The active learning of practical pharmacotherapy has been performed at 22 medical schools, 2 dental schools, one Pharmacy school and one Nursing school as a part of pharmacological education from 2010 to 2021. This active learning program is named Case & Communication based approach (C&C approach), since it is studied through communication between medical doctors / dentists / pharmacists / nurses and patients based on cases presented beforehand. The educational effectiveness was evaluated by a questionnaire survey. The highly effectiveness of role-play in pharmacology education was observed regarding all four topics: (a) understanding of medical treatment, (b) understanding patient's feelings, (c) improvement of awareness and motivation as a medical stuff and (d) positive influence upon study attitude. In addition, many students realized the importance of physician-patient communication, understanding of patient's feeling, and accurate and extensive knowledge of pharmacotherapy in their free description. This role-play program in pharmacology education may be effective for better understanding of pharmacotherapy, patient's feeling, and improvement of students' awareness and motivation as a medical stuff.