program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

Vascular Smooth Muscle, Hypertension

2-P2-0114:0015:30 The mechanism of serotonin-induced constriction in 2K1C hypertensive rat mesenteric arteries Yuka Terada, Manami Tani, Miku Komatsu, Katsutoshi Yayama Lab. Cardiovasc. Pharmacol. Fac. Pharma. Sci. Kobe Gakuin Univ.

2-P2-0214:0015:30 Pathophysiological roles of excitation-transcription coupling in vascular smooth muscle cells. Yoshiaki Suzuki, Takumi Ozawa, Nanami Nakajima, Yuji Imaizumi, Hisao Yamamura Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

2-P2-0314:0015:30 Effects of pressure stress on MAPK activation induced by interleukin-1β and angiotensin II in cultured human pulmonary artery smooth muscle cells. Sachiko Hiraide, Takuji Machida, Shota Takihana, Mikoto Ohshita, Kenji Iizuka Dept. of Pharmacol. Sci., Schl. of Pharmaceut. Sci., Health Sci. Univ. of Hokkaido

2-P2-0414:0015:30 Fingolimod ameliorates the development of PAH in monocrotaline-induced pulmonary hypertensive rats Moe Fujiwara¹, Aya Yamamura², Yoshiaki Suzuki¹, Hisao Yamamura¹ ¹Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., ²Dept. Physiol., Aichi Med. Univ.

2-P2-0514:0015:30 Involvement of Mitofusin2 on functional interaction between SR and mitochondria in rat aortic smooth muscle cells Sou Inagaki, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., Nagoya, Japan

2-P2-0614:0015:30 Possible selective inhibitory effects of docosahexaenoic acid (DHA) on U44619- and prostaglandin F_2α (PGF_2α)-induced contractions of coronary and cerebral arteries isolated from the pig. Kento Yoshioka, Kohhei Uemura, Akina Yamaguchi, Guanghan Ou, Keyue Xu, Fumiko Yamaki, Keisuke Obara, Yoshio Tanaka Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

2-P2-0714:0015:30 The contribution of Na^+/Ca²⁺ exchanger 1 in pulmonary arterial hypertension in mice. Satomi Kita^1,2, Hideaki Tagashira², Asahi Nagata², Tomo Kita², Takahiro Iwamoto² ¹Dept. Pharmacol., Facul. Pharmaceut. Sci., Tokushima Bunri Univ., ²Dept. Pharmacol., Facul. Med., Fukuoka Univ.

2-P2-0814:0015:30 Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II-induced hypertension model mice Misaki Yamamoto¹, Fumi Takahashi-Yanaga², Toshiyuki Sasaguri¹ ¹Dept Clin Pharmacol, Faculty Med Sci, Kyushu Univ, ²Dept Pharmacol, Faculty Med, Univ Occup Environ Health

2-P2-0914:0015:30 Functional expression of two-pore domain K⁺channels in pulmonary arterial hypertension Natsumi Shima¹, Aya Yamamura², Yoshiaki Suzuki¹, Hisao Yamamura¹ ¹Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceutic. Sci., Nagoya City Univ., ²Dept. Physiol, Aichi Medical Univ.

2-P2-1014:0015:30 Relaxation of rat pulmonary arterial smooth muscles by pine resin-derived compounds Ishida Masashi, Suzuki Yoshiaki, Hisao Yamamura Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

2-P2-1114:0015:30 Junctophilin-2 promotes the proliferation of vascular smooth muscle cells Shibahara Emina Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Poster Sessions

Kidney, Urination

2-P2-1214:0015:30 Losartan, angiotensin II type 1 receptor blocker improves prostatic hyperplasia in spontaneously hypertensive rats Shogo Shimizu¹, Yoshiki Nagao¹, Tamaki Kataoka^1,2, Shiho Kamada^1,2, Reina Okamoto^1,2, Takahiro Shimizu¹, Youichirou Higashi¹, Takaaki Aratake^1,3, Suo Zou¹, Masaki Yamamoto¹, Motoaki Saito¹ ¹Department of Pharmacology, Kochi Medical School, Kochi University, ²Center for Innovative and Translational Medicine, Kochi Medical School, Kochi University, ³Research Fellow of Japan Society for the Promotion of Science

2-P2-1314:0015:30 Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect in spontaneously hypertensive rats Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

2-P2-1414:0015:30 Pleiotropic effects of erythropoietin on renal and aortic injury in sucrose-induced insulin resistant rats Hiroe Toba, Yota Kaino, Satoka Zaizen, Momoyo Nishikawa, Akihiro Yamaoka, Miyuki Kobara, Tetsuo Nakata Dept. Clin. Pharmacol.

