program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Poster Sessions

CNS: Neurotransmitter, Synapse 2

2-P-13513:0014:00 Loss of drebrin from dendritic spines in hippocampal neurons from Alzheimer's disease model mouse Noriko Koganezawa¹, Yuki Kajita², Hiroyuki Yamazaki¹, Takashi Saito^3,4, Yuko Sekino⁵, Takaomi C Saido³, Tomoaki Shirao¹ ¹Dept. Neurobiol. Behav., Gunma Univ. Grad. Sch. Med., ²Dept. Physiol., Tohoku Univ. Sch. Med., ³Proteolytic Neurosci., RIKEN CBS, ⁴Dept. Neurocognitive Sci., Nagoya City Univ. Grad. Sch. Med. Sci., ⁵Endowed Lab. Human Cell-Based Drug Discovery, Grad. Sch. Pharm. Sci. Univ. Tokyo

2-P-13613:0014:00 Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex Yukie Kawahara¹, Yoshinori Ohnishi¹, Yoko Ohnishi¹, Hiroshi Kawahara², Akinori Nishi¹ ¹Dept. Pharmacol., Kurume Univ. Sch. Med., ²Dept. Dental Anesthesio., Tsurumi Univ. Sch. Dental Med.

2-P-13713:0014:00 An α₂ receptor agonist and antagonist respectively decreases and increases acetylcholine efflux in the nucleus accumbens of freely moving rats Yuri Aono, Hiroki Kawashima, Tadashi Saigusa Dept. Pharmacol. Nihon Univ. Sch. Dent. at Matsudo

2-P-13813:0014:00 Local administration of the orexin receptor antagonist MK-4305, but not orexin-A, into the nucleus accumbens increases accumbal dopamine efflux in freely moving rats Hiroki Kawashima, Yuri Aono, Tadashi Saigusa Dept. Pharmacol., Nihon Univ. Sch. Dent. at Matsudo

2-P-13913:0014:00 A dendritic spine shrinkage in response to extracellular high K⁺ is inhibited by Co²⁺ or Cd²⁺ Naoko Konishi, Toshinori Sawano, Jin Nakatani, Hidekazu Tanaka Lab. Pharrm., Grad.sch. Life sci., Ritsumeikan Univ.

2-P-14013:0014:00 Involvement of the cAMP-dependent pathway in the dextromethorphan-induced inhibition of spontaneous glutamate transmission in the nucleus tractus solitarius neurons of guinea pigs Yoshiaki Ohi, Daisuke Kodama, Akira Haji Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.

2-P-14113:0014:00 M1 muscarine receptors inhibit GABA release from striatal medium spiny neurons onto cholinergic interneurons. Etsuko Suzuki, Toshihiko Momiyama Department of pharmacology, Jikei university school of medicine

Poster Sessions

CNS: Glia 1

2-P-14213:0014:00 Serotonergic regulation of the inwardly rectifying potassium (Kir) 4.1 channel expression in mice astrocytes. Saki Shimizu¹, Kaoru Furui¹, Aya Kato¹, Akari Sawashima¹, Akio Ikeda², Yukihiro Ohno¹ ¹Dept. Pharmacol., Osaka Univ. Pharm. Sci., ²Dept. Epilepsy Mov. Dis. Physiol. , Kyoto Univ.

2-P-14313:0014:00 Neuronal hyperexcitability mediated by GqPCR-mediated signaling in astrocytes Eiji Shigetomi¹, Yukiho Hirayama¹, Fumikazu Sano^1,2, Kenji Tanaka³, Haruhiko Bito⁴, Schuichi Koizumi¹ ¹Dept. Neuropharmacol. Interdiscipl. Grad. Sch. Med., Univ. Yamanashi, ²Dept. Pediatr., Interdiscipl. Grad. Sch. Med., Univ. Yamanashi, ³Dept. Neuropsych., Keio Univ. Sch. Med., ⁴Dept. Neurochem., Grad. Sch. Med., Univ. Tokyo

2-P-14413:0014:00 Chemogenetic inhibition of macrophages and microglia exerts anti-allodynic effects on different types of neuropathic pain in male mice Yuya Ideguchi, Fumihiro Saika, Norikazu Kiguchi, Daichi Kobayashi, Shinsuke Matsuzaki, Shiroh Kishioka Dept. Pharm., Wakayama Med Univ

2-P-14513:0014:00 Regulation of receptor chaperone molecule RTP4 in microglial cells Yusuke Kuroiwa¹, Mini Yokote¹, Masashi Kawanishi¹, Hiroshi Ueda², Wakako Fujita³ ¹Dept. Pharmacol. Therap. Innov., Sch. Pharmaceu. Sci., Nagasaki Univ., ²Dept. Mol. Pharmacol., Grad. Sch. Pharmaceu. Sci., Kyoto Univ., ³Dept. Frontier Life Sci., Grad. Sch. Biomed. Sci., Nagasaki Univ.

2-P-14613:0014:00 Investigation of a new type of microglia appearing in the ischemic core area Toshinori Sawano¹, Natsumi Yamaguchi¹, Yousuke Inoue¹, Ryotaro Nishi², Jin Nakatani¹, Shinobu Inagaki^3,4, Takayuki Nakagomi⁵, Tomohiro Matsuyama⁵, Hidekazu Tanaka¹ ¹Lab. Pharm., Dept. Biomed Sci., Col. Life Sci., Ritsumeikan Univ., ²Lab. Med. Cell Biol., Dept. Biomed Sci., Col. Life Sci., Ritsumeikan Univ., ³United Grad. Sch. Child Develop., Osaka Univ., ⁴Dept. PT., Yukioka Col. Health Sci., ⁵Lab. Neurogenesis and CNS Repair., Inst. Adv. Med. Sci., Hyogo Col. Med.

2-P-14713:0014:00 Microglia enhance the functional maturation of blood-brain barrier. Yukari Shigemoto-Mogami, Kazue Hoshikawa, Kimiko Kitamura, Kaoru Sato Lab. of Neuropharmacol, Divi. Pharmacol, NIHS

2-P-14813:0014:00 Preparation of peripheral blood-derived microglia-like cells and its intra-hippocampal injection to ameliorate amyloid-β burden and cognitive impairment in a mouse model of Alzheimer's disease Eriko Kuroda¹, Kaneyasu Nishimura², Yuki Toda¹, Susumu Nakata³, Yoshihisa Kitamura⁴, Eishi Ashihara¹, Kazuyuki Takata² ¹Dept. Clin. Transl. Physiol., Kyoto Pharm. Univ., ²Div. Integ. Pharm. Sci., Kyoto Pharm. Univ., ³Dept. Clin. Onco,, Kyoto Pharm. Univ., ⁴Lab. Pharmacol. Neurobiol., Ritsumeikan. Univ.

