program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Symposium14

New advances in brain research by manipulation and imaging of molecular functions

2-S14-19:0010:30 Visualization of AMPA receptors in living animal brain with positron emission tomography Tomoyuki Miyazaki¹, Waki Nakajima¹, Tetsu Arisawa¹, Makoto Higuchi², Takuya Takahashi¹ ¹Yokohama City Univ. Sch. Med., Dept.Physiol., ²Department of Functional Brain Imaging Research, NIRS, QST.

2-S14-29:0010:30 A novel ligand for chemogenetic receptors, deschloroclozapine, enables rapid and selective modulation of neuronal activity and behavior in living animals Yuji Nagai Dept. Functional Brain Imaging, NIRS, QST

2-S14-39:0010:30 CRMP2 Binding Compound Accelerates Recovery from Central Nervous System damage Jitsuki Susumu, Takuya Takahashi Dept. Physiol., Yokohama City Univ. Grad. Sch. of Med.

2-S14-49:0010:30 Optical inactivation of synaptic molecules by chromophore-assisted light inactivation Kiwamu Takemoto Dept. Biochem. Mie Univ.

Symposium20

Monitoring and mathematical analysis of neuronal activity to understand emotional control

2-S20-110:3012:00 Monitoring neuronal activation at the local and global levels provides a new role of claustral neurons in the neuronal mechanisms of anxiety-related behaviors Atsushi Kasai¹, Kaoru Seiriki^1,2, Hitoshi Hashimoto^1,3,4,5,6 ¹Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut.Sci., Osaka Univ., ²Inst. Transdiscip. Grad. Degree Prog., Grad. Sch. Pharmaceut. Sci., Osaka Univ., ³Unit. Grad. Sch. Child Dev., Osaka Univ., ⁴Inst. Datability Sci., Osaka Univ., ⁵Open Tarnsdiscip. Res. Initi., Osaka Univ., ⁶Dep. Mol Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ.

2-S20-210:3012:00 Neural mechanisms of willpower unraveled by neuronal activity monitoring. Natsuko Hitora-Imamura Dept. of Pharmacol., Grad. Sch. of Pharmaceut. Sci., Hokkaido Univ.

2-S20-310:3012:00 Toward understanding social emotions: neural mechanisms of reward processing for self and other in the macaque brain Atsushi Noritake NIPS

2-S20-410:3012:00 Optical and computational dissection of prefrontal neural circuit for fear memory Masakazu Agetsuma^1,2,3, Issei Sato⁴, Yasuhiro Tanaka⁵, Atsushi Kasai⁶, Yoshiyuki Arai³, Miki Yoshitomo¹, Hitoshi Hashimoto⁶, Junichi Nabekura¹, Takeharu Nagai³ ¹Natl. Inst. Physiol. Sci., ²JST・PRESTO, ³Osaka Univ. ISIR, ⁴Univ. Tokyo Frontier Sci., ⁵Tamagawa Univ. Brain Sci. Inst., ⁶Osaka Univ. Pharmaceut. Sci.

Oral Sessions

Immunity, Inflammation, Allergy (3), Respiratory Organ

2-O-C1-115:3015:42 Transcriptome analysis of bleomycin-induced pulmonary fibrosis in transgenic mice with modifying p38 signal in the lungs: exploration of the novel therapeutic targets for idiopathic pulmonary fibrosis Matsuda Shuichi^1,2, Jundal Kim³, Fumihiro Sugiyama⁴, Yuji Matsuo², Junji Ishida³, Kazuya Murata^3,4, Kanako Nakamura⁵, Kana Namiki⁶, Tatsuhiko Sudo⁷, Tomoyuki Kuwaki⁸, Masahiko Hatano¹, Koichiro Tatsumi², Akiyoshi Fukamizu³, Yoshitoshi Kasuya^1,6 ¹Dept. Biomed. Sci., Grad. Sch. Med., Chiba Univ., ²Dept. Respirology, Grad. Sch. Med., Chiba Univ., ³Life Sci. Ctr. for Survival Dynamics, Tsukuba Adv. Res. Alliance, Tsukuba Univ., ⁴Lab. Anim. Resour. Ctr. & Trans-Border Med. Res. Ctr., Tsukuba Univ., ⁵Grad. Sch. Sci. & Tech., Tsukuba Univ., ⁶Dept. Biochem. & Mol. Pharmacol., Grad. Sch. Med., Chiba Univ., ⁷Chem. Biol. Core Facility & Antibiotics Lab., RIKEN Adv. Sci. Inst., ⁸Dept. Physiol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ

2-O-C1-215:4215:54 The role of Myeloid-derived suppressor cells (MDSCs) in the pathogenesis of bleomycin-induced pulmonary fibrosis. Kotaro Kurakane¹, Rika Suzuki¹, Yuta Kondo¹, Yuri Kozakai¹, Ichiro Horie², Yoichiro Isohama¹ ¹Lab.appl. Pharmacol., Fac. of Pharm. Sci.,Tokyo Univ. of Sci, ²Fac. of Pharm., Sanyo-Onoda City University

