program｜The 94th Annual Meeting of the Japanese Pharmacological Society

YIA

Cardiovascular (3)

3-Y-G1-19:009:12 Voltage-dependence in I_CaL block predicts EAD in drug-induced arrhythmias Kimura Akira¹, Shingo Murakami² ¹Chuo Univ. Grad. Ele., ²Chuo Univ. Grad. Sci.& Eng.

3-Y-G1-29:129:24 Electrophysiological analysis of the anti-atrial fibrillatory action of oseltamivir using the paroxysmal atrial fibrillation canine model Ryuichi Kambayashi¹, Yoshio Nunoi¹, Ai Goto¹, Yoshiki Hirokawa¹, Hiroko Izumi-Nakaseko¹, Mihoko Hagiwara-Nagasawa¹, Yoshinori Takei², Akio Matsumoto³, Shinichi Kawai⁴, Atsushi Sugiyama^1,2,3,4 ¹Dept. Pharmacol., Faculty Med., Toho Univ., ²Dept. Translational Research & Cellular Therapeutics, Faculty Med., Toho Univ., ³Dept. Aging Pharmacol., Faculty Med., Toho Univ., ⁴Dept. Inflammation & Pain Control Research, Faculty Med., Toho Univ.

3-Y-G1-39:249:36 Effect of hyperglycemia on the cardiovascular functions in the isoflurane-anesthetized intact dogs Hirokawa Yoshiki¹, Ryuichi Kambayashi², Ai Goto¹, Yoshio Nunoi², Hiroko Izumi-Nakaseko^1,2, Mihoko Hagiwara-Nagasawa², Yoshinori Takei³, Akio Matsumoto⁴, Shinichi Kawai⁵, Jörg Täubel⁶, Atsushi Sugiyama^1,2,3,4,5 ¹Dept. Pharmacol., Grad. Sch. Med., Toho Univ., ²Dept. Pharmacol., Faculty. Med., Toho Univ., ³Dept. Translational Research & Cellular Therapeutics., Faculty. Med., Toho Univ., ⁴Dept. Aging Pharmacol., Faculty. Med., Toho Univ., ⁵Dept. Inflammation & Pain Control Research, Faculty. Med., Toho Univ., ⁶Molecular & Clinical Sciences Research Institute, St George's University of London.

3-Y-G1-49:369:48 Biological sex differences in morphological function of embryonic murine coronary arteries Shion Nagasawa¹, Masami Kodama², Kazuho Sakamoto¹, Junko Kurokawa¹ ¹Sch. Pharmaceut. Sci, University of Shizuoka, ²IQB, The University of Tokyo

YIA

Cardiovascular (4)

3-Y-G2-110:0010:12 TRPC5 channel-Caveolin-1-eNOS signalplexes coordinate interplay between Ca²⁺ and NO signals in endothelial cells Reiko Sakaguchi^1,2, Nobuaki Takahashi^1,3, Takashi Yoshida^1,4, Nozomi Ogawa¹, Yoshifumi Ueda¹, Satoshi Hamano¹, Kaori Yamaguchi¹, Seishiro Sawamura¹, Shinichiro Yamamoto^1,4, Yuji Hara¹, Masayuki Mori¹, Tetsushi Furukawa⁵, Shunichi Shimizu⁴, Ryuji Inoue⁶, Yasuo Mori^1,2 ¹Department of Engineering, Kyoto Univ, ²iCeMS, Kyoto Univ, ³Hakubi Project, Kyoto Univ, ⁴Faculty of Pharmaceutical Sciences, Teikyo Heisei Univ, ⁵Medical Research Institute, Tokyo Medical and Dental Univ, ⁶Department of Physiology, Fukuoka Univ.

3-Y-G2-210:1210:24 Acute hypoxia enhances the proliferation of brain capillary endothelial cells via upregulation of Ca²⁺-activated Cl^- channel TMEM16A. Takahisa Suzuki¹, Yoshiaki Suzuki¹, Kiyohumi Asai², Yuji Imaizumi¹, Hisao Yamamura¹ ¹Dept. Mol. and Cell. Pharmacol., Grad. Sch. Pharm., Nagoya City Univ., ²Dept. Mol. Neurobiol., Grad. Sch. Med., Nagoya City Univ.

3-Y-G2-310:2410:36 CAMKII inhibitor as novel cardioprotective agent on doxorubicin cardiotoxicity クルニアワン　プリヨノアグン, Junichiro Miake, Youkou Syuu, Katsunori Ichihara, Tatsuya Sawano, Keiko Nagata, Takeshi Imamura Tottori University, Medical department, pharmacology

3-Y-G2-410:3610:48 Development of high efficient method in human iPS induction from patient derived primary cells. Tanaka Naomichi, Takaaki Senbonmatsu Saitama medical university international medical center

YIA

Otolaryngology, Ophthalmology (1), Bone, Joint, Dental (2)

3-Y-G3-111:0011:12 Arginase 1 is involved in lacrimal hyposecretion in male NOD mice. Yuta Ohno¹, Keitaro Satoh^1,2, Akiko Shitara¹, Haruna Nagase¹, Masanori Kashimata¹ ¹Dept. Pharmacol., Asahi Univ. Sch. Dent., ²Dept. Pharmacol., Meikai Univ. Sch. Dent.