2-P-14913:0014:00 Loss of P2Y₁ receptor causes ocular hypertension and glaucoma-like phenotype in mice Hamada Kentaro¹, Youichi Shinozaki¹, Takahiro Segawa², Kazuhiko Namekata³, Nobuhiko Ohno^4,5, Takayuki Harada³, Kenji Kashiwagi⁶, Schuichi Koizumi¹ ¹Dept. Neuropharmacol., Interdiscip. Grad. Sch. Med. Univ. Yamanashi, ²Cent. Life Sci. Res., Univ. Yamanashi., ³Vis. Res. Project, Tokyo Metr. Inst. Med. Sci., ⁴Dev. Ultrastruct. Res., Natl. Inst. Physiol. Sci., ⁵Div.Anatomy,Jichi Med.Univ., ⁶Dept.Opthalmol.,Interdiscip.Grad.Sch.Med.Univ.Yamanashi

2-P-15013:0014:00 Microglial Cav1.2 Ca²⁺ channel is involved in the pathophysiology of Parkinson's disease Xinshuang Wang, Hironao Saegusa, Soontaraporn Huntula, Tsutomu Tanabe Dept. Phamacol. Neurobiol., Grad. Sch. Med., Tokyo Med. Dent. Univ. (TMDU)

2-P-15113:0014:00 Human induced pluripotent stem cell (hiPSC)-derived astrocytes are functional in hiPSC-derived neural networks Kanako Takahashi¹, Kaori Chujyo¹, Aoi Odawara², Ikuro Suzuki², Kaoru Sato¹ ¹Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci., ²Dept. Electro., Grad. Sch. Engineering, Tohoku Inst. Tech.,

Poster Sessions

CNS: Pain, Sensary Neuron 2

2-P-15213:0014:00 Neuropathic and inflammatory pain increases glutamatergic excitatory postsynaptic current on adult rat spinal dorsal horn neurons. Daisuke Uta^1,3, Tsugunobu Andoh¹, Toshiaki Kume¹, Megumu Yoshimura^2,3, Kohei Koga³ ¹Dept. Appl. Pharmacol., Grad. Sch. Med. Pharm. Sci., Univ. Toyama, ²Nogata Nakamura Hospital, ³Dept. Integ. Physiol., Grad. Sch. Med. Sci., Kyushu Univ.

2-P-15313:0014:00 Involvement of spinal cholecystokinin-8 and histamine in diabetic neuropathic pain in mice Takafumi Hayashi¹, Chizuko Watanabe², Soh Katsuyama³, Tsukasa Sakurada⁴, Tsuneyoshi Suzuki¹, Shinobu Sakurada² ¹Lab. Pharmaceu. Sci., Fac. Pharmaceut. Sci., Tohoku Med. & Pharmaceut. Univ., ²Dept. Physiol. & Anato., Fac. Pharmaceut. Sci., Tohoku Med. & Pharmaceut. Univ., ³Ctr. Exp. Pharm. Practice, Fac. Pharmaceut. Sci., Tokyo Univ. Pharmaceut. & Life Sci., ⁴Ctr. Supporting Pharmaceut. Educ., Fac. Pharmaceut. Sci., Daiichi Univ. Pharm.

2-P-15413:0014:00 Histamine H3 receptor inverse agonist alleviate mechanical allodynia through the activation of H1R and H2R in periaqueductal gray matter. Yu Mei¹, Takeo Yoshikawa¹, Takuro Matsuzawa¹, Hidetoshi Tozaki-Saitoh², Kazuhiko Yanai¹ ¹Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ., ²Dept. Life-Innovation., Grad. Sch. Pharm., Kyushu Univ.

2-P-15513:0014:00 Mirogabalin ameliorates neuropathic pain by activating the descending noradrenergic system involving its binding to the α₂δ-1 subunit of voltage-gated Ca²⁺ channels Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe Lab. of Pharmacol., Sch. of Pharmacy, Kitasato Univ.

2-P-15613:0014:00 Continuous morphine infusion induces allodynia through Delta-2 opioid receptors in the spinal cord Takaaki Komatsu¹, Soh Katsuyama², Tsukasa Sakurada¹ ¹Drug analysis laboratory, Daiichi University of Pharmacy, ²Center for experimental pharmacy, Tokyo university of pharmacy and life science

2-P-15713:0014:00 Partial ligation of the infraorbital nerve-induced cortical hyperexcitation is suppressed by applications of oxytocin and/or low-level laser irradiation Noma Daichi^1,2, Satoshi Fujita^1,3, Masayuki Kobayashi¹ ¹Dept. Pharmacol., Nihon Univ. Sch. Dent., ²Dept. Orthodont., Nihon Univ. Sch. Dent., ³Dept. Biol., Nihon Univ. Sch. Dent.

2-P-15813:0014:00 The change of functional roles of sulfatide in early and chronic inflammatory pain. Motoki Morita^1,2, Shun Watanabe^1,2, Natsumi Nomura^1,2, Misa Oyama^1,2, Takashi Iwai^1,2, Mitsuo Tanabe^1,2 ¹Lab. Pharm., Sch. Pharm., kitasato Univ., ²Medical Reserch Labolatory, Sch. Pharm., Kitasato Univ.

2-P-15913:0014:00 Mechanism of bilateral pain under the inflammatory state Chizuko Watanabe, Masaru Yoshizumi, Shinobu Sakurada, Hirokazu Mizoguchi Dept. Physiol. Anat., Tohoku Med. Pharm. Univ

2-P-16013:0014:00 Therapeutic and Preventive Effects of TRK-700 in Rat Models of Chemotherapy-induced Peripheral Neuropathy (CIPN). Tatsuya Nishi¹, Takashi Morimoto¹, Kojiro Hara¹, Kensuke Saeki², Chihiro Yoshida¹, Tomohiko Suzuki¹, Mie Kaino¹ ¹Pharmaceutical Research Laboratories, Toray Industries Inc., ²Hashima Laboratory, Nihon Bioresearch Inc.

Poster Sessions

CNS: Psychology, Behavior 2

2-P-16113:0014:00 Detection of linalool and 2-phenethyl alcohol in mouse brain after intraperitoneal administration of lavender and rose essential oils Toyoshi Umezu¹, Tomoharu Sano², Junko Hayashi² ¹Health Effect Assess. Sect., Cent. Health Environm. Risk Res., Natl. Inst. Environm. Stud., ²Fund. Analytic. Chem. Sect., Cent. Environm. Measure. Anal., Natl. Inst. Environm. Stud.

2-P-16213:0014:00 C3orf70 is associated with neural and neurobehavioral development Koki Miura¹, Yoshifumi Ashikawa¹, Takashi Shiromizu¹, Yuka Adachi¹, Toshio Tanaka², Yuhei Nishimura¹ ¹Dept. Integrative Pharm., Mie Univ. Grad. Sch. Med., ²Dept. Systems Pharm., Mie Univ. Grad. Sch. Med.

2-P-16313:0014:00 The Preclinical Profile of DSR-141562: A Novel Phosphodiesterase 1 Inhibitor for the Treatment of Positive Symptoms, Negative Symptoms and Cognitive Impairments Associated with Schizophrenia. Takeshi Enomoto, Ayaka Tatara, Masao Goda, Yohei Nishizato, Kantaro Nishigori, Atsushi Kitamura, Mami Kamada, Shiori Taga, Takashi Hashimoto, Kazuhito Ikeda, Yuki Fujii Research Division, Sumitomo Dainippon Pharma Co., Ltd.

2-P-16413:0014:00 Repeated restraint stress increases active coping behavior in lactating female mice Yoshikage Muroi, Ikuko Horie, Toshiaki Ishii Dept. Vet. Med., Obihiro Univ.

