The 93rd Annual Meeting of the Japanese Pharmacological Society

March 17 (Tue) Room G

Oral Sessions
2-O-0218:509:02
EP4 signaling facilitates mucosal repair after DSS-induced colitis by enhancement of lymphangiogenesis
Yoshiya Ito, Kanako Hosono, Ken Kojo, Masataka Majima
Department of Pharmacology, Kitasato University School of Medicine
2-O-0229:029:14
Functional analysis of mutant SLCO2A1 transporter responsible for human intractable small intestinal ulcer
Seki Satowa1, Gen Tanaka2, Tadakazu Hisamatsu1, Hiroyuki Sakurai2
1Dept. Gastroenterology. Hepatology., Kyorin Univ., 2Dept. Pharmacology. Toxicology., Kyorin Univ.
2-O-0239:149:26
The effects of TJ-14 (Hange-shashin-to), Japanese kampo medicines, on spontaneous electrical activity of circular smooth muscle cells in the mouse proximal colon
Yoshihiko Kito
Dept. Pharmacol., Fac. Med., Saga Univ.
2-O-0249:269:38
Role of NOX1 in intestinal barrier dysfunction
Junjie Liu1, Kazumi Iwata1, Misaki Matsumoto1, Kai Zhu2, Masato Tsutsui3, Chihiro Yabe1
1Department of Pharmacology, Kyoto Prefectural University of Medicine, 2Department of Nephrology, Renmin Hospital of Wuhan University,china, 3Department of Pharmacology, University of The Ryukyus
Oral Sessions
2-O-0309:459:57
Dysregulated ABCA1 increases risk for pathogenesis of normal tension glaucoma
Youichi Shinozaki1, Kazuhiko Namekata2, Takahiro Segawa3, Nobuhiko Ohno4,5, Takayuki Harada2, Kenji Kashiwagi6
1Dept. Neuropharm., Grad. Sch. Med., Univ. Yamanashi, 2Vis. Res. Project., Tokyo Metr. Inst. Med. Sci., 3Cent. Life Sci. Res., Univ. Yamanashi, 4Dev. Ultrastruct. Res., Natl. Inst. Physiol. Sci., 5Div. Anatomy, Jichi Med. Univ., 6Dept. Ophthalmol, Interdiscip. Grad. Sch. Med. Univ. Yamanashi
2-O-0319:5710:09
Visualization of Ca2+ release and filling mechanisms in the endoplasmic reticulum of astrocytes
Yohei Okubo1, Masamitsu Iino2, Kenzo Hirose1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2Div. Cell. Mol. Pharmacol., Nihon Univ. Sch. Med.
2-O-03210:0910:21
Dynamics of neuron-induced astrocyte tiling and self-avoidance
Mariko Hayashi1, Yuko Sekino2, Kaoru Sato3
1Med.Sch. Int.Univ.Health & Welfare, 2Grad.Sch.Pharm. Univ.Tokyo, 3Nat.Inst.Health Sci.
2-O-03310:2110:33
Histamine H1 receptor on neurons and astrocytes plays different roles in mouse behavior
Takeo Yoshikawa1, Aniko Karpati1, Fumito Naganuma1,2, Takuro Matsuzawa1, Kazuhiko Yanai1
1Dept Pharmacol. Tohoku Univ Grad Sch Med, 2Div. Pharmacol. Sch Med. TMPU
2-O-03410:3310:45
Molecular hydrogen as therapeutic medical gas for nervous disease
Yasushi Satoh1,2, Toshiaki Ishizuka2
1National Defence Medical College, Dept. Biochemistry, 2National Defence Medical College, Dept. Pharmacology
Oral Sessions
2-O-04010:5011:02
Sulfite protects neurons from oxidative stress
Yuka Kimura, Norihiro Shibuya, Hideo Kimura
Dept. Pharmacol., Sch. of Pharm., Sanyo-Onoda City Univ
2-O-04111:0211:14
C9-ALS/FTD-linked proline–arginine dipeptide repeat protein causes neuronal cell death by associating with paraspeckle components
Hiroaki Suzuki, Masaaki Matsuoka
Dept. Pharmacol., Sch. of Med., Tokyo Medical Univ.
2-O-04211:1411:26
The efficacy and safety of a laser thrombolytic system in an animal thrombosis model
Yuji Matsumoto1, Kazuya Hokamura1, Daisuke Yamashita2, Yoshiyuki Shimizu2, Youhei Takata2, Tsuyoshi Kosugi2, Yoshinori Tamaoki2, Toshiyuki Kawashima2, Yutaka Yamashita2, Hiroyuki Okada2, Teiji Nakayama3, Kazuo Umemura1
1Dep. Pharmacol., Hamamatsu Univ. Sch. Med., 2Hamamatsu Photonics K.K., 3Dep. Neurosurg., Hamamatsu Medical Center
2-O-04311:2611:38
Potential role of immediate early expression of G protein-coupled receptor 3 in mast cells after cerebral brain ischemia
Shigeru Tanaka1, Yuhki Hamakawa1, Yuhki Yanase2, Masahiro Yamamoto1, Hiroko Shiraki1, Kana Harada1, Izumi Hide1, Norio Sakai1
1Dept. Mol. & Pharm. Neurosci., Grad. Sch. Biomed. & Health. Sci., Hiroshima Univ., 2Dept. Derma., Grad. Sch. Biomed. & Health. Sci., Hiroshima Univ.
