program｜The 94th Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

Neurotransmitter, Synapse 2, Learning, Memory

2-P1-0114:0015:30 Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory Yukie Kawahara¹, Yoshinori Ohnishi¹, Yoko Ohnishi¹, Hiroshi Kawahara², Akinori Nishi¹ ¹Dept. of Pharmacol., Kurume Univ. Sch. of Med., ²Dept. of Dent. Anesthesiology, Tsurumi Univ. Sch. of Dent. Med.

2-P1-0214:0015:30 Investigation of the roles of orexin receptor subtypes in regulation of basal dopamine efflux in the nucleus accumbens of freely moving rats Kawashima Hiroki, Yuri Aono, Tadashi Saigusa Dept. Pharmacol., Nihon Univ. Sch. Dent. at Matsudo

2-P1-0314:0015:30 The expression of G protein-coupled receptor 3 modulates presynaptic function in differentiated PC12 cells Humiaki Ikawa¹, Shigeru Tanaka¹, Tomohiro Noguchi², Kenta Sasaki², 佳奈原田¹, Izumi Hide¹, Norio Sakai¹ ¹Dept. of Mol. and Pharmacol. Neuroscience, Grad. Sch. of Biomed. and Health Sciences, Hiroshima Univ., ²Hiroshima Univ. of Fac. of Med.

2-P1-0414:0015:30 The role of synchronous firing on the neural circuit development Kashima Tetsuhiko, Yuji Ikegaya Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo

2-P1-0514:0015:30 The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons Mengxuan Gao¹, Asako Noguchi¹, Yuji Ikegaya^1,2,3 ¹Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, ²Inst. Beyond AI, ³Center for Information and Neural Networks

2-P1-0614:0015:30 Induction of theta phase precession using a neurofeedback system. Aoki Yuki¹, Yuji Ikegaya^1,2,3, Takuya Sasaki^1,4 ¹Lab. of Chem. Pharmcol., Grad. Sch. of Pharmaceut. Sci., The Univ. of Tokyo, ²Inst. for AI and Beyond, ³Center for Information and Neural Networks, ⁴Japan Sci. and Tech. Agency, PRESTO

2-P1-0714:0015:30 Urethane anesthesia suppresses hippocampal subthreshold activity and neuronal synchronization. Yagishita Haruya¹, Yuya Nishimura¹, Asako Noguchi¹, Yu Shikano¹, Yuji Ikegaya^1,2,3, Takuya Sasaki^1,4 ¹Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, ²Institute for AI and Beyond, The University of Tokyo, ³Center for Information and Neural Networks, National Institute of Information and Communications Technology, ⁴Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

2-P1-0814:0015:30 Spike activity of dorso-ventral hippocampus in response to aversive stimulus Sakura Okada¹, Yuji Ikegaya^1,2,3, Takuya Sasaki^1,4 ¹Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, ²Institute of AI and Beyond, The University of Tokyo, ³Center for Information and Neural Networks, National Institute of Information and Communications Technology, ⁴Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency

2-P1-0914:0015:30 Activity of histamine neurons in the tuberomammillary nucleus associated within learning and memory Nishimura Kyoka, Ayame Kubo, Rintaro Shimizume, Natuko Hitora（Imamura）, Masabumi Minami, Hiroshi Nomura Hokkaido Univ.

2-P1-1014:0015:30 The neural projection mechanism from the anterior cingulate cortex to the periaqueductal gray underlying behavioral selection in a conflict situation Honshuku Yuki, Ryoki Saito, Takuji Soga, Masabumi Minami, Natsuko HitoraｰImamura Dept. Pharmacology, Grad. School of Pharmaceutical Sciences, Hokkaido Univ.

2-P1-1114:0015:30 Indispensability of glial glutamate transporters during a neurodevelopmental period to cognitive behaviors and brain development Mizuki Uchida¹, Norio Ozaki², Akira Yoshimi¹, Yukihiro Noda¹ ¹Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm., ²Dept. Psychiatry, Nagoya Univ. Grad. Sch. Med.

2-P1-1214:0015:30 Evaluation of cognitive function in diabetic germ-free mice Hiroyuki Kobayashi¹, Hiroyasu Murasawa¹, Akiko Pawlak¹, Kazutaka Katayama², Daisuke Kishigai², Saki Shimato¹, Miki Sugiyama¹, Masae Okuyama¹, Takahito Imaizumi¹, Nozomu Shimato¹, Hiroko Nonomura¹, Ryusei Nishiyama¹, Takuji Mizuki¹, Yasushi Hirasawa¹ ¹Nihon Bioresearch Inc., ²OrientalBioService Inc.

