Due to the coronavirus pandemic situation, the pharmacological role-playing was conducted by online in 2020 and 2021. We reported consideration of pros and cons of the online pharmacology role-playing from results of a two-year student questionnaire survey. Two hundred twenty five 3rd-grade medical students joined the role-playing at Dokkyo Medical University. Twenty-four students were assigned as physicians or patients and played the informed consent in two cases; hypertension accompanying diabetes and dementia with polypharmacy. The remaining students were observers. All students answered the questionnaire with a score of one to five, regarding the usefulness of study on disease and pharmacotherapy, understanding the patients‘ feeling, improvement of motivation to become a doctor, and change of attitude to studying. The percentage of students who scored five or four was 63 to 83% for the players and 71 to 80% for the observers. The frequent answers regarding necessary points of the study were “quality of the study” and “communication ability” and “perspective from the patients” for the players, and “communication ability”, “quality of the study” and “perspective from the patients” for the observers in order of frequency. Most students described positive impression in the free entry field that was considered as pons. A description of the difficulty of adjusting the online settings was considered as cons. Online pharmacological role-playing may be a useful approach for the medical students to learn the pharmacotherapy and doctor-patient relationship.