Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, and has become a pandemic since March 2020. Morbidity and mortality vary between populations. For instance, African Americans in the U.S. are disproportionately affected by COVID-19 and show higher mortality compared to the other race and ethnic groups. However, it is not clarified whether the difference in genetic susceptibility to SARS-CoV-2 infection may exist or not. We surveyed publicly available database of genomic variants across populations (Latino, European, East Asian, South Asian etc. including Japanese) to find allelic variation across populations in the genes involved in viral entry to the host cells such as ACE2, TMPRSS2 and CTSB/L, and sensing molecules of viral genomic RNAs such as TLR3/7/8. Overall, amino acid residues that are critical for host-viral interaction and sensing of viral genome are highly conserved across populations. Genetic determinant for the binding affinity between SARS-CoV-2 and ACE2 does not show significant difference between populations. Therefore, SARS-CoV-2 uses highly conserved molecules as its virion interaction, whereas its immune response appears to be genetically biased in individuals to some extent.