Effect of an antirheumatic gold compound, Auranofin (AF), have been revealed.  1-10 µM of AF inhibited prostaglandin E₂ (PGE₂) production and nitric oxide (NO) production in macrophages treated with some stimulatory compounds.  We found that AF reduced cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) mRNA levels, but not affected their enzyme activities.  We then revealed that AF partly inhibited the nuclear-translocation of NF-κB while PGE₂ production was almost completely inhibited.
  In the review on manuscripts, AF is reported to down-regulate the mRNA levels of SLC47A1, SLC22A1, ATP1A3, ABCG2, SLCO1B1, PIK3CA, and up-regulate the mRNA levels of ABCC3, ABCB1, SLC22A3, ABCC2, SLC31A2, CLTD, CLTB.  PGs are known to be transported by 4 transporters, OATP-PG (SLC22A22), SLC21A2 (OATP2A1, SLCO2), SLC21A11 (OATP3A1), and ABCC4, though I could not identify whether AF reduced PGE₂ concentration in cellular cultured medium as described above via these transporters by downregulation for export of PGE₂.