The extract from Indonesian ginger (Zingiber purpureum Rosc.; bangle) induces neurogenic and various neurotrophic effects like nerve growth factor. However, its effects on dementia such as Alzheimer‘s disease (AD) are still unknown. Since memory impairment in AD correlates with the expression of neurofibrillary tangles (NFTs), we synthesized trans-banglene (t-banglene), the active component of bangle, and investigated its effect on memory impairment using tauopathy mouse model. Five-month-old rTg4510 mice and age-matched control mice (tTA) were administered t-banglene (50 mg/kg, p.o.) or vehicle for 21 days, and assessed object recognition memory by using novel object recognition test. Vehicle-treated rTg4510 group showed lower exploratory ratio than vehicle-treated tTA group, whereas treatment with t-banglene recovered the exploratory ratio. Therefore, we demonstrated that t-banglene improve memory performance in tauopathy-associated memory impairment. It has been reported that bangle extracts elicit neurotrophic effects via activation of Wnt/β-catenin signaling. Dysfunction of Wnt/β-catenin signaling leads hyperphosphorylation of tau protein followed by deposition of NFTs. It is possible that t-banglene improves memory dysfunction in tauopathy due to decrement of NFT formation following enhancement of Wnt/β-catenin signaling.