Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a calmodulin-dependent protein kinase regulating protein translation through phosphorylation of eEF2. We previously demonstrated that eEF2K mediates development of systemic hypertension. We recently revealed that A484954, a selective eEF2K inhibitor induces vasorelaxation through activating smooth muscle inward rectifier K+ (Kir) channel in rat isolated mesenteric artery. Here we further explored acute effects of A484954 on blood pressure (BP). BP was measured by a carotid cannulation method in rats. A484954 potentiated isoproterenol-induced decrease of diastolic BP. A484954 potentiated adrenaline-induced decrease of diastolic BP. In summary, we for the first time demonstrated that A484954 augments isoproterenol- and adrenaline-induced BP decrease perhaps through the activation of beta-2 receptor-Kir channel.

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