program｜The 93rd Annual Meeting of the Japanese Pharmacological Society

Morning Seminar3

Development of non-invasive drug and biomedicine delivery technologies based on the physiological nose-to-brain routes

2-MS38:208:50 Development of non-invasive drug and biomedicine delivery technologies based on the physiological nose-to-brain routes Takanori Kanazawa Lab. Pharmaceutics, Sch. Pharm, Nihon Univ.

Oral Sessions

2-O-0168:509:02 Role of the prostaglandin I₂-IP system in liver regeneration of mice Koh-Ichi Yuhki¹, Tomohiro Hirata¹, Yoshitaka Imamichi¹, Hitoshi Kashiwagi¹, Shuh Narumiya², Fumitaka Ushikubi¹ ¹Dept. Pharmacol., Asahikawa Med. Univ., ²Dept. Drug Discovery Med., Kyoto Univ. Grad. Sch. Med.

2-O-0179:029:14 Caffeine induces the reversion of activated hepatic stellate cells via antagonizing adenosine receptors. Momoka Yamaguchi¹, Tomoya Morishita¹, Syn-Ya Saito^1,2, Tomohisa Ishikawa¹ ¹Dept. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, ²Fac. Vet. Med., Okayama Univ. Sci.

2-O-0189:149:26 The prostaglandin E₂-EP4 system protects the liver in Concanavalin A-induced hepatitis Yoshitaka Imamichi¹, Koh-Ichi Yuhki¹, Hitoshi Kashiwagi¹, Shima Kumei¹, Katsura Nakanishi¹, Fumiaki Kojima², Shuh Narumiya³, Fumitaka Ushikubi¹ ¹Dept. Pharmacol., Asahikawa Med. Univ., ²Dept. Pharmacol., Kitasato Univ., ³Dept. Drug Discovery Medicine, Kyoto Univ. Grad. Sch. Med.

2-O-0199:269:38 The role of steroidogenic acute regulatory protein-related lipid transfer domain containing 10(STARD10) in the development of nonalcoholic steatohepatitis (NASH) Masanori Ito, Daisuke Ohshima, Taichiro Tomida, Yoshinori Mikami, Satomi Adachi-Akahane Department of Physiology, Faculty of Medicine, Toho University

2-O-0209:389:50 Macrophage activation enhances liver fibrosis induced by carbon tetrachloride Yuki Tomonari, Takayuki Iwaki, Kazuo Umemura Dept. Pharm., Hamamatsu Univ.

Oral Sessions

2-O-0259:5010:02 Nardilysin in hepatocyte regulates adaptive thermogenesis in brown adipose tissue through the control of skin blood flow. Hirotaka Iwasaki^1,3, Kiyoto Nishi², Takayuki Imai^1,4, Daiki Yasukawa^1,5, Motoharu Chatani^1,4, Shintaro Matsuda^1,3, Mikiko Ohno^1,3, Eiichiro Nishi^1,3 ¹Dept. Pharm., Shiga Univ. Med. Sci., ²Univ. of Washington, ³Cardio. Med., Kyoto Univ. Grad. Sch. Med., ⁴Div. Gastro., Dept. Med., Shiga Univ. Med. Sci., ⁵Div. Surg., Dept. Med., Shiga Univ. Med. Sci.

2-O-02610:0210:14 The effect of copper chelating compound, cuprizone, on adipocyte differentiation in vitro Yoshinori Ichihara, Tatsuya Sawano, Yuhang Zhou, Priyono Agung, Junichiro Miake, Takeshi Imamura Division of pharmacology, Faculty of Medicine, Tottori University

2-O-02710:1410:26 Differentiation-inducing factor-1 accelerates bone marrow-derived mesenchymal stem cells differentiation into adipocyte Shin Ishikane¹, Eigo Ikushima¹, Tomohiro Takiguchi^1,2, Yumiko Toyohira¹, Fumi Takahashi¹ ¹Dept. Pharmacol., Sch. Med., Univ. of Occup. and Environ. Health., ²Dept. Clin. Pharmacol., Grad. Sch. Med. Sci., Kyushu Univ.

2-O-02810:2610:38 Natural product drug discovery using zebrafish screening: Anti-obese constituents hunting by combination with culture cells and mice experiments. Yasuhito Shimada^1,2,3, Liqing Zang^2,4, Hiroko Nakayama^2,4, Kanae Hata⁴, Izumi Matsuoka⁴, Youngil Kim⁵, Djong-Chi Chu⁵, Lekh Raj Juneja⁵, Norihiro Nishimura^2,4 ¹Dept. Int Pharm., Grad. Sch. Med., Mie Univ., ²Mie Univ. Zebrafish Drug Screen. Cen., ³Mie Univ. Adv. Sci. Res. Cen., Bioinfo., ⁴Grad. Sch. Reg. Innov., Mie Univ., ⁵Rohto Co., Ltd.