2-P2-1514:0015:30 Repeated ischemia/reperfusion before contralateral nephrectomy leads to acceleration of AKI to CKD progression in rats Shuhei Kobuchi Dept. Pharm., Pharmacol., Hyogo Univ. Health Sci.

2-P2-1614:0015:30 Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats Takaomi Shimokawa¹, Masayo Yamagata¹, Kohei Hayashi¹, Shuhei Tomita², Kozo Yoneda¹ ¹Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ., ²Dept. Pharmacol., Fac. Med., Osaka City Univ.

2-P2-1714:0015:30 Effects of agmatine and pirfenidone on renal fibrosis after acute kidney injury Takahiro Sugiura, Shoko Otsu, Keita Owaki, Mana Naito, Shiori Murase, Yasushi Hirasawa, Takahiko Nagase Nihon Bioresearch Inc.

2-P2-1814:0015:30 Effect of hydrogen sulfide on bladder of cyclophosphamide-induced cystitis in rats Suo Zou¹, Takahiro Shimizu¹, Shogo Shimizu¹, Hideaki Ono^1,2, Yohei Shimizu^1,2, Yurika Hata^1,2, Masaki Yamamoto¹, Takaaki Aratake^1,3, Youichirou Higashi¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., ²Ctr. for Innov. and Transl. Med., Kochi Univ., ³Res. Flw. of Jpn. Soc. for the Promo. of Sci.

2-P2-1914:0015:30 Deep neural network approach for understanding water-taking behavior after Tolvaptan Hiroaki Kaminaga, Yuta Mochimaru, Morio Azuma, Hiroyoshi Tsuchiya, Taka-aki Koshimizu Jichi Medical Univ. Div. Mol. Pharmacol.

2-P2-2014:0015:30 Brain α7 nicotinic receptor stimulation inhibits the rat micturition reflex via brain GABA_A receptors Yohei Shimizu^1,2, Takahiro Shimizu¹, Hideaki Ono^1,2, Suo Zou¹, Masaki Yamamoto¹, Yurika Hata^1,2, Takaaki Aratake^1,3, Shogo Shimizu¹, Youichirou Higashi¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., ²Ctr. Innov. and Translational Med., Kochi Med. Sch., Kochi Univ., ³Research Fellow of Japan Society for the Promotion of Science

2-P2-2114:0015:30 Involvement of AGN-1 protein, which binds to protein phosphatase 6, in centrosome formation during the process of cell division Suzuki Nana, Hinako Osada, Ryoji Kojima Lab. of Anal. Pharmacol. Fac. of Pharm. Meijo Univ.

2-P2-2214:0015:30 Prenatal glucocorticoid administration accelerates glomeruli and renal tubules development in the fetal rats. Yuko Takeba, Tsukasa Kobayashi, Masanori Ootaki, Yuki Ohta, Kiesuke Kida, Minoru Watanabe, Taroh Iiri, Naoki Matsumoto Dept. Pharmacol. St. Marianna Unv Sch Med

2-P2-2314:0015:30 The production and role of hydrogen sulfide and hydrogen polysulfides in mammalian cells Norihiro Shibuya, Yuka Kimura, Hideo Kimura Sanyo-Onoda City University

Poster Sessions

Immunity, Inflammation, Allergy, Skin, Adipose tissue 2

2-P2-2414:0015:30 AGEs synergistically potentiated the LPS-HMGB1-induced proinflammatory response through their direct interactions Shuji Mori¹, Masahiro Watanabe¹, Hidenori Wake², Keyue Liu³, Kiyoshi Teshigawara³, Hideo Takahashi², Masahiro Nishibori³, Takao Toyomura¹ ¹Sch Pharm, Shujitsu Univ, ²Fac Med, Kindai Univ, ³Grad Sch Med Dent & Pharm Sci, Okayama Univ