2-P1-1314:0015:30 The cognitive impairment induced via activation of hypoxia inducible factor-1 alpha signaling pathway Daisuke Kodama, Yoshiaki Ohi, Akira Haji Lab. Neuropharmacol., Sch. Pharm. Aichi-Gakuin Univ.

Poster Sessions

Glia Cell 2, Pain, Sensary Neuron, Inflammation 1

2-P1-1414:0015:30 Microsomal prostaglandin E synthase-1 induced by hemoglobin in microglia contributes to inflammation and neuronal death Yuri Ikeda-Matsuo^1,2, Norika Yunoki¹, Minori Kaji¹, Satoshi Uematsu³, Shizuo Akira⁴, Tatsuo Takahashi¹, Mitsuo Tanabe² ¹Lab. Pharmacol., Fac. Pharmac. Sci., Hokuriku Univ., ²Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ., ³Dept. Immunol. Genomics, Osaka City Univ. Grad. Sch. Med., ⁴Lab. Host Defense, WPI Immunol. Front. Res. Ctr, Osaka Univ.

2-P1-1514:0015:30 Thrombin increases kynurenine 3-monooxygenase expression in microglia Masatoshi Ohnishi, Shunpei Tasaka, Mana Furutaguchi, Takuya Shigemasa, Takao Kai, Yuki Shimizu, Yuui Urabe, Yukino Yano, Atsuko Inoue Dept. Pharmacotherap. Fukuyama Univ.

2-P1-1614:0015:30 P2Y₂ receptor/PYK2 signaling mediates dying cell phagocytosis by microglia Izumi Hide, Hiroko Shiraki, Mayuka Kumagai, Takuya Maeda, Kana Harada, Shigeru Tanaka, Norio Sakai Dept. Mol. Pharmacol. Neurosci., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

2-P1-1714:0015:30 Extracellular Zn²⁺ suppress IL-6 secretion from M2/M1 switched microglia through ZIP zinc transporter Takaaki Aratake^1,2, Youichirou Higashi¹, Sou Kedahana¹, Yusuke Morishita¹, Takahiro Shimizu¹, Shogo Shimizu¹, Suo Zou¹, Masaki Yamamoto¹, Rina Nakamura¹, Toshifumi Akizawa¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., ²JSPS Research Fellow

2-P1-1814:0015:30 LPS decrease KCC2 expression in primary rat cerebral cortex cells and PC-12 cells Kazuo Tomita¹, Sayuri Yamanishi^1,3, Kento Igarashi^1,2, Yoshikazu Kuwahara^1,4, Koh-ichi Tanaka^1,2,5, Jyun-ichi Kitanaka⁵, Nobue Kitanaka⁵, Akihiro Kurimasa⁴, Shoichi Miyawaki³, Nobuyoshi Nishiyama², Motohiko Takemura⁵, Tomoaki Sato¹ ¹Dept. Applied Pharm., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ³Dept. Orthodontics and Dentofacial Orthopedics, Grad. Sch. Med. & Dent. Sci., Kagoshima Univ, ⁴Dept. Radiation Biol. Med., Facul. Med, Tohoku Med. Pharm. Univ., ⁵Dept. Pharmacol., Hyogo Col. Med.

2-P1-1914:0015:30 Regulation of receptor chaperone molecule RTP4 in neuronal cells by opioid receptor activation Wakako Fujita, Jun Aruga Dept. Med. Pharmacol., Grad. Sch. Biomed. Sci., Nagasaki Univ.

2-P1-2014:0015:30 Regulation of receptor chaperone molecule RTP4 in microglial cells under the inflammatory stress Yusuke Kuroiwa¹, Wakako Fujita² ¹Dept. Pharmacol. Therap. Innov., Sch. Pharmaceu. Sci., Nagasaki Univ., ²Dept. Med. Pharmacol., Grad. Sch. Biomed. Sci., Nagasaki Univ.

2-P1-2114:0015:30 p38 MAPK is directly inhibited by PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor Junsuke Uwada Div. Cell. Signal Transduct., Dept. Biochem., Asahikawa Med. Univ.

