program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

CNS: Neuron

3-P-26512:5013:50 Assessment to anti-epilepsy drugs in human iPSC-derived neural network Remi Yokoi, Yuto Ishibashi, Aoi Odawara, Ikuro Suzuki Tohoku Institute of Technology, Department of Electronics

3-P-26612:5013:50 Tumor necrosis factor alpha protects retinal ganglion cells against excitotoxicity via reduction of oxidative stress in the mice Kenji Sakamoto^1,2, Yuki Haginoya¹, Hiroki Sakai¹, Daiki Asano¹, Akane Morita¹, Asami Mori¹, Tsutomu Nakahara¹ ¹Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., ²Lab. Med. Pharmacol., Fac. Pharma-Sci., Teikyo Univ.

3-P-26712:5013:50 Enhancement by a Src family inhibitor of the interaction of Pyk2 and Fyn in hypothalamic neurons Sayomi Nakamine, Shiho Okitsu, Hideyuki Yamamoto Dept. of Biochem. Grad. Sch. of Med., Univ. of Ryukyus

3-P-26812:5013:50 An examination whether KCC2, a K⁺-Cl^- co-transporter, is efficient as a target to attenuate the neuronal dysfunction that is associated with radiation therapy for brain tumor by using oxytocin. Kento Igarashi^1,2, Kazuo Tomita^1,2, Koh-Ichi Tanaka^1,2, Yoshikazu Kuwahara^1,3, Nobuyoshi Nishiyama³, Akihiro Kurimasa³, Tomoaki Sato¹ ¹Lab. of applied pharmacology, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., ²Dept. Pharm., Pharm., Hyogo Univ. of Health Sciences, ³Dept. Rad. Biol. and Med., Med., Tohoku Medical and Pharmaceutical Univ.

Poster Sessions

CNS: Glia 2

3-P-26912:5013:50 Effects of CNB-001, a synthetic curcumin derivative, on thrombin-induced phosphorylation of MAP kinases in primary cultured rat microglia Shohei Yamamoto¹, Tatsuhiro Akaishi¹, David Schubert², Kazuho Abe¹ ¹Lab. Pharmacol., Fac. Pharm., Musashino Univ., ²Cell. Neurobiol. Lab., Salk Inst.

3-P-27012:5013:50 Prostaglandin E₂ increases expression of mRNA for cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in microglia. Takayuki Nagano, Naohiko Tsuda, Kenichi Fujimura, Yuji Ikezawa, Yuki Higashi, Shinya H. Kimura, Motohiko Takemura Dept. Pharmacol., Hyogo Col. Med.

3-P-27112:5013:50 Roles for microglial N-type Ca²⁺ channel in aging-related enhanced neuroinflammation Hironao Saegusa, Soontaraporn Huntula, Xinshuang Wang, Shuqin Zong, Tsutomu Tanabe Dept. Pharmacol. Neurobiol., Grad. Sch. Med., Tokyo Med. Dent. Univ. (TMDU)

3-P-27212:5013:50 Dysfunction of microglia in hyperglycemia Rina Otsuka, Tomomitsu Iida, Takeo Yoshikawa, Kazuhiko Yanai Dept. Pharm., Sch. Med., Tohoku Univ.

3-P-27312:5013:50 TLR4-activated p38 and NF-κB and GM-CSF receptor-mediated JAK2/STAT5 pathways are important for microglial long-term survival Mayumi Kamigaki¹, Izumi Hide², Yasushi Kodama¹, Norio Sakai², Kumatoshi Ishihara¹ ¹Lab. of Pharmacol. and Pathophysiol., Hiroshima Int. Univ., ²Dept. of Mol. and Pharmacol. Neurosci, Grad. Sch. of Biomed and Health Sci, Hiroshima Univ.

3-P-27412:5013:50 Involvement of EPAC and TPL2 in IL-1β production in microglial cells following activation of β-adrenergic receptors Hidetoshi Saitoh¹, Izumi Sasaki¹, Tomohiro Yamashita², Makoto Tsuda¹ ¹Dept. Life innov, Grad. Sch. Phamaceut., Kyushu Univ., ²Lab. Global Healthcare, Grad. Sch. Phamaceut., Kyushu Univ.

3-P-27512:5013:50 Activation of toll-like receptor 4 induces downregulation of sigma-1 receptor in microglia Momoka Iwamoto, Masatoshi Takemura, Yoki Nakamura, Kazue Nakashima, Norimitsu Morioka Dept. Pharmacol., Grad.Sch. Biomed. & Helth Sci., Hiroshima Univ.

3-P-27612:5013:50 P2Y₂ receptor is involved in upregulation of phagocytic receptor AXL tyrosine kinase in TLR4-activated microglia Izumi Hide¹, Hiroko Shiraki¹, Yuhki Yanase², Takuya Maeda¹, Akihiro Masuda¹, Kana Harada¹, Shigeru Tanaka¹, Michihiro Hide², Norio Sakai¹ ¹Dept. Mol. Pharmacol. Neurosci., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., ²Dept. Dermatol., Grad. Sch. Biomed. Sci., Hiroshima Univ.

3-P-27712:5013:50 Expression of nucleoside transporters and hydrogen peroxide-induced thymidine incorporation in astrocytes Koh-ichi Tanaka^1,2,3, Kento Igarashi^1,2, Kazuo Tomita^1,2, Nobue Kitanaka³, Junichi Kita³, Tomoaki Sato², Motohiko Takemura³, Nobuyoshi Nishiyama¹ ¹Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., ²Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci., ³Dept. Pharmacol., Hyogo Col. Med.

3-P-27812:5013:50 Fibroblast growth factor 2 modulates purine metabolic enzymes through MAPK pathway in rat spinal cord astrocytes Ryota Eguchi, Ken-Ichi Otsuguro Lab. Pharm., Facul. Vet. Med., Hokkaido Univ.

3-P-27912:5013:50 Layer-specific transcriptome analysis of microglia in the medial prefrontal cortex Kazutoshi Matsushita, Masayuki Taniguchi, Tomoyuki Furuyashiki Div. Pharmacol., Grad. Sch. Med., Kobe Univ.

Poster Sessions

CNS: Psychiatric Disoder, Developmental Disoder 2

3-P-28012:5013:50 Computer chemistry of non-peptide oxytocin agonists. Taizou Hayano¹, Shiroh Kishioka² ¹Div.neuro-psychiat.Nokamikousei -Hp．, ²Dept.Pharmacol.Med-coll.WakayamaMed-Univ.

