Backgrounds: Although steroid treatment is very effective, many serious side effects have also been reported, including induction / exacerbation of infections, adrenal dysfunction, and hyperlipidemia. The purpose of this study was to investigate the effects of oyster extract on the toxicity and pharmacological actions of steroids.
Methods: (Toxicity) Rats were orally administered oyster extract for 28 days, and steroids were subcutaneously administered for 14 days from the 14th day to the 28th day of oyster extract administration. Rats were sacrificed on the 28th day of administration, hematology and blood biochemistry and tissue weight measurements were performed.
(Pharmacology) Rats were orally administered oyster extract for 14 days, and steroids were subcutaneously administered 30 minutes after the administration on the 14th day. Thirty minutes later, 0.1 mL of 1% carrageenin saline was subcutaneously administered to the right hind limb footpad, and the volume of the right hind limb footpad was measured 3, 4, and 5 hours after the administration of carrageenan.
Conclusion and Discussion: It was suggested that oyster extract suppresses the decrease of corticosterone caused by steroids. In addition, it has not inhibited the anti-inflammatory effect on steroids, so it may be effective in reducing side effects.