Parkinson‘s disease (PD) characteristically presents with multiple symptoms as well as distinctive motor impairments. Smell disorders, followed by mild cognitive impairment, frequently occur in the early stage of PD, and both are progressed as motor symptoms. To elucidate the mechanisms underlying these prodromal symptoms, the development of appropriate animal models is required. This study aimed to verify whether short-term intranasal administration of rotenone (Rot) causes these impairments in mice. Chemosensory/cognitive/motor function was assessed in 1-week Rot administrated-mice (1w-Rot) 1 week after finishing intranasal Rot administration. Motor function was also examined in 4-week Rot administrated-mice (4w-Rot) from 0 to 5 week after starting intranasal Rot administration. After behavioral test, the number of catecholamine neurons (CA-Nos) in the substantia nigra (SN) was examined. Intranasal Rot administration for 1 week simultaneously caused olfactory, taste, and taste memory impairments. Interestingly, motor deficits were induced from the third week after starting 4-week intranasal Rot administration. Despite no apparent change in SN CA-Nos of 1w-Rot, that of 4w-Rot was significantly reduced by 75% at the fifth week. These results suggest that 1w-Rot is useful as a mouse model for the early stage of PD.