3-P-28112:5013:50 Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome Masayuki Baba¹, Kazumasa Yokoyama², Kaoru Seiriki^1,3, Kensuke Matsumura^1,3,4, Momoka Kondo¹, Kana Yamamoto¹, Atsushi Kasai¹, Yukio Ago^1,5, Kazuki Nagayasu¹, Atsuko Hayata^1,6, Shun Yamaguchi^7,8, Daisuke Mori^9,10, Norio Ozaki⁹, Tadashi Yamamoto^11,12, Kazuhiro Takuma^6,13, Ryota Hashimoto^14,15, Hitoshi Hashimoto^1,6,16,17,18, Takanobu Nakazawa^1,13 ¹Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., ²Pharmaceut. Res. Div., Takeda Pharmaceut. Co. Ltd., ³Interdiscip. Program Biomed. Sci., Inst. Transdiscip. Grad. Degree Program, Osaka Univ., ⁴JSPS, ⁵Lab. Biopharmaceutics, Grad. Sch. Pharmaceut. Sci., Osaka Univ., ⁶United Grad. Sch. Child Dev., Osaka Univ., ⁷Dept. Morphological Neurosci., Gifu Univ. Grad. Sch. Med., ⁸Ctr. Highly Adv. Integration Nano Life Sci., Gifu Univ., ⁹Dept. Psychiatry, Nagoya Univ. Grad. Sch. Med., ¹⁰Brain Mind Res. Ctr., Nagoya Univ., ¹¹Lab. IImmunogenetics, Ctr. Integr. Med. Sci., RIKEN, ¹²Cell Signal Unit, Okinawa Inst. Sci. Tech. Grad. Univ., ¹³Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., ¹⁴Dept. Pathol. Mental Diseases, Natl. Inst. Mental Health, Natl. Ctr. Neurology Psychiatry, ¹⁵Osaka Univ.

3-P-28212:5013:50 The role of prostaglandin E₂ in environmental factors of psychiatric disorders Hirotake Hida^1,2, Akihiro Mouri³, Mitsuhira Takasu², Rina Muto², Mizuki Uchida², Tomoyuki Furuyashiki⁴, Shuh Narumiya⁵, Toshitaka Nabeshima³, Kiyofumi Yamada¹, Akira Yoshimi², Norio Ozaki⁶, Yukihiro Noda^1,2 ¹Hosp Pharm, Nagoya Univ Hosp, ²Div Clin Sci & Neuropsychopharmacol, Grad Sch Pharm, Meijo Univ, ³Regulatory Sci, Grad Sch Health Sci, Fujita Health Univ, ⁴Div Pharmacol, Grad Sch Med, Kobe Univ, ⁵Dept Drug Discovery Med, Grad Sch Med, Kyoto Univ, ⁶Dept Psych, Grad Sch Med, Nagoya Univ

3-P-28312:5013:50 Nox1 deficiency alleviated behavioral abnormalities in obsessive-compulsive disorder model mice via inhibition of D₂ receptor/β-arrestin pathway-mediated synaptic facilitation Nozomi Asaoka¹, Shuji Kaneko², Chihiro Yabe-Nishimura¹ ¹Dept. Pharm., Grad. Sch. Med., Kyoto Pref. Univ. Med., ²Dept. Mol Pharm., Grad. Sch. Pharm. Sci., Kyoto Univ.

3-P-28412:5013:50 Alteration of parvalbumin expression and perineuronal nets formation in the anterior cingulate cortex of Fabp3 KO mice Yui Yamamoto^1,3, Kohji Fukunaga², Yuji Owada³, Keiju Kamijo¹ ¹Dept. Anatomy, Tohoku Med. and Pharm. Univ., ²Dept. Pharmacology, Tohoku Univ. Grad. Sch. Pharm., ³Dept. Organ Anatomy, Tohoku Univ. Grad. Sch. Med.

3-P-28512:5013:50 Yokukansan and keishito ameliorate ASD-like sociability deficits in ovariectomized mice Linyu Li¹, Kinzo Matsumoto¹, Ryota Araki², Takeshi Yabe², Fujiwara Hironori^1,3 ¹Div. Med. Pharm., Inst. Nat. Med., Univ. of Toyama, ²Lab. Func. Biomol. Chem. Pharmacol., Fac. Pharm. Sci., Setsunan Univ., ³Fac. Pharm., Iryo Sosei Univ.

3-P-28612:5013:50 Involvement of hippocampal alpha2A-adrenoceptors in impulsive-like behaviors induced by Intermittent sleep deprivation in mice Fukie Yaoita¹, Kouta Namura¹, Kaede Shibata¹, Sayaka Sugawara¹, Masahiro Tsuchiya², Takeshi Tadano³, Koichi Tan-No¹ ¹Dept. Pharmacol., Fac. Pharmaceuticalsci., Tohoku Medical and Pharmaceutical Univ., ²Dept. Nursing, Tohoku Fukushi Univ., ³Grad. Sch. Med. Sci., Kanazawa Univ.

Poster Sessions

CNS: Depression, Anxiety 2

3-P-28712:5013:50 Changes in prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji Dept. Pharmacol., Sch. Pharma., Int. Univ. Health and Welfare

3-P-28812:5013:50 Differential effects of ketamine metabolites on depression-like behaviors induced by chronic corticosterone injection in mice Rei Yokoyama¹, Yukio Ago^2,3, Momoko Higuchi¹, Wataru Tanabe¹, Shinji Tukada¹, Atsushi Kasai¹, Kaoru Seiriki^1,4, Takanobu Nakazawa^1,5, Kenji Hashimoto⁶, Hitoshi Hashimoto^1,7,8,9,10 ¹Lab Mol Neuropharmacol, Grad Sch Pharmaceut Sci, Osaka Univ, Osaka, Japan, ²Lab Biopharmaceut, Grad Sch Pharmaceut Sci, Osaka Univ, Osaka, Japan, ³Global Ctr Med Eng Informat, Osaka Univ, Osaka, Japan, ⁴Inst Transdiscip Grad Deg Prog, Osaka University, Osaka, Japan, ⁵Dept Pharmacol, Grad Sch Dentistry, Osaka Univ, Osaka, Japan, ⁶Div Clin Neurosci, Chiba Univ Ctr Forensic Mental Hlth, Chiba, Japan, ⁷Mol Res Ctr Children’s Mental Dev, United Grad Sch Child Dev, Osaka Univ, Osaka, Japan, ⁸Inst Datability Sci, Osaka Univ, Osaka, Japan, ⁹Inst Open Transdiscip Res Initiatives, Osaka Univ, Osaka, Japan, ¹⁰Dept Mol Pharmaceut Sci, Grad Sch Med, Osaka Univ, Osaka, Japan

3-P-28912:5013:50 The claustrum neuronal ensembles that were activated by social defeat stress mediate anxiety-like behavior through regulating the activation of multiple stress-responsive nuclei Misaki Niu¹, Atsushi Kasai¹, Takahiro Kuwaki¹, Masato Tanuma¹, Kaoru Seiriki^1,2, Nakazawa Takanobu^1,3, Akihiro Yamanaka⁴, Hitoshi Hashimoto^1,5,6,7,8 ¹Lab Mol Neuropharmacol, Grad Sch Pharmaceut Sci, Osaka Univ, Osaka, Japan, ²Inst Transdiscip Grad Deg Prog, Osaka University, Osaka, Japan., ³Dept Pharmacol, Grad Sch Dentistry, Osaka Univ, Osaka, Japan, ⁴Dept Neurosci II, Res Inst Environ Med, Nagoya Univ, Japan, ⁵Mol Res Ctr Children’s Mental Dev, United Grad Sch Child Dev, Osaka Univ, Osaka, Japan, ⁶Inst Datability Sci, Osaka Univ, Osaka, Japan, ⁷Inst Open Transdiscip Res Initiatives, Osaka Univ, Osaka, Japan, ⁸Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Japan

3-P-29012:5013:50 Involvement of serotonergic system in the antidepressant-like effect of a novel curcumin derivative CUD003 in mice Hirokazu Matsuzaki¹, Yuka Hashizume¹, Yushi Matsuoka¹, Xuan Meiyan², Jun Takayama², Takeshi Sakamoto², Yuan Bo¹, Mari Okazaki¹ ¹Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., ²Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.

