Sudachi (Citrus sudachi) is a small sour citrus. It grows exclusively in Tokushima region of Shikoku island, but is a typical seasoning for Japanese fish cuisine. We have demonstrated that repetitive administration of crude sudachi peel extends life span in diabetic model rats, and successfully identified a couple of molecules and fractions which are beneficial for our health in terms of energy metabolism from peels of sudachi. A limonene-derivative, which turned out to facilitate expression of a longevity gene, sirt1, exhibited lipid-lowering effects in HFD-fed mice as well as in cultured cells, for instance. Our recent results on the metabolic effects of such components in sudachi peel will be shared in the current symposium.

To: 要旨(抄録)