Lewy body dementias (LBD) are classified into Parkinson's disease, Lewy body dementias, and pure autonomic failure according to the main lesion, and the lesions overlap in principle.
On the other hand, we have clarified that the olfactory bulb / amygdala subtype secondary to Alzheimer's disease is characterized by the absence of Lewy bodies in the peripheral autonomic nervous system. In addition, multiple system atrophy and LBD-accumulated α-synuclein are stained with Gallyas silver stains, the former being positive and the latter being negative, and it is said that they differ in RT-QUIC and transmission to experimental animals. In LBD, cortical Lewy bodies and brainstem Lewy bodies have morphological differences with or without cores, and differences due to RT-QUIC have been reported. However, the differences in our previous Western blot studies did not confirm the differences observed in prion disease. There has been no report on the difference in the mechanism of α-synuclein aggregation in the Lewy body of the peripheral and central nervous system between primary and secondary LBD, and this is a topic for the future.