3-P-29112:5013:50 Activating transcription factor 4(ATF4)-dependent activation of the human tryptophan hydroxylase 2 gene is mediated through binding to a CCAAT-enhancer-binding protein (CEBP)-ATF composite site in its promoter Nawa Yukino¹, Hanae Kaneko¹, Masaaki Tsubonoya¹, Tomoko Hiroi¹, Ryoya Takahashi², Hiroaki Matsui¹ ¹Inst RI Res, St. Marianna Univ Grad Sch Med, ²Dept Biochem, Fac Pharm Sci, Toho Univ

3-P-29212:5013:50 The contribution of the NMDA receptors in the bed nucleus of the stria terminalis for the induction of depressive-like behaviors in mice Sakura Maeda¹, Miki Kanno¹, Nao Fukuwada¹, Miho Moriya¹, Rino Hashimoto¹, Tohru Matsuki², Kenjiro Seki¹ ¹Dept. Pharmacol., Pharmaceutical Sci., Ohu Univ., ²Dept. Cell Pathol., Inst. Dev. Res., Aichi Dev Disability Center

3-P-29312:5013:50 Overgeneralization of context fear memory promotes the despair behavior in PTSD-considered model mouse Miho Moriya¹, Rino Hashimoto¹, Sakura Maeda¹, Tohru Matsuki², Kenjiro Seki¹ ¹Dept. Pharmacol., Pharmaceutical Sci., Ohu Univ., ²Dept. Cell Pathol., Inst. Dev.Res., Aichi Developmental Disability Center

3-P-29412:5013:50 The effect of salt intake on the defensive strategies against inescapable innate fear and fear stress-associated learned despair in mice Rino Hashimoto, Ryuma Kamimura, Miho Moriya, Sakura Maeda, Kenjiro Seki Dept. Pharmacol., Pharmaceutical Sci., Ohu Univ.

Poster Sessions

Pheripheral nervous system

3-P-29512:5013:50 Effects of sunitinib perfusion on vascular function in the rat mesenteric arteries. Furukawa Chisato¹, Nakagawa Kentaro², Kawasaki Hiromu³, Shibata Kazuhiko⁴, Takatori Shingo⁵ ¹Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University., ²Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University., ³Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University., ⁴Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University., ⁵Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University.

3-P-29612:5013:50 Inducible COX-2 expression is regulated by the ARE-binding proteins in inflammatory response in satellite glial cells. Chisato Wakabayashi¹, Masatoshi Ohnishi¹, Tasuku Fujiwara¹, Marina Akagi¹, Hiroshi Matsuoka², Akihiro Michihara², Atsuko Inoue¹ ¹Dept. Pharmacother., Fac. Pharm., Fukuyama Univ., ²Lab. Genom. Fn. Pathophysiol., Fukuyama Univ.

3-P-29712:5013:50 Dorsal Root Ganglia Homeobox (DRGX) in the DRG neurons is involved in neuropathic pain Ito Takaya^1,2, Sakai Atsushi², Maruyama Motoyo^2,3, Miyagawa Yoshitaka⁴, Okada Takashi⁴, Fukayama Haruhisa¹, Suzuki Hidenori² ¹Anesthesiol. & Clin. Physiol., Grad. Sch., Tokyo Med. & Dent. Univ., ²Dept. of Pharmacol., Nippon Med. Sch., ³Div. of Lab. Animal Sci., Nippon Med. Sch, ⁴Dept. of Mol. & Med. Genetics, Nippon Med. Sch.

3-P-29812:5013:50 Effects of silybin, flavonolignans, on catecholamine secretion and tyrosine hydroxylase activity in cultured bovine adrenal medullary cells Yumiko Toyohira¹, Ruka Sakamaki², Shin Ishikane¹, Fumi Takahashi¹ ¹Dept. Pharmacol., Univ. Occup. & Environ. Health, Japan, Sch. Med., ²Dept. Nutri. Sci., Seinan Jo Gakuin Univ.

Poster Sessions

Kidney, Urination 2

3-P-29912:5013:50 Establishment of high HPRT activity Urat1-Uox double knockout mouse and the effects of xanthine oxidoreductase inhibitor Takuji Hosoya^1,3, Shunya Uchida², Shigeru Shibata², Naoko H.Tomioka¹, Makoto Hosoyamada¹ ¹Dept. Human Physiol. Pathol., Grad. Sch. Pharma-Sci., Teikyo Univ., ²Dept. Int. Med., Sch. Med., Teikyo Univ., ³Dept. Biol. Res., FUJIYAKUHIN CO., LTD.

3-P-30012:5013:50 Inhibition of renal tubular cells by novel anti-HIV therapeutic agents and interaction with organic anion transporters Kaneko Meika¹, Naohiko Anzai¹, Yoshie Reien¹, Nobuyo Kuwata², Hiroaki Mitsuya² ¹Dept. Pharm., Grad. Sch. Med., Chiba Univ., ²National Center for Global Health and Medicine

3-P-30112:5013:50 Screening of endogenous compound potentially applicable for estimation of effective renal plasma flow Natsuki Oikawa, Yusuke Masuo, Takahiro Ishimoto, Yukio Kato Fac. Pham., Kanazawa Univ.

3-P-30212:5013:50 Repeated ischemia/reperfusion leads to acceleration of AKI to CKD progression in rats Shuhei Kobuchi Dept. Pharm.,Pharmacol., Hyogo Univ. Health Sci.

3-P-30312:5013:50 Production of hydrogen sulfide in mammalian cells Norihiro Shibuya, Yuka Kimura, Hideo Kimura Div. of Pharmacol., Fac. of Pharmaceu. Sci., Sanyo-Onoda City Univ

3-P-30412:5013:50 Prenatal glucocorticoid administration accelerates kidney development in the fetal rats. Yuko Takeba, Makoto Yamamoto, Yuki Nakamura, Tsukasa Kobayashi, Masanori Ootaki, Yuki Ohta, Keisuke Kida, Minoru Watanabe, Taroh Iiri, Naoki Matsumoto

3-P-30512:5013:50 Interaction of Osp94, a hypertonic stress sensitive molecular chaperone, with mRNAs of tau alternative splicing variants Umemura Ayana¹, Chihiro Matsuda¹, Misaki Inayoshi¹, Yasuyoshi Mizutani², Ryoji Kojima¹ ¹Lab., Anal. Pharmacol. Fac.,Pharm. Meijo Univ., ²Dept. Mol. Oncol., Fujita Health Univ., Sch. Med.

