program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Symposium28

Breakthrough in GPCR research and new insights of drug targets

3-S28-18:3010:00 Overview of recent GPCR research Hitoshi Kurose Kyushu Univ., Grad. Sch. Pharmaceut. Sci.

3-S28-28:3010:00 Shedding light on complexity of G-protein coupling by large-scale functional assays Asuka Inoue Grad. Sch. of Pharm. Sci., Tohoku Univ.

3-S28-38:3010:00 Time-resolved Conformational Analysis during GPCR-Gs Coupling Yang Du¹, Nguyen Minh Duc², Søren G.f. Rasmussen³, Daniel Hilger¹, Xavier Kubiak³, Liwen Wang⁴, Jennifer Bohon^4,5, Hee Ryung Kim², Marcin Wegrecki³, Awuri Asuru⁴, Mark R. Chance^4,5, David T. Lodowski⁴, Brian K. Kobilka⁴, Ka Young Chung² ¹Molecular and Cellular Physiology, School of Medicine, Stanford University, USA, ²School of Pharmacy, Sungkyunkwan University, Republic of Korea, ³Department of Neuroscience, University of Copenhagen, Denmark, ⁴Department of Nutrition, Center for Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University, USA, ⁵Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, USA

3-S28-48:3010:00 TAK-071, a novel M₁ positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects Haruhide Kimura Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited

3-S28-58:3010:00 Development of protein-ligand binding prediction method by deep learning Masakazu Sekijima Advanced Computational Drug Discovery Unit, Tokyo Institute of Technology

Oral Sessions

3-O-08710:1010:22 Functional involvement of Na⁺/Ca²⁺ exchanger type 1 in brown adipose tissue thermogenesis Tomo Kita¹, Hideaki Tagashira¹, Takayuki Nemoto¹, Satomi Kita^1,2, Takahiro Iwamoto¹ ¹Dept. Pharmacol., Facl. Med., Fukuoka Univ., ²Dept. Pharmacol., Facl. Pharmaceu. Sci., Tokushima Bunri Univ.

3-O-08810:2210:34 The class III histone deacetylase SIRT1-mediated post-translational modification of Ca²⁺-activated K⁺ channel K_Ca3.1 in cancer cells Susumu Ohya¹, Junko Kajikuri¹, Hiroaki Kito¹, Kyoko Endo^1,2 ¹Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ., ²Dept. Pharmacol., Kyoto Pharm. Univ.

3-O-08910:3410:46 Ca²⁺-activated K⁺ channel K_Ca2.2 inhibiter as a possible therapy for advanced prostate cancer Satomi Niwa¹, Satoshi Tanaka¹, Susumu Ohya² ¹Dept. Pharmacol., Kyoto Pharm. Univ., ²Dept. Pharmacol., Grad. Sch. Med., Nagoya City Univ.

3-O-09010:4610:58 Inhibition of LAT1 activates GCN2-ATF4 survival pathway in Breast cancer cells. Takashi Yamaga, Junichi Suehiro, Hiroyuki Sakurai Dept. Phrmacol., Sch. Med., Kyorin Univ.

3-O-09110:5811:10 Regulation of inflammatory cytokine response by aquaporin 5 and its pathophysiological significance in AQP5 transgenic mice Keisuke Osada, Yuko Kikusima, Shingo Matsuyama, Yoichiro Isohama Lab. appl. Pharmacol., Facul. of Pharm. Sci., Tokyo Univ. of Sci.

Oral Sessions

3-O-10313:5014:02 Closed-loop stimulation of the medial septum terminates epilepsy seizures in rats Yuichi Takeuchi^1,2, Mark Harangozo², Lizeth Pedraza², Tamas Foldi², Gabor Kozak², Antal Berenyi^2,3 ¹Dept. Neuropharmacol., Grad. Sch. Pharmaceutical Sci., Nagoya City Univ., ²Dept. Physiol., Univ. Szeged, Hungary, ³Neurosci. Inst., New York Univ., USA

3-O-10414:0214:14 Effects of intrastriatal memantine infusion in a mouse model of hemi-parkinsonism Jiro Kasahara¹, Masatoshi Ogawa¹, Yu Zhou¹, Ryosuke Tsuji¹, Satoshi Goto² ¹Dept Neurbiol Therapeu, Inst Biomed Sci, Grad Sch Pharmaceu Sci, Tokushima Univ, ²Dept Neurodegener Dis Res, Inst Biomed Sci, Grad Sch Med Sci, Tokushima Univ

3-O-10514:1414:26 Development of a new treatment for hyperbilirubinemia induced psychiatric disorders; preclinical study Arata Oh-Nishi¹, Shoko Miura², Keiko Tsuchie², Michiyo Fukushima¹, Ryosuke Arauchi², Tsuyoshi Miyaoka², Masatoshi Inagaki² ¹Immuno-Neuropsychiatry, faculty of medicine, Shimane Univ, ²Psychiatry, faculty of medicine, Shimane Univ

3-O-10714:3814:50 Improving the accuracy of diagnosis for neurodegenerative disorders with artificial intelligence Yasuhiro Kanatani¹, Yoko Sato², Hiroyuki Kobayashi¹ ¹Dept. Clinical Pharm., Sch. Med., Tokai Univ, ²Div. Biomed Eng., Res Inst., Nat Def Med Col.