The management of intravenous therapy is an important task for nurses. Extravasation of drugs is an adverse event of infusion therapy that can occur with a variety of drugs. The frequency of extravasation of anticancer drugs ranges from 0.01% to 6.5% in Europe and the United States and from 0.14% to 10.8% in Japan. Although the frequency has decreased over the years, extravasation of anticancer drugs classified as vesicants, can cause necrosis and other skin injuries, thereby increasing the patient's suffering. To treat extravasation, a nurse can administer cold or hot compresses. Cooling is used to localize the drug, and heating is used to promote drug absorption. Hot compresses are recommended for some drugs. However, in an experimental study on laboratory animals, we found that heating may exacerbate skin disorders. Meanwhile, cooling may reduce (or not exacerbate) skin injuries. Therefore, we continue investigating the effective cooling temperature and duration against skin injury caused by extravasation, with the aim of establishing the safety of compresses and providing care that brings comfort to patients. In this presentation, we would like to share the results of our study on skin injuries caused by extravasation.