2-P-16513:0014:00 Noradrenergic neurons in the locus coeruleus are critical for coping with social stress in lactating female mice Ayane Nakamura, Yoshikage Muroi, Toshiaki Ishii vet. pharmacol., Obihiro univ.

2-P-16613:0014:00 Roles of orexin neurons in motivated behaviors in rats Hiroyuki Mizoguchi¹, Ayumu Inutsuka², Kentaro Katahira³, Kiyofumi Yamada⁴, Akihiro Yamanaka⁵ ¹Res. Ctr. Next-Generation Drug Dev., Res. Inst. Environmental Med., Nagoya Univ. , Nagoya, Japan., ²Dept. Physiol., Jichi Med. Univ., Shimotsuke, Japan., ³Dept Psychol, Grad Sch Inform, Nagoya Univ, Nagoya, Japan, ⁴Dep. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med. ,Nagoya, Japan., ⁵Dept. Neuroscience II, Res. Inst. Environmental Med., Nagoya Univ., Nagoya, Japan.

Poster Sessions

CNS: Psychiatric Disoder, Developmental Disoder 1

2-P-16713:0014:00 Alteration of the protein levels and/or posttranslational modification of CRMP 2 (Collapsin Response Mediator Protein 2) in the peripheral blood samples from young schizophrenia patients Munetaka Nomoto^1,2, Naoya Yamashita^2,4, Aoi Jitsuki-Takahashi¹, Haruko Nakamura¹, Hiroko Makihara^1,5, Fumio Nakamura⁶, Snyder Evan Y³, Yoshio Hirayasu², Yoshio Goshima¹ ¹Depts. Mol Pharmacol & Neurobiol, Yokohama City Univ. Grad Sch. Med., ²Depts.Psychiatry , Yokohama City Univ. Grad Sch. Med., ³Sanford Burnham Prebys Medical Discovery Institute, ⁴Juntendo Univ., ⁵Biological Science and Nursing, Yokohama City Univ. Grad Sch. Med., ⁶Dept.Bio-Chemi,Tokyo women’s medical univ.

2-P-16813:0014:00 Analysis of changes in the expression of dopamine-related genes in fibromyalgia patient specific-iPS cell derived-dopaminergic neurons Yukari Suda¹, Naoko Kuzumaki¹, Reiko Kagawa¹, Yuri Ikeda¹, Hiroaki Matsumoto¹, Michiko Narita², Takahiro Kato³, Hideyuki Okano⁴, Minoru Narita¹ ¹Dept. Pharmacol., Hoshi Univ., ²Institute of Medical Science, Tokyo Medical Univ., ³Dept. Neuropsychiatry, Kyushu Univ., ⁴Dept. Physiol., Keio Univ.

2-P-16913:0014:00 Adolescent social isolation rearing impaired social behavior and synaptic function in basolateral amygdala in mice Hiroshi Kuniishi^1,2, Yuko Nakatake¹, Masayuki Sekiguchi², Mitsuhiko Yamada¹ ¹Dept Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, ²Dept Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry

Poster Sessions

CNS: Depression, Anxiety 1

2-P-17013:0014:00 Epigenomic regulation of prefrontal microglia induced by social defeat stress Masayuki Taniguchi¹, Shiho Kitaoka¹, Shigehiro Kuraku², Mitsutaka Kadota², Tomoyuki Furuayshiki¹ ¹Division of Pharmacology, Kobe University Graduate School of Medicine, ²Laboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research

2-P-17113:0014:00 Social defeat stress increased interfaces between microglia and neurons in the medial prefrontal cortex of mice Midori Nagai, Hirotaka Nagai, Tomoyuki Furuyashiki Division of Pharmacology, Graduate School of Medicine, Kobe University

2-P-17313:0014:00 Glucose infusion ameliorates restraint stress-induced elevation of plasma adrenaline level and impairment of cardiac function in rats Naoko Yamaguchi¹, Yoshihiko Kakinuma², Kaoru Mimura¹, Shoshiro Okada¹ ¹Dept. Pharmacol., Aichi Med. Univ., ²Dept. Physiol., Nippon Med. Sch.

2-P-17413:0014:00 Social defeat stress decreases serotonin reuptake in the prefrontal cortex. Ryota Araki, Eri Tanaka, Yugo Nagamine, Yuka Tamura, Takeshi Yabe Lab. Funct. Biomol. Chem. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ.

2-P-17513:0014:00 The role of AMPK in the hippocampus of the olfactory bulbectomized mice. Takayo Odaira¹, Osamu Nakagawasai¹, Wataru Nemoto¹, Kohei Takahashi^1,2, Wakana Sakuma¹, Koichi Tan-No¹ ¹Dept. Pharmacol., Fac. Pharm. Sci., Tohoku Med. Pharm. Univ., ²Dept. Pharmacol., Fac. Pharm. Sci., Int. Univ. Health and Welfare.

2-P-17613:0014:00 Anxiolytic behaviors and the disruption of brain redox signaling in chronic kidney disease model mice Yuki Kurauchi¹, Hina Kawamoto¹, Hiroshi Watanabe², Toru Maruyama², Takahiro Seki¹, Hiroshi Katsuki¹ ¹Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., ²Dept. Biopharmaceutics, Grad. Sch. Pharm. Sci., Kumamoto Univ.

2-P-17713:0014:00 Induction of resilience for depression-like behavior by Shati/Nat8l knockdown in the striatum of mice Hajime Miyanishi¹, Shin-Ichi Muramatsu^2,3, Atsumi Nitta¹ ¹Dept. Pharm. Thera and Neuropharm., Fac Pharm. Sci., Grad. Sch. Med. and Pharm. Sci., Toyama Univ., ²Div. Neuro Gene. Thera., Op Innov Cen., Jichi Med Univ., ³Cen. Gene and Cell Thera., Ins. Med. Sci., Tokyo univ.

2-P-17813:0014:00 Intranasal administration of resolvin E1 attenuates lipopolysaccharide-induced depression-like behaviors via BDNF/VEGF release and mTORC1 activation in the medial prefrontal cortex Shun Aoki¹, Satoshi Deyama¹, Kohei Ishimura², Hayato Fukuda^2,3, Satoshi Shuto², Masabumi Minami⁴, Katsuyuki Kaneda¹ ¹Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ., ²Lab. Org. Chem. for Drug Develop., Grad. Sch. Pharmaceut. Sci, Hokkaido Univ., ³Pharmaceut. Org. Chem. Lab., Grad. Sch. Biomed. Sci., Nagasaki Univ., ⁴Dept. Pharmacol., Grad. Sch. Phamaceut. Sci., Hokkaido Univ.

Poster Sessions

CNS: Learning, Memory 2

2-P-17913:0014:00 Evaluation of brain functions Using Aged Germ-free Mice Hiroyuki Kobayashi¹, Hiroyasu Murasawa¹, Akiko Pawlak¹, Kazutaka Katayama², Daisuke Kishigami², Yasushi Hirasawa¹ ¹Nihon Bioresearch Inc., ²Oriental BioService Inc.

2-P-18013:0014:00 Differences in learning ability according to individuality and left-right asymmetry of the rat brain hippocampal NR1 receptor Hirotaka Oikawa¹, Shouhei Miyazaki², Takahiko Fujikawa^1,2,3 ¹Suzuka Univ. Med. Sci., Faculty. Pharm. Sci., ²Suzuka Univ. Med. Sci., Grad. Sch. Pharm. Sci., ³Mie Univ. Grad. Sch. Med.