3-P-30612:5013:50 Interaction of AGN-1 protein, which binds to protein phosphatase 6, with tau alternative splicing variants mRNAs Suzuki Nana, Ryoji Kojima Lab. Anal. Pharmacol., Fac. Pharm., Meijo Univ.

3-P-30712:5013:50 Membrane proteomics for sex differences in renal proximal tubules using Sry gene-modified mice Hashiguchi Takeaki¹, Pornparn Kongpracha², Nagamori Shushi², Junko Kurokawa¹ ¹Department of Bio-informational Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, ²Laboratory of Bio-Molecular Dynamics, Department of Collaborative Research, Nara Medical University

Poster Sessions

Respiratory Organ

3-P-30812:5013:50 Establishment of chronic obstructive pulmonary disease model using intratracheal mist spray Yukiko Kawasaki, Takahiro Sugiura, Takahito Imaizumi, Yukari Nagatsu, Yasushi Hirasawa Nihon Bioresearch Inc.

3-P-30912:5013:50 Effects of topical dosed anti-coagulant on LPS-induced exacerbation in asthma model mice Genki Kimura, Keitaro Ueda, Yuki Nishimoto, Yasuo Kizawa Lab. Physiol. & Anat., Nihon Univ. Sch. Pharmacy

3-P-31012:5013:50 Protective effect of a metallothionein inducer on cadmium-induced lung epithelial injury. Ken-Ichiro Tanaka, Kazuma Kimura, Toshifumi Sugizaki, Yukari Nakano, Mikako Shimoda, Masahiro Kawahara Musashino Univ.

3-P-31112:5013:50 A pharmacological study on Asthma-COPD overlap (ACO) model in mice Maki Takahashi¹, Jun-Ichi Fuchikami¹, Ryota Yagi¹, Yoshiyuki Suzuki¹, Yasuki Akie¹, Kazutetsu Aoshiba² ¹CMIC Pharma Science Co., Ltd., ²Tokyo Medical University Ibaraki Medical Center

Poster Sessions

Digestive Organ 2

3-P-31212:5013:50 Analysis of oral pathogenic bacteria in the patients of eosinophilic esophagitis Haruki Usuda, Tetsuya Tanaka, Takayuki Okamoto, Koichiro Wada Dept. Pharmaco., Fac. Med., Shimane Univ.

3-P-31312:5013:50 Influence on the rat fetal liver maturation with antenatal glucocorticoid administration. Tsukasa Kobayashi¹, Yuko Takeba¹, Yuki Ohta¹, Masanori Ootaki¹, Yuki Nakamura¹, Minoru Watanabe², Keisuke Kida¹, Taroh Iiri¹, Naoki Matsumoto¹ ¹Department of Pharmacology, St Marianna University School of Medicine, ²Institute for Animal Experimentation, St Marianna University Graduate School of Medicine

Poster Sessions

Cardiovascular: Hypertension

3-P-31412:5013:50 Identification of B38-CAP as an ACE2-like enzyme to suppress hypertension and cardiac dysfunction in mice. Keiji Kuba¹, Takafumi Minato¹, Satoru Nirasawa², Teruki Sato^1,3, Tomokazu Yamaguchi¹, Hiroyuki Watanabe³, Yumiko Imai⁴, Saori Takahashi⁵ ¹Dep. Biochem. & Metabolic Science, Akita Univ. Grad. Sch. Med., ²Biological Resources and Post-Harvest Division, Japan International Research Center for Agricultural Sciences, ³Dept. of Cardiovascular Med., Akita Univ. Grad. Sch. of Med., ⁴Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition, ⁵Akita Research Institute of Food and Brewing

3-P-31512:5013:50 Involvement of mitochondrial Na⁺/Ca²⁺ exchanger in hypoxia-induced pulmonary arterial hypertension. Satomi Kita^1,2, Hideaki Tagashira², Tomo Kita², Ai Sinayama¹, Takahiro Iwamoto² ¹Dept. Pharmacol., Facul. Pharmaceut. Sci., Tokushima Bunri Univ., ²Dept. Pharmacol., Facul. Med., Fukuoka Univ.

3-P-31612:5013:50 Expression analysis of mast cell-related genes in fetal and neonatal periods of spontaneously hypertensive rats (SHR) Tetsuya Tanaka, Haruki Usuda, Tomomi Niibayashi, Takayuki Okamoto, Koichiro Wada Dept. Pharmacol., Faculty of Med., Shimane Univ.

3-P-31712:5013:50 Serum Indoxyl Sulfate as a Potential Independent Biomarker of Arterial Stiffness in Patients with Coronary Artery Disease Tsung-Jen Lin¹, Bang-Gee Hsu^2,3, Ji-Hung Wang^3,4, Yu-Hsien Lai^1,5, Chin-Hung Liu ¹PhD program in Pharmacol. & Toxicol., Dept. Med., Sch. Med., Tzu Chi Univ., Hualien, Taiwan, ²Div. Nephrol., Buddhist Tzu Chi General Hosp., Hualien, Taiwan, ³Sch. Med., Tzu Chi Univ., Hualien, Taiwan, ⁴Div. Cariol., Buddhist Tzu Chi General Hosp., Hualien, Taiwan, ⁵Dept. Pharmacol., Sch. Med., Tzu Chi Univ., Hualien, Taiwan

Poster Sessions

Cardiovascular: Disoder

3-P-31812:5013:50 withdraw

3-P-31912:5013:50 Angiotensin II type 1 receptor antagonist restores dysfunction of vascular reactivity independent of perivascular adipose tissue-mediated mechanisms in rats with metabolic syndrome Satomi Kagota, Kana Fumoto, Miho Shimari, Kazumasa Shinozuka Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ.

3-P-32012:5013:50 Effects of allopurinol, a xanthine oxidase inhibitor, on TNF-α-induced endothelial cells Deguchi Mari¹, Airi Furuya¹, Saki Miyagi¹, Shoichiro Ohta², Suzuki Yasuhiro¹ ¹Sch. Pharmaceu. Sci., Ohu Univ., ²Dept. Human Life Sci. Sch. Nurs., Fukushima Med. Univ.

3-P-32112:5013:50 Febuxostat attenuates the induction of vascular cell adhesion protein 1 by TNF-α in Human Umbilical Vein Endothelial Cells. Airi Furuya¹, Mari Deguchi¹, Saki Miyagi¹, Shoichiro Ohta², Yasuhiro Suzuki¹ ¹Sch. Pharmaseu. Sci., Ohu Univ. 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan., ²Dept. Human Life Sci. Sch. Nurs., Fukushima Med Univ. 1 Hikarigaoka, Fukushima 960-1295, Japan.

