program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Symposium18

Exploration of novel druggable receptors applicable for treatment of pediatric diseases

2-S17-19:0010:30 Novel therapeutic targets for heart diseases regulating the immature heart-specific intracellular Ca²⁺ signaling pathways Tomoe Nakamura-Nishitani Dept. Pharmacol. Sch. Med. Wakayama-Med. Univ

2-S17-29:0010:30 A novel way of modification of AT₁ angiotensin receptors to alleviate pediatric heart failure Hiroyuki Kawagishi^1,2, Takuro Tomita-Numaga², Tsutomu Nakada³, Toshihide Kashihara², Mitsuhiko Yamada² ¹Dept. of Biotech., Institute for Biomedical Sci., Shinshu Univ., ²Dept. of Mol. Pharm., Shinshu Univ. Sch. of Med., ³Dept. of Instrumental Analysis, Res. Ctr. for Supports to Advanced Sci., Shinshu Univ.

2-S17-39:0010:30 Drug screening using transgenic zebrafish model. Kawahara Genri, Yukiko Hayashi Department of Pathophysiology, Tokyo Medical University

2-S17-49:0010:30 Fibulin-1 integrates subendothelial extracellular matrices and contributes to anatomical closure of the ductus arteriosus. Satoko Ito^1,2, Utako Yokoyama^1,2, Taichi Nakakoji², Yuko Kato¹, Junichi Saito^1,2, Naoki Nicho², Masuda Munetaka³, Toshihide Asou⁴, Yoshihiro Ishikawa² ¹Department of Physiology, Tokyo Medical University, ²Cardiovascular Research Institute, Yokohama City University, ³Department of Surgery, Yokohama City University, ⁴Department of Cardiovascular Surgery, Kanagawa Children’s Medical Center

Symposium23

The latest measurement technology aimed at acquiring biometric information and its application to drug development

2-S23-110:3012:00 Microsensing systems using diamond electrode for in vivo and in vitro detection of drug kinetics Hiroshi Hibino Div. Glocal Pharmacol., Dept. Pharmacol., Grad. Sch. Med., Osaka Univ.

2-S23-210:3012:00 Current status and prospects of phenotype analysis of drug transporters using endogenous metabolites Hiroyuki Kusuhara Grad. Sch. of Pharm. Sci., the Univ. of Tokyo

2-S23-310:3012:00 Quantitative analysis of peptides and proteins as biomarkers in biological samples by peptide adsorption-controlled (PAC)-LC/MS Ryoya Goda Daiichi Sankyo Co., Ltd.

2-S23-410:3012:00 Epigenetic analysis of pharmacokinetic-related genes using organ-specific liquid biopsy Takeshi Hirota¹, Ichiro Ieiri² ¹Fac. Pharmaceut. Sci., Kyushu Univ., ²Dept. Pharm., Kyushu Univ. Hosp.

YIA

Glia Cell (3)

2-Y-F1-115:3015:42 Inhibitory effect of panaxytriol on the lipopolysaccharide-induced microglial activation Genki Hiramatsu¹, Kosuke Matsuda¹, Daisuke Uta¹, Kenichi Mihara², Ysuhunobu Andoh⁴, Toshiaki Kume¹ ¹Dept. Appl Pharmcol. Toyama Univ., ²Dept. Appl Pharmcol. Toyama Univ., ³KIM's Korean Ginseng Co. Ltd., ⁴Dept. Pharmacol & Pathophysiol. Kinjo Gakuin Univ.

2-Y-F1-215:4215:54 Real-time imaging unveils mechanisms underlying synaptic engulfment by microglia Megumi Andoh¹, Yuji Ikegaya^1,2,3, Ryuta Koyama^1,4 ¹Lab. of Chem. Pharmacol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo, ²Inst. for AI and Beyond, ³Center for Information and Neural Networks, ⁴Japan Sci. and Tech. Agency, PRESTO

2-Y-F1-315:5416:06 Identification of scavenger inducing factor for the accelerated removal of inflammatogenic DAMPs Otani Kento^1,2, Jun Tsuyama¹, Koji Hase², Takashi Shichita¹ ¹Stroke Renaissance Project, Tokyo Met. Inst. of Med. Sci., ²Dept. Biochem., Grad. Sch. of Pharmaceutical Sci., Keio Univ.

2-Y-F1-416:0616:18 A subpopulation of microglia emerged in a recovery phase of neuropathic pain Kohno Keita, Makoto Tsuda Dept. Mol. and Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ.