2-P-18113:0014:00 Aminothioneine activates BDNF expression and enhances learning and memory in mice. Satoru Mitazaki¹, Momoko Fukuda¹, Satoshi Matsumoto², Mamoru Fukuchi¹ ¹Lab. of Mol. Neurosci., Fac. of Pharmacy, Takasaki Univ., ²LS corp.

2-P-18213:0014:00 The effect of anthocyanin-rich blackcurrant extracts on behavioral abnormalities in SAMP8 mice Minori Shimada¹, Hayato Maeda¹, Naoki Nanashima², Kiyofumi Yamada³, Akira Nakajima¹ ¹Dept. Appl. Biol. Food Sci., Fac. Agric. Life Sci., Hirosaki Univ., ²Dept. Biomed. Sci., Grad. Sch. Health Sci., Hirosaki Univ., ³Dept. Neuropsychopharmacol. Hosp. Pharm., Grad. Sch. Med., Nagoya Univ.

2-P-18313:0014:00 Quantification of phosphorylated TrkB in human blood extracellular vesicles and effect of food-derived antioxidant Ruri Matsumoto¹, Takahiro Ishimoto¹, Satoshi Matsumoto², Yusuke Masuo¹, Makoto Suzuki², Yukio Kato¹ ¹Fac. Pharm., Kanazawa Univ., ²L•S Corporation Co. Ltd.

Poster Sessions

CNS: Sleep, Awake

2-P-18413:0014:00 The mechanism of sleep spindles generation: New insights from a computational model and EEG data of the transgenic mice Yamada Tetsuya Dept. of Systems Pharmacology, Grad. Sch. of Med., The Univ. of Tokyo

Poster Sessions

CNS: Neurodegenerative 2

2-P-18513:0014:00 Increased GTRAP3-18 expression by miR-96-5p is mediated by a RNA-binding protein Chisato Kinoshita¹, Kazue Kikuchi-Utsumi¹, Nobuko Matsumura¹, Toshio Nakaki², Koji Aoyama¹ ¹Dept. Pharm., Grad. Sch. Med., Teikyo Univ., ²Fac. Pharm-Sci., Teikyo Univ.

2-P-18613:0014:00 Galantamine inhibits aggregation of α-synuclein in human neuroblastoma SH-SY5Y cells Sora Nozaki, Masanori Hijioka, Masahisa Tsuji, Yoshihisa Kitamura Lab. Phrmacology and Neurobioligy, College of Pharmaceutical Sciences, Ritsumeikan University

2-P-18713:0014:00 Motor dysfunction is triggered by miRNA-mediated knockdown of LAMP2A in mouse cerebellar neurons Masahiro Sato¹, Tomoko Ohta¹, Takahiro Seki¹, Ayumu Konno², Hirokazu Hirai², Yuki Kurauchi¹, Hiroshi Katsuki¹ ¹Dept. Chemico-Pharmacol. Sci., Grad Sch. Pharm. Sci., Kumamoto Univ., ²Dept. Neurophysiol. Neural repair., Gunma Univ. Grad. Sch. Med.

2-P-18813:0014:00 Midnolin is a strong genetic risk factor for Parkinson's disease in Japanese and British populations. Yutaro Obara¹, Hidenori Sato², Takahiro Nakayama³, Takeo Kato⁴, Kuniaki Ishii¹ ¹Dept. Pharmacol., Fac. Med., Yamagata Univ., ²Genome Info. Unit, Inst. Promotion Med. Sci. Res., Yamagata Univ., ³Res. Inst. Bio-sys. Info., Tohoku Chem. Co., LTD., ⁴Yamagata City Ins. Pub Health

2-P-18913:0014:00 Analysis of astrocyte and microglia in Alzheimer's disease model mouse with higher uric acid level Naoko H. Tomioka, Makoto Hosoyamada Dept. Human Physiol. Phathol., Fac. Pharma-Sci., Teikyo Univ.

2-P-19013:0014:00 β₃-adrenoceptor agonist protects dopaminergic neurons in the 6-hydroxydopamine model of Parkinson's disease. Yasuhiro Yoshioka, Kensuke Asakai, Kento Isshiki, Kiyono Motoyama, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.

2-P-19113:0014:00 Derivatives of calmodulin-like skin protein, named CLSP(1-61) and CLSPCOL, as anti-Alzheimer disease agents Yuichi Hashimoto, Masaaki Matsuoka Dept. Pharmacol. Tokyo Med. Univ.

2-P-19213:0014:00 Effects of AGEs on the rat neuronal cells in the intrauterine hyperglycaemic environment. Akio Nakamura¹, Haruka Okami², Manami Shimizu³, Satomi Ooi¹, Yayoi Tokunaga¹, Yo Sasaki⁴, Ritsuko Kawaharada³ ¹Department of Food and Health Sciences, Jissen Women’s University, Hino, Japan., ²Department of nutrition, Tunoda Hospital, Japan, ³Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki, Japan, ⁴Department of Genetics, Washington University School of Medicine , St. Louis, Missouri 63110, U.S.A.

2-P-19313:0014:00 Induction of reactive oxygen species by activation of the EP2 receptor contributes to prostaglandin E2-induced cytotoxicity in motor neuron-like NSC-34 cells Hiroshi Nango, Yasuhiro Kosuge, Hiroko Miyagishi, Yoshihisa Ito, Kumiko Ishige Lab. Pharmacol., Sch. Pharm., Nihon univ.

2-P-19413:0014:00 Novel protein targets for 15-deoxy-Δ^12,14-prostaglandin J₂ were identified in neuronal plasma membranes Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma Dept. Pharmaceutic. Health Care, Himeji Dokkyo Univ.

2-P-19513:0014:00 A neuroprotective role of aquaporin-4 against other than amyloid β deposition or neuroinflammation in the 5xFAD transgenic mice model. Yoichiro Abe¹, Natsumi Ikegawa², Minetaka Murakami², Takumi Tanaka², Takako Niikura², Kyosuke Muramatsu³, Kaoru Yamada³, Tadafumo Hashimoto³, Motohito Goto⁴, Taichi Yamamoto⁴, Kenji Kawai⁴, Wakami Goda¹, Keitaro Yoshida⁵, Satoko Hattori⁶, Tsuyoshi Miyakawa⁶, Kenji Tanaka⁵, Masaru Mimura⁵, Takeshi Iwatsubo³, Jun-Ichi Hata⁴, Masato Yasui¹ ¹Dept. Pharmacol., Keio Univ. Sch. Med., ²Dept. Information and Communication Sci., Sophia Univ., ³Dept. Neuropathol., Grad. Sch. Med., Univ. of Tokyo, ⁴CIEA, ⁵Dept. Neuropsychiatry, Keio. Univ. Sch. Med., ⁶Div. Syst. Med.; Sci., Inst. Comp. Med. Sci., Fujita Health Univ,

2-P-19613:0014:00 Discovery and evaluation of a novel tau PET tracer [¹⁸F]THK-5562 for Alzheimer's disease Yiqing Du¹, Ryuichi Harada^1,2, Pradith Lerdsirisuk³, Michinori Ezura⁴, Yuki Shimizu³, Takahiro Morito¹, Hiroyuki Arai², Yukitsuka Kudo², Shozo Furumoto³, Kazuhiko Yanai¹ ¹Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ., ²Dept. Geriatrics and Gerontology, Div. Brain Science, Inst. Development, Aging and Cancer, Tohoku Univ., ³Cyclotron and Radioisotope Ctr., Tohoku Univ., ⁴Dept. Neurology, Grad. Sch. Med., Tohoku Univ., ⁵Div. Pharmacol., Fac. Med., Tohoku Medical and Pharmaceutical Univ.

