program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Oral Sessions

3-O-0758:408:52 Effects of class I antiarrhythmics on the guinea pig pulmonary vein myocardium Hiiro Haruhito, Masahiko Irie, Mizuki Kuramochi, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.

3-O-0768:529:04 Electropharmacological analysis of ranolazine in vivo using the halothane-anesthetized dogs Yoshio Nunoi^1,2, Ryuichi Kambayashi¹, Mihoko Nagasawa-Hagiwara¹, Kouki Chiba¹, Ai Goto¹, Hiroko Nakaseko-Izumi¹, Akio Matsumoto³, Yoshinori Watanabe², Atsushi Sugiyama^1,3 ¹Dept. Pharmacol., Faculty Med., Toho Univ., ²Div. Cardiovasc. Surg., Dept. Surg., Faculty Med, Toho Univ., ³Dept. Aging Pharmacol., Faculty Med., Toho Univ.

3-O-0779:049:16 Analysis of in vivo electropharmacological effects of vanoxerine Mihoko Hagiwara-Nagasawa¹, Ryuichi Kambayashi¹, Koki Chiba¹, Ai Goto¹, Yoshio Nunoi¹, Hiroko Izumi-Nakaseko¹, Akio Matsumoto², Atsushi Sugiyama^1,2 ¹Dept. Pharmacol., Faculty Med., Toho Univ., ²Dept. Aging Pharmacol., Faculty Med., Toho Univ.

3-O-0789:169:28 Analysis of safety margin against lamotrigine-induced cardiovascular adverse events in the halothane-anesthetized dogs Ai Goto¹, Mihoko Hagiwara-Nagasawa², Ryuichi Kambayashi², Yoshio Nunoi², Koki Chiba¹, Hiroko Izumi-Nakaseko^1,2, Akio Matsumoto³, Atsushi Sugiyama^1,2,3 ¹Dept. Pharmacol., Grad. Sch. Med., Toho Univ., ²Dept. Pharmacol., Faculty. Med., Toho Univ., ³Dept. Aging Pharmacol., Faculty. Med., Toho Univ.

3-O-0799:289:40 Canstatin, a C-terminal fragment of type IV collagen α2 chain, prevents ischemia/reperfusion-induced ventricular arrhythmia in rats Yurie Shimizu, Akira Sugiyama, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

3-O-0809:409:52 Periostin prolongs action potential duration thorough inhibiting voltage-dependent Na⁺ channel activity in rat ventricular myocytes Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

Oral Sessions

3-O-09210:0010:12 Cardiovascular functions of renal tubule- and vascular smooth muscle-specific transgenic mice expressing dominant negative TRPM7 mutant Hideaki Tagashira¹, Tomo Kita¹, Takayuki Nemoto¹, Tomohiro Numata², Satomi Kita^1,3, Takahiro Iwamoto¹ ¹Dept. Pharmacol., Fac. of Med., Fukuoka Univ., ²Dept. physiol., Fac. of Med., Fukuoka Univ., ³Dept. Pharmacol., Fac. of Pharma. Sci., Tokushima Bunri Univ.

3-O-09310:1210:24 MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages Jianbo An^1,2, Taeko Naruse², Kunihiko Hinohara², Yurie Soejima³, Motoji Sawabe³, Yasuaki Nakagawa⁴, Koichiro Kuwahara⁵, Keiji Kuba¹, Akinori Kimura² ¹Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, ²Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, ³Department of Molecular Pathology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, ⁴Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, ⁵Department of Cardiovascular Medicine, Shinshu University School of Medicine

3-O-09410:2410:36 PGE₂-EP4 signaling induces blood flow recovery via accumulation of Tregs. Hideki Amano¹, Koji Eshima², Yoshiya Ito¹, Shizuo Akira³, Shuu Narumiya⁴, Masataka Majima¹ ¹Dept. Pharmacol, Kitasato Univ School of Medicine, ²Dept.Immunol. Kitasato Univ School of Medicine, ³Lab. Host Defense, WPI Immunol. Frontier Res. Ctr, Osaka Univ, ⁴Dept. Drug Discovery Medicine Kyoto Univ School of Medicine,

3-O-09510:3610:48 Obligatory roles of caveolae in excitation-transcription coupling in vascular smooth muscle cells. Yoshiaki Suzuki, Takumi Ozawa, Yuji Imaizumi, Hisao Yamamura Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

3-O-09610:4811:00 The mechanism of serotonin-induced increase in intracellular Ca²⁺ and constriction via Rho kinase in rat thoracic aortas Yuka Terada, Minami Kishimoto, Karin Torii, Katsutoshi Yayama Labo. Cardiovasc Pharm., Faculty Pharm. Sci., Kobe Gakuin Univ.