2-P2-2514:0015:30 Evaluation and comparison of two of LPS-induced acute lung injury (ARI) mice models Ushijima Souta, Sayuri Nishikawa, Hideaki Kamaga, Kousuke Morizumi, Seiichi Katayama, Katsuhide Nishi Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, LSI Medience Corporation

2-P2-2614:0015:30 Withdraw ¹, ²Sakurajyuji medical corporation

2-P2-2714:0015:30 Effects of dasatinib on airway inflammation induced by lipopolysaccharide and/or ovalbumin Yuki Nishimoto¹, Yukiko Eguchi¹, Yuka Koizumi¹, Nanaka Ito¹, Naoki Ishikawa¹, Minami Saito¹, Genki Kimura¹, Kazuhiro Ito², Yasuo Kizawa¹ ¹Lab. Physiol. & Anat., Nihon Univ. Sch. Pharmacy, ²Imperial College London, UK

2-P2-2814:0015:30 Thioredoxin-albumin fusion protein prevents urban aerosol-induced lung injury Ken-ichiro Tanaka¹, Maho Kubota¹, Mikako Shimoda¹, Mayumi Ikeda², Yu Ishima², Masahiro Kawahara¹ ¹Musashino Univ., ²Tokushima Univ.

2-P2-2914:0015:30 Pharmacological studies on pulmonary fibrosis model induced by intratracheal instillation of bleomycin in mice Jun-ichi Fuchikami¹, Maki Takahashi¹, Yoshiyuki Suzuki¹, Atsuko Ichikawa¹, Yasuki Akie¹, Hiroyuki Nakamura² ¹CMIC Pharma Science Co., Ltd., ²Lab. of Chem. Pharmac., Grad. Sch. of Pharmaceut. Sci., Chiba Univ.

2-P2-3014:0015:30 Generation of ACE2-Expressing Airway and Alveolar Epithelial Cells from Human Induced Pluripotent Stem Cells Tsuji Kayoko, Yasunari Kanda Div. Pharmacol, NIHS

2-P2-3114:0015:30 Expression of glucocorticoid receptors (GRs) in eosinophils derived from steroid-resistant asthma model of mice Kennosuke Hashimoto, Maki Matsuo, Ayaka Mori, Hayato Shimora, Momo Utsumi, Rina Ano, Masaya Matsuda, Kazuyuki Kitatani, Takeshi Nabe Lab. of Immunopharmacol., Fac. of Pharm. Sci., Setsunan Univ., Osaka, Japan

2-P2-3214:0015:30 Characterization of Staphylococcus aureus derived from atopic dermatitis using a cell imaging system. Ryu Miyake^1,2, Kazumasa Iwamoto², Motoyuki Sugai³, Michihiro Hide², Norio Sakai¹ ¹Dept. of Mol. Pharmacol Neurosci., Grad. Sch. of Biomed and Health Sci., Hiroshima Univ., ²Dept. of Dermatology, Grad. Sch. of Biomed and Health Sci., Hiroshima Univ., ³Antimicrobial Resistance Res. Ctr., Nat. Insti. of Infectious Diseases

2-P2-3314:0015:30 Functional role of NCX1 in brown adipose tissue thermogenesis Tomo Kita¹, Hideaki Tagashira¹, Takayuki Nemoto¹, Satomi Kita^1,2, Takahiro Iwamoto¹ ¹Dept. Pharmacol. Fac. Med. Fukuoka Univ., ²Dept. Pharmacol. Fac. Pharmaceut. Sci. Tokushima Bunri Univ.

