[Background and Purpose] We have reported that myocardial ischemia was observed by anaphylaxis (The 94th Annual Meeting of the Pharmacological Society). In this study, we examined the effect of Suramin, an antagonist of both P2X and P2Y2 receptors, on electrocardiogram ST-segment elevation and hemodynamics during anaphylaxis induction.
[Method] Rats received Suramin 100 or 300 micro-M or physiological saline as a control 30 minutes prior to the induction of anaphylaxis following administration of compound 48/80 (C48/80). Blood pressure and electrocardiography recording were started before Suramin administration and continued until 30 minutes after anaphylaxis induction and assessment.
[Results] ST-segment elevation was observed after C48/80 administration, which was significantly suppressed by each dose of Suramin pretreatment. After induction of anaphylaxis, heart rate, systolic and diastolic blood pressure, and rate pressure product (RPP) decreased which was significantly suppressed by pretreatment with 300 micro-M of Suramin.
[Consideration] These results suggest that pretreatment with Suramin may partially improve the hemodynamic deterioration due to anaphylaxis.