2-P1-2214:0015:30 Novel TREK-1 activators suppress neuronal excitability and pain behavior in rodent model. Kenji Goryo¹, Takashi Miyano¹, Masahiko Irie¹, Rieko Matsumura¹, Masako Tanabe¹, Kenta Kagaya¹, Shun Saito¹, Takehiko Inohana², Misa Hayashi², Kuniyoshi Koyachi², Junji Kamon¹ ¹Pharmaceut. Res. Dept., Biol. Res. Lab., Nissan Chemical Corporation, ²Pharmaceut. Res. Dept., Chem. Res. Lab., Nissan Chemical Corporation

2-P1-2314:0015:30 Activation of spinal dorsal horn astrocytes by noxious stimulus involves descending noradrenergic signaling Riku Kawanabe, Kohei Yoshihara, Makoto Tsuda Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.

2-P1-2414:0015:30 Neuron-derived ATP promotes paclitaxel-induced HMGB1 release from macrophages: role of ATP as a neuroimmune mediator in chemotherapy-induced peripheral neuropathy Risa Domoto, Riki Kamaguchi, Maiko Iemura, Fumiko Sekiguchi, Atsufumi Kawabata Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ.

2-P1-2514:0015:30 Repagermanium hydrolysate suppresses H₂S-dependent Ca_v3.2 channel hyperactivity and visceral or somatic pain by trapping sulfide Nene Koike¹, Kaho Sugimoto¹, Hiroshi Masuda¹, Yasuhiro Shimada², Katsuyuki Sato², Takashi Nakamura², Hiroaki Yamaguchi³, Genzou Tanabe⁴, Shinsuke Marumoto⁵, Yoshihito Kasanami¹, Fumiko Sekiguchi¹, Tsuyako Ohkubo⁶, Shigeru Yoshida⁷, Atsufumi Kawabata¹ ¹Lab. Pharmacol. Pathophysiol, Fac. Pharm., Kindai Univ., ²Asai Germanium Res. Inst Co., Ltd., ³Yamagata Univ. Grad. sch. Med. Sci., ⁴Lab.Org. Chem., Fac. Pharm., Kindai Univ., ⁵Joint Res. cent, Kindai Univ., ⁶Div. Basic Med. Sci. Fundam. Nurs., Fac. Nurs., Fukuoka Nurs. Coll., ⁷Dept. Life Sci., Fac. Sci. Engineer., Kindai Univ.

2-P1-2614:0015:30 Macrophage-derived HMGB1 contributes to the accelerated neurite outgrowth in dorsal root ganglion neurons isolated from the mice subjected to sciatic nerve injury Fumiko Sekiguchi¹, Yui Nakatake¹, Maho Tsubota¹, Masahiro Nishibori², Atsufumi Kawabata¹ ¹Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., ²Dept. Pharmacol., Okayama Univ. Grad. Sch. Med.

2-P1-2714:0015:30 The mechanism of the modulation of pain signaling by b-series gangliosides Shun Watanabe^1,2, Motoki Morita^1,2, Daichi Kitamura^1,2, Misa Oyama^1,2, Takashi Iwai^1,2, Mitsuo Tanabe^1,2 ¹Lab. Pharmacology, Sch. Pharm., Kitasato Univ., ²Medicinal Research Lab., Sch. Pharm., Kitasato Univ.

2-P1-2814:0015:30 Study on the Evaluation System of Post-Stroke Pain Model in Rats Takashi Tashiro, Yoshiyuki Hayashida, Saeko Yoshihara, Masana Kamioka, Ikuo Takahashi, Seiichi Katayama, Naoyuki Hironaka, Katsuhide Nishi LSI Medience Corporation

2-P1-2914:0015:30 "Quality of Lipid" in the dorsal root ganglion Shota Yamamoto¹, Takao Shimizu^1,2, Hideo Shindou^1,3 ¹Department of Lipid Signaling, National Center for Global Health and Medicine, ²Institute of Microbial Chemistry, The Microbial Chemistry Research Foundation, ³Department of Lipid Science, Graduate School of Medicine, The University of Tokyo

Poster Sessions

Depression, Anxiety 1

2-P1-3014:0015:30 SSRI improves a long-lasting decrease in sociability with attenuation of morphological changes in hippocampal microglial cells in tumor-resected mice Yusuke Onaka¹, Yui Tanaka¹, Yukinori Nakashima¹, Taro Yamaguchi¹, Masanori Yoneyama¹, Norihito Shintani², Hitoshi Hashimoto^2,3,4,5,6 ¹Lab. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ., ²Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceutic. Sci., Osaka Univ., ³United Grad Sch. Child Develop., Osaka Univ., ⁴Instit. for Datability Sci., Osaka Univ., ⁵Dept. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ., ⁶Instit. for Open and Transdisciplinary Res. Initiatives, Osaka Univ.

