Backgrounds: Although there are reports of cystometry and water load models in rodents, there are few reports on the evaluation of micturition function in cynomolgus monkeys. This time, we evaluated the micturition function of a water load model using cynomolgus monkeys. As a positive control, desmopressin acetate used for nocturia was used.
Methods:Water loading was performed after administration of desmopressin acetate or vehicle, and micturition volume was continuously measured up to 6 hours after water loading. From the obtained measurement data, the total amount of urination volume, the number of urination, and the amount of urination volume once were calculated.
Conclusion and Discussion: In a water loading model of cynomolgus monkeys treated with desmopressin acetate, urine output decreased with increasing dose. As a result, it was suggested that the water load model using cynomolgus monkeys can evaluate the micturition function.