[Introduction] Subarachnoid hemorrhage (SAH) is a life-threatening type of stroke and can be frequently caused by a ruptured aneurysm of cerebrovascular blood vessels. Although one-third of patients could survive with good recovery; one-third will survive with a disability, and one-third will die. It is well accepted that lowering blood cholesterol levels is mandatory in the prevention of cerebral circulatory disorder. However, the relationship between cholesterol and the cerebral aneurysm is still controversial. In this study, we elucidate the above relationship by monitoring aneurysm and SAH in aneurysm model of LDL receptor/ Apobec 1 double knock out (LA^-/-) mice and that of control mice.
[Method] Hashimoto model of animal cerebral aneurysms was performed.
Briefly, the left kidney was excised one week before the experiment. Elastase was administered to the subarachnoid space to damage the cerebral artery and sustained-release deoxycorticosterone was placed subcutaneously. Drinking water was substituted with 1 % salt solution.
[Results] 1) lesser amount of cerebral aneurysm and SAH were detected in the aneurysm model of LA^-/- mice compared to control mice. 2) The collagen layer of the cerebral vessels was sturdier in LA^-/- mice than control mice.
[Conclusion] In this study, we identified the relationship between cholesterol level and subarachnoid hemorrhage. As the next step, whether blood cholesterol is directly related to rupture cerebral artery or influences through enhancement of the coagulation system, is still needed to clarify further.