2-P1-3114:0015:30 Effects of intracerebroventricular injection of anti- and pro-inflammatory mediators on depression-like behaviors. Takahisa Otsuka, Hiroe Suzuki, Natsuko Hitora-Imamura, Masabumi Minami Department Pharmacology., Graduate School of Life Science, Hokkaido University

2-P1-3214:0015:30 The anti-alcoholism drug disulfiram produces anxiolytic effects in mice. Nagayama Yoshifumi¹, Daisuke Yamada¹, Yuya Terashima², Kosyo Makino³, Yoshino Takahashi³, Yoshitake Sano⁴, Etsuko Toda², Misaki Ohashi¹, Toshinori Yoshioka¹, Kotaro Okano¹, Tomoki Omata¹, Hideyo Takahashi³, Kouji Matsushima², Akiyoshi Saitoh¹ ¹Lab Pharmacol., Fac Pharm Sci, Tokyo Univ of Science., ²Lab Mol. Reg. Dis., RIBS, Tokyo Univ of Science., ³Lab Med.Chem., Tokyo Univ of Science., ⁴Lab Dept. Appl. Biol. Sci., Tokyo Univ of Science.

2-P1-3314:0015:30 Antidepressant-like effect of captopril via hippocampal angiotensin (1-7) / MAS1 pathway in olfactory bulbectomized mice. Miharu Wakou, Osamu Nakagawasai, Taisei Koyama, Takayo Odaira, Wakana Sakuma, Ryota Yamagata, Wataru Nemoto, Koichi Tan-No Dept. Pharmacol., Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Uni.

2-P1-3414:0015:30 Possible change in transcriptional regulation of 5-HT_1A receptor in the midbrain of stress-maladaptive mice Hiroko Miyagishi^1,2, Minoru Tsuji¹, Yasuhiro Kosuge², Kumiko Ishige², Hiroshi Takeda^1,3 ¹Dept. Pharmacol., Sch. Pharm., International Univ. Health and Welfare, ²Lab. Pharmacol., Sch. Pharm., Nihon Univ., ³Dept. Pharmacol., Sch. Pharm. at Fukuoka, International Univ. Health and Welfare

2-P1-3514:0015:30 Analysis of mRNA expression levels for cyclooxygenase isozymes and prostanoid synthases in the rat hypothalamic paraventricular nucleus after restraint stress Yuqiu Wu¹, Naoko Yamaguchi¹, Kazuhiro Yoshikawa², Shoshiro Okada¹ ¹Dept Pharmacol, Sch Med, Aichi Med Univ, Aichi, Japan, ²Div Res Creation & Biobank, Res Creation Support Ctr, Aichi Med Univ, Aichi, Japan

2-P1-3614:0015:30 Social cognitive improvement via activation of the hippocampal α7 nicotinic acetylcholine receptor in stressed mice Kana Hosoi¹, Mizuki Uchida¹, Erika Ota¹, Akira Yoshimi¹, Norio Ozaki², Yukihiro Noda¹ ¹Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Fac. & Grad. Sch. Pharm., ²Dept. Psychiatry, Nagoya Univ. Grad. Sch. Med.

2-P1-3714:0015:30 Kamishoyosan reduces aggressive behavior of isolated-reared mice toward inanimate objects and involvement of estrogen receptor β Kento Igarashi^1,2, Toshiko Kuchiiwa³, Satoshi Kuchiiwa⁴, Kazuo Tomita^1,2, Koh-ichi Tanaka^1,2, Nobue Kitanaka⁵, Junichi Kitanaka⁵, Nobuyoshi Nishiyama², Motohiko Takemura⁵, Tomoaki Sato¹ ¹Lab. of applied pharmacology, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., ²Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ³Dept. of Clinical Pshychol., Grad. Sch. Human Sci., Kagoshima Immaculate Heart Univ., ⁴Dept. Neuroanatomy, Field of Neurol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., ⁵Dept. Pharmacol., Hyogo Col. Med.

2-P1-3814:0015:30 Evaluation of antipsychotic properties of M₄muscarinic acetylcholine receptor agonists in mice Yumika Toyoshima^1,2, Motoki Nakamura¹, Emi Yoshida¹, Chifuyu Ohashi¹, Konosuke Hirose¹, Yuto Ishizaki¹, Yoshihiro Nakamura¹, Mei Higaki¹, Saki Shimizu¹, Takaaki Sumiyoshi², Yukihiro Ohno¹ ¹Dept. Pharmacol., Osaka Univ. Pharm. Sci., ²Dept. Life Sci. and Biotech., Kansai Univ.

