program｜The 94th Annual Meeting of the Japanese Pharmacological Society

YIA

Learning, Memory, Cognition (5)

3-Y-F1-19:009:12 Oral administration of food-derived amino acid ergothioneine enhances learning and memory by phosphorylation of TrkB and promotion of neurogenesis in the hippocampal dentate gyrus Yusuke Matsuo¹, Takahiro Ishimoto¹, Shunsuke Nakao¹, Yusuke Masuo¹, Satoshi Matsumoto², Makoto Suzuki², Yukio Kato¹ ¹Fac. Pharm., Kanazawa Univ., ²L•S Corporation Co. Ltd.

3-Y-F1-29:129:24 The effects of Ninjinyoeto on spatial memory impairment in a rat model with cerebral ischemia and β-amyloid injection Masaki Nagao¹, Akinobu Hatae², Kazuma Mine², Soichiro Tsutsumi², Marika Hiarata², Kazuma Matsui², Hiroya Omori², Takuya Watanabe^1,2, Kaori Kubota^1,2, Shutaro Katsurabayashi², Katsunori Iwasaki^1,2 ¹Ins. Aging and Brain Sci., Fukuoka Univ., Fukuoka, Japan, ²Dept. Neuropharmacol. Fac. Pharm. Sci. Fukuoka Univ. Fukuoka, Japan

3-Y-F1-39:249:36 The mice with exonic Reln deletion show cognitive dysfunction but not attention impairment in the touchscreen operant tasks Geyao Dong¹, Taku Nagai¹, Jingzhu Liao¹, Daisuke Mori², Bolati Wolar¹, Toshitaka Nabeshima^3,4, Norio Ozaki², Kiyofumi Yamada¹ ¹Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, ²Department of Psychiatry, Nagoya University Graduate School of Medicine, ³Advanced Diagnostic System Research Laboratory Fujita Health University, Graduate School of Health Sciences, ⁴Aino University

3-Y-F1-49:369:48 The role of voltage-dependent potassium channels in the medial prefrontal cortex in nicotine-induced enhancement of object recognition memory Esaki Hirohito¹, Shoma Izumi¹, Akari Fukao², Masaki Domoto¹, Tong Zhang¹, Naoya Nishitani^1,2, Satoshi Deyama^1,2, Katsuyuki Kaneda^1,2 ¹Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ., ²Lab. Mol. Pharmacol., Sch. Pharmaceut. Sci., Kanazawa Univ.

YIA

Cerebral Circulation, Metabolism, Ischemia (3)

3-Y-F2-110:0010:12 Anti-high mobility group box-1 (HMGB1) antibody therapy for spinal cord ischemia-reperfusion injury in rabbits Muraoka Genya¹, Keyue Liu², Handong Qiao², Daiki Ousaka², Dengli Wang², Yasuhiro Fujii¹, Shingo Kasahara¹, Masahiro Nishibori² ¹Dept. Cardiovascular Surg., Okayama Univ., ²Dept. Pharmacol., Okayama Univ.

3-Y-F2-210:1210:24 The identification of neuro-reparative lipids in ischemic stroke Nakamura Akari^1,2, Seiichirou Skai¹, Makoto Murakami³, Takashi Shichita^1,4 ¹Tokyo Metropolitan Inst., ²Tokyo Medical and Dental Univ., ³Tokyo Univ., ⁴Japan Agency for Medical Research and Development

3-Y-F2-310:2410:36 TRPA1 plays a protective role in cognitive impairment and white matter injury in chronic cerebral hypoperfusion Masashi Kakae, Hiroki Nakajima, Misa Morishima, Shota Tobori, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ.

3-Y-F2-410:3610:48 Imaging of water kinetics during cytotoxic edema using indirect MRI with O¹⁷-labeled water Tomoe Ishikawa¹, Yutaka Hoshino², Hiroyuki Kameda², Yuji Komaki⁴, Miyuki Unekawa³, Yutaka Tomita³, Jin Nakahara³, Kohsuke Kudo², Masato Yasui¹ ¹Dept., Pharmacol., Sch., Med., Keio Univ., ²Dept., Radiol., Hokkaido Univ Hosp., ³Dept., Neurol., Sch., Med., Keio Univ., ⁴Central., Inst., Exp., Anim.

YIA

Methodology, Technology (2)

3-Y-F3-111:0011:12 Development of Brain Molecular PET Imaging with a ¹⁸F-labeled Small Protein Affinity Ligand Takahiro Morito¹, Ryuichi Harada^1,2, Ren Iwata³, Yiqing Du¹, Nobuyuki Okamura⁴, Yukitsuka Kudo², Kazuhiko Yanai^1,3 ¹Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med., ²Dept. Gerontol. Geriatrics, Tohoku Univ., ³CYRIC, Tohoku Univ., ⁴Div. Pharmacol., Fac. Med., Tohoku Med. Pharmaceut. Univ.

3-Y-F3-211:1211:24 Characterization of a novel monoamine oxidase-B tracer [¹⁸F]SMBT-1 for imaging of reactive astrocytes Yiqing Du¹, Ryuichi Harada^1,2, Yu Akaida³, Takahiro Morito¹, Hiroyuki Arai², Mari Yoshida⁴, Yukitsuka Kudo², Shozo Furumoto³, Nobuyuki Okamura⁵, Kazuhiko Yanai¹ ¹Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ., ²Dept. Geriatrics and Gerontology, Div. Brain Science, Inst. Development, Aging and Cancer, Tohoku Univ., ³Cyclotron and Radioisotope Ctr., Tohoku Univ., ⁴Inst. Development, Aging and Cancer, Aichi Medical Univ., ⁵Div. Pharmacol., Fac. Med., Tohoku Medical and Pharmaceutical Univ.