2-O-C1-315:5416:06 The role of vascular endothelial growth factor receptor 1 tyrosine kinase signaling in bleomycin-induced pulmonary fibrosis Hideki Amano¹, Yoshio Mastui², Yoshiya Ito¹, Koji Eshima³, Ko Hatanaka¹, Kanako Hosono¹, Masabumi Shibuya⁴, Masataka Majima^1,5 ¹Department of Pharmacology Kitasato University School of Medicine, ²Department of Thoracic Surgery Kitasato University School pf Medicine, ³Department of Immunology Kitasato University School pf Medicine, ⁴Gakubunkan Institute of Physiology and Medicine Jobu University, ⁵Department of Medical Therapeutics Kanagawa Institute of Technology

2-O-C1-416:0616:18 Evaluation of the pathological effects of ozone exposure on a mouse model of allergic asthma and acute respiratory distress syndrome Kengo Tomita¹, Toa Okawara², Takashi Kurihara¹, Yuji Tsuji³, Tomoki Fukuyama² ¹Medical Enviroment Engineeing Group, Center for Environmental Engineering, Institute of Technology, Shimizu Corporation, ²Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, ³Mechanical/Electrical Design Department, Design Division, Shimizu Corporation

Oral Sessions

Immunity, Inflammation, Allergy (4), Cardiovascular Disorders

2-O-C2-116:3016:42 Effect of a LAT1-inhibitor on T cell-mediated allergic inflammation Osamu Kaminuma^1,2,3, Mayumi Saeki², Tomoe Nishimura², Takachika Hiroi², Kento Miura¹, Norimasa Yamasaki¹, Sawako Ogata¹, Daiki Ito¹, Teidai Koyama¹, Akio Mori³, Hitoshi Endo⁴, Naohiko Anzai^5,6, Keitaro Hayashi⁶ ¹Hiroshima Univ., ²Tokyo Metropol. Inst. Med. Sci., ³Sagamihara Natl. Hosp., ⁴J-Pharma Co. Ltd., ⁵Chiba Univ., ⁶Dokkyo Med. Univ. Sch. Med.

2-O-C2-216:4216:54 Verification of prognostic factors related to pulmonary hypertension combined with Systemic Scleroderma Yasuhiro Kanatani¹, Yoko Sato², Hiroyuki Kobayashi¹ ¹Tokai Univ. Sch. Med. Clin. Pharmacol., ²Shizuoka Gen Hosp. Res. Sup. Ctr. Stat.

2-O-C2-316:5417:06 Inhibition of excessive cell proliferation by Rho kinase 2 (ROCK2) in idiopathic pulmonary arterial hypertension Aya Yamamura, Nayeem Md Junayed, Rie Takahashi, Motohiko Sato Dept. Physiol., Aichi Medical Univ.

2-O-C2-417:0617:18 Role of TNF-α in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina Daiki Asano¹, Akane Morita¹, Asami Mori², Kenji Sakamoto², Toshihide Kashihara¹, Tsutomu Nakahara¹ ¹Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., ²Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.

Oral Sessions

Methodology, Technology (1)

2-O-C3-117:3017:42 Quencher based chemical tag technology using exchangeable probes for live-cell super-resolution imaging Daisuke Asanuma^1,2, Shigeyuki Namiki¹, Kenzo Hirose¹ ¹Dept. Pharmacol., Grad. Sch. Med., The Univ. of Tokyo, ²JST PRESTO

2-O-C3-217:4217:54 In vivo imaging analysis of Ca²⁺ signaling in pancreatic β-cells with transgenic mice expressing ratiometric Ca²⁺ indicator Kazunori Kanemaru¹, Isamu Taiko^1,2, Masamitsu Iino¹ ¹Div. Cel. Mol. Pharm., Nihon Univ. Sch. Med., ²Dept. Physiol., Nihon Univ. Sch. Med.

2-O-C3-317:5418:06 Whole-organ analysis of the tumor microenvironment by tissue clearing Shimpei Kubota¹, Kei Takahashi¹, Tomoyuki Mano², Katsuhiko Matsumoto³, Takahiro Katsumata², Shoi Shi², Kazuki Tainaka⁴, Hiroki Ueda^2,3, Shogo Ehata¹, Kohei Miyazono¹ ¹Dept. Mol. Pathol., Univ. Tokyo, ²Dept. Sys. Pharm., Univ. Tokyo, ³RIKEN BDR, ⁴Brain Research Institute, Niigata University

2-O-C3-418:0618:18 Clustering of theraputic drugs using a public database for adverse events Ryutaro Shinkawa, Yuhei Nishimura Dept. Integrative Pharm., Mie Univ. Grad. Sch. Med.

2-O-C3-518:1818:30 Highly efficient production of recombinant monoclonal antibodies from genome-edited transgenic chicken bioreactor Takehiro Mukae, Kyoko Yoshii, Isao Oishi Biomedical Research Institute, AIST