3-P-32212:5013:50 Impaired endothelium-dependent vasodilator responses of retinal blood vessels in adult rats with a history of retinopathy of prematurity Asami Mori¹, Ayuki Nakano¹, Daiki Sumida¹, Rho Kondo¹, Daiki Asano¹, Akane Morita¹, Kenji Sakamoto^1,2, Tsutomu Nakahara¹ ¹Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., ²Lab. Med. Pharmacol., Fac Pharma-Sci. Teikyo Univ.

3-P-32312:5013:50 Menaquinone-4 accelerates calcification of human aortic valve interstitial cells in high-phosphate medium through PXR Kazuhiko Seya¹, Wei Yang², Zaiqiang Yu², Mari Chiyoya², Kazuyuki Daitoku², Shigeru Motomura³, Tadaastu Imaizumi¹, Ikuo Fukuda², Ken-Ichi Furukawa³ ¹Dept. Vascul. Biol., Hirosaki Univ. Grad. Sch. Med., ²Dept. Thorac. Cardiovasc. Surg., Hirosaki Univ. Grad. Sch. Med., ³Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med.

Poster Sessions

Cardiovascular: Vascular Smooth Muscle

3-P-32412:5013:50 Pressure stress delays the transient cyclooxygenase-2 expression by interleukin-1β stimulation in cultured human pulmonary artery smooth muscle cells. Sachiko Hiraide, Takuji Machida, Shota Takihana, Mikoto Ohshita, Kenji Iizuka Dept. of Pharmacol. Sci., Schl. of Pharmaceut. Sci., Health Sci. Univ. of Hokkaido

3-P-32512:5013:50 Nitric oxide-insensitive soluble guanylate cyclase-mediated vasorelaxation in smokers Masashi Tawa¹, Takeshi Kinoshita², Takayoshi Masuoka¹, Yuka Yamashita¹, Katsuya Nakano¹, Matomo Nishio¹, Tomio Okamura³, Takaharu Ishibashi¹ ¹Dept. Pharmacol., Kanazawa Med. Univ., ²Div. Cardiovasc. Surg., Dept. Surg., Shiga Univ. Med. Sci., ³Dept. Pharmacol., Shiga Univ. Med. Sci.

Poster Sessions

Cardiovascular: Arrhythmia, Channel

3-P-32612:5013:50 Involvement of Na⁺ / Ca²⁺ exchanger in the spontaneous Ca²⁺ Transients of Guinea-Pig Pulmonary Vein Cardiomyocytes Odaka Ryosuke, Iyuki Namekata, Haruhito Hiiro, Tamano Ohmori, Shogo Hamaguchi, Hikaru Tanaka Dept.Pharmacol.,Toho Univ.Fclt.Pharmacent.Sci.

3-P-32712:5013:50 Cardiac effects of a specific I_f channel blocker ivabradine in anesthetized rabbits: simultaneous assessment of the atrial and ventricular automaticity Satoshi Kawakami, Yoshinobu Nagasawa, Megumi Aimoto, Akira Takahara Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ.

3-P-32812:5013:50 Establishment of the diet-induced obese rat model for atrial fibrillation. Tatsuya Sawano¹, Junichiro Miake¹, Akihiro Okamura², Takuya Tomomori², Aiko Takami², Agung Priyono¹, Yuhang Zhou¹, Yoshinori Ichiahra¹, Kazuhiro Yamamoto², Takeshi Imamura¹ ¹Divsion of Pharmacology, Tottori University Faculty of Medicine, ²Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine.

3-P-32912:5013:50 Effects of thrombospondin-4 on voltage-gated ion channels in rat ventricular myocytes Muneyoshi Okada, Momoko Aratani, Takahiro Koyama, Keisuke Imoto, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

3-P-33012:5013:50 Drug-induced arrhythmia prediction method based on voltage-dependent I_CaLblock Kimura Akira, Shingo Murakami Dept. EECE, Faculty of Sci.& Eng., Chuo Univ.

3-P-33112:5013:50 A simple and dual expression plasmid system in prokaryotic (E. coli) and mammalian cells. Manabu Murakami¹, Takayoshi Ohba², Agnieszka M. Murakami¹, Shirou Itagaki³ ¹Dept. Pharmacol., Hirosaki Univ. Graduate Sch. of Medicine, ²Dept. Cell Physiology, Akita Uni. Grad. Sch. Med.,, ³Collaboration Center, Sapporo Med. Univ.

3-P-33212:5013:50 Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity. Mikiko Ohno¹, Hiroshi Matsuura², Takeru Makiyama³, Hirohiko Kojitani³, Kiyoto Nishi³, Hirotaka Iwasaki¹, Shintaro Matsuda³, Takeshi Kimura³, Eiichiro Nishi¹ ¹Dept. Pharm., Grad. Sch. Med., Shiga Univ. Med. Sci., ²Dept. Phisio. Grad. Sch. Med., Shiga Univ. Med. Sci., ³Dept. Cardiovasc. Med, Grad. Sch. Med., Kyoto Univ.

3-P-33312:5013:50 Utility of isoflurane-anesthetized guinea pigs for the assessment of the QT-interval prolongation induced by drugs with positive chronotropic action Naoto Kusama, Yoshinobu Nagasawa, Satoshi Kawakami, Megumi Aimoto, Akira Takahara Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci. Toho Univ.

Poster Sessions

Blood, Lymphocyte, Hematopoietic System

3-P-33412:5013:50 Evaluation of atherosclerotic lesions by BCR/ABL1 tyrosine kinase inhibitor effects in a familial typeⅡ_a model mouse. Masamitsu Takaba¹, Takayuki Iwaki², Takaaki Ono¹, Yuji Matsumoto², Kazuo Umemura² ¹Third Division, Department of Internal Medicine, Hamamatsu University School of Medicine, ²Pharmacology, Hamamatsu University School of Medicine

3-P-33512:5013:50 Histidine-rich glycoprotein regulates neutrophil condition in sepsis Hidenori Wake¹, Shuji Mori², Hideo Takahashi³, Dengli Wang¹, Kiyoshi Teshigawara¹, Masahiro Nishibori¹ ¹Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. and Pharm. Sci., ²Shujitu Univ. Sch. Pharm., ³Dept. Pharmacol., Kindai Univ. Facul. Med.

3-P-33612:5013:50 Regulation of erythropoiesis in zebrafish model by the kinase of ribosomal protein S19 Hidetsugu Torihara, Sayomi Nakamine-Higa, Shiho Okitsu, Hideyuki Yamamoto Dept. of Biochem. Grad. Sch. of Med., Univ. of the Ryukyus

Poster Sessions

Skin, Adipose Tissue

3-P-33712:5013:50 Sairei-to, a traditional Japanese herbal medicine, inhibits UVB-induced skin inflammation Manami Oyama, Kenta Murata, Nina Fujita, Ryuji Takahashi Kampo Research Laboratories, Kracie Pharma, Ltd., Tokyo, Japan.

