Visualization (or “Understanding” or “Research into”) of physiological and pathological phenomena has taken a leap forward by recent advanced optical bio imaging technique. Traditionally, physiological phenomena including cell division, cell function, molecular transport and cell death were detected by biochemical methods. However, this information lacked high resolution spatial and temporal information. Using recent optical techniques, both spatial and temporal information can be integrated across the molecular, cellular and systems levels that allow us to further investigate the hierarchical interaction of brain systems that ultimately reveal the pathological mechanism. In this session, we will discuss the current and potential future state of the construction of bio-imaging center, and will further discuss by understanding hierarchical physiological system that leads to the creation of healthy society.