Glycation stress is a concept of biological stress caused by excess sugars, aldehyde and its subsequent reactions in the body. Especially, it is thought that accumulation of Advanced Glycation End products (AGEs) cause skin yellowing, deep wrinkles and a decrease in skin elasticity due to crosslinking to collagen or elastin in the dermis.
We have reported that phlorotannins, polyphenols unique to brown algae, could inhibit the formation of N-ε-carboxymethyllysine resulting from glycation of collagen.
The aim of this study was to investigate the anti-glycation and skin protection effects against UV exposure by long-term intake of the brown algae extract powder containing phlorotannins as a supplement.
This study have performed a randomized, double-blind, placebo-controlled, parallel group study.
Forty-two healthy Japanese adult female were randomly divided into two groups: one group consuming supplements containing brown algae extract powder (Phlorotannins intake group) and the other group consuming supplements not containing brown algae extract powder (placebo group). In both groups, each supplement was consumed daily, and blood AGEs concentration and Minimal Erythema Dose were measured every 4 weeks. In addition, the condition of skin was analyzed by using the skin image analyzer.
In this presentation, we will introduce the skin protection effect against UV exposure and the anti-glycation effects by consuming the brown algae extract powder for eight weeks.