The program of pharmacology role-play was started as a part of pharmacological Practice for 3rd-grade medical students at Kurume University in 2013. Pharmacology role-play is active learning program, in which medical students learn how medical doctors chose medicines to treat the presented cases and explain the medical treatment to patients. Students have the basis of pharmacotherapy after almost 1 year of pharmacology course, and this program becomes the first step of the education of clinical pharmacology. Pharmacology role-play was highly evaluated by students, as presented by other symposiasts. However, we realized that this program works well for students playing the role of doctor or patient, but that students without any roles behave like observers. To improve this issue, personal drug training was added to the program of pharmacology role-play in 2016. All the students, not only those playing the role of doctor, need to select therapeutic drugs for the presented cases based on the elements of personal drug (i.e. efficacy, safety, compatibility and cost). This process is required to make a report of personal drug, and facilitate the discussion at pharmacology role-play. Thus, the program of pharmacology role-play integrated with personal drug training seems useful to make all students participate in the activity and to improve motivation for learning clinical pharmacology. In this session, we will discuss the effectiveness of this integrated program.