2-P2-3414:0015:30 The role of microsomal Prostaglandin E syntase-1 (mPGES-1)/PGE₂ axis facilitates granulation tissue formation Tetsuya Hyodo^1,2, Hideki Amano¹, Yoshiya Ito¹, Kanako Hosono¹, Ko Hatanaka¹, Koji Eshima³, Satoshi Uematsu⁴, Shizuo Akira⁵, Akira Takeda² ¹Dept. of Pharmacol., Kitasato Univ. Sch. of Med., ²Dept. of Plast. and Reconst. Surg., Kitasato Univ. Sch. of Med., ³Dept. of Immunol., Kitasato Univ. Sch. of Med., ⁴Dept. of Immunol. and Geno., Osaka City Univ. Grad. Sch. of Med., ⁵Lab. of Host Defense, WPI Immunol. Frontier Res. Ctr. (IFReC), Osaka Univ.

2-P2-3514:0015:30 Saireito, a traditional Chinese medicine, suppressed photodamage and reduction of lymphatic vessel density in UVB-irradiated skin. Manami Oyama, Kenta Murata, Nina Fujita, Ryuji Takahashi Kampo Res. Lab., Kracie Pharma, Ltd.

2-P2-3614:0015:30 Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice Murata Kenta, Manami Oyama, Nina Fujita, Ryuji Talahashi Kracie Pharma Ltd. Kampo research Lab

Poster Sessions

Cancer, Chemotherapy, Antibody Therapy 2

2-P2-3714:0015:30 Role of translation factors in proliferation of breast cancer stem cells. Naoya Hirata, Shigeru Yamada, Yasunari Kanda Div. Pharmacol. NIHS

2-P2-3814:0015:30 Elevated serum cholesterol levels after the discontinuation of imatinib in patients with chronic myeloid leukemia Masamitsu Takaba¹, Takaaki Ono¹, Takayuki Iwaki², Kazuo Umemura² ¹Division of Hematology, Hamamatsu University School of Medicine, ²Department of Pharmacology, Hamamatsu University School of Medicine

2-P2-3914:0015:30 Healing effects of rebamipide on oral stomatitis in 5-fluorouracil-untreated and -treated Golden Syrian hamsters Mitsutoshi Satoh¹, Takuya Shiraishi¹, Kousei Sekikawa¹, Miku Motohashi¹, Hiroyuki Tanaka², Yayoi Kawano³, Takehisa Hanawa³ ¹Dept. Toxicol. Pharmacol., Pharmaceut. Sci., Meiji Pharmaceut. Univ., ²Dept. Practical Pharm., Pharmaceut. Sci., Toho Univ., ³Lab. Preform. Design, Pharmaceut. Sci., Tokyo Univ. of Sci.

2-P2-4014:0015:30 Timosaponin AIII disturbs morphological plasticity and migration by suppressing membrane dynamics. Takeshi Terabayashi¹, Katsuhiro Hanada², Shigeru Matsuoka³, Takahiro Akamine¹, Toshimasa Ishizaki¹ ¹Dept. Pharmacol., Fac. Med., Oita Univ., ²Clin. Eng. Res. Ctr., Fac. Med., Oita Univ., ³Dept. Cli. Pharmcol & Therap., Fac. Med., Oita Univ.

2-P2-4114:0015:30 O-GlcNAcylation-mediated regulation of FOXM1 expression through its ubiquitination in a human gastric adenocarcinoma cell line, NUGC-3 Kazumasa Moriwaki¹, Yasuhiro Ueda², Toshihisa Taheuchi², Kazuhide Higuchi², Michio Asahi¹ ¹Dept. Pharmacol., Fac. Med., Osaka Med. College, ²Dept. Int. Med. II, Fac. Med., Osaka Med. College

2-P2-4214:0015:30 Genome-wide analysis of DNA methylation identifies apoptosis-related gene UQCRH in renal cancer Ehata Shogo^1,2, Kosuke Miyakuni¹, Jun Nishida¹, Kohei Miyazono¹ ¹Dept. Mol. Pathol., Grad. Sch. Med., Univ. Tokyo, ²Environ. Sci. Ctr., Univ. Tokyo

2-P2-4314:0015:30 The migration inhibitory effect of anti-collapsin response mediator protein 2 antibody on the renal cell carcinoma Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami Fac. Pharmaceut. Sci., Himeji Dokkyo Univ.

