Systemic sclerosis (SSc) is an autoimmune disorder characterized by progressive fibrosis in the connective tissue in multiple organs. In severe case, SSc might cause life-threatening complications. However, the current treatment methods for SSc are only conservative and more effective drugs are waited. The murine sclerosis model induced by repeated administration of BLM is known as one of the models which develops SSc-like dermal fibrosis. The aim of this study is to confirm the pathologic state of the BLM induced scleroderma model in BALB/c mice and evaluate the effectiveness of immunosuppressive agents on this model. We measured the hydroxyproline (HYP) content of the skin and conducted histopathologic examinations. The HYP content of the skin and the thickness of the dermal connective tissue increased in BLM treated groups compared to the vehicle treated group. It indicates the repeated administration of BLM induce dermal fibrosis. Effects of the immunosuppressive agents were evaluated on this model. The results indicate usefulness of the BLM induced sclerosis model in evaluating the effect of therapeutic agents, which leads to treatment of SSc, for dermal fibrosis.

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