2-P1-3914:0015:30 Adolescent social isolaion induced dissociable effects on synaptic transmissions in medial and lateral OFC-BLA pathways Hiroshi Kuniishi^1,2, Masayuki Sekiguchi², Mitsuhiko Yamada¹ ¹Dept Neuropsychopharmacoly, National Institute of Mental Health, National Center of Neurology and Psychiatry, ²Dept Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry

2-P1-4014:0015:30 A novel bipolar syndrome animal model via reduction of Teneurin-4, the protein encoded by ODZ4, in the prefrontal cortex of mice Takashi Asano¹, Kazuki Tokoro¹, Naotaka Izuo¹, Fumitaka Nakano¹, Masaya Miyashita¹, Shin-ichi Muramatsu^2,3, Atsumi Nitta¹ ¹Department of Pharmaceutical Therapy and Neuropharmacology, The University of Toyama, Japan, ²Department of Neurology, Jichi Medical University, Japan., ³Center for Gene and Cell Therapy, Institute of Medical Science, The University of Tokyo, Japan.

2-P1-4114:0015:30 Neural ensembles in the insular cortex encode social exploration Masaaki Sato^1,2, Isamu Miura³, Eric Overton², Nobuo Kunori⁴, Junichi Nakai⁵, Takakazu Kawamata³, Nobuhiro Nakai^2,6, Toru Takumi^2,6 ¹Dept Neuropharmacol, Hokkaido Univ Grad Sch Med, ²RIKEN CBS, ³Dept Neurosurg, Tokyo Women's Med Univ, ⁴AIST, ⁵Div Oral Physiol, Tohoku Univ Grad Sch Dent, ⁶Dept Physiol Cell Biol, Kobe Univ Sch Med

2-P1-4214:0015:30 Development of epigenome therapeutic agents and treatments to improve cognitive impairments in schizophrenia Fukuda Mayu, Jun Mukai Tsukuba Univ. Ctr. Neurosci.

2-P1-4314:0015:30 Enriched environment reverts decreased sociability in prenatal folate deficiency mice Misato Yoshikawa, Hiroaki Aso, Masahiko Watanabe, Katsuya Suemaru Dept. Public Health Shujitsu Univ.

2-P1-4414:0015:30 Reduced expression of NMDA receptors (NR2A and NR2B) in the hippocampus of WD repeat domain 3 gene hetero knockout mice Kobayashi Momoko, Hiroki Furuie, Hideki Miwa, Misa Yamada, Mitsuhiko Yamada Dept. of Neuropsychopharmacology, Natl. Inst. of Mental Health, Natl. Ctr. of Neurology and Psychiatry

Late-Breaking Session

2-P1-LB4514:0015:30 Physiological function of the descending projection from the insular cortex to the parabrachial nucleus revealed by optogenetics Kensuke Hirose, Yuka Nakaya, Masayuki Kobayashi Dept. of Pharmacol. Nihon Univ. Sch. of Dent.

2-P1-LB4614:0015:30 Restoration of CLSP activity rescues Alzheimer disease Masaaki Matsuoka, Yuichi Hashimoto, Shinya Kusakari, Mikiro Nawa, Yuka Toyama Department of Pharmacology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan

2-P1-LB4714:0015:30 The Nrf2 gene may not be involved in the anti-inflammatory effects of Nrf2 activators Yasuhiko Izumi¹, Momoko Uegomori¹, Fumika Kobayashi¹, Koya Koya Yamaki¹, Toshiaki Kume², Yutaka Koyama¹ ¹Lab. Pharmacol., Kobe Pharm. Univ., ²Dept. Appl. Pharmacol, Grad. Sch. of Med. and Pharm. Sci., Univ. of Toyama

2-P1-LB4814:0015:30 Influence of mitochondria dysfunction in microglia on inflammation-evoked type I interferon expression Momoka Iwamoto, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka Dept. Pharmacol., Grad.Sch. Biomed. & Helth Sci., Hiroshima Univ.

2-P1-LB4914:0015:30 The effects of chronic administration of methamphetamine on circadian rhythm of mice Nakaya Mizuki, Ryousuke Sato, Kouki Nagasawa, Yukina Yoshida, Juri Hayashi, Yuki Ishi, Kazuko Hamada, Toshiyuki Hamada IUHW

March 9 (Tue) Room P1