Oral Sessions

3-O-11313:5014:02 Comparison of the effects of bisoprorol and atenorol on post-infarct cardiac remodeling. Miyuki Kobara, Nessa Naseratun, Yuusuke Watanabe, Hiroe Toba, Tetsuo Nakata Dept. Clinical Pharm., Kyoto Pharmaceutical University

3-O-11414:0214:14 Development of a screening system for the compounds that induce the cell cycle activity in mammalian cardiomyocytes Risa Matsui¹, Shoki Fukuyama¹, Yusuke Kametani¹, Yuriko Wada¹, Kotaro Matsumoto¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine., Grad. Sch. Pharm., Osaka Univ., ²Education and Research Project for Pharm.D., Grad. Sch. Pharm., Osaka Univ.

3-O-11514:1414:26 Contribution of the loss of insulin signaling to diastolic dysfunction in the early onset of diabetic cardiomyopathy Yoshinori Mikami, Masanori Ito, Taichiro Tomida, Daisuke Ohshima, Satomi Adachi-Akahane Dept. Physiol., Fac. Med., Toho Univ.

3-O-11614:2614:38 β2-adrenergic stimulation induces Arid5a through cAMP/PKA/CREB axis to promote IL-6 upregulation Shota Tanaka¹, Atsuki Imaeda¹, Kotaro Matsumoto¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Education and Research Project for Pharm.D, Grad. Sch. Pharm., Osaka Univ.

3-O-11714:3814:50 β2 adrenergic signaling of cardiac fibroblasts induces cardiac hypertrophy through paracrine system Atsuki Imaeda¹, Shota Tanaka¹, Kotaro Matsumoto¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Education and Research Project for Pharm.D, Grad. Sch. Pharm., Osaka Univ.

Oral Sessions

3-O-12815:0215:14 Voluntary wheel running improves cardiac dysfunction associated with cancer cachexia induced by human stomach cancer cell line 85As2 Miki Nonaka¹, Susumu Ueno², Ryo Kakigi³, Nagomi Kurebayashi⁴, Takashi Murayama⁴, Kanako Miyano¹, Kiyoshi Terawaki⁵, Takashi Sakurai⁴, Yasuhito Uezono^1,6 ¹Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., ²Dept. Occup. Toxicol., Inst. Ind. Ecol. Sci., Univ. Occup. Environ. Hlth., ³Fac. Management & Information Sci, Josai International University, ⁴Dept. Pharmacol., Juntendo Univ. Sch. Med., ⁵Tsumura Res. Labo., Tsumura & Co., ⁶Ctr. Suppo. Palliat. Psycho. Care, Natl Cancer Ctr. Hosp.

3-O-12915:1415:26 Analysis of onset mechanism for tyrosine kinase inhibitor imatinib induced-left ventricular diastolic dysfunction Koki Chiba¹, Mihoko Hagiwara-Nagasawa², Ryuichi Kambayashi², Ai Goto¹, Tsukasa Hara³, Ryosuke Amagai³, Yoshio Nunoi², Hiroko Izumi-Nakaseko^1,2, Ayako Okado-Matsumoto³, Akio Matsumoto⁴, Atsushi Sugiyama^1,2,4 ¹Dept. Pharmacol., Grad. Sch. Med., Toho Univ., ²Dept. Pharmacol., Faculty Med., Toho Univ., ³Lab. Biochem., Dept. Biol., Faculty Sci., Toho Univ., ⁴Dept. Aging Pharm., Faculty Med., Toho Univ.

3-O-13015:2615:38 Maresin 1, an anti-inflammatory lipid mediator, induces physiological hypertrophy in neonatal rat cardiomyocytes Arisa Kobayashi¹, Wahyuni Tri¹, Ryuta Igarashi¹, Masashi Tomimatsu¹, Kotaro Matsumoto¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio¹ ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Educational and Research Project for Pharm.D, Grad. Sch. Pharm., Osaka Univ.

3-O-13115:3815:50 Dad1 inhibits cardiomyocyte death by promoting cell adhesion Mori Shota¹, Rumi Kimura¹, Shota Fuchigami¹, Kotaro Matsumoto¹, Makiko Maeda², Masanori Obana¹, Yasushi Fujio^1,2 ¹Laboratory of Clinical Science and Biomedicine, Grad. Sch. Pharm., Osaka Univ., ²Project Laboratory of Clinical Pharmacology, Grad. Sch. Pharm., Osaka Univ.

3-O-13215:5016:02 Impact of extracellular substrate stiffness on macrophage activation Okamoto Takayuki, Haruki Usuda, Tanaka Tetsuya, Koichiro Wada Dept. Pharmacol., Fac. of Med., Shimane Univ.

3-O-13316:0216:14 Resident cardiac macrophages are involved in cardioprotection through metabolic regulation of cardiomyocytes Takahiro Ishii^1,2, Ryuzaburo Yuki¹, Fujimi Kudo¹, Munehiko Shibata¹, Hiroyuki Takano², Ichiro Manabe¹ ¹Department of Disease Biology and Molecular Medicine,Chiba Univ. Grad. Sch. Of Med. Sci., ²Department of Molecular Cardiovascular Pharmacology,Chiba Univ. Grad. Sch. Of Pharm. Sci.

March 18 (Wed) Room F