Poster Sessions

Kidney, Urination 1

2-P-19713:0014:00 Brain nitric oxide can induce frequent urination via brain glutamatergic receptors in rats Hideaki Ono^1,2, Takahiro Shimizu¹, Suo Zou¹, Masaki Yamamoto¹, Yohei Shimizu^1,2, Yurika Hata^1,2, Shogo Shimizu¹, Youichirou Higashi¹, Takaaki Aratake^1,3, Tomoya Hamada¹, Yoshiki Nagao¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ., ²Center for Innovative and Translational Medicine, Kochi University, ³Research Fellow of Japan Society for the Promotion of Science

2-P-19813:0014:00 Roles of brain hydrogen sulfide in micturition of rats Yamamoto Masaki^1,2, Takahiro Shimizu¹, Sou Zou¹, Hideaki Ono^1,3, Yohei Shimizu^1,3, Yurika Hata^1,3, Shogo Shimizu¹, Youichirou Higashi¹, Takaaki Aratake^1,4, Tomoya Hamada^1,2, Yoshiki Nagao^1,2, Rina Nakamura¹, Toshihumi Akizawa¹, Mikiya Fujieda², Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sch., Kochi Univ, ²Dept. of Pediatr., Kochi Med. Sch., Kochi Univ., ³Center for Innovative and Translational Medicine, Kochi Univ., ⁴JSPS Research Fellow

2-P-19913:0014:00 Effects of acute arginine treatment on vascular endothelial dysfunction associated with ischemic acute kidney injury. Keisuke Nakagawa¹, Ayaka Shimomura¹, Atsuhiko Yamamoto¹, Shuhei Kobuchi², Mamoru Ohkita¹, Yasuo Matsumura¹ ¹Lab. Pathol. Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci., ²Dept. Pharm., Pharmacol., Hyogo Univ. Health Sci.

2-P-20013:0014:00 Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats Takaomi Shimokawa^1,2, Masayo Yamagata¹, Kohei Hayashi¹, Shuhei Tomita², Kozo Yoneda¹ ¹Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ., ²Dept. Pharmacol., Fac. Med., Osaka City Univ.

2-P-20113:0014:00 Effects of prednisolone on adriamycin-induced nephropathy in rats Takumi Yamazawa, Cheng Jun Ma, Kikuyo Nakaoka, Masakazu Imaizumi, Kousuke Morizumi, Seiichi Katayama, Naoyuki Hironaka, Katsuhide Nishi Pharm. Dept., LSI Medience Corp.

2-P-20213:0014:00 Altered gene expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal interstitial fibrosis in mice Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto Dept. Pharmacol., Kawasaki Med. Sch.

2-P-20313:0014:00 Age-related differences in responses to hydrogen sulfide in the bladder of spontaneously hypertensive rats Suo Zou¹, Takahiro Shimizu¹, Shogo Shimizu¹, Hideaki Ono^1,2, Yohei Shimizu^1,2, Yurika Hata^1,2, Masaki Yamamoto¹, Takaaki Aratake^1,3, Yoshiki Nagao¹, Tomoya Hamada¹, Youichirou Higashi¹, Motoaki Saito¹ ¹Dept. of Pharmacol., Kochi Med. Sci., Kochi Univ., ²Cent. for Innovative and Translational Med., Kochi Univ., ³Research Fellow of Japan Society for the Promotion of Science

2-P-20413:0014:00 Different protective effect of N-acetyl cysteine and tempol on mouse renal interstitial fibrosis Sakai Mayu, Iori Tani, Iori Soma, Kazuma Komine, Shigeyoshi Honma, Makoto Yoshida Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare

Poster Sessions

Cardiovascular: Hear function, Heart failure 2

2-P-20513:0014:00 Phospholamban is downregulated by parkin-mediated degradation in failing heart Shunichi Yokoe, Michio Asahi Dept. of Pharm., Osaka. Med. Col

2-P-20613:0014:00 Changes in HSPA9 in the failing heart following myocardial infarction Emi Yano, Tetsuro Marunouchi, Satoko Suzuki, Chiharu Suzuki, Kouichi Tanonaka Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

2-P-20713:0014:00 Sexual differences on effects of voluntary exercise on heart failure in DCM model mice. Masami Sugihara¹, Ryo Kakigi³, Takashi Murayama², Takashi Miida¹, Takashi Sakurai², Sachio Morimoto⁴, Nagomi Kurebayashi² ¹Dept. Clin Lab Med., Juntendo Univ Sch. Med, ²Dept.Pharmacol.,Juntendo Univ Sch .Med, ³Fac. Mgmt. & Info. Sci., Josai Int. Univ., ⁴Dept. of Health Sci. at Fukuoka, IUHW

2-P-20813:0014:00 Comparison of transplantation effects of cardiac progenitor cell types on the mitochondrial energy-producing ability after myocardial infarction in rats Yuiki Saotome, Tetsuro Marunouchi, Emi Yano, Kouichi Tanonaka Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.

2-P-20913:0014:00 Effect of Bcl-2 associated athanogene (BAG) 3 on cardiac disease in alpha-B crystallin R120G transgenic mouse Atsushi Sanbe, Mika Ojima, Rieko Higashio, Masamichi Hirose Dept. pharmacol., Sch. Pharm. Iwate Med. Univ.

Poster Sessions

Cardiovascular: Others

2-P-21013:0014:00 Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure via CMKLR1 in rats Yamamoto Atsunori¹, Kengo Matsumoto¹, Satoshi Kameshima², Naoko Yamaguchi³, Syousirou Okada³, Muneyoshi Okada¹, Hideyuki Yamawaki¹ ¹Lab. Vet Pharmacol., Sch., Vet. Med., Kitasato Univ., ²Lab. Small Animal Internal Med., Sch., Vet. Med., Kitasato Univ., ³Dept. Pharmacol., Sch Med., Aichi Med. Univ.

2-P-21113:0014:00 The inhibitory effect of Orengedokuto on human aortic valve calcification Xu Liu¹, Zaiqiang Yu¹, Wei Yang¹, Kazuyuki Daitoku¹, Shigeru Motomura³, Tadaatu Imaizumi², Ikuo Fukuda¹, Ken-Ichi Furukawa³, Kazuhiko Seya² ¹Dept. Thorac. Cardiovasc. Surg., ²Dept. Vascul. Biol., ³Dept. Pharmacol.

2-P-21213:0014:00 Moxifloxacin elevates the risk of aortic aneurysm and aortic dissection by increasing osteopontin protein expressions in macrophages Koshun Inada, Mitsuhisa Koga, Yasufumi Kataoka, Atsushi Yamauchi Fac. Pharmaceut. Sci.

