toxicopharmacology (2)

3-O-E5-115:3015:42 Therapeutic potential of 5-HT_2C receptor antagonism for obsessive-compulsive disorder. Hatakama Hikari¹, Nozomi Asaoka², Kazuki Nagayasu¹, Hisashi Shirakawa¹, Shuji Kaneko¹ ¹Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., ²Dept. Phamacol., Grad. Sch. Med. Sci., Kyoto Pref. Univ. Med.

3-O-E5-215:4215:54 Striatal TRPV1 activation by acetaminophen improves tardive dyskinesia induced by dopamine D₂ receptor blockers Koki Nagaoka¹, Takuya Nagashima¹, Nozomi Asaoka², Hiroki Yamamoto¹, Chihiro Toda¹, Gen Kayanuma¹, Soni Siswanto¹, Kazuki Nagayasu¹, Hisashi Shirakawa¹, Shuji Kaneko¹ ¹Dept. Mol. Pharmacol., Grad. Sch. Pharmceut. Sci., Kyoto Univ., ²Dept. Pharmacol., Grad. Sch. Med., Kyoto Pref. Univ. Med.

3-O-E5-315:5416:06 Aripiparzole as a partial agonist at 5-HT_2A receptor coupled to Galpha_q/11 Yuji Odagaki, Masakazu Kinoshita Dept. Psychiatry, Fac. Med., Saitama Med. Univ.

3-O-E5-416:0616:18 INTERACTION BETWEEN CHOLINERGIC AND OPIOID SYSTEMS IN ALCOHOL SEEKING BEHAVIOR Anggadiredja Kusnandar Pharmacol.

3-O-E5-516:1816:30 Animal model for donepezil-induced nausea and vomiting using pica behavior in mice Kouichi Yamamoto¹, Yuhki Sato², Kyosuke Kirikihira¹, Akito Jotaki¹, Ayana Michihara², Yumi Miyake² ¹Dept Med Sci Tech, Div Health Sci, Sch Med, Osaka Univ, ²Dept Physical Pharmaceutics, Fukuyama Univ

March 10 (Wed) Room E