E. grandiflorum have a relatively weak inhibitor of PDE5 in comparison to substances like sildenafil (viagra).  Furthermore, because of its estrogenic action and vasodilating action, it has been used as a therapeutic agent for vascular dementia. However, studies on the efficacy of E. grandiflorum as a drug for treating dementia are scare. In this study, we investigated the effects of oral administrations of E.grandiflorum on the function of CNS and blood glucose level in adult male rats with hyperglycemia. We used a battery of behavioral tests including the Morris water maze test, an open-field test and the elevated plus-maze test. Rats were given normal food and water or high fat diet and 20% sucrose solution for 2 month, and they were put in a hyperglycemic state. After that, rats were orally administered with saline or E.grandiflorum extract (0.15 or 0.58 mg/kg/day) for 1 month from the beginning of 1 month after feeding high fat diet etc. It was shown that the extract of E.grandiflorum does not affect spatial learning memory, locomotor activity, emotionality and blood glucose level of hyperglycemic rats. It may need a higher amount of the E.grandiflorum extract to act as an anti-dementia drug.