【Background】
Recently, even dogs have developed an aging society. It is recognized that oxidative stress is relative to aging and disease. Many traditional Chinese medicines have been said that they had anti-oxidantive effect. But, there are no repot that these medicines have anti-oxidative effect in dogs. In this study, therefore, I examined anti-oxidative effect of Juzen-taiho-to, one of the traditional Chinese medicines, in dogs.
【Material and Method】
Five healthy female beagle dogs (38-41months of age and weighing 8.6-10.7 kg) were orally administered Juzen-taiho-to at 450 mg/kg with food for 28 days. Blood samples were taken from five dogs at day0, 7, 14, 21 and 28. Using the blood samples, anti-oxidant level, oxidative stress level and blood fluidity were determined.
【Results / Discussion】
Although improvement tendency was seen in anti-oxidant level and blood fluidity, the significant difference was not observed. But oxidative stress level at day 14, 21, and 28 was significantly lower than day 0. So, Juzen-taiho-to may have anti-oxidative effect in dogs by reducing oxidative stress. In addition, because traditional Chinese medicine is habitually administered for long term, further effects may be expected by administering Juzen-taiho-to in dogs for longer term.