2-P2-4414:0015:30 Differentiation-inducing factor-1 inhibits growth and metastasis of triple negative breast cancer cells through AMPK-mediated inhibition of mTORC1-S6K signaling pathway Fumi Tetsuo, Masaki Arioka, Koichi Miura, Sasaguri Toshiyuki Kyushu Univ. Dept. of Clinical Pharmacol.

2-P2-4514:0015:30 Human H1R may contribute to the colorectal cancer metastasis Matsumoto Rei¹, Kaori Ueki¹, Yuta Masuda¹, Masato Mashimo², Keijo Fukushima¹, Hiromichi Fujino¹ ¹Pharmacol. Life Sci. Fac. Pharmaceut. Sci. Tokushima Univ., ²Pharmacol. Fac. Pharmaceut. Sci. Doshisha Women's Coll. Liberal Arts

2-P2-4614:0015:30 The anti-cancer effect of PGD₂ may result from the biased activity on EP4 receptor. Takano Harumi¹, Kanaho Senoo¹, Mayu Yamashita¹, Yumi Araki¹, John W. Regan², Keijo Fukushima¹, Hiromichi Fujino¹ ¹Pharmacol. Life Sci. Fac. Pharmaceut. Sci. Tokushima Univ., ²Pharmcol/Toxicol. Coll. Pharm. Univ of Arizona

Late-Breaking Session

2-P2-LB4714:0015:30 Involvement of TRPC3-Nox2 axis in Duchenne muscular dystrophy Koichi Ayukawa¹, Chiemi Toyama¹, Kazuhiro Nishiyama¹, Yuri Kato¹, Tomohiro Tanaka², Akiyuki Nishimura², Motohiro Nishida^1,2 ¹Graduate School of Pharmaceutical Sciences, Kyushu University, ²National Institute for Physiological Sciences and Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences

2-P2-LB4814:0015:30 Suppression of SARS-CoV-2-induced lung injury by ACE2-like carboxypeptidase B38-CAP in COVID-19 mouse model Tomokazu Yamaguchi¹, Takafumi Minato¹, Midori Hoshizaki^1,2, Masamitsu Asaka³, Satoru Nirasawa⁴, Mayumi Niiyama⁵, Masaki Imai⁶, Saori Takahashi⁷, Daichi Utsumi³, Jianbo An¹, Satoshi Nagata⁵, Haruhiko Kamada⁵, Yoshihiro Kawaoka⁶, Yasuhiro Yasutomi³, Yumiko Imai², Keiji Kuba¹ ¹Department of Biochemistry and Metabolic Science, Akita University, ²Laboratory of Regulation of Intractable Infectious Diseases, NIBIOHN, ³Tsukuba Primate Research Center, NIBIOHN, ⁴Biological Resources and Post-Harvest Division, Japan International Research Center for Agricultural Sciences, ⁵Laboratory of Antibody Design, NIBIOHN, ⁶Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, ⁷Akita Research Institute of Food and Brewing

2-P2-LB4914:0015:30 Novel role of pyruvate dehydrogenase PDH ーregulation of histone acetylation and gene expression in breast cancer cells Nakayama Koh Dept. of Pharmacol., Asahikawa Med. Univ.

2-P2-LB5014:0015:30 Mitochondrial fusion factor OPA1 sustains gefitinib-resistance in lung adenocarcinoma cells Masafumi Noguchi¹, Susumu Kohno², Keitaro Shibata¹, Takashi Kohno³, Noriko Gotoh⁴, Chiaki Takahashi⁴, Atsushi Hirao⁵, Luca Scorrano¹, Atsuko Kasahara⁴ ¹Dept. of Biol., Univ. of Padua, Venetian Inst. of Mol. Med., ²Cancer Res. Inst., Kanazawa Univ., ³National Cancer Ctr. Res. Inst., ⁴Inst. for Frontier Sci. Initiative, Cancer Res. Inst., Kanazawa Univ., ⁵Cancer Res. Inst., WPI Nano Life Sci. Inst., Kanazawa Uni.

March 9 (Tue) Room P2