It is my greatest honor to receive the 12th Setsuro Ebashi Award of the Japanese Pharmacological Society. By establishing an original intravital multiphoton microscopy, I have been studying on ‘real' cellular dynamics with immune and inflammatory systems in intact tissues and organs. Especially I have first succeeded in visualizing in vivo behaviors of different cell types in bones, such as osteoclasts, which led to significant conceptual advances on dynamic bone/immune systems. This research activity with dynamic imaging technology is not only contributing to development of basic biological science in general, but also serving as a novel way for analyzing in vivo pharmacological actions of different emerging drugs. In this lecture I will outline my research so far as well as present my current trial for launching ‘immunopharmacology in Japan to the world', based on our original research trend.