2-O-04411:3811:50
Neuroprotection against cerebral ischemic injury via VNUT-mediated pathway
Yuri Hirayama1,2, Ha Pham Ngoc Le2, Schuichi Koizumi2, Naohiko Anzai1
1Dept. Pharmacol., Grad. Sch. Med., Chiba Univ., 2Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med., Univ. Yamanashi
YIA
2-YIA-4116:2016:32
Effects of Goreisan on LPS-induced diarrhea and decrease in aquaporin 3 expression in intestinal epithelial cells.
Kazuhito Murakami, Shingo Matsuyama, Yoichiro Isohama
Lab. Appl. Pharmacol., Facul. of Pharm. Sci., Tokyo Univ. of Sci.
2-YIA-4216:3216:44
Progranulin deficiency on macrophages exacerbates choroidal neovascularization via inflammation
Kei Takahashi, Miruto Tanaka, Takahiro Sasaki, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
2-YIA-4316:4416:56
EP3 signaling in dendritic cells promotes liver repair after ischemia reperfusion injury in mice.
Nakamoto Shuji1, Yoshiya Ito1, Takuya Goto1, Nobuyuki Nishizawa2, Ken Kojo2, Yusuke Kumamoto2, Masataka Majima1
1Dept. Mol. Pharmacol., Grad. Sch. Med., Kitasato Univ., 2Dept. Surg., Med., Kitasato Univ.
2-YIA-4416:5617:08
Prostaglandin F2α receptor antagonist attenuated LPS-induced sepsis in mice.
Toko Maehara, Fumiyoshi Higashitarumi, Risa Kondo, Ko Fujimori
Dept. Pathobiochem., Osaka Univ. Pharmaceut. Sci.
2-YIA-4517:0817:20
Caveolin-1 regulates P2X7-mediated ATP signaling in pro-inflammatory macrophages.
Yuuki Sawai, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Oral Sessions
2-O-06517:2517:37
Fatty-acid-binding protein 3 is critical for α-Synuclein uptake and MPP+-induced mitochondrial dysfunction in dopaminergic neurons
Ichiro Kawahata1, Luc Bousset2, Ronald Melki2, Kohji Fukunaga1
1Dept. Pharm., Grad. Sch. Pharm. Sci., Tohoku Univ., 2Lab. Neuro. Dis., CEA, MIRcen & CNRS
2-O-06617:3717:49
The analysis for βCTF mediated vesicular traffic impairment in Alzheimer disease
Nobumasa Takasugi, Nanaka Kaneshiro, Masato Komai, Takashi Uehara
1. Dept. Medicinal Pharmacol ., Grad. Sch. Med. Den. Pharmaceutical Sci., Okayama
2-O-06717:4918:01
Functional analysis of Gpnmb gene in Alzheimer's disease model mice
Kohichi Kawahara, Natsuki Kumakura, Yukina Kojima, Takuya Hasegawa, Takehiko Maeda
Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.
2-O-06818:0118:13
CRMP2 dephosphorylation at S522 rather than hyperphosphorylation as an early-stage marker of Alzheimer's disease
Aderemi Caleb Aladeokin1, Tomoko Akiyama2, Ayuko Kimura2, Yayoi Kimura2, Hisashi Hirano2, Maho Morishima3, Shigeo Murayama3, Takaomi Saido4, Yoshio Goshima1
1Dept. of Molecular Pharmacology & Neurobiology, Yokohama City University, Yokohama, Japan, 2Advanced Medical Research Center, Yokohama City University, Yokohama, Japan, 3Lab. of Neuropathology, Tokyo Metropolitan Institute of Medical Sciences, Tokyo, Japan, 4RIKEN Center for Brain, Saitama, Japan
2-O-06918:1318:25
Identification of a polyglutamine protein aggregation inhibitor QAI1 and its therapeutic effects on polyglutamine neurodegenerative diseases.
Yoshitaka Nagai1,2,3, Eiko N. Minakawa3, H. Akiko Popiel3, Hiroshi Yamane3, Masayoshi Tada4, Toshiaki Takahashi4, Toshihide Takeuchi1,3, Hideki Mochizuki2, Tatsushi Toda5, Keiji Wada3, Osamu Onodera4
1Dept. Neurotherapeutics, Grad. Sch. Med., Osaka Univ., 2Dept. Neurology, Grad. Sch. Med., Osaka Univ., 3Dept. Degener Neurol Dis, Natl Ctr Neurology&Psychiatry, 4Dept. Neurology, Brain Res. Inst., Niigata Univ., 5Dept. Neurology, Grad. Sch. Med., Univ. Tokyo
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