Poster Sessions

Otolaryngology, Ophthalmology

2-P-21313:0014:00 An APJ agonist suppresses the loss of retinal neuronal cells in diabetes model mouse fed a high-fat diet Fumiya Shibagaki, Yuki Ishimaru, Kiichi Akai, Kana Tokuda, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.

2-P-21413:0014:00 Characterization of lacrimal gland in male NOD mice associated with tear hyposecretion. Yuta Ohno, Keitaro Satoh, Masanori Kashimata Dept. Pharmacol., Asahi Univ. Sch. Dent.

2-P-21513:0014:00 Protective effect of endogenous apelin against age-related loss of retinal ganglion cells in mice Yuki Ishimaru¹, Akihide Sumino^1,2, Fumiya Shibagaki¹, Hikari Chitose¹, Reina Miura¹, Akinori Tanimura¹, Akiko Yamamuro¹, Yasuhiro Yoshioka¹, Sadaaki Maeda¹ ¹Lab. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., ²Lab. Food Chem., Yokohama Univ. Pharm.

2-P-21613:0014:00 Effect of Piezo 1, a mechanoreceptor, on intraocular pressure and trabecular meshwork Wataru Morozumi, Satoshi Inagaki, Yuki Iwata, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.

2-P-21713:0014:00 A preventive role of autophagy in the cochlea to noise-exposure Masanori Yoneyama, Taro Yamaguchi, Yusuke Onaka, Kiyokazu Ogita Lab. Pharmacol., Facul. Pharmaceu. Sci., Setsunan Uni.

2-P-21813:0014:00 Elucidation of ROS effects on auditory transmission impairment Lin Chen, Hiroaki Mouri, Naoaki Saito, Takehiko Ueyama Biosignal Research Center., Kobe Univ

Poster Sessions

Immunity, Inflammation, Allergy 2

2-P-21913:0014:00 Effect of Compound48/80 on antigen dependent degranulation in BMMC Kazuki Yoshida, Tetsurou Takao, Masaaki Ito, Isao Matsuoka Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

2-P-22013:0014:00 Tofacitinib, an oral janus kinase inhibitor, induces CD86^-MHC II⁺macrophages Natsumi Mizuno, Tomoko Endo, Yoshiki Yanagawa Dept. Pharmacol., Grad. Sch. Pharm., Health Sci. Univ. Hokkaido

2-P-22113:0014:00 Calcium/calmodulin-dependent regulation of Rac1 and Rac2 GTPases in histamine-induced chemotaxis of mouse mast cells Nishio Yusuke, Inui Makoto, Kuramasu Atsuo Dept. Pharmacology, Yamaguchi Univ. Grad. Sch. Med.

2-P-22213:0014:00 Effects of lotus extract on acetaminophen-induced hepatic inflammation Megumi Furukawa¹, Nobuo Izumo², Kazuya Watanabe², Maho Yonezawa², Yasuo Watanabe² ¹Ctr. Pharm. Educ. Yokohama Univ. Pharm., ²Genar. Health Med. Ctr. Yokohama Univ. Pharm.

2-P-22313:0014:00 Influence of cyclophosphamide on L-Asparaginase-induced allergy in animal model Ai Nogami-Hara¹, Yuta Hori¹, Chie Mitsuhata¹, Koji Kajiyama¹, Kentaro Susuki¹, Akira Shimada², Mitsunobu Mio¹ ¹Lab. Pharmacol., Sch. Pharm., Shujitsu Univ., ²Dept. Pediatr. Hematol. Oncol., Okayama Univ.

2-P-22413:0014:00 Protective effects of anti-oxidative stress antibody on mice after lipopolysaccharides injection Handong Qiao¹, Shangze Gao¹, Hidenori Wake¹, Keyue Liu¹, Kiyoshi Teshigawara¹, Shuji Mori², Masahiro Nishibori¹ ¹Okayama University, ²Shujitsu University

Poster Sessions

Tumor, Chemical Treatment, Antibody Medicine 1

2-P-22513:0014:00 Anti-tumor activity and adverse effects of a novel compound with high specificity to tetraplex DNA Hikaru Fukuda^1,3, Shinobu Satou², Sen Higashi¹, Manabu Habu³, Tomoko Osumi¹, Masaaki Sasaguri³, Kazuhiro Tominaga³, Shigeori Takenaka², Hiroshi Takeuchi¹ ¹Div. Appl. Pharmacol., Kyushu Dent. Univ., ²Dept. Appl. Chem., Res. Ctr. Bio-microsens. Tech., Kyushu Inst. Tech., ³Div. Maxillofacial Surg., Kyushu Dent. Univ.

2-P-22613:0014:00 Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor Rafikul Islam¹, Masanari Umemura¹, Rina Nakakaji^1,2, Kohei Osawa^1,2, Ryo Tanaka¹, Yoshihiro Ishikawa¹ ¹Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, ²Department of Oral & Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

2-P-22713:0014:00 Relationship between autophagy and apoptosis of menthol-induced cytotoxicity in lung cancer cell line, A549 Kenji Takahashi, Toshio Ohta Lab. Vet. Pharm., Joint Dep. Vet. Med., Tottori Univ.

2-P-22813:0014:00 BET inhibitor suppresses neutrophil-dependent lung metastasis of inflammatory renal cancer cells Ehata Shogo¹, Jun Nishida¹, Daizo Koinuma¹, Kohei Miyaono¹ ¹The. Univ. Tokyo, Grad. Sch. Med., Dept. Mol. Pathol., ²The. Univ. Tokyo, Environ. Sci. Ctr.

2-P-22913:0014:00 Cytocidal effects of active bufadienolide compounds against human glioblastoma cell line U-87 Bo Yuan¹, Lingyu Han², Hideki Hayashi³, Baolin Bian², Norio Takagi³, Mari Okazai¹ ¹Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., ²China Academy of Chinese Medical Sciences, ³Dep. Applied Biochem., Tokyo Univ of Pharm & Life Sci.

2-P-23113:0014:00 Evaluation of cytotoxicity of bispecific antibody against mesothelioma Yuki Kanamori^1,2, Yasuhiro Moriwaki¹, Shinako Takimoto², Hidemi Misawa¹, Kohzoh Imai², Shoutaro Tsuji² ¹Div Pharmacol, Dept Pharm, Keio Univ, ²Res Inst, Kanagawa Cancer Ctr

2-P-23213:0014:00 Elucidation of mechanism of growth inhibition of human colorectal stem cell by dietary polyphenol antioxidant. Kimika Hayashi¹, Mohamed Elbadawy¹, Yuta Goto¹, Megumi Yamanaka¹, Yuta Shinohara^1,2, Syoichi Hazama^3,4, Hiroko Takenouchi⁴, Masao Nakashima⁴, Ryouichi Tsunedomi⁴, Nobuaki Suzuki⁴, Hiroaki Nagano⁴, Makoto Shibutani⁵, Tomohiro Nakano⁶, Mihoko Koyanagi⁶, Shinmo Hayashi⁶, Masahiro Kaneda⁷, Tatsuya Usui¹, Kazuaki Sasaki¹ ¹Lab. of Vet Pharm., Dept. of Vet Med., Fac. of Agri., Tokyo Univ. of Agri. and Tech., ²Pet Health & Food Division, Isukura Industry CO., LTD, ³Dept. of Gastro., Breast and Endo. Surg., Yamaguchi Univ. Grad. Sch. of Med., ⁴Dept. of Trans Res. and Dev. Therap. aga Can.,Yamaguchi Univ. Sch. of Med., ⁵Lab. of Vet Path., Dept. of Vet Med., Fac. of Agri., Tokyo Univ. of Agri. and Tech., ⁶San-ei-gen F-F-I CO., LTD, ⁷Lab. of Vet. Ana., Dept. of Vet Med., Fac. of Agri., Tokyo Univ. of Agri. and Tech.