3-Y-G3-211:1211:24 Evaluation of primate dental pulp regeneration by quantitative fluorescence imaging of macrophages Yu Toida, Takanori Sato, Tadahiro Iimura Dept Pharmacol, Hokkaido Univ Grad Sch Dent Med

3-Y-G3-311:2411:36 Teriparatide improves bone quality through augmenting the linearity of bone collagen fibers, revealed by novel analysis of nonlinear optics imaging and AI-based morphometrical recognition method Takanori Sato, Yu Toida, Tadahiro Iimura Dept. Pharmocol. Grad. Sch. Dent Med., Hokkaido Univ.

3-Y-G3-411:3611:48 Ca²⁺ release-activated Ca²⁺ channels are involved in osteoarthritic marker induction by interleukin-1β in mouse chondrocytes Risa Kurose, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Oral Sessions

Herbal Medicine, Natural Products, Bioactive Substances

3-O-G4-114:3014:42 Mycobacterial protease clp as a promising anti-TB drug target Takehiro Yamaguchi¹, Yuriko Ozeki², Sohkichi Matsumoto², Kentaro Tokudome¹, Shinji Matsunaga¹, Shuhei Tomita¹ ¹Phamacol., Osaka City Univ., ²Bacteriol., Niigata Univ.

3-O-G4-214:4214:54 Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of the copper chaperone ATOX1 Masato Katsuyama¹, Chihiro Yabe-Nishimura² ¹Radioisotope Ctr., Kyoto Pref. Univ. Med., ²Dept. Pharmacol., Kyoto Pref. Univ. Med.

3-O-G4-314:5415:06 From zebrafish to human: Rhamnan sulfate improves constipation with alteration of gut microbiota. Yasuhito Shimada^1,2,3, Hiroko Nakayama^3,4, Fumiyoshi Okazaki^2,3,5, Liqing Zang^3,4, Masahiro Terasawa^3,6, Koichi Mastuda⁶, Kaoru Nishiura⁶, Ryota Uchida⁶, Norihiro Nishimura^3,4 ¹Dept. Int Pharm., Grad. Sch. Med., Mie Univ., ²Mie Univ. Adv. Sci. Res. Cen., Bioinfo., ³Mie Univ. Zebrafish Drug Screen. Cen., ⁴Grad. Sch. Reg. Innov., Mie Univ., ⁵Grad. Sch. Bioresource, Mie Univ., ⁶Konan Chemical Manufacturing Co., Ltd

3-O-G4-415:0615:18 Sorghum (Sorghum bicolor L.Moench) extract enhances thiazolidinediones-induced 3T3-L1 preadipocyte differentiation but inhibits adipogenic genes Makoto Sakurai¹, Ikumi Aizu¹, Yuko Oba¹, Marina Tonosaki¹, Mei Nagata², Katsuyoshi Kamiie², Atsuko Masumi¹ ¹Dept. Mol.Pharmacol. Pharm.Sci. Aomori Univ., ²Dept. Mol.Biol. Pharm.Sci. Aomori Univ.

Oral Sessions

Intracellular and Intercellular Signaling (2)

3-O-G5-115:3015:42 Mitotic ER exit site disassembly and reassembly are regulated by the phosphorylation status of TANGO1 Maeda Miharu, Yukie Komatsu, Kota Saito Dept. Biol. Inform. and Exp. Therap., Grad Sch. of Med., Akita Univ

3-O-G5-215:4215:54 Axonal targeting of TrkA-APP complex via transcytosis Naoya Yamashita, Takashi Sakurai Dept. of Cell and Mol Pharmacol., Juntendo Univ., Sch. Med.

3-O-G5-315:5416:06 Ubiquitin ligase RNF183 promotes the lysosomal degradation of NKCC1 under hypertonic conditions Masayuki Kaneko^1,2, Takumi Okamoto^1,2, Kazunori Imaizumi² ¹Dept. Pharmacol. Therap. Innov., Nagasaki Univ. Grad. Sch. Biomed. Sci., ²Dept. Biochem., Grad. Sch. Biomed. & Hlth. Sci., Hiroshima Univ.

3-O-G5-416:0616:18 Probiotic ferrichrome exhibited the anti-tumor effect mediating the endoplasmic stress pathway in colorectal cancer cells Hiroaki Konishi¹, Takuya Iwama², Hiroki Tanaka³, Shotaro Isozaki², Chikage Yamamura², Satoshi Ichikawa⁵, Kentaro Moriichi^2,4, Mikihiro Fujiya^1,2,4 ¹Dept. Gastroenterol & Adv Med Sci, Asahikawa Med Univ, ²Dept. Med, Asahikawa Med Univ, ³Dept. Pathol, Asahikawa Med Univ, ⁴Joint Res Dept. Telemed & Telecare, Asahikawa Med Univ, ⁵Cent. Res. & Educ. Drug Discov, Fac. Pharmaceut. Sci, Hokkaido University

3-O-G5-516:1816:30 SIRT1, a histone deacetylase, mediates the proper DNA damage response via histone H2AX deacetylation in the cardiomyocyte. Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.