3-P-33812:5013:50 Effect of Jumihaidokuto on UVB-induced skin damage Murata Kenta, Manami Oyama, Nina Fujita, Ryuji Takahashi Kracie Pharm.Ltd.

3-P-33912:5013:50 Role of Prostaglandin D₂ for delayed wound healing in Streptozotocin-induced diabetic mice Kamauchi Tomoko¹, Toshio Kubota¹, Tsukasa Sakurada², Kosuke Aritake³ ¹Ctr. Pharm. Care. Comm. Health, Daiichi Univ. of Pharm., ²Ctr. Supp. Pharm. Edu., Daiichi Univ. of Pharm., ³Lab. Chem Pharm., Daiichi Univ. of Pharm.

Poster Sessions

Tumor, Chemical Treatment, Antibody Medicine 2

3-P-34012:5013:50 Establishment of a molecular targeting therapy for dog bladder cancer by using dog bladder cancer organoid culture Goto Yuta¹, Mohamed Elbadawy^1,2, Megumi Yamanaka¹, Kimika Hayashi¹, Yuta Shinohara^1,3, Tatsuya Usui¹, Kazuaki Sasaki¹ ¹Lab. Vet Pharm., Dept. Vet Medi., Fac. Agri., Tokyo Univ of Agri and Tech, ²Dept. Pharm., Fac.Vet Medi., Benha Univ, ³Div. Pet Health & Food, Iskura Industry CO., LTD,

3-P-34112:5013:50 The role of a novel hyaluronan depolymerization factor, HYBID, on glioma Shohei Tsuji¹, Shinsuke Nakamura¹, Tetsuya Yamada^1,2, Shinya Sato³, Shintaro Inoue³, Masamitsu Shimazawa¹, Hideaki Hara¹ ¹Molecular Pharmacology, Depertment of Biofunctional Evaluation, Gifu Pharmaceutical University., ²Depertment of Neurosurgery Gifu University school of medicine., ³Cosmetic Health Science, Gifu Pharmaceutical University.

3-P-34212:5013:50 Inhibitors of H₂S-generating enzymes reduce the survival of human multiple myeloma-derived KMS-11 cells with resistance to bortezomib, a proteasome inhibitor Fumiko Sekiguchi¹, Yukiho Fukushima¹, Shiori Hiramoto¹, Hirokazu Tanaka², Ryuji Ashida², Itaru Matsumura², Atsufumi Kawabata¹ ¹Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., ²Dept. Hematol. Rheumatol., Fac. Med., Kindai Univ.

3-P-34312:5013:50 Combined effect of anti-PD-L1 antibody with low molecular weight compound in the tumor-bearing mouse model Hiroyuki Okada, Shinichirou Tunesumi, Tomohiro Tanaka, Shigenori Enoki, Seiichi Katayama, Naoyuki Hironaka, Katuhide Nishi Pharm.Dept.,LSI Medience Corp.

3-P-34412:5013:50 Combination therapy of liposome-entrapped muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) against syngeneic tumors in mice Motoharu Tanaka¹, Shigeru Abe² ¹Dept. Health & Nut., Faculty Hum. Sci., Tokiwa Univ., ²Inst. Med. Mycol., Teikyo Univ.

3-P-34512:5013:50 15-deoxy-Δ^{12, 14}-prostaglandin J₂ inhibits cell migration of renal cell carcinomas independently of PPARγ and CRTH2 Yasuhiro Yamamoto, Hiromi Koma, Tatsurou Yagami Fac. Pharmaceut. Sci., Himeji Dokkyo Univ.

3-P-34612:5013:50 Differentiation-inducing factor-1 exhibits anti-metastatic effects by inhibiting cellular motility and adhesion in malignant melanoma cells Masaki Arioka, Momoko Kubo, Fumi Tetsuo, Toshiyuki Sasaguri Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan

3-P-34712:5013:50 Effect of probenecid on 3D-cultured prostate cancer spheroids Junsuke Uwada¹, Takashi Yazawa¹, Shoichiro Mukai², Naoki Terada², Takanobu Taniguchi¹ ¹Div. Cell. Signal Transduct., Dept. Biochem., Asahikawa Med. Univ., ²Dept. Urology, Fac. Med., Univ. of Miyazaki

3-P-34812:5013:50 Development of new therapeutic drugs for glioma targeting choline transporter-like protein 1 Masato Inazu^1,2, Saiichiro Watanabe¹, Nozomi Nishijima¹, Kaho Hirai¹, Akane Hase¹, Kaoru Shibata¹, Riko Gido¹, Tsuyoshi Yamanaka² ¹Inst. Med. Sci., Tokyo Med. Univ., ²Dept. Mol. Preventive Med., Tokyo Med. Univ.

3-P-34912:5013:50 Pyridinium fullerene derivative inhibits cell growth by suppression of Wnt signaling in virus-infected non-Hodgkin's B-cell lymphoma cell. Ayano Kadota¹, Misato Moriguchi¹, Tadashi Watanabe¹, Shigeo Nakamura², Takumi Yasuno³, Tomoyuki Ohe³, Tadahiko Mashino³, Masahiro Fujimuro¹ ¹Dept. of Cellbiology, Kyoto Pharm. Univ., ²Dept. of Chem., Nippon Medical School., ³Faculty of Pharmacy, Keio Univ.

3-P-35012:5013:50 Establishment and characterization of a novel murine model for head and neck cancer cachexia Zi-Xuan Hong¹, Kuo-Chu Lai² ¹Ms program in Pharmacol. & Toxicol., Dept. Med., Sch. Med., Tzu Chi Univ., Hualien, Taiwan, ²Dept. Pharmacol., Sch. Med., Tzu Chi Univ., Hualien, Taiwan

3-P-35112:5013:50 QSAR analysis of tumor-specificity of newly synthesized 3-styrylchromone derivatives against human oral squamous cell carcinoma cell lines Hiroshi Sakagami¹, Haixia Shi^1,2, Yoshihiro Uesawa³, Junko Nagai³, Kenjiro Bandow⁴, Akito Tomomura⁴, Mineko Tomomura⁵, Kaori Hoshi⁶, Koichi Takao⁶, Yoshiaki Sugita⁶ ¹Meikai Univ. Res. Inst. Odontol., ²Shanghai Ninth People’s Hospital, Shanghai Jiatong Univ. Sch. Med, ³Dept. Med.Mol. Inform., Meiji Pharm. Univ., ⁴Div. Biochem., Meikai Univ. Sch. Dent, ⁵Dept. Health Sci., Meikai Univ., ⁶Facult. Pharm. Sci., Josai Univ.