3-Y-F3-311:2411:36 A novel method of long-lasting single-particle tracking based on regenerative fluorescent labeling Shinkuro Kobayashi, Shigeyuki Namiki, Daisuke Asanuma, Kenzo Hirose Dept. Pharm., Grad. Sch. Med., the Univ. of Tokyo

3-Y-F3-411:3611:48 In vivo fluorescence imaging of extracellular ATP dynamics in brain ischemia Nami Kitajima¹, Kenji Takikawa¹, Hiroshi Sekiya², Daisuke Asanuma¹, Hirokazu Sakamoto¹, Shigeyuki Namiki¹, Masamitsu Iino³, Kenzo Hirose¹ ¹Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo, ²Dept. of Physiol., Grad. Sch. of Med., Univ. of Tokyo, ³Dept. of Cell. and Mol. Pharmacol., Nihon Univ. Sch. of Med.

Oral Sessions

Cardiovascular (1)

3-O-F4-114:3014:42 5-hydroxytryptophan supplement recovers impaired platelet aggregation in Quinonoid dihydropteridine reductase deficient mice Yui Suganuma¹, Taiki Kano¹, Kazuhisa Ikemoto¹, Chiho Sumi-Ichinose¹, Hiroshi Ichinose², Kazunao Kondo¹ ¹Dept. Pharmacol., Sch. Med., Fujita Health Univ., ²Sch. Life Sci. Tech., Tokyo Tech.

3-O-F4-214:4214:54 Human aortic valve interstitial cells obtained from patients with calcified aortic valve stenosis are VEGFR2 positive and contribute to ectopic calcification Zaiqiang Yu¹, Xu Liu¹, Kazuyuki Daitoku¹, Ikuo Fukuda¹, Shigeru Motomura², Tadaatsu Imaizumi³, Ken-Ichi Furukawa⁴, Tomoh Matsumiya³, Kazuhiko Seya³ ¹Dept. Thorac. Cardiovasc. Surg., ²Dept. Pharmacol., ³Dept. Vascul. Biol., ⁴Dept. Orthop. Surg.

3-O-F4-314:5415:06 Anti-Cancer Agent Oxaliplatin Caused Erectile Dysfunction in Rats through Both Neural and Endothelial Dysfunction Tomoya Kataoka¹, Jun Suzuki², Yuto Kawaki², Yohei Kito², Yuji Hotta², Yoshihiro Kawade², Yasuhiro Maeda³, Kazunori Kimura^1,2 ¹Department of Clinical Pharmaceutics, Graduate School of Medical Sciences, Nagoya City University, ²Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, ³Center for Joint Research Facilities Support, Fujita Health University

3-O-F4-415:0615:18 Establishment of a novel experimental autoimmune vasculitis model Takafumi Seo¹, Shota Tanaka¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Laboratory of Clinical Pharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

Oral Sessions

Cardiovascular (2), Cell Death (1), Intracellular and Intercellular Signaling (1)

3-O-F5-115:3015:42 Recombinant soluble thrombomodulin reduces lipopolysaccharide-induced endothelial cellular stiffening Takayuki Okamoto¹, Haruki Usuda¹, Tetsuya Tanaka^1,2, Koichiro Wada¹ ¹Dept. Pharmacol., Fac. of Med., Shimane Univ., ²Dept. Human Nutrition, Fac., Contemporary Life Science, Chugoku Gakuen Univ.

3-O-F5-215:4215:54 CXCL10 is an anti-angiogenic factor downstream of p53 in cardiomyocytes. Ryuta Igarashi¹, Masashi Tomimatsu¹, Makiko Maeda^1,2, Syota Tanaka¹, Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Laboratory of Clinical Pharmacology and Therapeutics, Grad. Sch. Pharm., Osaka Univ.

3-O-F5-315:5416:06 Amino acid transporter LAT1 is upregulated in tumor-associated vascular endothelial cells and plays essential roles in tumor angiogenesis by promoting proliferation and regulating VEGF-A-dependent pro-angiogenic mTORC1 activation. Ryuichi Ohgaki^1,2, Lili Quan¹, Suguru Okuda¹, Hiroki Okanishi¹, Shushi Nagamori³, Hitoshi Endou⁴, Yoshikatsu Kanai^1,2 ¹Dept. Bio-sys Pharm., Grad. Sch. Med., ²Integ. Front. Res. Med. Sci. Div., OTRI, Osaka Univ., ³Dept. Lab. Med., Jikei Univ. Sch. Med., ⁴J-Pharma Co.,Ltd.

3-O-F5-416:0616:18 Tctex-1 augments parathyroid hormone receptor-mediated G_s signaling by activating adenylyl cyclase Masaki Saito^1,2, Ayano Chiba², Takeya Sato¹, Jun Sukegawa^1,3 ¹Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med., ²Dept. Cellular Signalling, Grad. Sch. Pharmaceut. Sci., Tohoku Univ., ³Dept. Hum. Health Nutr., Shokei Gakuin Univ.

3-O-F5-516:1816:30 Global Regulation of Protein S-palmitoylation by Nitric Oxide Naoko Adachi¹, Douglas Hess², Izumi Koganemaru¹, Takehiko Ueyama¹, Naoaki Saito¹ ¹Biosignal Res. Ctr., Kobe University, ²ITMM, Case Western Reserve University

March 10 (Wed) Room F