2-P-23313:0014:00 Gold Nanoparticles inhibits cytokine release and alleviates sepsis through of MAPK and NFκB activation Ching-Hu Chung Mackay Medical College

2-P-23413:0014:00 Histamine receptor antagonists inhibited proton regulators in oral cancer cell lines Introduction Masahito Ogasawara¹, Masashi Kon^1,2, Hiroyuki Yamada², Haruki Tamura¹, Arisa Yamada¹ ¹Div. of Bioregulatory Pharm.,Dept. of Pharm., Iwate Med Univ., ²Dept. Oral Surg. Sch. of Dent., Iwate Med Univ.

Poster Sessions

Receptor, Channel, Transporter 1

2-P-23513:0014:00 Functional regulation of serotonin transporter by SNARE protein Syntaxin 3 Motoike Serika^1,2, Kei Taguchi¹, Tomoaki Urabe^1,3, Kana Harada¹, Izumi Hide¹, Shigeru Tanaka¹, Masahiro Irifune², Norio Sakai¹ ¹Dept. Mol. Pharmacol. Neurosci., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., ²Dept. Dental Anesthesiology, Grad. Sch. Biomed. Health Sci., Hiroshima Univ., ³Dept. Anesthesiology Critical Care, Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

2-P-23613:0014:00 Analysis of oxytocin as a positive allosteric modulator（PAM）of the opioid δ- and κ-receptors. Yuki Yoshida¹, Hideki Takahashi^2,3, Haruka Ono^2,3, Yoshiyuki Meguro^2,4, Miyano Kanako², Miki Nonaka², Shigeto Hirayama^2,3, Takaaki Mizuguchi³, Masaki Kobayashi¹, Ryoma Tagawa¹, Hideaki Fuji³, Yoshikazu Higami¹, Yasuhito Uezono^2,5,6 ¹Lab. Mol. Patho & Metab., Grad. Pharmaceu., Tokyo Univ Sci., ²Div. Cancer Pathophysiol., NCCRI., ³Lab. Med. Chem., Kitasato Univ. Sch. Pharmacy., ⁴Dept. Surg., Jichi Med. Univ., Sch. Med., ⁵Div. Suppo. Care Res., EPOC, NCC., ⁶Cent. Suppo. Care., NCCH.

2-P-23713:0014:00 Binding profiles of antipsychotics to mouse cerebral cortical muscarinic receptors using [N-methyl-³H]scopolamine ([³H]NMS) Keisuke Obara, Saki Horiguchi, Toma Shimada, Takumi Ikarashi, Kento Yoshioka, Fumiko Yamaki, Yoshio Tanaka Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci.

2-P-23813:0014:00 Molecular analysis of TRPA1 activation by JT010 in human, mouse, and chicken Masaki Matsubara, Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki Lab. Cellular Pharmacol., Sch. Pharm., Aichi-gakuin Univ.

2-P-23913:0014:00 Aggravation of adriamycin-induced nephropathy in SLC41A2 knockout mice Takayuki Nemoto¹, Hideaki Tagashira¹, Tomo Kita¹, Satomi Kita², Takahiro Iwamoto¹ ¹Dept. Pharmacol., Facl. Med., Fukuoka Univ., ²Dept. Pharmacol., Facl. Pharmace. Sci., Tokushima Bunri Univ.

2-P-24013:0014:00 Mutational study of receptor-activated cation channels (TRPC6) and a possible linkage to pulmonary hypertension Ryo Okada¹, Onur K. Polat², Ryosuke Matsuzaki¹, Masayuki X. Mori^1,2 ¹Dept. Chem., Sch. Med., UOEH, ²Dept. Synth. Chem. Biol. Chem., Grad. Sch. Eng., Kyoto Univ.

2-P-24113:0014:00 Molecular function analysis on the role of TRPV6 in the onset of digestive system disease Kotani Hiroshi¹, Shin Hamada², Tatsuya Hirano¹, Tetsuya Kawamoto¹, Reiko Sakaguchi¹, Masayuki Mori¹, Yasuo Mori¹, Atsushi Masamune² ¹Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto Univ., ²Division of Gastroenterology, Tohoku University Graduate School of Medicine

2-P-24213:0014:00 Down-regulation of K_Ca3.1 contribute to the antiproliferative effect of vitamin D receptor agonists in mouse preosteoblasts Hiroaki Kito, Susumu Ohya Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

2-P-24313:0014:00 Role of a magnesium ion-permeable cation channel TRPM7 in skeletal muscle regeneration Takeuchi Mari¹, Kotaro Hirano¹, Yuji Hara^1,2, Yasuo Mori¹, Masato Umeda¹ ¹Grad. Sch. Eng., Kyoto Univ., ²AMED, PRIME

2-P-24413:0014:00 Hypoxia increases K_2P5.1 K⁺ channel expression in CD4⁺ T cells of the mouse IBD model Kyoko Endo¹, Hiroaki Kito², Ryo Tanaka¹, Junko Kajikuri², Satoshi Tanaka¹, Takayoshi Suzuki³, Susumu Ohya² ¹Dept.Pharmacol., Div. Pathol. Sci., Kyoto Pharmaceut. Univ., ²Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ., ³Dept. Compl. Mol. Chem., Inst. Sci. Indust. Res., Osaka Univ.

2-P-24513:0014:00 BK channel is functionally expressed in neuroendocrine pancreatic tumor QGP-1 cells. Sayuri Noda, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Poster Sessions

NO, NOS 2

2-P-24613:0014:00 Interleukin-4 may suppress expression of E-type prostanoid receptor4 in human colorectal cancer HCA-7 cells. Kana Kitagawa¹, Ayaka Hamaguchi¹, Masato Mashimo², John W. Regan³, Keijo Fukushima¹, Hiromichi Fujino¹ ¹Dept. Pharmacol. Life Sci. Gard. Sch. Pharm. Sci. Tokushima Univ., ²Lab.Pharmacol. Facult. Pharm. Sci. Doshisha Women's Col. Liberal Arts, ³Dept. Pharm/Tox.,Col. Pharm., Univ.of Arizona

2-P-24713:0014:00 Involvement of Fibulin-4 in activation mechanism of lysyl oxidase Kaori Kitagawa, Tomoyuki Nakamura Dept. Pharmacol., Kansai Med. Univ.

2-P-24813:0014:00 Physiological role of Addicsin-Arl6ip1 complex in oxidative stress control Misushi J Ikemoto^1,2 ¹Biomed. Res. Inst, AIST, ²Grad. Sch. of Sci. Toho Univ.