Poster Sessions

Bioactive substance

3-P-35212:5013:50 Identification of peptides inhibiting the specific binding between AGEs and RAGE Shuji Mori¹, Masahiro Watanabe¹, Hidenori Wake², Keyue Liu², Kiyoshi Teshigawara², Hideo Takahashi³, Masahiro Nishibori², Takao Toyomura¹ ¹Dept Pharmacol, Sch Pharm, Shujitsu Univ, ²Dept Pharmacol, Grad Sch Med Dent & Pharm Sci, Okayama Univ, ³Dept Pharmacol, Fac Med, Kindai Univ

3-P-35312:5013:50 15-keto-prostaglandin E₂, the metabolite of prostaglandin E₂, may work as biased agonist for EP2 and EP4 receptors. Suzu Endo¹, Kanaho Senoo¹, Harumi Takano¹, Yumi Araki¹, John W. Regan², Keizyo Fukushima¹, Hiromiti Fujino¹ ¹Dept. Pharmacol. Life Sci. Gard. Sch. Pharm. Sci. Tokushima Univ., ²Dept. Pharm/Tox,. Col. Pharm., Univ. of Arizona

3-P-35412:5013:50 Comparison of cytoprotective effects of piceatannol and resveratrol through SIRT1 activation Ryusuke Hosoda¹, Atsushi Kuno¹, Hiroki Hmada², Yoshiyuki Horio¹ ¹Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., ²Dept. Life. Sci., Okayama Sci. Univ. Sch. Sci.

Poster Sessions

Receptor, Channel, Transporter 2

3-P-35612:5013:50 TRPM2 channel regulates tumor angiogenesis via interacting with Stat3 Kurogi Ryuhei, Yoshifumi Ueda, Yuji Yamada, Yoshiaki Hasegawa, Yasuo Mori Lab. Mol. Biol. Grad. Sch. Eng. Kyoto Univ.

3-P-35712:5013:50 Effects of catecholamine (CA) metabolites on β-adrenoceptor (β-AR)-mediated relaxation evaluated in mouse/guinea pig (GP) trachea and rat thoracic aorta (TA) Fumiko Yamaki, Anna Koike, Hikari Kono, Xiaoyue Zhang, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka Dept. Chem. Pharmacol., Pharmaceut. Sci., Toho Univ.

3-P-35812:5013:50 Splicing polymorphism and its function in TRPA1 channel Yuki Kurita¹, Makoto Uchiyama¹, Emiko Mori¹, Nobuaki Takahashi^1,2, Yasuo Mori¹ ¹Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ., ²The Hakubi Cent., Kyoto Univ.

3-P-35912:5013:50 Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor Suno Ryoji¹, Sangbae Lee², Shoji Maeda³, Satoshi Yasuda⁴, Keitaro Yamashita⁵, Kunio Hirata^6,7, Takeshi Murata^4,7, Masahiro Kinoshita⁸, Masaki Yamamoto⁶, Brian Kobilka³, Nagarajan Vaidehi², So Iwata⁹, Takuya Kobayashi¹ ¹Dept. Med.　Kansai Medical Univ., ²Beckman Research Inst. of the City of Hope, ³Stanford University School of Medicine, ⁴Dept. Science, Chiba Univ., ⁵Dept. Science, Univ. of Tokyo, ⁶RIKEN SPring-8 center, ⁷JST, PRESTO, ⁸IAE, Kyoto Univ., ⁹Grad. Sch. Med., Kyoto Univ.

3-P-36012:5013:50 Structural analysis of sphingosine 1-phosphate receptor Shota Suzuki^1,2, Yoko Hiroaki¹, Atunori Oshima^1,3, Yoshinori Fujiyoshi³ ¹Cellular and Structural Physiology Institute, ²Graduate school of pharmaceutical science, Nagoya University, ³Tokyo medical and dental University

3-P-36112:5013:50 Annexin A2 is involved in activation of ERK upon endothelin-1 stimulation Yuichi Mazaki, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa Dept. Cell. Pharmcol., Grad. Sch. Med., Hokkaido Univ.

3-P-36212:5013:50 Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury Mariko Hara-Chikuma, Manami Tanaka, Masato Yasui Department of Pharmacology, School of Medicine, Keio University

3-P-36312:5013:50 Amino acid starvation induces glycine transporter 1 gene expression. Hiroto Uchiyama^1,2, Shun Watanabe^1,2, Motoki Morita^1,2, Misa Oyama^1,2, Takashi Iwai^1,2, Mitsuo Tanabe^1,2 ¹Lab. Pharm., Sch. Pharm. Sci., Kitasato Univ., ²Medicinal Research Laboratories, Sch. Pharm., Kitasato Univ.

Poster Sessions

Organella, Cytoskelton

3-P-36412:5013:50 SIRT1, a protein deacetylase, contributes to mitophagy by promoting autophagosome-lysosome fusion in the cardiomyocyte. Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio Dept. Pharmacol., Sapporo Med. Univ. Sch. of Med.

Poster Sessions

Cell death

3-P-36512:5013:50 Hyaluronan synthase inhibitor induces apoptosis in canine mammary tumor cells through inhibition of spheroid formation Jun Yamazaki, Shuta Ijichi, Runa Yoshida, Yuri Kimoto, Yuta Inoue, Moe Watanabe, Marina Yamada, Teruyoshi Saito Lab. Vet. Pharmacol., Dept. Vet. Med., Nihon Univ. Coll. Biores. Sci.

3-P-36612:5013:50 Azulene derivatives act on mitochondria and induce apoptosis of cancer cells. Chieko Kasami¹, Nana Ube¹, Junichi Yamaguchi², Hideki Inoue¹ ¹Appl. BioSci., Kanagawa Inst. Tech, ²Appl. Chem., Kanagawa Inst. Tech

3-P-36712:5013:50 Protective effects of Rab1a protein against cytotoxicity Masahiko Watabe Gen. Med. Edu. Res. Ctr. (G-MEC), Teikyo Univ.

Poster Sessions

Regeneration, Stem Cells

3-P-36812:5013:50 Expression profile of xenobiotic efflux transporters in mouse neural stem cells Kenya Takata, Takahiro Ishimoto, Yusuke Masuo, Yukio Kato Fac. Pharm., Kanazawa Univ.