YIA

Pain, Sensary Neuron (2)

2-Y-F2-116:3016:42 Intrathecal injection of sulfatides induced mechanical allodynia via glial cells activation and nitric oxide production Motoki Morita^1,2, Shun Watanabe^1,2, Misa Oyama^1,2, Takashi Iwai^1,2, Mitsuo Tanabe^1,2 ¹Lab. Pharm., Sch. Pharm., Kitasato Univ., ²Medical Research Lab.,Sch. Pharm.,Kitasato Univ.

2-Y-F2-216:4216:54 Treatment with anti-interleukin-6 receptor antibody improves mechanical hypersensitivity and cognitive dysfunction in mice with neuropathic pain Kodai Moriwaki¹, Kazue Nakashima², Toshiki Yoshii¹, Yoki Nakamura², Norimitsu Morioka² ¹Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., ²Sch. Pharmaceu. Sci., Hiroshima Univ.

2-Y-F2-316:5417:06 Comprehensive analysis of epigenetic modification under a persistent postoperative pain-like state Tanaka Kenichi^1,3, Yoshiyuki Yamabe^1,3, Michiko Narita^2,3, Hideyuki Takesima⁴, Yusuke Hamada^1,3, Daisuke Sato^1,3, Yosuke Katsuda^1,5, Masako Iseki⁵, Takahiro Ochiya², Naoko Kuzumaki¹, Toshikazu Ushijima⁴, Minoru Narita^1,3,5 ¹Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, ²Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan, ³Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan, ⁴Div. Epigenomics, Natl. Cancer Ctr. Res. Inst., Tokyo, Japan, ⁵Dept. Anesthesiol., Pain Med., Juntendo Univ., Tokyo, Japan

2-Y-F2-417:0617:18 Inhibitory effects of anti-high mobility group box-1 neutralizing antibody on nociceptive hypersensitivity in Parkinson’s disease Fumiaki Sato¹, Yoki Nakamura², Simeng Ma², Takahiro Kochi^2,3, Kazue Hisaoka-Nakashima², Wang Dengli⁴, Keyue Liu⁴, Hidenori Wake⁴, Masahiro Nishibori⁴, Norimitsu Morioka² ¹Sch. Pharmaceu. Sci., Hiroshima Univ., ²Dept. Pharmacol., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., ³Dept. Dent. Anesth., Grad. Sch. Biomed. & Health Sci., Hiroshima Univ., ⁴Dept. Pharmacol., Grad. Sch. Med., Dentistry & Pharmaceu. Sci., Okayama Univ.

YIA

Drug Addiction, Drug Abuse

2-Y-F3-117:3017:42 An essential role of the median raphe serotonin neurons projecting to the interpeduncular nucleus in reward processing. Kawai Hiroyuki¹, Yuma Nagai¹, Masashi Koda¹, Naoya Nishitani², Kazuki Nagayasu¹, Hisashi Shirakawa¹, Shuji Kaneko¹ ¹Dept. Mol. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., ²Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ.

2-Y-F3-217:4217:54 Distinct role of heterogeneously expressed receptors on D₂-receptor-containing medium spiny neurons in the development of behavioral sensitization induced by abused drugs Kensuke Yamashita¹, Kotaro Oikawa¹, Yusuke Hamada^1,2, Daisuke Sato¹, Michiko Narita^2,3, Naoko Kuzumaki¹, Tomohisa Mori¹, Minoru Narita^1,2 ¹Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, ²Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan, ³Dept. Mol and Cell Med., Tokyo Medical., Univ., Tokyo, Japan

2-Y-F3-317:5418:06 Piccolo knockdown in the nucleus accumbens suppressed methamphetamine-induced alterations Yuka Kusui¹, Kyosuke Uno^1,2, Shin-ichi Muramatsu^3,4, Atsumi Nitta¹ ¹Dept. Pharm Therap and NeuroPharm, ²Dept. Funct Molphology, ³Univ. Jichiika, ⁴Univ. Tokyo Ctr. Therap gene

2-Y-F3-418:0618:18 Oxytocin reverses 3,4-Methylenedioxypyrovalerone-induced impairment of hippocampal synaptic plasticity in mice Takahshi Junpei¹, Daisuke Yamada¹, Kosho Makino², Ryo Fujikawa¹, Toshinori Yoshioka¹, Eri Koga¹, Hideyo Takahashi², Akiyoshi Saitoh¹ ¹Lab Pharmacol., Fac Pham Sci, Tokyo Univ of Science, ²Lab Med Chem., Fac Pham Sci, Tokyo Univ of Science