2-O-02910:3810:50 Systemic administration of EphrinB2 suppressed bone loss in ovariectomized mice through promoting osteoblast differentiation and inhibiting osteoclast differentiation Takahashi Tatsuo^1,2, Fumiha Abe¹, Kana Utsue¹, Kana Shinoda¹, Kyosuke Yamazaki¹, Sanako Yasuda¹, Yuri Ikeda-Matsuo¹, Masaaki Nomura³ ¹Dev. Pharmacol., Dept. Clin. Pham., Fac. Pharmac. Sci., Hokuriku Univ., ²Healthy Aging Res. Group, Hokuriku Univ., ³Dev. Pharmacother., Dept. Clin. Pham., Fac. Pharmac. Sci., Hokuriku Univ.

Oral Sessions

2-O-03510:5011:02 Impact of CYP2D6*10 on venlafaxine and its desmethylated metabolite pharmacokinetics in Japanese psychiatric patients Hazuki Komahashi-Sasaki¹, Takashi Watanabe¹, Yoshimasa Inoue¹, Taro Sasaki¹, Masataka Shinozaki¹, Yuki Hayashi¹, Kazuko Kato², Jinichi Kuroda³, Norio Furukori^1,4, Kazutaka Shimoda¹ ¹Dept. Psychiatry., Dokkyo Med Univ.,, ²Sakura La Mental Clinic.,, ³Tochigi Pref., Okamotodai Hosp.,, ⁴Dept. Neuropsychiatry., Hirosaki Univ Grad Sch. Med.,

2-O-03611:0211:14 A post-transplantation patient in whom a specific interval was required until the blood concentration of fluconazole reached a steady state Yasutaka Sakamoto^1,2, Hikaru Isono², Hirofumi Koike¹, Yuki Enoki², Kazuaki Taguchi², Maki Hagihara³, Kenji Matsumoto³, Hideaki Nakajima³, Yukiko Sahashi¹, Kazuaki Matsumoto² ¹Department of Pharmacy, Yokohama City University Hospital, ²Division of Pharmacodynamics, Keio University Faculty of Pharmacy, ³Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine

2-O-03711:1411:26 Pharmacokinetic analysis of enantiomers in Venlafaxine and O-desmethylvenlafaxine Taro Sasaki¹, Takisha Watanabe¹, Yoshimasa Inoue¹, Hazuki Komahashi-Sasaki¹, Masataka Shinozaki¹, Yuki Hayashi¹, Kazuko Kato³, Jinichi Kuroda², Norio Furukori¹, Kazutaka Shimoda¹ ¹Dept. Psychiatry., Dokkkyo Med Univ., ²Tochigi Pref. Okamotodai Hosp., ³Sakura La Mental Clinic

2-O-03811:2611:38 Simultaneous and real-time quantification of multiple drugs with a diamond electrode Seishiro Sawamura¹, Genki Ogata¹, Sayaka Kuwabara¹, Rito Kato¹, Kai Asai², Olga Razvina¹, Yasuaki Einaga², Hiroshi Hibino¹ ¹Dept Mol Physiol, Niigata Univ Sch Med, ²Dept of Chem, Fac of Sci and Tech, Keio Univ

2-O-03911:3811:50 Rasagiline Pharmacokinetics are affected by cytochrome P-450 1A2 genetic variants in different doses Rabiea Bilal¹, Naseem Saud², Sualeha Riffat³ ¹Dept. Pharm., CMH LMDC, NUMS, ²Dept. Pharm., UHS, ³Dept. Pharm., UVAS

YIA

2-YIA-3516:2016:32 The role of Prostaglandin D₂synthase in retinal angiogenesis Sekihachi Erika¹, Keisuke Omori¹, Koji Kobayashi¹, Nanae Nagata¹, Tatsuro Nakamura¹, Kaori Kurata², Akiyoshi Uemura², Takahisa Murata¹ ¹Department of Animal Radiology, The University of Tokyo, ²Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences

2-YIA-3616:3216:44 TRPC3-Nox2 complex formation mediates nutritional deficiency-induced cardiomyocyte atrophy Tomohiro Tanaka^1,4, Suhaini Binti Sudi^1,2,3, Sayaka Oda^1,2,5, Takuro Numaga-Tomita⁷, Kazuhiro Nishiyama⁶, Akiyuki Nishimura⁶, Caroline Sunggip³, Superchoke Mangmool⁸, Motohiro Nishida^1,2,4,5,6 ¹Nat. Ins. Physiol. Sci. (NIPS), Nat. Ins. Natural Sci. (NINS), ²EXCELLS, NINS, ³Univ. Malaysia Sabah (UMS), ⁴CNSI, NINS, ⁵SOKENDAI, ⁶Dept. Pharm., Grad. Sch. Kyushu Univ., ⁷Dept. Mol. Phar., Sch. Med., Shinshu Univ., ⁸Faculty of Pharm.,Mahidol Univ.