3-P-36912:5013:50 Development of Alveolar Epithelial Type II Cells from Human Induced Pluripotent Stem Cells Tsuji Kayoko, Yasunari Kanda Div. Pharmacol. NIHS

3-P-37012:5013:50 Development of human intestinal organoids from iPS cell technology Shigeru Yamada^1,2, Yasunari Kanda¹ ¹Div. Pharmacol. NIHS, ²PEIJ

3-P-37112:5013:50 Role of a mechanosensitive ion channel PIEZO1 in muscle satellite cells Kotaro Hirano¹, Seiji Takabayashi¹, Mari Takeuchi¹, Masaki Tsuchiya¹, Yuji Hara^1,2, Masato Umeda¹ ¹Grad. Sch. Eng., Kyoto Univ., ²AMED, PRIME

3-P-37212:5013:50 LPA-induced increase in triple-negative breast cancer stem cells via IL-8 production. Naoya Hirata^1,2, Shigeru Yamada^1,2, Yasunari Kanda¹ ¹Div. Pharmacol. NIHS, ²PEIJ

3-P-37312:5013:50 Assessment of drug-induced contractility by simultaneous recording of cell motion imaging and electrical impedance Satsuka Ayano, Sayo Hayashi, Yasunari Kanda Division of Pharmacology, National Institute of Health Sciences (NIHS)

3-P-37412:5013:50 Assessment of developmental neurotoxicity using human iPS cells Tsunemoto Kazunobu¹, Shigeru Yamada^1,2, Yasunari Kanda¹ ¹NIHS, ²PEIJ

3-P-37512:5013:50 取り下げ Department of Pharmacology,Faculty of Medicine,Osaka Medical College

Poster Sessions

Toxicology, Pharmacometrics

3-P-37612:5013:50 Deep learning for the prediction of seizure liability and MoA of drugs based on the electrophysiological activities in hiPS cell-derived neurons Yuto Ishibashi, Naoki Matsuda, Aoi Odawara, Remi Yokoi, Ikuro Suzuki Tohoku Institute of Technology, Department of Electronics

3-P-37712:5013:50 Bisphosphonate induces the mitophagy of osteoblastic cells by forming the chelate with intracellular metal ions Masamichi Tajima Div. Pharmacol., Dept. Diagn Ther Sci, Meikai Univ. Sch. Dent.

3-P-37812:5013:50 Clioquinol changes the expression profiles and redox states of proteins involved in copper/zinc homeostasis Masato Katsuyama¹, Chihiro Yabe-Nishimura² ¹RI Ctr., Kyoto Pref. Univ. Med., ²Dept. Pharmacol., Kyoto Pref. Univ. Med.

3-P-37912:5013:50 Molecular mechanisms for cigarette smoke tar phase-induced cell death Tsunehito Higashi, Yuichi Mazaki Dept. Cell. Pharm., Grad. Sch. Med., Hokkaido Univ.

3-P-38012:5013:50 High-throughput immunocytochemical assay to detect adverse effects of substances using cultured hippocampal neurons Hanamura Kenji¹, Anggraeini Puspitasari², Reiko Roppongi², Mai Yamamura¹, Yuko Sekino³, Tomoaki Shirao¹ ¹Dept. Neurobiol. & Behav., Gunma Univ. Grad. Sch. Med., ²GIAR, Gunma Univ., ³Lab. Human Cell-Based Drug Discovery, Grad. Sch. Pharm. Sci., The Univ. Tokyo

3-P-38112:5013:50 Assessment of Developmental Neurotoxicity during Neuronal Differentiation using a Triple-Transgenic Zebrafish Line Adachi Yuka¹, Junko Koiwa¹, Takashi Shiromizu¹, Toshio Tanaka², Yuhei Nishimura¹ ¹Dept. Integrative Pharm., Mie Univ. Grad. Sch. Med. 2-174 Edobashi, Tsu, Mie 514-8507, ²Dept. Systems Pharm., Mie Univ. Grad. Sch. Med. 2-174 Edobashi, Tsu, Mie 514-8507

3-P-38212:5013:50 Development of drug assessment in central and peripheral neuronal networks using oriented nanofiber devices． Takahashi Sayuri¹, Aoi Odawara¹, Naoki Matsuda¹, Yuto Ishibashi¹, Masaki Sudo², Ikuro Suzuki¹ ¹1） Tohoku Institute of Technology, ²2） Stem Cell & Device Laboratory, Inc.

Poster Sessions

Clinical Research, Clinical Trial

3-P-38312:5013:50 Relationship between the tendency of various addiction and the psychological characteristic in undergraduate students Ken-Ichi Tanaka, Michiko Konno Saitama Pref. Univ. Grad. Sch. Heal. & Soci. Seav.

3-P-38412:5013:50 Clinical study of risk factors associated with magnesium oxide for treatment of constipation in different age groups Mitsutoshi Satoh¹, Yuudai Yamashita¹, Miki Takada¹, Goro Ikushima² ¹Dept. Toxicol. Pharmacol., Div. Pharm. Pract., Meiji Pharmaceut. Univ., ²Dept. Pharm., Matsudo City Gen. Hosp.

3-P-38512:5013:50 Predication of the risk of anaphylaxis during the general anesthesia Shuang Liu¹, Yasuyuki Suzuki^1,2, Masaki Mogi¹ ¹Dept. Pharmacol., Grad. Sch. Med., Ehime Univ., ²Saiseikai Matsuyama Hosp.

3-P-38612:5013:50 Retrospective survey on the approved antibody drugs in Japan for the perspective of antibody "microdose" dose. Miyagi Saki¹, Kaori Matsuno¹, Airi Furuya¹, Mari Deguchi¹, Akihiro Inano², Yasuhiro Suzuki¹ ¹Sch. Pharmaceu. Sci., Ohu Univ., ²Cent. Clin. Res. Fukushima Med. Univ.

3-P-38712:5013:50 Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: a retrospective cohort study Hayato Akimoto¹, Kotoe Teduka², Yayoi Nishida¹, Yasuo Takahashi², Satoshi Asai^1,2 ¹Nihon Univ. Sch. of Med., ²Nihon Univ. Sch. of Med.

Poster Sessions

Others

3-P-38812:5013:50 Clustering therapeutic drugs using FDA Adverse Event Reporting System Shinkawa Ryutaro, Yuhei Nishimura, Yuya Suzumura, Taichi Yamada, Takafumi Moriguchi Dept. Integrative Pharm., Mie Univ. Grad. Sch. Med.

3-P-38912:5013:50 Introduction of Interprofessional education at St. Marianna University School of Medicine and Showa Pharmaceutical University Yuki Ohta¹, Iori Hirosawa², Kazuhiro Watanabe², Masanobu Hirohara², Tomoyuki Hamamoto², Yoshiko Miyazaki², Atsushi Mochizuki¹, Sachihiko Nobuoka¹, Naoki Matsumoto¹ ¹St. Marianna Univ. Sch. Med., ²Showa Pharm. Univ.

3-P-39012:5013:50 Survey and Promotion of Use of Radioisotopes in Molecular Imaging and Cancer Research Hiroyuki Tsunokuni, Asami Kitaoka, Nobutaka Nakamura, Yoshiharu Yonekura, Takashi Yamashita Japan Radioisotope Association

3-P-39112:5013:50 Pretest for the development of a novel medication adherence assessment tool focusing on the autonomy of the elderly (1st report) -Factors affecting the total score of adherence assessment tools Kanako Sakane¹, Yuta Kobayashi¹, Mayumi Miyamoto¹, Miki Fukuma¹, Yuko Tsumoto¹, Hiromi Uchida² ¹Dept. Nursing., Fac. Med., Shimane Univ., ²Tenri Health Care Univ.

3-P-39212:5013:50 withdraw

March 18 (Wed) Poster