2-P-24913:0014:00 Application of hepatitis B virus-like particles to drug delivery vehicle. Chiho Sakai¹, Hirohumi Ookawa¹, Kouhei Hosokawa¹, Tadashi Watanabe¹, Keiji Ueda², Masahiro Fujimuro¹ ¹Dept. of Cellbiology, Kyoto Pharm. Univ, ²Dept. of Virology, Osaka University Graduate School of Medicine

2-P-25013:0014:00 The glycan binding region of PTPδ is involved in Sema3A signaling by reinforcing the binding with NRP1 Kohtaro Takizawa, Fumio Nakamura Dept. Biochem., Sch. of. Med., Tokyo Women's Med Univ.

2-P-25113:0014:00 Sir2B regulates cell-cell adhesion Hideo Taniura, Shuhei Soeda, Aya Igeta, Rio Kawamoto, Futa Shimizu, Yoshiaki Nakagawara, Daisuke Fukuoka, Shusei Tojo, Yuka Tokumura, Ai Fujii, Yui Sano, Minori Nakamura Lab. Neurochem., Dept. Pharmacy, Ritsumeikan Univ.

Poster Sessions

Genome, Transcription Control

2-P-25213:0014:00 Long interspersed element-1 retrotransposition induced by valproic acid depends on NR2A Noriyuki Okudaira Div. Pharm., Meikai Univ.

2-P-25313:0014:00 Characterization of the human E2F4 promoter region and its response to 12-O-tetradecanoylphorbol-13-acetate Masashi Asai^1,2, Hiroshi Hamada¹, Naoya Osamura¹, Yoriko Kirinoki¹, Fumiaki Uchiumi¹ ¹Dept. of Gene Regulation, Fac. of Pharm. Sci., Tokyo Univ. of Sci., ²Ctr. for Pharm. Educ., Fac. of Pharm. Sci., Yokohama Univ. of Pharm.

Poster Sessions

Pharmacophore, Chemical Biology

2-P-25413:0014:00 molecular dynamics simulation of CYP2D6 and CYP2C19 Masanori Ootaki¹, Yuki Ohta¹, Minoru Watanabe^1,2, Tsukasa Kobayashi¹, Yuki Nakamura¹, Daiki Watanabe¹, Keisuke Kida¹, Yuko Takeba¹, Taroh Iiri¹, Naoki Matsumoto¹ ¹Dept. Pharm., St. Marianna Univ. Sch. Med., ²Inst. Anim. Exp., St. Marianna Univ. Grad. Sch. Medi.

Poster Sessions

Drug Metabolism, SNPs

2-P-25513:0014:00 Expression of cytochrome P450 (CYP) enzymes in human keratinocytes of Japanese Hiroko Makihara^1,2, Kazusa Kaiga¹, Maho Asao², Tomoko Akase^1,2 ¹Grad. Sch.Med., Dept. Nurs., Yokohama City Univ., ²Sch.Med., Nurs.Crs., Biol. Sci. Nurs., Yokohama City Univ.

Poster Sessions

Herbal Medicine, Natural Products

2-P-25613:0014:00 Fermented ginseng suppresses AITC-induced nocifensive behavior Kanda Hirosato^1,2, Yoko Kogure¹, Shiori Ogawa¹, Syuji Shimono¹, Hisatomi Ito³, Toshitsugu Miyazaki³, Kentaro Igami³, Satoshi Yamamoto¹, Yi Dai^1,2 ¹Dept of Pharmacol, Hyogo Univ. of Hlth. Sci., ²Chinese Med. Confucius Inst at Hyogo Col. of Med., ³Production Development Division., Nagase Beauty Care & CO., Ltd.

2-P-25713:0014:00 Effect of Choreito, a traditional Kampo medicine, on detrusor smooth muscle function and bladder blood flow in a rat model of pelvic congestion with frequent urination Katsuhiko Noguchi¹, Kimio Sugaya¹, Saori Nishijima¹, Katsumi Kadekawa¹, Shiho Okitsu², Mayuko Sakanashi³, Hideyuki Yamamoto², Youhei Tokita⁴ ¹Southern Knights’ Laboratory Co., Ltd., ²Dept. Biochemistry, Grad. Sch. Med., Univ. the Ryukyus, ³Dept. Pharmacy, Col. Pharmacy, Kinjo Gakuin University, ⁴Tsumura & Co.

2-P-25813:0014:00 Rhynchophylline attenuates allergic bronchial asthma by inhibiting TGF-1-induced Smad and MAPK signaling transductions in vivo and in vitro Meng Wang^1,2, Qianyu Bi¹, Xuming Ji³ ¹College of traditional Chinese Medicine，Shandong University of traditional Chinese Medicine, ²Medical Department ,Jining No. 1 People's Hospital, ³School of Basic Medical Science, Zhejiang University of Traditional Chinese Medicine

2-P-25913:0014:00 Ameliorating effect of Maoto on the production of inflammatory cytokines induced by polyI:C stimulation Keisuke Ogura, Akinori Nishi, Akiko Nakayama, Hitomi Kanno, Yoshio Tahara, Atsushi Kaneko Tsumura Kampo Research Laboratories, Tsumura and Co., Ibaraki, Japan

2-P-26013:0014:00 Study of Anti-proliferative Effects of Traditional Chinese Medicine and Crude Drug Extract on Dog Bladder Cancer Stem Cells Yuta Shinohara^1,2, Elbadawy Mohamed^1,3, Megumi Yamanaka¹, Yuta Goto¹, Kimika Hayashi¹, Abugomaa Amira¹, Tatsuya Usui¹, Kazuaki Sasaki¹ ¹Dept. Vet Med., Fac. agr., Tokyo Univ of Agr and Tech., ²Division. Pet Health and Food., Iskara Industry CO., LTD., ³Dept. Pharm., Fac. Vet med., Benha Univ.

2-P-26113:0014:00 The active ingredient from processed aconitine root as Na_v1.7 voltage-gated sodium channels blocker Yoshihiko Nakatani^1,2, Junya Yamaguchi², Yasuyuki Yokoyama², Arata Uehara², Maki Katasho², Yasuji Saito², Toshiaki Makino³, Taku Amano² ¹Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, ²Department of Pharmacotherapeutics, School of Pharmacy, International University of Health and Welfare, ³Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University

2-P-26213:0014:00 Herbal drug TRP channel screening Sho Sanechika, Katsuya Ohbuchi, Chika Shimobori, Atsushi Kaneko, Masahiro Yamamoto TSUMURA Kampo Research Laboratories Kampo Research ＆ Development Division

Poster Sessions

Others

2-P-35513:0014:00 The Na/Ca exchange was affected by KB-R7943, nicorandil and monensin in breast cancer cells Natsuko Matsushita¹, Maki Kuraji¹, Akari Ookubo¹, Yuki Takatori¹, Ayaha Maeda¹, Yuki Kimura¹, Yoshiko Shimizu¹, Rei Takahashi², Katsuharu Tsuchida¹ ¹Doshisha.Woman's.Col.,Fac.Pharm.Sci., ²Doshisha.Woman's.Col.,Fac.Pharm.Sci.

3-P-38312:5013:50 Relationship between the tendency of various addiction and the psychological characteristic in undergraduate students Ken-Ichi Tanaka, Michiko Konno Saitama Pref. Univ. Grad. Sch. Heal. & Soci. Seav.

March 17 (Tue) Poster