2-YIA-3716:4416:56 Heparan sulfate promotes the differentiation of muscle cells and contributes to maintain motor function in mice Mariko Yokoyama¹, Takeo Yoshikawa¹, Takuro Matsuzawa¹, Yu Yamaguchi², Kazuhiko Yanai¹ ¹Dept. Pharmacol., Grad. Sch. Med., Tohoku Univ., ²Sanford Burnham Prebys Medical Discovery Institute

2-YIA-3816:5617:08 Characteristics of PDGFRα positive mesenchymal stromal cells in various tissues Kurosawa Tamaki^1,2, Noriyuki Kaji³, Madoka Uezumi², Heying Zhou², Akiyoshi Uezumi², Masatoshi Hori¹ ¹Lab. of Veterinary Pharmacol., Dept. of Veterinary Med. Sci., Grad. Sch. of Agr. and Life Sci., Tokyo Univ., ²Muscle Aging and Regenerative Med., Tokyo Metropolitan Inst. of Gerontol., ³Lab. of Veterinary Pharmacol., Sch. of Veterinary Med., Azabu Univ.

2-YIA-3917:0817:20 Development of a novel functional assay to evaluate drug effects using human iPS cell-derived cardiomyocytes. Masahiko Yamaguchi, Momoka Nakagawa, Yusuke Sano, Kazuho Sakamoto, Junko Kurokawa Dept. Bio-Inform. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka

2-YIA-4017:2017:32 Characterization of anti-atrial fibrillatory effect of anti-influenza drug oseltamivir assessed by the persistent atrial fibrillation dog, halothane-anesthetized dog and patch-clamp study Ryuichi Kambayashi¹, Mihoko Hagiwara-Nagasawa¹, Ai Goto¹, Koki Chiba¹, Ryota Nishiyama², Satomi Oyama², Yoshio Nunoi¹, Hiroko Izumi-Nakaseko¹, Akio Matsumoto³, Atsushi Sugiyama^1,3 ¹Dept. Pharmacol., Faculty Med., Toho Univ., ²Drug Research Dept. TOA EIYO LTD., ³Dept. Aging Pharmacol., Faculty Med., Toho Univ.

Oral Sessions

2-O-06117:3517:47 Bacterial toxin, streptolysin O caused vascular endothelial dysfunction: Relationship between dysbiosis and hypertension Masashi Mukohda¹, Sho Nakamura², Kosuke Takeya³, Akira Matsuda⁴, Takanori Yano⁵, Risuke Mizuno¹, Hiroshi Ozaki¹ ¹Lab. of Vet. Pharm., Faculty of Vet. Med., Okayama Univ. of Science, ²Lab. of Animal Health, Faculty of Vet. Med., Okayama Univ. of Science, ³Lab. of Biochem., Faculty of Vet. Med., Okayama Univ. of Science, ⁴Lab. of Internal Med., Faculty of Vet. Med., Okayama Univ. of Science, ⁵Dept. Applied Microbio., Faculty of Science, Okayama Univ. of Science

2-O-06217:4717:59 Effects of chemerin-9 on contractility of isolated pulmonary artery from pulmonary artery hypertensive rat Ayaho Omori, Tomoko Kodama, Makoto Goshima, Chiharu Kakuda, Muneyoshi Okada, Hideyuki Yamawaki Lab. Vet Pharmacol., Sch. Vet. Med., Kitasato Univ.

2-O-06317:5918:11 Novel roles of histidine-rich glycoprotein in physiological placental development and in prevention of hypertensive disorders of pregnancy. Kiyoshi Teshigawara¹, Keyue Liu¹, Hidenori Wake¹, Dengli Wang¹, Shuji Mori², Hideo Takahashi³, Masahiro Nishibori¹ ¹Dept. of Pharm., Okayama Univ. Grad. Sch. of Med., Dent. and Pharm. Sci., ²Sch. of Pharm., Shujitsu Univ., ³Dept. of Pharm., Kinki Univ., Fac. of Med.

2-O-06418:1118:23 Effects of NADPH oxidase deletion in the stroke-prone spontaneously hypertensive rat Koichi Fujikawa, Yuki Hashizoe, Toru Nabika Dept. Funct. Pathol., Shimane Univ.

March 17 (Tue) Room F